Download or read book HLA and Disease Associations written by J.L. Tiwari and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.
Download or read book Oeil et Maladies syst miques written by SÈVE Pascal, KODJIKIAN Laurent and published by Lavoisier. This book was released on 2013-11-25 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les maladies systémiques regroupent un cadre hétérogène de maladies (connectivites, vascularites, granulomatoses…) dont la pathogénie est caractérisée par une atteinte de plusieurs organes. Bien qu’il s’agisse pour la plupart de maladies orphelines, ces pathologies sont susceptibles d’intéresser tous les médecins du fait de leur polymorphisme clinique. L’atteinte ophtalmologique est fréquente dans bon nombre de ces maladies, principalement en rapport avec une atteinte inflammatoire ou vasculaire. Elle constitue souvent une clé pour le diagnostic et peut mettre en jeu le pronostic fonctionnel en raison du risque de cécité. La sémiologie oculaire des maladies systémiques et les moyens d’explorations ophtalmologiques sont souvent mal connus des internistes ou des spécialistes d’organes. Inversement, les maladies systémiques sont l’objet de nombreuses interrogations de la part des ophtalmologistes. De ce constat est né Œil et Maladies systémiques qui présente, en 50 chapitres : • les principaux syndromes ophtalmologiques et les moyens d’explorations, destinés principalement aux non-ophtalmologistes • l’expression ophtalmologique des maladies systémiques (connectivites et vascularites, certaines maladies infectieuses et autres affections multiviscérales) ainsi que les aspects diagnostiques, pronostiques et thérapeutiques. Le professeur Pascal Sève, interniste, et le professeur Laurent Kodjikian, ophtalmologiste, tous deux rattachés à hôpital de la Croix-Rousse à Lyon, ont coordonné l’ouvrage dont les rédacteurs sont issus des diverses spécialités concernées : ophtalmologistes et internistes bien sûr, mais également spécialistes d’organes tels que dermatologues, néphrologues, neurologues, etc., tous référents reconnus dans leur domaine d’expertise. Ce livre apporte des réponses utiles et précises aux praticiens confrontés aux atteintes ophtalmologiques des maladies systémiques. Il intéressera donc les ophtalmologistes, internistes, rhumatologues, neurologues, pneumologues et autres spécialistes d’organes.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1378 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Autoimmune Diseases of the Endocrine System written by Robert Volpe' and published by CRC Press. This book was released on 1990-10-05 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive, easy-to-read discussion of the organ-specific autoimmune endocrine diseases emphasizing new contributions and trends for research and management. It begins with a brief chapter introducing the general principles of immunology, followed by discussions covering topics such as immunogenetics and animal models and how they can be applied toward interpreting human autoimmune endocrine diseases, autoimmune thyroid diseases, insulin-dependent diabetes mellitus hypophysitis, and Addison's disease. The book also discusses future trends toward gaining an understanding of these disorders and possible therapeutic principles. It is well-illustrated and will prove to be a useful reference source for internists, endocrinologists, and postgraduate students interested in human autoimmune endocrine diseases.
Download or read book Genomics Circuits and Pathways in Clinical Neuropsychiatry written by Thomas Lehner and published by Academic Press. This book was released on 2016-06-07 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. - Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics - Identifies key concepts, methods, and findings - Includes coverage of multiple disorders from autism to schizophrenia - Reviews specific genes associated with disorders - Discusses the genetic architecture of these syndromes - Explains how recent findings are influencing the understanding of biology - Clarifies the promise of these findings for future treatment
Download or read book Hepatitis Bibliography from MEDLARS written by and published by . This book was released on with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: References to journal articles generated from MEDLARS data base. Excludes literature dealing primarily with drug, toxic, or noninfectious hepatitis. Index medicus format, with subject and author sections.
Download or read book Vascular Manifestations of Systemic Autoimmune Diseases written by Ronald A. Asherson and published by CRC Press. This book was released on 2001-01-25 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all
Download or read book Molecular Biology of HLA Class II Antigens written by Jack Silver and published by CRC Press. This book was released on 1990-02-28 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication covers the recent veritable explosion in knowledge regarding the genetic organization, structure, and function of the HLA class II region. It deals with the nature of diversity of HLA class II alleles, the molecular basis of this diversity, and the mechanisms by which HLA class II expression is regulated. Also addressed is the relationship of class II polymorphism to susceptibility to autoimmune diseases such as rheumatoid arthritis, insulin dependent diabetes mellitus, and pemphigus vulgaris. The book presents information on allele specific oligonucleotide (ASO) probes and their use in identifying susceptible individuals. It includes chapters which describe how cells transfected with HLA class II genes can be used for functional analysis. An appendix representing a compilation of all the known DR?? DQ?, DQ? sequences is included. This serves as an excellent source of comparison of newly derived sequences. This publication provides information on the enormous progress in the HLA field. It is intended for both the established investigator and the beginner.
Download or read book Le Virus D pstein Barr Et Les Maladies Associ es written by and published by . This book was released on 1993 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Key Players in Systemic Sclerosis The Immune System and Beyond written by Philippe Guilpain and published by Frontiers Media SA. This book was released on 2021-11-29 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Review of Gerontology and Geriatrics Volume 2 1981 written by and published by Springer Publishing Company. This book was released on 1981-01-15 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in this long-running series presents the usual critical and intensive review chapters divided into five sections but also addresses particular topics of special interest, including drugs and their use, and misuse, among the aged; the nonmedication orientation to treatment of various disorders; the immune system; and clinical procedures in the management of urinary incontinence. As with all the volumes, the contributors represent an international array of leading experts.
Download or read book The Immunology of the Fetus written by Gerard Chaouat and published by CRC Press. This book was released on 2020-04-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1989, this book provides information on the diagnosis and treatment of neonatal immunodeficiencies. It includes a survey on the "riddle of the fetal allograft". Also discussed in the text are Ontogeny, immunological aspects of differentiation, and treatment of spontaneous abortion. This book is useful to predoctoral students, researchers in obstetrics, animal husbandry, and reproductive immunology.
Download or read book Epigenetic Aspects of Autoimmune Diseases written by Wesley H. Brooks and published by Frontiers Media SA. This book was released on 2022-09-22 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Blood Group Antigens and Disease written by George Garratty and published by . This book was released on 1983 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Origins of Native Americans written by Michael H. Crawford and published by Cambridge University Press. This book was released on 2001-02-26 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating account of the genetic, archaeological and demographic evidence for the peopling of the New World.
Download or read book Advances in Inflammatory Bowel Diseases written by P. Rutgeerts and published by Springer Science & Business Media. This book was released on 1998-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1646 pages. Available in PDF, EPUB and Kindle. Book excerpt:
