Download or read book Glutathione S Transferases written by Gerard J. Mulder and published by CRC Press. This book was released on 1996-05-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme

Download or read book Conjugation Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.

Download or read book Whole Organ Approaches to Cellular Metabolism written by James Bassingthwaighte and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of capillary-tissue exchange physiology has been galvanized twice in the past 25 years. A 1969 conference at the National Academy of Sciences in Copenhagen resulted in the book Capillary Permeability: The Transfer of Mole cules and Ions Between the Capillary Blood and the Tissue (Crone and Lassen, 1970). It focused on the physiochemical aspects of transcapillary water and solute transport. The field has matured considerably since. This volume was designed as the successor to the 1970 book, and was created at a gathering of the authors at McGill University. It too captures the breadth of a field that has been dramatically enriched by numerous technical and conceptual advances. In 1970 it was already known that the capillary wall was not merely a "cellophane bag" exerting steric hindrances on solute particles. Instead, the endothelial surface was recognized as the site of binding reactions and permeation by passive or carrier-mediated trans port. Furthermore, the cells of the blood could traverse evanescent wide openings in the "zippered" clefts. Today, research priorities have turned more to cell-cell interactions, toward understanding the utility of the gap junctional connections between endothelial cells and neighboring smooth muscle cells, neuronal twigs, and the parenchymal cells of organs. New discoveries in the past few years have revealed the critical importance of the close relationships between the endothelial cells and the parenchymal cells.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1556 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Food Engineering written by Murlidhar Meghwal and published by CRC Press. This book was released on 2016-11-18 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents a selection of recent advances and emerging trends in food process engineering from several disciplines. Exploring the key concepts of food engineering, Food Engineering: Emerging Issues, Modeling, and Applications presents the information in four parts: Modeling in food engineering; Research advances in food engineering; Role of food engineering in human health; Emerging issues and applications in food engineering.

Download or read book Target Organ Toxicity Volume I written by Gerald M. Cohen and published by CRC Press. This book was released on 2020-01-29 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Download or read book Glutathione Antioxidant Enzymes in Animal Models that Mimic Diabetic Retinopathy written by Tonya G. Ketcham and published by . This book was released on 2002 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Target Organ Toxicity written by Gerald M. Cohen and published by Taylor & Francis. This book was released on 2022-07-30 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1986: The purpose of this 2 volume set is to provide a valuable reference for established investigators and postgraduate students in toxicology.

Download or read book Turkish Journal of Biology written by and published by . This book was released on 1999 with total page 1540 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Target Organ Toxicity written by Cohen and published by CRC Press. This book was released on 1986-08-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Download or read book Masters Abstracts International written by and published by . This book was released on 1994 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glutathione written by Y. Sakamoto and published by . This book was released on 1983 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Enzymatic Basis of Detoxication Volume 2 written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Download or read book Glutathione In The Nervous System written by Christopher Ari Shaw and published by CRC Press. This book was released on 1998-02-27 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.

Download or read book Deutsche Pharmakologische Gesellschaft written by Deutsche Pharmakologische Gesellschaft and published by Springer. This book was released on 2013-12-30 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biological Basis of Detoxication written by John Caldwell and published by Elsevier. This book was released on 2012-12-02 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.

Download or read book Glutathione Transferases and Gamma Glutamyl Transpeptidases written by Helmut Sies and published by Gulf Professional Publishing. This book was released on 2005-11-22 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on particular aspects of the so-called Phase II of drug detoxication, which has important ramifications for endogenous metabolism and nutrition. This volume on glutathione transferases and gamma-glutamyl transpeptidases serves to bring together methods and concepts in a rapidly developing field of cell and systems biology.