Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Histocompatibility written by George Snell and published by Elsevier. This book was released on 2012-12-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histocampatibility covers the genetic, immunologic, and the chemical studies on allograft rejection process. The book is composed of 13 chapters that describe how these studies relate to medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer research. After briefly dealing with the early studies on isografts and allografts in laboratory animals, the book describes the histogenetic methods of gene manipulation and transplantation that permit identification of individual histocompatibility loci. The following chapter examines the significance of congenic resistant lines in determining the diversity of histocompatibility loci and allele and immune response genes. Other chapters present immunogenetic and serological methods, as well as the applications of these methods in studying alloantigens and H-2 complex loci and of immunogenetic methods to human. The book also discusses the practical implication of HLA immunogenetics in organ transplantation and describes the biochemical, immunochemical, and dynamic properties of alloantigens. A chapter discusses the associations between HLA system and disease and the various mechanisms that have been suggested to explain these associations. The last chapter focuses on allograft reaction and on established facts of cellular immunity. This book is a valuable source of information for researchers in the fields of medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer.

Download or read book The HLA Complex in Biology and Medicine written by Narinder K Mehra and published by Boydell & Brewer Ltd. This book was released on 2010-11-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

Download or read book The Major Histocompatibility Complex Region of Domestic Animal Species written by Lawrence B. Schook and published by CRC Press. This book was released on 1996-08-28 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (Mhc) is one of the few identified gene systems in domestic animals that is associated with quantitative traits such as disease resistance, immune response, growth, and reproduction. As knowledge of this important system increases, we move closer toward the reality of genetic enhancement of animal welfare and production efficiency. This book represents the current state of knowledge on the Mhc of agriculturally important animals and explores the latest advances in technology. For the first time, the unique findings of recent Mhc research are presented in a single source. The Major Histocompatibility Complex Region of Domestic Animal Species begins with a discussion of the evolution of Mhc. The chapters are then organized with respect to specific species, with a chapter devoted to each. The Mhc of mice and humans are used as a common reference for comparisons between diverse species. The text concludes with a look at future strategies and directions in Mhc research. Comparative immunologists and geneticists, veterinarians, animal breeders, researchers, and university and postgraduate students will all benefit from this detailed look at the evolution, structure, and organization of Mhc.

Download or read book EBMT HANDBOOK written by and published by . This book was released on 2025 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Histocompatibility written by Bahaa Abdel-Salam and published by BoD – Books on Demand. This book was released on 2012-05-02 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents some recent researches related to histocompatibility for scientists interested in this field. It includes 10 chapters, in different topics, prepared by Sundararajulu Panneerchelvam and Mohd Nor Norazmi; Giada Amodio and Silvia Gregori; Adema Ribic; Bahaa K. A. Abdel-Salam; Kai-Fu Tang; Roberto Biassoni, Irene Vanni and Elisabetta Ugolotti; Wei-Cheng Yang, Lien-Siang Chou and Jer-Ming Hu; Shatrah Othman and Rohana Yusof; Masahiro Hirayama, Eiichi Azuma and Yoshihiro Komada; Gustav Roder, Linda Geironson, Elna Follin, Camilla Thuring and Kajsa Paulsson.

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics of Human Histocompatibility Antigens and Their Relation to Disease written by E. Thorsby and published by Ardent Media. This book was released on 1973 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Histocompatibility Testing 1984 written by E.D. Albert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Major Histocompatibility Complex written by M. Kasahara and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi zation of the MHC in humans and other model vertebrates, MHC-parasite co evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen eral.

Download or read book Minor Histocompatibility Antigens written by Derry Roopenian and published by CRC Press. This book was released on 1999-08-01 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the widespread application of solid tissue and bone marrow transplantation as a treatment for an array of life threatening disorders, there is a pressing need for clinicians and experimentalists to understand the basis of immunological rejection of tissue transplants. While much previous work focuses on characterization of antigens encoded by

Download or read book Current Trends in Histocompatibility written by Ralph Reisfeld and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information about histocompatibility antigens is expanding so rapidly that of all advances. In these volumes, we have it is difficult to remain abreast made an effort to bring together the most current work on topics that have generated most of the recent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we hope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla vii Contents I. Role of Histocompatibility Antigens in Cell-Cell Interaction Chapter 1 Histocompatibility Antigens and the T-Cell Repertoire . . . . . . . . . . . . . . 3 Harald von Boehmer 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. H-2 Restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. H-2 Restriction of T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. B Cells Are Not H-2-Restricted . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 1. Influence on the T-Cell Repertoire . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 2. H-2-Gene Complementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 3. The B-Cell Repertoire Is Not Directly Influenced by H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Frequency of Cells Specific for Allogeneic H-2 Antigens . . . . . . . . 12 4. 1. Allospecific T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. 2. Allospecific B Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book The Major Histocompatibility System in Man and Animals written by D. Götze and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Major Histocompatibility Complex MHC in Health and Disease written by Jerzy K. Kulski and published by MDPI. This book was released on 2020-01-15 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

Download or read book Molecular Evolution of the Major Histocompatibility Complex written by Jan Klein and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.

Download or read book The Major Histocompatibility Complex MHC HLA in Medicine written by Federico Garrido and published by Springer Nature. This book was released on with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Biology of the Major Histocompatibility Complex written by Benvenuto Pernis and published by Elsevier. This book was released on 2012-12-02 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Biology of the Major Histocompatibility Complex documents the proceedings of a symposium on ""Cell Biology of the Major Histocompatibility Complex"" held at Arden House on the Harriman Campus of Columbia University from June 8 -10, 1984. The meeting was the ninth of the P & S Biomedical Sciences Symposia. The book is organized into five parts. Part I on the structure of MHC molecules includes papers on human histocompatibility antigens; the cloning of human MHC; and organization of the genes of the H-2 complex. Part II on alternate forms of MHC molecules includes studies on the expression of a secreted form of the MHC class I antigen and alternative splicing in the H-2 multigene family. Part III deals with MHC biosynthesis, intracellular transport, and membrane expression. It includes studies on the manipulation of glycans on antigens of the MHC and dynamics of MHC molecules in lymphoid cells. Part IV on homologues of class I MHC molecules covers topics such as Tla expression in normal and malignant cells and the Qa series of antigens. Part V on the association of MHC with antigens includes studies such as histocompatibility molecules as immune response gene products and molecular nature of T-cell recognition of antigen.