Download or read book Genomics Personalized Medicine and Oral Disease written by Stephen T. Sonis, DMD, DMSc and published by Springer. This book was released on 2015-09-17 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.
Download or read book Genomics Personalized Medicine and Oral Disease written by DMD Sonis (DMSc, Stephen T.) and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section of the book provides basic information about genetics, genomics, and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral microbiome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.
Download or read book Personalized Oral Health Care written by Peter J. Polverini and published by Springer. This book was released on 2016-01-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the oral health care environment as the transition is made to a system increasingly focusing on disease prevention, early intervention to minimize disease progression, and a personalized approach that meets each individual’s needs. Descriptions are provided of an array of technologies based on rapid advances in genomic medicine and omics technology that are already entering clinical practice and promise to have a huge impact on risk assessment, diagnosis, and therapy. Detailed consideration is also paid to personalized health insurance in the new environment, the impact of personalized health care on the economics of health care, and the consequences for the global diagnostic market place and improved access to care. The changes in dental education required to produce dentists better equipped to participate in the new health care environment are examined, and the book concludes by considering key opportunities and challenges.
Download or read book Translational Systems Medicine and Oral Disease written by Stephen Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care
Download or read book Genetic Basis of Oral Health Conditions written by Alexandre Rezende Vieira and published by Springer Nature. This book was released on 2019-11-28 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patient’s condition is pure "bad luck", whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.
Download or read book Oral Cancer written by Gokul Sridharan and published by BoD – Books on Demand. This book was released on 2022-01-07 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral cancer is a common disease with a high incidence of morbidity and mortality. Despite technological advancements in diagnosis and treatment, the five-year survival rate is low. Researchers worldwide are attempting to identify new and novel methods for early diagnosis and better treatment of oral cancer to improve survival rate and quality of life post recovery. This book examines current concepts in oral cancer and emphasizes future perspectives for diagnosis and treatment of disease for better clinical outcomes and patient care.
Download or read book Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2012-11-29 with total page 1343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Download or read book Molecular Medicine written by R.J. Trent and published by Academic Press. This book was released on 2012-08-22 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances. Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicine The only book in Molecular Medicine to reach its fourth edition Identifies current practice as well as future developments Presents extensive tables, well presented figures and resources for further understanding
Download or read book Omics for Personalized Medicine written by Debmalya Barh and published by Springer Science & Business Media. This book was released on 2013-10-14 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.
Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2022-04-09 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients
Download or read book Integrative Preventive Medicine written by Richard H. Carmona and published by Oxford University Press. This book was released on 2017-12-12 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most clinicians, the science and evidence for many integrative therapies is largely unknown or considered suspect. Most physicians don't have time to learn integrative approaches and aren't sure what to recommend or which approaches have merit or improved outcomes. Here, clinicians have easy access to the best practices in integrative medicine and expectations for outcomes
Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2019-08-15 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Offers comprehensive coverage of infectious and inflammatory disease genomics Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine Presents an up-to-date overview on major opportunities for genomic and personalized medicine Includes case studies that highlight the practical use of genomics in the management of patients
Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2017-03-30 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients
Download or read book Genomic and Personalized Medicine Principles methodology and translational approaches written by Geoffrey S. Ginsburg and published by . This book was released on 2009 with total page 1478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides an indepth look at one of the most promising avenues for advances in preventing and treating human genetic diseases. This handbook presents basic principles of human disease genetics and epidemiology/statistics, with a thorough understanding of applications and methods of genome technologies. With full color throughout, this reference provides a detailed assessment of the current developments in genomic medicine for each of the major disease groups. With the latest information on diagnostic testing, population screening, predicting disease susceptibility and more, this handbook is an essential tool for specialists and graduate students across medical disciplines including: human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and biomedical sciences. Provides information on genomic applications and impact on medicine to the major disease groups: Cancer, Cardiovascular, Infectious Disease, Neurological, Renal, Psychiatr.
Download or read book Genomic Medicine The Genetic Information Revolution in Clinical Practice written by Edenilson Brandl and published by Edenilson Brandl. This book was released on with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to the world of genomics and its incredible applications in medicine. In this book, we will explore the scientific and technological advances that have revolutionized our understanding of the human genome and how these discoveries are transforming the field of health. Genomics, which studies the structure, function and sequence of our genetic material, has played a fundamental role in the identification of genetic variants associated with diseases and in the development of new therapeutic strategies. By mapping the human genome, it has become possible to better understand the origins of diseases and offer personalized treatments, opening doors to precision medicine. In this book, we'll delve into a number of fascinating and interconnected topics. We'll start by exploring gene therapy, an innovative approach that aims to correct genetic defects directly at the DNA level. We will see how genomics has the potential to transform the landscape of dentistry, revealing valuable information about oral health and contributing to more effective treatments. In addition, we will examine the interface between genomics and regulatory medicine, considering the ethical and social implications of genomic discoveries. We will also explore the role of genomics in mental health, seeking to identify genetic markers that may aid in the diagnosis and treatment of psychiatric disorders. Genomics has a significant impact on personalized medicine, and we will discuss its applications in a variety of diseases, from pediatric infectious diseases to metabolic and endocrine diseases. Furthermore, we will investigate its role in addressing chronic, rare and genetic diseases in children. As we move forward, we will also explore genomics in emerging areas such as nanomedicine, precision medicine in developing countries, and synthetic biology. We will investigate its influence in the field of obstetrics, stem cells, genetic engineering, neurodegenerative diseases, urological diseases and aging. By the end of this book, I hope you will have a deeper understanding of the vast possibilities offered by genomics in the search for more effective, personalized and well-being treatments for each individual. Genomics is transforming medicine as we know it, and it is an ever-evolving field filled with promise and exciting discoveries. Ready to embark on this fascinating journey? Let's explore together the secrets of the human genome and its implications for the health and well-being of humanity.
Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Download or read book Genetics and Genomics in Medicine written by T. Strachan and published by . This book was released on 2015 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
