Download or read book High Reynolds Number Microfluidic Systems for Drug Delivery written by Jeanne Casstevens Stachowiak and published by . This book was released on 2008 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Microfluidics written by Ryan Kelly and published by BoD – Books on Demand. This book was released on 2012-03-07 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microfluidics provides a current snapshot of the field of microfluidics as it relates to a variety of sub-disciplines. The chapters have been divided into three sections: Fluid Dynamics, Technology, and Applications, although a number of the chapters contain aspects that make them applicable to more than one section. It is hoped that this book will serve as a useful resource for recent entrants to the field as well as for established practitioners.
Download or read book Microsystems for Pharmatechnology written by Andreas Dietzel and published by Springer. This book was released on 2016-01-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.
Download or read book Microfluidics in Pharmaceutical Sciences written by Dimitrios A. Lamprou and published by Springer Nature. This book was released on with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport Phenomena in Microfluidics and Microbicide Drug Delivery Systems written by Stéphane André Joseph Verguet and published by . This book was released on 2008 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microfluidics for Pharmaceutical Applications written by Hélder A. Santos and published by William Andrew. This book was released on 2018-10-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. - Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness - Includes a variety of case studies that explain principles - Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world
Download or read book Biomedical Applications of Microfluidic Devices written by Michael R. Hamblin and published by Academic Press. This book was released on 2020-11-12 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. - Covers basic principles and design of microfluidics devices - Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery - Includes chemical applications in organic and inorganic chemistry - Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students
Download or read book Introduction to Microfluidics written by Patrick Tabeling and published by . This book was released on 2010-05-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics deals with fluids flowing in miniaturized systems, and has practical applications in the pharmaceutical, biomedical and chemical engineering fields. This text provides an introduction to this emerging discipline.
Download or read book Microfluidics written by Yujun Song and published by John Wiley & Sons. This book was released on 2018-01-04 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.
Download or read book Microfluidics for Biological Applications written by Wei-Cheng Tian and published by Springer Science & Business Media. This book was released on 2009-03-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.
Download or read book MEMS based Transdermal Drug Delivery written by Richa Mishra and published by CRC Press. This book was released on 2023-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces transdermal drug delivery and the developments that have taken place in various transdermal drug delivery techniques including the system-level design approach of a novel miniaturized medical device to offer precise and painless drug delivery via a skin-based transdermal route. It discusses the microelectromechanical systems (MEMS)-based fabrication technique and the design, fabrication and characterization of different MEMS-based components like microneedles and micropumps. It further includes a MEMS-based component micropump with design, analysis, fabrication and characterization of the transdermal drug delivery device and challenges encountered in the design improvements. Features: Summarizes transdermal drug delivery systems especially with a focus on MEMS and microneedles, including theoretical concepts Emphasizes system integration by describing simulation and design techniques as well as experimental fabrication Discusses system-level integration for miniaturized therapeutic devices Includes working simulation models covering microneedles and micropump analysis Explores future direction in development of pertinent devices. The book is aimed at researchers, professionals, and graduate students in biomedical engineering, microelectronics, micro-electro-mechanical-systems, and drug delivery.
Download or read book Microfluidic Assembly of Nanoparticles for Gene drug Delivery written by Chee Guan Koh and published by . This book was released on 2008 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics is a versatile technology specialized for manipulation of liquid flows at the micrometer and picoliter scale and has been applied to proteomics, diagnostics, and therapeutics. Microfluidic devices generally operate at low Reynolds number so the flow is strictly laminar which allows well-defined mixing to be controlled solely by interfacial diffusion. Therefore, in this study, microfluidic devices with hydrodynamic focusing (MF) were developed for assembling polymer-DNA (polyplex) and lipid-polymer-DNA (lipopolyplex, LP) nanoparticles.
Download or read book Highly Integrated Microfluidics Design written by Dan E. Angelescu and published by Artech House. This book was released on 2011 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of microfluidics has lead to the concept of lab-on-a-chip, where several functional blocks are combined into a single device that can perform complex manipulations and characterizations on the microscopic fluid sample. However, integration of multiple functionalities on a single device can be complicated. This a cutting-edge resource focuses on the crucial aspects of integration in microfluidic systems. It serves as a one-stop guide to designing microfluidic systems that are highly integrated and scalable. This practical book covers a wide range of critical topics, from fabrication techniques and simulation tools, to actuation and sensing functional blocks and their inter-compatibility. This unique reference outlines the benefits and drawbacks of different approaches to microfluidic integration and provides a number of clear examples of highly integrated microfluidic systems.
Download or read book Convection enhanced Drug Delivery written by Keith Benjamin Neeves and published by . This book was released on 2006 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promising treatments of many brain diseases are often thwarted due to their inability to cross the blood-brain barrier. Convection-enhanced drug delivery (CED) uses direct infusion of drug-containing solutions into tissue to circumvent the bloodbrain barrier. The aim of this thesis was to combine models of transport in porous media with microfabricated devices to develop novel methods for controlling the distribution of infused drugs. We used a poroelastic model of the brain to explore the effect of infusion induced dilation on transport. We calculated that during infusions at flow rates greater than one microliter/minute, the effective pore size of the extracellular matrix was doubled by dilation from approximately fifty nanometers to one-hundred nanometers. A computational fluid dynamic model of the rat brain determined the perturbation of the flow field between white and gray matter. We found no further perturbation of the flow field when the ratio of permeabilities between white and gray matter exceeded one-hundred. The results of our models suggest that the material properties of a targeted tissue region dictate the transport of infused solutions. To better control and manipulate drug distribution we developed a novel microfluidic platform for delivering drug-solutions at flow rates relevant for CED. The microfluidic devices consisted of parylene channels with a cross-section area of fifty microns by ten microns on a silicon structure with a cross-sectional area of one-hundred microns by one-hundred microns. These probes were tested in the normal rat brain and demonstrated performance advantages over standard needles, including no channel occlusion and attenuation of backflow. We expanded on the simple single channel device to implement more advanced strategies using multiple channels. A two-channel device was fabricated for infusing an enzyme or mannitol solution prior to infusing polystyrene nanoparticles. By pre-treating the targeted tissue region with enzymes or mannitol we increased the effective pore size of the extracellular matrix which resulted in a doubling of the distribution volume of nanoparticles. (Abstract).
Download or read book Microfluidic Devices for Biomedical Applications written by Xiujun (James) Li and published by Elsevier. This book was released on 2013-10-31 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. - Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications - Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies - Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering
Download or read book Essentials of Micro and Nanofluidics written by A. Terrence Conlisk and published by Cambridge University Press. This book was released on 2013 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces students to the basic physical principles to analyze fluid flow in micro and nano-size devices. This is the first book that unifies the thermal sciences with electrostatics and electrokinetics and colloid science; electrochemistry; and molecular biology. The author discusses key concepts and principles, such as the essentials of viscous flows, an introduction to electrochemistry, heat and mass transfer phenomena, elements of molecular and cell biology, and much more. This textbook presents state-of-the-art analytical and computational approaches to problems in all of these areas, especially electrokinetic flows, and gives examples of the use of these disciplines to design devices used for rapid molecular analysis, biochemical sensing, drug delivery, DNA analysis, the design of an artificial kidney, and other transport phenomena. This textbook includes exercise problems, modern examples of the applications of these sciences, and a solutions manual available to qualified instructors.
Download or read book Microfluidics Based Microsystems written by S. Kakaç and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains an archival record of the NATO Advanced Study Institute on Microfluidics Based Microsystems – Fundamentals and App- cations held in Çe ?me-Izmir, Turkey, August 23–September 4, 2009. ASIs are intended to be high-level teaching activity in scientific and technical areas of current concern. In this volume, the reader may find interesting chapters and various microsystems fundamentals and applications. As the world becomes increasingly concerned with terrorism, early - spot detection of terrorist’s weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. NATO Public Diplomacy division, Science for Peace and Security section support research, Advanced Study Institutes and workshops related to security. Keeping this policy of NATO in mind, we made such a proposal on Microsystems for security. We are very happy that leading experts agreed to come and lecture in this important NATO ASI. We will see many examples that will show us Microfluidics usefulness for rapid diagnostics following a bioterrorism attack. For the applications in national security and anti-terrorism, microfluidic system technology must meet the challenges. To develop microsystems for security and to provide a comprehensive state-of-the-art assessment of the existing research and applications by treating the subject in considerable depth through lectures from eminent professionals in the field, through discussions and panel sessions are very beneficial for young scientists in the field.
