Download or read book Hereditary Angioedema in Sweden written by Patrik Nordenfelt and published by Linköping University Electronic Press. This book was released on 2017-10-23 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Hereditary angioedema (HAE) due to C1-inhibitor deficiency, type I and II, is a rare disease with an estimated prevalence of 1/50,000. Angioedema in the larynx can be life threatening and angioedema in the abdomen and skin can give severe and disabling pain. Data on patients with HAE in Sweden were scarce before our study. Aim: To study the prevalence of HAE, and to investigate clinical manifestations, treatments, and Health-Related Quality of Life (HR-QoL) in adults and children in Sweden. Method: In studies, I and II, all patients received a written questionnaire followed by a phone interview with questions about clinical manifestations, medication, sick leave and QoL. In study III the patients completed EuroQol 5 Dimensions 5 Levels (EQ-5D-5L) questionnaires for both the attack-free state (EQ5D today), and the last HAE attack (EQ5D attack). Questions were also asked about sick-leave. In study IV all adults received questionnaires with EQ-5D-5L and RAND-36, Angioedema Quality of Life instrument (AE-QoL), and Angioedema Activity Score (AAS) form, and questionnaires on sick leave and prophylactic medication. Results: We identified 146 patients, 110 adults and 36 children with HAE, type I (n=136) or II (n=10), giving a minimal HAE prevalence of 1.54/100,000. For adults, the median age at onset of symptoms was 12 years and median age at diagnosis was 22 years. Median age at onset of symptoms for children was 4 years and at diagnosis 3 years. During the previous year, 47% of adults experienced at least 12 attacks, 21% 4-11 attacks, 11% 1-3 attacks, while 22% were asymptomatic. For children, the corresponding figures were about the same. The median number of attacks in those having attacks was 14 in adults and 6 in children last year. Adult females reported on average 19 attacks the previous year versus nine for males. Irrespective of location nine out of 10 reported pain. Trigger factors were experienced in 95 % of adults and 74 % of children. Plasma-derived C1-inhibitor concentrate (pdC1INH) had a very good effect on acute attacks. Long-term prophylaxis with androgens and pdC1INH reduced the annual attack frequency by more than 50 %. Of the children’s parents, 73% had been on parental leave to care for the child due to HAE symptoms. Health and QoL were generally rated as good. In study III 103 of 139 responded and reported an EQ5D today score that was significantly higher than the EQ5D attack score. Attack frequency had a negative effect on EQ5D today. Children had significantly higher EQ-5D-5L than adults. Forty four percent had been absent from work or school during the latest attack. In study IV 64 of 133 adults responded. The most affected HR-QoL dimensions in EQ-5D-5L were pain/discomfort and anxiety/depression, in RAND-36 energy/fatigue, general health, health transition, pain, and in AE-QoL fears/shame and fatigue/mood. Females had significantly lower HR-QoL in RAND-36 for general health and energy/fatigue. There was an association between AAS and EQ-5D-5L/RAND-36 (except physical function) /AEQoL. There was no significant difference in HR-QoL in patients with and without prophylactic medication. Conclusion: The minimal prevalence of HAE type I and II in Sweden is 1.54/100,000. Median age at onset was 12 years. Adult females had twice as many attacks as males, adults had also twice as many attacks as children. For acute treatment, pdC1INH had a very good effect. For long term prophylaxis, androgens and pdC1INH had good effect. The most affected HR-QoL dimensions in EQ-5D-5L were pain/discomfort and anxiety/ depression, in RAND-36 energy/fatigue, general health, health transition and pain, and in AE-QoL fears/shame and fatigue/mood. Children reported better HR-QoL than adults. AE-QoL is more disease-specific in HAE than the generic instruments EQ-5D-5L and RAND-36. However, the latter highlights the pain aspect, whereas AE-QoL does not. Patients with high disease activity should thus be considered for more intensive treatment to improve their HR-QoL.

Download or read book Urticaria and Angioedema written by Selda Pelin Kartal and published by BoD – Books on Demand. This book was released on 2017-05-31 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the latest advances and scientific knowledge from the leading experts in urticaria and angioedema. The book consists of 15 chapters in which urticaria classification, urticaria etiopathogenesis, urticaria clinics, urticarial syndromes, angioedemas, diagnosis, pathogenesis and pathophysiology of urticaria, and treatment options are discussed. This book also emphasizes on the various laboratory tests necessary for urticarias. One chapter of the book is devoted to comorbidities in chronic spontaneous urticaria. Another chapter is related with pathophysiology and treatment of hereditary angioedema. We are grateful to all the contributors and leading experts for their valuable chapters, which provide an in-depth view of all aspects of the content, backed with the most current literature in the field. We hope that this book will provide interesting knowledge and serve as a comprehensive guide to many physicians dealing with urticaria and angioedemas in their clinical practice.

Download or read book Healthcare and Culture written by Maria Francesca Freda and published by IAP. This book was released on 2017-02-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with current issues, pertinent every healthcare relationship. Changes in medicine as well as some constant aspects over time arise within a cultural ground and generate new questions and issues that are not only purely medical, but also bioethical, social, political, economic and psychological of course. On the one hand, changes in medicine generate new questions for society, on the other hand, the society poses new questions to the medicine, new challenges, and in some cases they can conflict with consolidated models and practices. Never the progress of Western medicine and its therapeutic practices have been as significant as in the last decades but the increase of specific competence and effectiveness of medical treatments are not linearly translated into an increase of consensus, dialogue and alliance between medicine and society. How does psychology take on a position of interlocutor towards medicine and its transformations? How does Cultural Psychology, Health Psychology, Clinical Psychology confront themselves with the processes of meaning making generated by medicine? The interest of the book is aimed to grasp the construction of processes of cultural, relational and subjective meaning in the dialogical encounter between medicine and society, between doctor and patient. The book intends to focus in particular on two specific plans: on the one hand, to present a reflection and analysis on contemporary medicine and its on?going transformations of the healthcare relationship; on the other hand, to present and discuss experiences of intervention and possible models of intervention addressed to healthcare and doctor?patient relationships during its crucial steps (consultation, formulation and communication of diagnosis, therapy, conclusion). The book’s purposes are aimed to discuss crucial and current issues on the borders between medicine and psychology: consensus and sharing, decision?making and autonomy, subjectivity and narration, emotions and affectivity, medical semeiotics and cultural semiotics, training of physicians, and epistemological, theoretical and methodological issues.

Download or read book Clinical Allergy and Asthma Management in Adolescents and Young Adults written by Ravindran Chetambath and published by CRC Press. This book was released on 2021-11-29 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Features • Covers allergic diseases in general and asthma in detail, providing a comprehensive coverage of clinical features, diagnosis and management, using a case-based approach • Creates awareness of the fundamentals of clinical allergy, helping physicians make wise choices of medical and surgical management, especially in resource limited settings • Features insight from international authors with clinical experience in diagnosis and treatment of asthma in the specific age group of adolescents and young adults.

Download or read book An Invitation to Your Community written by Kirk Winters and published by . This book was released on 1995 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Rogers Textbook of Pediatric Intensive Care written by Donald H. Shaffner and published by Lippincott Williams & Wilkins. This book was released on 2015-07-29 with total page 5597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in vibrant full color throughout, Rogers’ Textbook of Pediatric Intensive Care, 5th Edition, continues its tradition of excellence as the gold standard in the field. For more than 25 years, readers have turned to this comprehensive resource for clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied in clinical practice. In the 5th Edition, more than 250 global contributors bring you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.

Download or read book HLA and Disease Associations written by J.L. Tiwari and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

Download or read book Pediatric Allergy Principles and Practice written by Stanley J. Szefler, MD and published by Elsevier Health Sciences. This book was released on 2015-08-11 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You'll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you're a student, resident, pediatrician or allergist, you'll appreciate this user-friendly and versatile source for providing optimal care! Includes diagnostic tests available for asthma, upper respiratory allergy, and more. Equips you with an understanding of the immune mechanisms underlying allergic diseases. Features coverage of drug allergies and cross-reactivity. Highlights clinical pearls discussing the best approaches to the care and treatment of pediatric patients. Appendices listing common food allergies and autoantibodies in autoimmune diseases make for quick reference to essential material. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Revised asthma section examines current asthma guidelines; school-centered asthma programs; exercise-induced asthma; and new directions in asthma therapy. Includes the most current knowledge relating to emerging asthma within young children, medication adherence, and the impact of infection on the natural history of asthma. New information on gene therapy, stem-cell therapy, and a host of new immunodeficiency diseases helps you obtain the best results from the therapeutics for pediatric allergic and immunologic diseases. Features brand-new chapters on immunopathology; diagnostics and management; potential immunotherapeutic strategies for treating food allergies; current status of immunotherapy for food allergy; and biologic therapies. Focused coverage of today's hot topics in pediatric allergy includes the use of targeted biologics to treat specific activation pathways leading to severe allergic diseases; defects of innate immunity; rheumatic diseases of childhood; and inflammatory disorders. Discusses new studies examining potential etiologies for the increase in food allergy and examines potential immunotherapeutic strategies for treating food allergies. New evidence-based principles of medical care help you make the best use of available medications for your patients.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fetal Neonatal Hematology Oncology and Immunology written by MR Lokeshwar and published by JP Medical Ltd. This book was released on 2017-07-17 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns. Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions. The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders. Each topic explains new advances, all current treatment protocols, new drugs, and management approaches. Chapters are further enhanced by clinical images and tables. Key points Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches Includes discussion on neonatal malignancies and blood transfusion Highly illustrated with clinical images and tables

Download or read book The Metabolic Basis of Inherited Disease written by John Bruton Stanbury and published by . This book was released on 1972 with total page 1942 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Construction of LMS Parameters for the Centers for Disease Control and Prevention 2000 Growth Charts written by Katherine M. Flegal and published by . This book was released on 2013 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Henry s Clinical Diagnosis and Management by Laboratory Methods E Book written by Richard A. McPherson and published by Elsevier Health Sciences. This book was released on 2011-09-06 with total page 1769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

Download or read book Henry s Clinical Diagnosis and Management by Laboratory Methods First South Asia Edition E book written by Richard A. McPherson and published by Elsevier Health Sciences. This book was released on 2016-08-31 with total page 1820 pages. Available in PDF, EPUB and Kindle. Book excerpt: To interpret the laboratory results. To distinguish the normal from the abnormal and to understand the merits and demerits of the assays under study. The book attempts to train a laboratory medicine student to achievesound knowledge of analytical methods and quality control practices, tointerpret the laboratory results, to distinguish the normal from the abnormaland to understand the merits and demerits of the assays under study.

Download or read book Current Bibliography of Epidemiology written by and published by . This book was released on 1972 with total page 1438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Interpretation of Diagnostic Tests written by Jacques Burton Wallach and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the answers for a range of adult and paediatric conditions, this text summarises the available tests for most diseases, explaining what the results mean, and discussing differential diagnoses. It also includes additional tests based on molecular biology.

Download or read book Hereditary Angioedemas New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hereditary Angioedemas: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Hereditary Angioedemas in a compact format. The editors have built Hereditary Angioedemas: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hereditary Angioedemas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hereditary Angioedemas: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.