Download or read book Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases written by J. Cummings and published by Springer Science & Business Media. This book was released on 2005-10-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identification of biological markers relevant to disease monitoring and to the development of new therapeutic agents capable of modifying and ameliorating basic neurodegenerative mechanisms.
Download or read book Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases written by Jeffrey L. Cummings and published by Springer Science & Business Media. This book was released on 2005-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships.- Towards a Molecular Classification of Neurodegenerative Disease.- Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases.- Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases.- Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology?.- Identification of Genes that Modify the Age of Onset in a Large Familial Alzheimer's Disease Kindred.- Variable Phenotype of Alzheimer's Disease with Spastic Paraparesis.- Presenilin Mutations: Variations in the Behavioral Phenotype with an Emphasis on the Frontotemporal Dementia Phenoytpe.- Frontotemporal Dementias: Genotypes and Phenotypes.- Chromosome 17-Linked Frontotemporal Dementia with Ubiquitin-Positive, tau-Negative Inclusions.- Variations of the Phenotype in Frontotemporal Dementias.- Phenotype/Genotype Correlations in Parkinson's Disease.- Subject Index
Download or read book Cognitive Neurology written by and published by . This book was released on 2008 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many clinicians within neurology remain unaware of the significant advances that have taken place in the field of cognitive neuroscience in the last decades, and how these might affect clinical practice. This book provides an introduction to the cognitive and behavioral aspects of the clinical practice of neurology.
Download or read book Intracellular Traffic and Neurodegenerative Disorders written by Peter H. St.George-Hyslop and published by Springer Science & Business Media. This book was released on 2009-02-03 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Download or read book Two Faces of Evil Cancer and Neurodegeneration written by Thomas Curran and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Download or read book Alzheimer 100 Years and Beyond written by Mathias Jucker and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Download or read book Synaptic Plasticity and the Mechanism of Alzheimer s Disease written by Dennis J. Selkoe and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.
Download or read book The American Psychiatric Publishing Textbook of Geriatric Neuropsychiatry written by C. Edward Coffey and published by American Psychiatric Pub. This book was released on 2011 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rev. ed. of: The American Psychiatric Press textbook of geriatric neuropsychiatry. 2nd ed. 2000.
Download or read book Dementias written by Charles Duyckaerts and published by Elsevier. This book was released on 2008-06-09 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of the biology of dementias, including information on advancements in the way these disorders are perceived and studied. From earlier assumptions that cognitive deficits were simply age related, this handbook progresses into complex discussions of the diseases that affect the cortex of the human brain. Clinicians will find extensive diagnostic and research perspectives on a variety of interesting topics, including neuropathology, physiopathology, biology, clinics, and imaging information on all, or most, of the dementing disorders currently known. In addition, chapters devoted to legal and ethical issues give practitioners and health care workers an informative view on complex dementias and the way these disorders affect patients and families. Clinicians in all levels of expertise will find useful and synthetic information. * Comprehensive information on advancements in the study and diagnosis of dementias * Complex discussions of the diseases that affect the cortex of the human brain* Extensive diagnostic and research perspectives on topics including, but not limited to, neuropathology, physiopathology, and groundbreaking imaging techniques* A reference guide that is appropriate for clinicians in all levels of expertise, from researchers to basic health care providers
Download or read book The Right Therapy for Neurological Disorders written by E. Beghi and published by Karger Medical and Scientific Publishers. This book was released on 2016-07-26 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients’ values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.
Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Download or read book The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias written by Myron F. Weiner and published by American Psychiatric Pub. This book was released on 2009-03-02 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an up-to-date and comprehensive overview of dementia for psychiatrists and other health care practitioners who deal with cognitively impaired adults in outpatient, inpatient, and long-term care settings. With content ranging from clinical guidance to basic research, it contains information on nearly every subject related to dementing conditions or illnesses -- not only providing extensive coverage of clinical management issues but also enabling a deeper understanding of the causes of dementia. Designed to assist the practitioner faced with everyday dilemmas, from dosages of antipsychotic drugs to legal and ethical issues, this textbook describes in detail the most common conditions and diseases leading to dementia and covers pharmacologic, behavioral, and environmental treatments. It also considers a broader range of cognitive disorders and impairment in order to help practitioners recognize and treat primary brain diseases and systemic disorders affecting the brain before they reach the stage of dementia. Building on the editors' earlier work The Dementias: Diagnosis, Treatment, and Research, this new book expands on its scope, with nearly twice the number of contributors -- all clinicians or researchers at the vanguard of the field. New to this edition are chapters on epidemiology, history of dementia, biomarkers for Alzheimer disease, care of the late-stage dementia patient, prevention of dementia, and chapters devoted to: Vascular cognitive impairment, emphasizing the importance of early detection with development of appropriate treatments and risk factor control Dementia with Lewy bodies and other synucleinopathies, describing differences in cognitive profile between synucleinopathies and Alzheimer disease Frontotemporal dementias, including behavioral and language variants Traumatic brain injury, distinguishing between proximal and distal effects and risk factors for dementia later in life An abundance of charts and illustrations, extensive references and additional readings, and chapter-end key points make this a practical volume for learning, while appendixes include easily administered instruments useful in daily practice for grading cognition, day-to-day function, neuropsychiatric symptoms, and quality of life. Whether used as a clinical guide or as a sourcebook on technical and scientific developments, The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an important reference for psychiatrists, neurologists, geriatricians, primary care physicians, and other health professionals who deal with cognitively impaired adults.
Download or read book Science written by John Michels (Journalist) and published by . This book was released on with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: A weekly record of scientific progress.
Download or read book Evolutionary Biology Biodiversification from Genotype to Phenotype written by Pierre Pontarotti and published by Springer. This book was released on 2015-07-10 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents 20 selected contributions to the 18th Evolutionary Biology Meeting, which took place in September 2014 in Marseille. They are grouped under the following major themes: · Genotype to Phenotype · Genetic Mechanisms of Diversification · Evolutionary Mechanisms · Speciation and Biodiversity The aims of these annual meetings in Marseille are to bring together leading evolutionary biologists and other scientists who employ evolutionary biology concepts, e.g. for medical research, and to promote the exchange of ideas and encourage interdisciplinary collaborations. Offering an up-to-date overview of recent advances in the field of evolutionary biology, this book represents an invaluable source of information for scientists, teachers and advanced students.
Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-11-07 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Download or read book Neuropsychiatry and Behavioral Neuroscience written by Jeffrey L. Cummings and published by Oxford University Press. This book was released on 2003-01-23 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the long-awaited successor to Jeffrey Cummings' classic work, Clinical Neuropsychiatry, published in 1985. That book represented an integration of behavioral neurology and biological psychiatry into a single volume devoted to explicating brain-behavior relationships. It was clinically oriented and intended for practitioners caring for patients with neuropsychiatric disorders. The new title reflects the authors' effort to link the recent explosion of new information from neurochemistry, neuroanatomy, genetics, neuropharmacology, neuropathology, and neuroimaging to the clinical descriptions. Yet the clinical emphasis of its predecessor has been maintained. Each chapter has a consistent approach and the book as whole provides a practical, easy-to-use synthesis of clinical advice and basic science. The volume is enhanced by 4-color images throughout. It is intended for students, residents, fellows, and practitioners of neurology, psychiatry, neuropsychology, and cognitive neuroscience. It will also be of interest to individuals in neuroimaging.
Download or read book Adrenal Disorders written by Alice C. Levine and published by Humana Press. This book was released on 2017-10-24 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology. This book is divided into three thematic sections. The first covers adrenal physiology, presenting adrenal zonation and development, the regulation of steroidogenesis, and the pharmacology of glucocortisoids. Part two discusses the genetics and pathophysiology of a number of adrenal disorders, including autoimmune Addison’s disease, congenital adrenal hyperplasia, primary aldosteronism, adrenocortical tumors and hyperplasias, and pheochromocytomas and paragangliomas. The final section presents the latest diagnostic and management strategies for these disorders, addressing adrenal insufficiency, adrenal Cushing’s Syndrome and aldosteronism, among others. Over the past twenty years, our understanding of disorders of the adrenal glands has been altered and deepened. Providing a much-needed update to the literature, Adrenal Disorders: Physiology, Pathophysiology and Treatment will be an important resource for both academic and clinical endocrinologists working with the adrenal glands and managing patients with adrenal disorders.
