Download or read book Horizons in Cancer Research Volume 54 written by Hiroto S. Watanabe and published by Nova Science Publishers. This book was released on 2014-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Horizons in Cancer Research' presents original research results on the leading edge of cancer research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by Nova Science Publishers. This book was released on 2011 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Horizons in Cancer Research Volume 87 written by Hiroto S. Watanabe and published by . This book was released on 2024-07-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Horizons in Cancer Research Volume 85 written by Hiroto S. Watanabe and published by . This book was released on 2023-04-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest developments in cancer research.
Download or read book Horizons in Cancer Research Volume 78 written by Hiroto S. Watanabe and published by . This book was released on 2020-11-04 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compilation begins by discussing the common pediatric brain tumors, their key oncogenic drivers and signaling pathways. An update on the clinical trials against druggable targets is also provided.An outline of the metabolizing pathways in cancer and the mode of action of aerobic glycolysis in cancer cells is presented, also highlighting the roles of nanotechnology in energy-based cancer therapies.The authors review recent studies that characterize the specific mechanisms involved in mediating -tocotrienol reversal of epithelial-to mesenchymal transition in malignant breast cancer cells.The cytotoxic effects of Mannich bases derived from kojic acid on A375 human malignant melanoma are discussed and MRC-5 human lung cell lines are investigated using a sulphorhodamine B assay.Additionally, the cytotoxic effects and mechanisms displayed by metformin are assessed, alone or in combination with other agents. A better understanding of metformin-induced metabolic changes could aid in the discovery of new drugs, enhancing the efficacy of current melanoma therapeutics.In closing, the authors explore the way in which physical activity and exercise are negatively correlated to most type of cancers, as exercise shares common underlying metabolic pathways with those of some bioactive food compounds, such as polyphenols.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by . This book was released on 2014-01-01 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents original results on the leading edge of cancer research. Topics discussed include the risk factors, diagnosis and treatment options for glioblastoma; the biology of the interleukin-2 (il-2)-based immunotherapies in cancer and autoimmune disease; rna interference (rnai)/rna activation (rnaa) for cancer therapeutics; melanoma progression to metastatic disease; proteins, polysaccharide-peptide complexes and polysaccharides with antiproliferative and anticancer activities of mushrooms; low-molecular-weight compounds with anticancer activity of mushroom origin; lifestyle and cancer prevention; and the pathology and pathogenesis of Hodgkin's lymphoma.
Download or read book Horizons in Cancer Research Volume 73 written by Hiroto S. Watanabe and published by . This book was released on 2019-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Horizons in Cancer Research. Volume 73, after the identification of some small subgroups with a strong biological-molecular identity, the current evidence regarding the prognostic factors of patients with non-eradicable metastatic disease are examined. The goal is to discuss disease subgroups, which may sometimes provide conditions for decisions that are less compliant with current clinical practice and help define new stratification criteria for patients enrolled in prospective studies.Following this, the authors summarize the current knowledge on breast cancer with an introduction on the traditional markers used in the diagnosis of this disease, followed by an account of the emerging markers.Next, the underlying mechanisms of DNA replication, damage and repair are discussed. Further, RAD51 is proposed as a potential means of managing chemoresistant cancers. Certain drugs and strategies can sensitize chemotherapy via impacting on RAD51, which can be developed as chemotherapy modulators. The authors also discuss multiple myeloma, an incurable malignant tumor of plasma cells of the bone marrow, which is the most common primary neoplasm arising in bone. It causes approximately 1% of cancer-related deaths and is the 2nd most common hematological malignancy in the western world.Later, this collection discusses the prevalence and types of infectious complications that patients with multiple myeloma face, as well as present and emerging therapeutic approaches.The concluding study indicates proteins that have a promising future as new anticancer drugs, in conjunction with the in vitro and/or in vivo effects of these bioactive proteins derived from plants.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by . This book was released on 2020-03-28 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opening chapter of this compilation extensively reviews scientific literature analyzing new molecular targets, ongoing research and future perspectives in the management of gastroenteropancreatic neuroendocrine neoplasms, a rare group of pathologically and clinically heterogeneous tumors. The significance of PI3K pathway components in lung cancer progression are highlighted, as well as possible therapeutic targets that can be explored in an effort to control the disease. Following this, the authors assess the contributions of flavin-containing monooxygenases 3 along with cytochrome P450 enzymes in Bu metabolic pathways, and analyze their effects on Bu kinetics. The role of the pro-tumorigenic cytokines and the significance of dysregulated notch signaling in the progression of colonic inflammation and carcinogenic transformation is also discussed. The current concepts of nutritional oncology in head and neck cancer patients are revised through a systematic literature search. Significant malnutrition has been reported due to several factors, such as a reduced dietary intake due to dysphagia and odynophagia, or catabolic factors secreted by the head and neck tumors. Lastly, an overview of cervical cancer screening around the world is provided. In the United States, a combination of HPV-testing and cytology method, the HPV-test-alone, and cytology-alone are widely performed.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by . This book was released on 2021-07-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume presents seven chapters detailing recent progress in the field of cancer research. Chapter One explores the application of robotic surgery to radical cystectomy, highlighting patient selection, surgical approach, perioperative and oncologic outcomes as well as some areas of controversy in the literature. Chapter Two describes the principles of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedures with its potential risks for patients and staff. Chapter Three discusses findings related to ISG15 and protein ISGylation, and their association with interferon signaling in cancer. Chapter Four describes the potential for MCF-7 cells to curb or counteract breast cancer. Chapter Five discusses the potential of emerging technologies in breast conserving treatment. Chapter Six reviews the current literature surrounding the basis of employing the immune system for the treatment of the various non-melanoma skin cancers (NMSC), discusses approved immunotherapies for each type of NMSC as well as indications for use, and synthesizes ongoing investigational studies of immunomodulatory agents for these diseases. Finally, Chapter Seven discusses the use of gene therapy in management of squamous cell carcinoma.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by Nova Science Publishers. This book was released on 2016-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents original results on the leading edge of cancer research. Chapter One summarizes what is currently known regarding the epigenetic regulation of osteosarcoma pathways and oncogenes, as well as clinical trials of drugs that exert epigenetic regulation. Chapter Two critically discusses the role of ECM-dependent signaling in osteosarcoma progression. Chapter Three illustrates the harmful effects of ultraviolet radiation exposure by focusing on photocarcinogenesis. Chapter Four examines the psychology of sunscreen use and outlines the key psychological factors associated with sunscreen use. Chapter Five reviews the cellular and molecular mechanism of Regulatory T cells (Tregs) and Transforming Growth Factor-β mediating cervical cancer development. Chapter Six examines the affect of the American cranberry extract on expression of insulin-like growth factor-I and insulin-like growth factor binding proteins in human prostate cancer cells in vitro. Chapter Seven discusses the design of synthetic peptides to specifically interfere the papillomavirus binding factor/14-3-3beta binding to restore papillomavirus binding factor apoptotic functions. Chapter Eight examines brain development using correlations between Diffusion Kurtosis and neurite orientation dispersion and density imaging (NODDI) in neonates and young children. Chapter Nine highlights the opportunities that are available to prevent the late effects related to stress and fears, emphasizing the importance of teaching patients resiliency and how to cope.
Download or read book Horizons in Cancer Research Volume 75 written by Hiroto S. Watanabe and published by . This book was released on 2020-08-11 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Horizons in Cancer Research. Volume 75 analyses the strategic actions taken by the UK in the fight against cancer, reviewing the key investments and funding made available in the country.Following this, the authors discuss how efficient targeting of thioredoxin with compounds and proper knowledge of their mechanism of action may be an efficacious therapeutic intervention for cancer.This compilation goes on to xplore the otologic complications secondary to radiotherapy for nasopharyngeal cancer cases to provide a clinical perspective on this issue.An extensive review of the published studies about metastatic colorectal cancer kinetics and changes of growth curves under the pressure of pharmacological treatments is presented, and variables related to tumor cell kinetics derived from radiologic evaluations are discussed.The authors propose a new post treatment cancer care involving the systemic administration of nanomolar concentrations of drag-reducing polymers that aims to avoid metastasis following cancer surgery.A study is carried out to compare the molecular mechanism of cytochrome P450 enzyme family members on breast cancer, as well as to compare the distinct biological processes with each other.This compilation closes with a guide for researchers concerning preserving the heterogeneity of breast cancer cell lines in terms of either isolation, selection or culture method models in order to understand the limitations of various methods.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by Nova Science Publishers. This book was released on 2016-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents original results on the leading edge of cancer research. Chapter One reviews the most recent advances in the management, analyses the best possible treatment in each scenario, and discusses the future research direction on brain metastases from non-small cell lung cancer. Chapter Two discusses the positive effects of microscopic complete resection on controlling the local recurrence of a single brain metastasis. Chapter Three encapsulates the trends of the computer-aided diagnosis (CAD) development for the estimation of tumor malignancy. Chapter Four examines dendritic cells cross talk with cytomegalovirus pp65-specific cytotoxic T cells, Vγ 9γ δ T cells, and invariant NKT cells in patients with glioblastoma multiforme. Chapter Five addresses CD8+ T cell activation and regulation in the skin, paying special attention to what it is known about CD8+ T cell activity and its link with SCC development. Chapter Six discusses knowledge of the molecular basis of anti-cancer drug resistance and the mechanisms through which triterpenoids modulate ABC transporter-mediated multi drug resistance. Chapter Seven reviews cancer and heparan sulfate alterations. Chapter Eight focuses on Ganoderma lucidum targeting apoptosis. Chapter Nine examines the integrated model of cAMP-dependent DNA expression which reveals an inverse relationship between cancer and neurodegeneration. Chapter Ten studies the prognosis of male breast cancer.
Download or read book Horizons in Cancer Research Volume 82 written by Hiroto S. Watanabe and published by . This book was released on 2021-12-31 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents some of the latest research surrounding cancer. Chapter One provides a background on the importance of magnesium homeostasis, reviews the pre-clinical and clinical studies using magnesium therapy for cisplatin-induced acute kidney injury, and proposes future investigations to improve the translatability of these results to cancer treatment. Chapter Two discusses various liquid biomarkers of ovarian cancer such as exosomes, cell free DNA, miRNAs, circulating tumor cells, secretory proteins and autoantibodies and their subsequent detection via various nanobiosensors. Chapter Three explores the potential of mouse xenograft models for elucidating resistance mechanisms to cancer therapeutics. Chapter Four summarizes melatonin's beneficial effects in ovarian follicular cells and oocytes, followed by a comprehensive description of melatonin as an alternative treatment for ovarian cancer. Chapter Five deals with the gene signatures potentially implicated in the development of endometrial cancer. Lastly, Chapter Six updates current understanding of the role of glucocorticoid receptor-mediated actions in triple-negative breast cancer.
Download or read book Horizons in Cancer Research written by Hiroto S. Watanabe and published by . This book was released on 2016 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer A Comprehensive Review written by Gülçin GACAR and published by Akademisyen Kitabevi. This book was released on 2020-06-11 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Topics in Anti Cancer Research Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2021-12-13 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. The topics covered in this volume are: - Peptides can play a major role in combating cancer diseases - Studying of the CLL after treatment using fractal parameter of neoplastic lymphocytes detection (ΛNLD) - Mechanistic insight of rhenium-based compounds as anti- cancer agents - Targeting cancer-specific inflammatory components in cancer therapeutics - Marine natural products as a source of novel anticancer agents: a treasure from the ocean - PDX clinical trial design in anti-cancer research
