Download or read book Hearing Loss Mechanisms and Prevention written by Renjie Chai and published by Frontiers Media SA. This book was released on 2022-04-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hearing Loss Mechanisms Prevention and Cure written by Huawei Li and published by Springer. This book was released on 2019-03-26 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients’ ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialists and researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.

Download or read book Noise Induced Hearing Loss written by Colleen G. Le Prell and published by Springer Science & Business Media. This book was released on 2011-10-30 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure to loud noise continues to be the largest cause of hearing loss in the adult population. The problem of NIHL impacts a number of disciplines. US standards for permissible noise exposure were originally published in 1968 and remain largely unchanged today. Indeed, permissible noise exposure for US personnel is significantly greater than that allowed in numerous other countries, including for example, Canada, China, Brazil, Mexico, and the European Union. However, there have been a number of discoveries and advances that have increased our understanding of the mechanisms of NIHL. These advances have the potential to impact how NIHL can be prevented and how our noise standards can be made more appropriate.

Download or read book Noise Induced Hearing Loss written by and published by . This book was released on 2001 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Download or read book New Therapies to Prevent or Cure Auditory Disorders written by Sylvie Pucheu and published by Springer Nature. This book was released on 2020-03-25 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10–15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for these two perceptual disorders. Whereas some drug candidates are in the process of being developed, nowadays no effective treatment exists to cure hearing loss and tinnitus. The topic of this book was selected with the goal of emphasizing mechanisms that induce hearing loss and tinnitus which lead the selection of promising targets for hearing disorder treatment. Hair cells (HC) are the sensory cells of the inner ear required for both auditory and vestibular functions in all vertebrates. HC are progressively lost during ageing and they are in addition sensitive to physical and acoustic traumas, infectious diseases and chemicals present in commonly used treatments such as anticancer, antimalarial or antibiotics. As adult mammals--including humans--cannot regenerate dead HC, all the possible injury could result in irreversible and permanent hearing loss. It has been shown, however, that a limited capacity to regenerate HC exists in mouse at an early stage of development. The regenerative capacity of HC then appears simply “repressed” in adult mammals, and one could expect it will be possible to re-activate it with an appropriate therapeutic approach which is still to be defined. Immune-mediated inner ear disease has been introduced and accepted as one SNHL pathophysiology; it responds to immunosuppressive therapy and is one of the few reversible forms of bilateral SNHL. Macrophages are always present in the spiral ligament of the lateral wall and are activated in response to various types of stimuli, including noise exposure, ischemia, mitochondrial damage, and surgical stress. Recent studies have also revealed another type of immune cell, called perivascular melanocyte-like macrophages (PVM/Ms), in the stria vascularis. The book will include a review of inflammatory/immune cells in the cochlear lateral wall, the pathways involved in cochlear damage and their potential as therapeutic targets. The final chapter provides an overview of current animal model of tinnitus and hyperacusis. Nowadays no effective treatment exists to cure tinnitus and hyperacusis. One major obstacle to arises from the fact that tinnitus is a subjective phenomenon, the only possible diagnosis relies on self-reports of the subjects. The main constraint of the use of animal models is the subjective character of tinnitus. This chapter describe the advancement in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis.

Download or read book Auditory Trauma Protection and Repair written by Jochen Schacht and published by Springer Science & Business Media. This book was released on 2008-02-10 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has brought great advances in our understanding of the mechanisms underlying auditory pathologies. This volume presents recent developments in research and their potential translation to the clinical setting. It brings together the basic and clinical sciences very nicely in that while most chapters are written by basic scientists, each topic has a pretty direct clinical application or implication.

Download or read book Hearing Health Care for Adults written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The loss of hearing - be it gradual or acute, mild or severe, present since birth or acquired in older age - can have significant effects on one's communication abilities, quality of life, social participation, and health. Despite this, many people with hearing loss do not seek or receive hearing health care. The reasons are numerous, complex, and often interconnected. For some, hearing health care is not affordable. For others, the appropriate services are difficult to access, or individuals do not know how or where to access them. Others may not want to deal with the stigma that they and society may associate with needing hearing health care and obtaining that care. Still others do not recognize they need hearing health care, as hearing loss is an invisible health condition that often worsens gradually over time. In the United States, an estimated 30 million individuals (12.7 percent of Americans ages 12 years or older) have hearing loss. Globally, hearing loss has been identified as the fifth leading cause of years lived with disability. Successful hearing health care enables individuals with hearing loss to have the freedom to communicate in their environments in ways that are culturally appropriate and that preserve their dignity and function. Hearing Health Care for Adults focuses on improving the accessibility and affordability of hearing health care for adults of all ages. This study examines the hearing health care system, with a focus on non-surgical technologies and services, and offers recommendations for improving access to, the affordability of, and the quality of hearing health care for adults of all ages.

Download or read book Inflammatory Mechanisms in Mediating Hearing Loss written by Vickram Ramkumar and published by Springer. This book was released on 2018-07-18 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.

Download or read book Hearing Loss written by National Research Council and published by National Academies Press. This book was released on 2004-12-17 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of Americans experience some degree of hearing loss. The Social Security Administration (SSA) operates programs that provide cash disability benefits to people with permanent impairments like hearing loss, if they can show that their impairments meet stringent SSA criteria and their earnings are below an SSA threshold. The National Research Council convened an expert committee at the request of the SSA to study the issues related to disability determination for people with hearing loss. This volume is the product of that study. Hearing Loss: Determining Eligibility for Social Security Benefits reviews current knowledge about hearing loss and its measurement and treatment, and provides an evaluation of the strengths and weaknesses of the current processes and criteria. It recommends changes to strengthen the disability determination process and ensure its reliability and fairness. The book addresses criteria for selection of pure tone and speech tests, guidelines for test administration, testing of hearing in noise, special issues related to testing children, and the difficulty of predicting work capacity from clinical hearing test results. It should be useful to audiologists, otolaryngologists, disability advocates, and others who are concerned with people who have hearing loss.

Download or read book Hearing Loss in Musicians written by Plural Publishing, Incorporated and published by Plural Publishing. This book was released on 2009-03-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Noise and Military Service written by Institute of Medicine and published by National Academies Press. This book was released on 2006-01-20 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine carried out a study mandated by Congress and sponsored by the Department of Veterans Affairs to provide an assessment of several issues related to noise-induced hearing loss and tinnitus associated with service in the Armed Forces since World War II. The resulting book, Noise and Military Service: Implications for Hearing Loss and Tinnitus, presents findings on the presence of hazardous noise in military settings, levels of noise exposure necessary to cause hearing loss or tinnitus, risk factors for noise-induced hearing loss and tinnitus, the timing of the effects of noise exposure on hearing, and the adequacy of military hearing conservation programs and audiometric testing. The book stresses the importance of conducting hearing tests (audiograms) at the beginning and end of military service for all military personnel and recommends several steps aimed at improving the military services' prevention of and surveillance for hearing loss and tinnitus. The book also identifies research needs, emphasizing topics specifically related to military service.

Download or read book Neural Responses to Injury Prevention Protection and Repair Volume 6 Protecting the Auditory System and Prevention of Hearing Problems written by and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The experimental animals used during this period for the project, Neural Responses to Injury: Prevention, Protection, and Repair, Subproject: Protecting the Auditory System and Prevention of Hearing Problems, are as follows: Species, Guinea Pig, Number Allowed, 276, Number Used, 83, LSU IACUC# 1061. ANIMAL PROJECT: The SPECIFIC MMS of this study are to demonstrate and explore mechanisms for preventing the effects of intense sound. In years 01, and 02 we discovered that continuous, ipsilateral primary stimulation (CM-LIPS) will produce complex changes in the mechanics of the cochlea, possibly related to toughening In year 03 we discovered that ATP is involved in generating this complex mechanics. We extended the noise exposure studies and found that continuous noise is less effective than interrupted noise in inducing "toughing" Cellular mechanism studies discovered that ATP kills outer hair cells in vitro and in vivo, indicating that ATP may be a key player in noise-induced deafness and toughening. HUMAN PROJECT: We have found that binaural noise suppresses linear click evoked emissions twice as much as ipsilateral noise and 3 times as much as contralateral noise. However, subjects with noise exposure often show poor or reduced emissions when the stimulus is a click. Of 20 subjects enrolled and 13 completely tested so far in the multi-day protocol, subjects with noise exposure effects at higher frequencies show MORE suppression at and around 1500 Hz than do subjects with no hearing loss. This may support the original hypothesis in this program that "Noise Tender Ears" will show different emission suppression patterns from ears that are tough.

Download or read book Gene therapy for hearing loss From mechanism to clinic volume II written by Zuhong He and published by Frontiers Media SA. This book was released on 2024-05-23 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Free Radicals in ENT Pathology written by Josef Miller and published by Humana Press. This book was released on 2015-04-30 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and “white paper” that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.

Download or read book Noise and the Ear Noise Induced Hearing Loss and Hidden Society Burden written by Win Tin and published by Universiti Malaysia Sabah Press. This book was released on 2019-11-18 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the early success of some articles as author and co-author, Dr Win Tin has come up with his first book on Noise-Induced Hearing Loss and the Hidden Society Burden. He noticed that everyone needs peace of mind, especially after a long working day. We need to rest, physically and mentally to recoup, working again with enthusiasm the next day. Thus, it is important that we have a certain private, quiet, peaceful serene environment, day or night. But noise is all around us. The sound of grass cutters, the piling of structures nearby, children playing and shouting, or the traffic noise. These can make a lot of noise and the peace shattered. Noise-induced hearing loss is mainly caused by a certain amount of noise which has a deleterious effect on the ear when exposed to long periods of time e.g. years, and usually without the person noticing, as in occupational noise-induced hearing loss or single instances of extreme noise, as in acoustic trauma. This causes not only hearing loss but effects socially, financially, physically and mentally. Its problem is so big with compensation in millions, causing a huge hidden burden to the society, people and government. Yet it should be noted that this is the only preventable cause of sensorineural hearing loss, which can be prevented, while other causes are still not possible. The book introduces various noise, the pathogenesis and causes of noise-induced hearing loss, as seen in various strata of people. Apart from this, there is the Malaysian perspective as written by some researchers from Malaysia. Then there are also effects of noise not only on humans but also in birds and fish. Methods to diagnosis and ways to prevent, with up-to-date researches and treatment are also discussed. Thus, it is a comprehensive one for the knowledge of all levels, professionals and non-professionals. This book is important, and everybody should read or keep as a reference, as they will know in-depth, as most are unaware of the hidden problem. Young people, military, hospital workers, nurses, contractors, builders, architect, engineers, urban planners, public health doctors and everyone can benefit from this book. Hence, this book is useful not only for leisure reading but cherished for life. With the 25th anniversary of UMS, this book can be a milestone, for the wellness of UMS staff and people of Sabah.

Download or read book Naural Responses to Injury Prevention Protection and Repair Volume 6 Protecting the Auditory System and Prevention of Hearing Problems written by Nicolas Bazan and published by . This book was released on 1997 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: ANIMAL PROJECT: The SPECIFIC AIMS of this study are to demonstrate and explore mechanisms for preventing the effects of intense sound. In years 01, 02, 03 we discovered that continuous, ipsilateral sound stimulation (CM-LIPS) will produce complex changes in the mechanics of the cochlea. In year 04 we obtained additional evidence that ATP is involved in generating this mechanics. We completed the noise exposure studies and found that continuous noise is less effective than interrupted noise in inducing.