Download or read book Homocysteine Metabolism in Health and Disease written by Govind Prasad Dubey and published by Springer Nature. This book was released on 2022-05-12 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.
Download or read book Homocysteine in Health and Disease written by Ralph Carmel and published by Cambridge University Press. This book was released on 2001-07-19 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.
Download or read book Focus on Homocysteine and the Vitamins written by Christina Bolander-Gouaille and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Download or read book Homocysteine Metabolism From Basic Science to Clinical Medicine written by Ian Graham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Download or read book Homocysteine in Vascular Disease written by Lars Brattström and published by . This book was released on 1989 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Homocysteine in Protein Structure Function and Human Disease written by Hieronim Jakubowski and published by Springer Science & Business Media. This book was released on 2013-06-20 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
Download or read book Homocysteine and Vascular Disease written by K. Robinson and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.
Download or read book Focus on Homocysteine written by Christine Bolander-Gouaille and published by Springer. This book was released on 2013-03-09 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 8-10 years the research on homocysteine has become very active. Hundreds of articles are now published each year. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalized by treatment with folate and/or vitamines B 12 and B 6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialized journals. The author has realized the difficulties for the practitioner in keeping updated.
Download or read book Inborn Errors of Metabolism written by Brendan Lee and published by Oxford Monographs on Medical G. This book was released on 2014-10-13 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is an expansion on the known treatment model of IEMs, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this book includes coverage of newborn screening and an overarching treatment of IEMs as complex diseases.
Download or read book Homocysteine written by Kilmer S. McCully and published by . This book was released on 2014 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the aftermath of the discovery of the essential amino acid methionine in 1922, a new sulfur amino acid was discovered a decade later by Vincent DuVigneaud as a product of the degradation of methionine. This new amino acid, homocysteine, was found to be an important intermediate compound in the metabolism of methionine, cysteine and other sulfur amino acids through studies in animals. Although methylation reactions and one carbon metabolism were found to be related to the metabolism of homocysteine, little was known of the biomedical significance of this obscure sulfur amino acid in the 1950s. The studies of children with mental retardation, dislocated optic lenses, osteoporosis and other skeletal abnormalities, and a propensity for arterial and venous thrombosis, revealed the new inherited disease homocystinuria in 1962. A new concept of the importance of homocysteine in human disease was developed after the chance observation of rapidly advancing arteriosclerosis in children with different inherited enzymatic abnormalities of homocysteine metabolism by Kilmer McCully in 1969. This concept led to the development of the Homocysteine Theory of Arteriosclerosis, which stimulated an extraordinary effort to understand the importance of homocysteine in human disease by investigators in laboratories and clinics worldwide. As a result of over 17,500 published investigations in subsequent years, the obscure sulfur amino acid homocysteine was elevated to the status of "the cholesterol of the 21st century" because of its prominent involvement in human vascular disease. Extensive human studies identified the elevation of plasma homocysteine as a potent, independent risk factor for vascular disease, including coronary heart disease, cerebrovascular disease, and peripheral vascular disease. Many other important human diseases were subsequently found to be affected by homocysteine, as described by the authors of several chapters in the present book. These diseases, many of which are correlated with aging, include neurodegenerative diseases and dementia, epilepsy, uremia, osteoporotic fractures, anemia of renal failure, infection by HIV+, glaucoma, macular degeneration, bariatric surgery for obesity, celiac disease and psoriasis.
Download or read book Homocysteine written by Christina Bolander-Gouaille and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 15 years the research on homocysteine and the vitamins involved in its metabolism has become very dynamic. About 1,500 publications on the subject are now published each year. The research has long mainly focused on the association between homocysteine and cardiovascular disease, but also pregnancy complications/ fetal malformations. There is, however, an increasing interest in the connection between the homocysteine metabolism and neuropsychiatric disease with a steeply increasing number of publications. In particular, the association between homocysteine metabolism and cognitive decline/dementia attracts much interest. If simple, non-toxic homocysteine-lowering treatment with vitamins can reduce the incidence of, or delay the onset of dementia, it would have an enormous impact in societies with a rapidly increasing number of elderly at risk for dementia. This book summarises the research within the neuropsychiatric field, but also gives an overview of the underlying biochemistry and of diagnostic aspects. About 1,000 references are given. Christina Bolander-Gouaille, a pharmacist, has for over 10 years specialised in writing reviews/monographs on homocysteine and related vitamins. This is her third book in a series edited by Springer Verlag. This book, however, is written in collaboration with Teodoro Bottiglieri, who is director of neuropharmacology and senior research scientist at Baylor University, Institute for Metabolic Diseases in Dallas, USA.
Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.
Download or read book Homocysteine and Vascular Disease written by K. Robinson and published by Springer. This book was released on 2010-12-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.
Download or read book Glutathione and Sulfur Amino Acids in Human Health and Disease written by Roberta Masella and published by John Wiley & Sons. This book was released on 2009-08-06 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex roles of glutathione and sulfur amino acids in human health Glutathione (γ-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids. The twenty-two chapters explore such topics as: Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses Biological activities of GSH and sulfur amino acids and their role in modulating cell processes Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models. With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.
Download or read book Focus on Homocysteine written by Christina Bolander-Gouaille and published by . This book was released on 2014-01-15 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pioneer of the Homocysteine Theory written by Kilmer Serjus McCully and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This personal scientific memoir describes how a chance observation concerning artery disease in children with rare inherited abnormalities of metabolism, often called experiments of Nature, led to the discovery of a new theory of heart disease, cancer and diseases of ageing. As explained in subsequent chapters, this new theory places the amino acid homocysteine at the heart of altered metabolism of diseases of ageing. Not only does this theory illuminate and explain the origin of these diseases, development of this theory logically leads to a novel and revolutionary metabolic and nutritional program for disease prevention and treatment, potentially benefiting individuals and populations.
Download or read book Amino Acids in Nutrition and Health written by Guoyao Wu and published by Springer Nature. This book was released on 2021-03-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino acids (AAs) are not only building blocks of protein, but are also signalling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health and well-being of individuals. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
