Download or read book Genetics of the TolC Locus of Escherichia Coli K 12 written by Eleanor Noss Whitney and published by . This book was released on 1970 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The TolC Locus of Escherichia Coli K 12 written by Renato Morona and published by . This book was released on 1982 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Genetic Analysis of the TolA B Locus of Escherichia Coli K 12 written by Alan Bernstein and published by . This book was released on 1972 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic and Molecular Analysis of the RecR Locus of Escherichia Coli K 12 written by Akeel Abdulla Mahdi and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organization of Prokaryotic Cell Membranes written by Bijan K. Ghosh and published by CRC Press. This book was released on 2018-01-18 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes include a collection of authoritative articles covering the most active areas of prokaryotic biomembrane investigations, and will provide a great service not only to those interested in the field but also to microbiologists in general. These monographs will also serve to focus attention on prokaryotic membranes that are so often ignored by eukaryoticmembraneologists and proved an excellent reference source for many years to come.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1996 with total page 1340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microbiology Abstracts written by and published by . This book was released on 1983 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Efflux Mediated Antimicrobial Resistance in Bacteria written by Xian-Zhi Li and published by Springer. This book was released on 2016-11-09 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
Download or read book Studies on Escherichia Coli written by Mitchell Harris Singer and published by . This book was released on 1990 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of Bacteriology written by and published by . This book was released on 1984 with total page 1142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bad Bugs in the XXIst Century Resistance Mediated by Multi Drug Efflux Pumps in Gram Negative Bacteria written by Attilio Vittorio Vargiu and published by Frontiers Media SA. This book was released on 2016-08-12 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives.
Download or read book Prokaryotic Structure and Function written by Society for General Microbiology. Symposium and published by Cambridge University Press. This book was released on 1992-02-20 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book evaluates the increasing wealth of knowledge that has accumulated concerning the regulation of synthesis and assembly of structural components of the bacterial cell. It is now possible in many cases to trace the exact sequence of events triggered by a change in the physical or chemical environment of a bacterial cell, for instance, signaling, gene expression, transport of the gene product to its correct location, and assembly into a functional structure. The scope of this volume is broad, ranging from the organization of the nuclear material itself to the sequence of events leading to differentiation and development; from the synthesis of intracellular storage material to the assembly of specialized photosynthetic membranes, periplasmic electron transfer chains, and heat-resistant spores.
Download or read book Alkali Cation Transport Systems in Prokaryotes written by E. P. Bakker and published by CRC Press. This book was released on 1992-11-30 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alkali Cation Transport Systems in Prokaryotes is the first book that brings together the physiological, structural, and molecular biological aspects of the transport of sodium, potassium, and ammonium across the bacterial cell membrane. Sodium translocation plays a major role in energy coupling of some prokaryotes, and much of the book is devoted to new and exciting developments in this field. Over 30 experts have contributed to this excellent reference for microbiologists, biochemists, molecular biologists, cell biologists, chemotherapists, and researchers interested in bioenergetics.
Download or read book Canadian Journal of Microbiology written by and published by . This book was released on 1975 with total page 1218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Extremophiles Handbook written by Koki Horikoshi and published by Springer Science & Business Media. This book was released on 2010-12-08 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Extremophiles Handbook brings together the rapidly growing and often scattered information on microbial life in the whole range of extreme environments. This book will be a useful reference for finding clues to the origin of life and for exploring the biotechnology potential of these fascinating organisms.
Download or read book Synthetic Biology engineering complexity and refactoring cell capabilities written by Pablo Carbonell and published by Frontiers Media SA. This book was released on 2015-10-26 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rules of how complex behaviors arise, however, are not yet well understood. For instance, instead of considering cells as inert chassis in which synthetic devices could be easily operated to impart new functions, the presence of these systems may impact cell physiology with reported effects on transcription, translation, metabolic fitness and optimal resource allocation. The result of these changes in the chassis may be failure of the synthetic device, unexpected or reduced device behavior, or perhaps a more permissive environment in which the synthetic device is allowed to function. While new efforts have already been made to increase standardization and characterization of biological components in order to have well known parts as building blocks for the construction of more complex devices, also new strategies are emerging to better understand the biological dynamics underlying the phenomena we observe. For example, it has been shown that the features of single biological components [i.e. promoter strength, ribosome binding affinity, etc] change depending on the context where the sequences are allocated. Thus, new technical approaches have been adopted to preserve single components activity, as genomic insulation or the utilization of prediction algorithms able to take biological context into account. There have been noteworthy advances for synthetic biology in clinical technologies, biofuel production, and pharmaceuticals production; also, metabolic engineering combined with microbial selection/adaptation and fermentation processes allowed to make remarkable progress towards bio-products formation such as bioethanol, succinate, malate and, more interestingly, heterologous products or even non-natural metabolites. However, despite the many progresses, it is still clear that ad hoc trial and error predominates over purely bottom-up, rational design approaches in the synthetic biology community. In this scenario, modelling approaches are often used as a descriptive tool rather than for the prediction of complex behaviors. The initial confidence on a pure reductionist approach to the biological world has left space to a new and deeper investigation of the complexity of biological processes to gain new insights and broaden the categories of synthetic biology. In this Research Topic we host contributions that explore and address two areas of Synthetic Biology at the intersection between rational design and natural complexity: (1) the impact of synthetic devices on the host cell, or "chassis" and (2) the impact of context on the synthetic devices. Particular attention will be given to the application of these principles to the rewiring of cell metabolism in a bottom-up fashion to produce non-natural metabolites or chemicals that should eventually serve as a substitute for petrol-derived chemicals, and, on a long-term view, to provide economical, ecological and ethical solutions to today’s energetic and societal challenges.
Download or read book Microbiological Reviews written by and published by . This book was released on 1990 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
