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Book Generalized Inference in Repeated Measures

Download or read book Generalized Inference in Repeated Measures written by Samaradasa Weerahandi and published by John Wiley & Sons. This book was released on 2004-08-24 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to powerful and practical statistical modeling using MANOVA Numerous statistical applications are time dependent. Virtually all biomedical, pharmaceutical, and industrial experiments demand repeated measurements over time. The same holds true for market research and analysis. Yet conventional methods, such as the Repeated Measures Analysis of Variance (Rm ANOVA), do not always yield exact solutions, obliging practitioners to settle for asymptotic results and approximate solutions. Generalized inference in Multivariate Analysis of Variance (MANOVA), mixed models, and growth curves offer exact methods of data analysis under milder conditions without deviating from the conventional philosophy of statistical inference. Generalized Inference in Repeated Measures is a concise, self-contained guide to the use of these innovative solutions, presenting them as extensions of–rather than alternatives to–classical methods of statistical evaluation. Requiring minimal prior knowledge of statistical concepts in the evaluation of linear models, the book provides exact parametric methods for each application considered, with solutions presented in terms of generalized p-values. Coverage includes: New concepts in statistical inference, with special focus on generalized p-values and generalized confidence intervals One-way and two-way ANOVA, in cases of equal and unequal variances Basic and higher-way mixed models, including testing and estimation of fixed effects and variance components Multivariate populations, including basic inference, comparison, and analysis of variance Basic, widely used repeated measures models including crossover designs and growth curves With a comprehensive set of formulas, illustrative examples, and exercises in each chapter, Generalized Inference in Repeated Measures is ideal as both a comprehensive reference for research professionals and a text for students.

Book Longitudinal Data Analysis

Download or read book Longitudinal Data Analysis written by Garrett Fitzmaurice and published by CRC Press. This book was released on 2008-08-11 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory

Book Exploring Data Tables  Trends  and Shapes

Download or read book Exploring Data Tables Trends and Shapes written by David C. Hoaglin and published by John Wiley & Sons. This book was released on 2011-09-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: WILEY-INTERSCIENCE PAPERBACK SERIES The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "Exploring Data Tables, Trends, and Shapes (EDTTS) was written as a companion volume to the same editors' book, Understanding Robust and Exploratory Data Analysis (UREDA). Whereas UREDA is a collection of exploratory and resistant methods of estimation and display, EDTTS goes a step further, describing multivariate and more complicated techniques . . . I feel that the authors have made a very significant contribution in the area of multivariate nonparametric methods. This book [is] a valuable source of reference to researchers in the area." —Technometrics "This edited volume . . . provides an important theoretical and philosophical extension to the currently popular statistical area of Exploratory Data Analysis, which seeks to reveal structure, or simple descriptions, in data . . . It is . . . an important reference volume which any statistical library should consider seriously." —The Statistician This newly available and affordably priced paperback version of Exploring Data Tables, Trends, and Shapes presents major advances in exploratory data analysis and robust regression methods and explains the techniques, relating them to classical methods. The book addresses the role of exploratory and robust techniques in the overall data-analytic enterprise, and it also presents new methods such as fitting by organized comparisons using the square combining table and identifying extreme cells in a sizable contingency table with probabilistic and exploratory approaches. The book features a chapter on using robust regression in less technical language than available elsewhere. Conceptual support for each technique is also provided.

Book Computational Molecular Evolution

Download or read book Computational Molecular Evolution written by Ziheng Yang and published by OUP Oxford. This book was released on 2006-10-05 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular evolution has experienced explosive growth in recent years due to the rapid accumulation of genetic sequence data, continuous improvements to computer hardware and software, and the development of sophisticated analytical methods. The increasing availability of large genomic data sets requires powerful statistical methods to analyse and interpret them, generating both computational and conceptual challenges for the field. Computational Molecular Evolution provides an up-to-date and comprehensive coverage of modern statistical and computational methods used in molecular evolutionary analysis, such as maximum likelihood and Bayesian statistics. Yang describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes. The book emphasizes essential concepts rather than mathematical proofs. It includes detailed derivations and implementation details, as well as numerous illustrations, worked examples, and exercises. It will be of relevance and use to students and professional researchers (both empiricists and theoreticians) in the fields of molecular phylogenetics, evolutionary biology, population genetics, mathematics, statistics and computer science. Biologists who have used phylogenetic software programs to analyze their own data will find the book particularly rewarding, although it should appeal to anyone seeking an authoritative overview of this exciting area of computational biology.

Book Contemporary Bayesian Econometrics and Statistics

Download or read book Contemporary Bayesian Econometrics and Statistics written by John Geweke and published by John Wiley & Sons. This book was released on 2005-10-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tools to improve decision making in an imperfect world This publication provides readers with a thorough understanding of Bayesian analysis that is grounded in the theory of inference and optimal decision making. Contemporary Bayesian Econometrics and Statistics provides readers with state-of-the-art simulation methods and models that are used to solve complex real-world problems. Armed with a strong foundation in both theory and practical problem-solving tools, readers discover how to optimize decision making when faced with problems that involve limited or imperfect data. The book begins by examining the theoretical and mathematical foundations of Bayesian statistics to help readers understand how and why it is used in problem solving. The author then describes how modern simulation methods make Bayesian approaches practical using widely available mathematical applications software. In addition, the author details how models can be applied to specific problems, including: * Linear models and policy choices * Modeling with latent variables and missing data * Time series models and prediction * Comparison and evaluation of models The publication has been developed and fine- tuned through a decade of classroom experience, and readers will find the author's approach very engaging and accessible. There are nearly 200 examples and exercises to help readers see how effective use of Bayesian statistics enables them to make optimal decisions. MATLAB? and R computer programs are integrated throughout the book. An accompanying Web site provides readers with computer code for many examples and datasets. This publication is tailored for research professionals who use econometrics and similar statistical methods in their work. With its emphasis on practical problem solving and extensive use of examples and exercises, this is also an excellent textbook for graduate-level students in a broad range of fields, including economics, statistics, the social sciences, business, and public policy.

Book Statistical Methods in Spatial Epidemiology

Download or read book Statistical Methods in Spatial Epidemiology written by Andrew B. Lawson and published by John Wiley & Sons. This book was released on 2013-07-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology. Updated to include a new emphasis on bio-terrorism and disease surveillance. Emphasizes the importance of space-time modelling and outlines the practical application of the method. Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software. Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques. This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.

Book Multistate Systems Reliability Theory with Applications

Download or read book Multistate Systems Reliability Theory with Applications written by Bent Natvig and published by John Wiley & Sons. This book was released on 2010-12-07 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most books in reliability theory are dealing with a description of component and system states as binary: functioning or failed. However, many systems are composed of multi-state components with different performance levels and several failure modes. There is a great need in a series of applications to have a more refined description of these states, for instance, the amount of power generated by an electrical power generation system or the amount of gas that can be delivered through an offshore gas pipeline network. This book provides a descriptive account of various types of multistate system, bound-for multistate systems, probabilistic modeling of monitoring and maintenance of multistate systems with components along with examples of applications. Key Features: Looks at modern multistate reliability theory with applications covering a refined description of components and system states. Presents new research, such as Bayesian assessment of system availabilities and measures of component importance. Complements the methodological description with two substantial case studies. Reliability engineers and students involved in the field of reliability, applied mathematics and probability theory will benefit from this book.

Book Reliability and Risk

    Book Details:
  • Author : Nozer D. Singpurwalla
  • Publisher : John Wiley & Sons
  • Release : 2006-08-14
  • ISBN : 0470060336
  • Pages : 396 pages

Download or read book Reliability and Risk written by Nozer D. Singpurwalla and published by John Wiley & Sons. This book was released on 2006-08-14 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: We all like to know how reliable and how risky certain situations are, and our increasing reliance on technology has led to the need for more precise assessments than ever before. Such precision has resulted in efforts both to sharpen the notions of risk and reliability, and to quantify them. Quantification is required for normative decision-making, especially decisions pertaining to our safety and wellbeing. Increasingly in recent years Bayesian methods have become key to such quantifications. Reliability and Risk provides a comprehensive overview of the mathematical and statistical aspects of risk and reliability analysis, from a Bayesian perspective. This book sets out to change the way in which we think about reliability and survival analysis by casting them in the broader context of decision-making. This is achieved by: Providing a broad coverage of the diverse aspects of reliability, including: multivariate failure models, dynamic reliability, event history analysis, non-parametric Bayes, competing risks, co-operative and competing systems, and signature analysis. Covering the essentials of Bayesian statistics and exchangeability, enabling readers who are unfamiliar with Bayesian inference to benefit from the book. Introducing the notion of “composite reliability”, or the collective reliability of a population of items. Discussing the relationship between notions of reliability and survival analysis and econometrics and financial risk. Reliability and Risk can most profitably be used by practitioners and research workers in reliability and survivability as a source of information, reference, and open problems. It can also form the basis of a graduate level course in reliability and risk analysis for students in statistics, biostatistics, engineering (industrial, nuclear, systems), operations research, and other mathematically oriented scientists, wherein the instructor could supplement the material with examples and problems.

Book Introduction to Linear Regression Analysis

Download or read book Introduction to Linear Regression Analysis written by Douglas C. Montgomery and published by John Wiley & Sons. This book was released on 2013-06-06 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Fourth Edition "As with previous editions, the authors have produced a leading textbook on regression." —Journal of the American Statistical Association A comprehensive and up-to-date introduction to the fundamentals of regression analysis Introduction to Linear Regression Analysis, Fifth Edition continues to present both the conventional and less common uses of linear regression in today’s cutting-edge scientific research. The authors blend both theory and application to equip readers with an understanding of the basic principles needed to apply regression model-building techniques in various fields of study, including engineering, management, and the health sciences. Following a general introduction to regression modeling, including typical applications, a host of technical tools are outlined such as basic inference procedures, introductory aspects of model adequacy checking, and polynomial regression models and their variations. The book then discusses how transformations and weighted least squares can be used to resolve problems of model inadequacy and also how to deal with influential observations. The Fifth Edition features numerous newly added topics, including: A chapter on regression analysis of time series data that presents the Durbin-Watson test and other techniques for detecting autocorrelation as well as parameter estimation in time series regression models Regression models with random effects in addition to a discussion on subsampling and the importance of the mixed model Tests on individual regression coefficients and subsets of coefficients Examples of current uses of simple linear regression models and the use of multiple regression models for understanding patient satisfaction data. In addition to Minitab, SAS, and S-PLUS, the authors have incorporated JMP and the freely available R software to illustrate the discussed techniques and procedures in this new edition. Numerous exercises have been added throughout, allowing readers to test their understanding of the material. Introduction to Linear Regression Analysis, Fifth Edition is an excellent book for statistics and engineering courses on regression at the upper-undergraduate and graduate levels. The book also serves as a valuable, robust resource for professionals in the fields of engineering, life and biological sciences, and the social sciences.

Book Image Processing and Jump Regression Analysis

Download or read book Image Processing and Jump Regression Analysis written by Peihua Qiu and published by John Wiley & Sons. This book was released on 2005-05-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first text to bridge the gap between image processing andjump regression analysis Recent statistical tools developed to estimate jump curves andsurfaces have broad applications, specifically in the area of imageprocessing. Often, significant differences in technicalterminologies make communication between the disciplines of imageprocessing and jump regression analysis difficult. Ineasy-to-understand language, Image Processing and JumpRegression Analysis builds a bridge between the worlds ofcomputer graphics and statistics by addressing both the connectionsand the differences between these two disciplines. The authorprovides a systematic analysis of the methodology behindnonparametric jump regression analysis by outlining procedures thatare easy to use, simple to compute, and have proven statisticaltheory behind them. Key topics include: Conventional smoothing procedures Estimation of jump regression curves Estimation of jump location curves of regression surfaces Jump-preserving surface reconstruction based on localsmoothing Edge detection in image processing Edge-preserving image restoration With mathematical proofs kept to a minimum, this book isuniquely accessible to a broad readership. It may be used as aprimary text in nonparametric regression analysis and imageprocessing as well as a reference guide for academicians andindustry professionals focused on image processing or curve/surfaceestimation.

Book Time Series Analysis and Forecasting by Example

Download or read book Time Series Analysis and Forecasting by Example written by Søren Bisgaard and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: An intuition-based approach enables you to master time series analysis with ease Time Series Analysis and Forecasting by Example provides the fundamental techniques in time series analysis using various examples. By introducing necessary theory through examples that showcase the discussed topics, the authors successfully help readers develop an intuitive understanding of seemingly complicated time series models and their implications. The book presents methodologies for time series analysis in a simplified, example-based approach. Using graphics, the authors discuss each presented example in detail and explain the relevant theory while also focusing on the interpretation of results in data analysis. Following a discussion of why autocorrelation is often observed when data is collected in time, subsequent chapters explore related topics, including: Graphical tools in time series analysis Procedures for developing stationary, non-stationary, and seasonal models How to choose the best time series model Constant term and cancellation of terms in ARIMA models Forecasting using transfer function-noise models The final chapter is dedicated to key topics such as spurious relationships, autocorrelation in regression, and multiple time series. Throughout the book, real-world examples illustrate step-by-step procedures and instructions using statistical software packages such as SAS, JMP, Minitab, SCA, and R. A related Web site features PowerPoint slides to accompany each chapter as well as the book's data sets. With its extensive use of graphics and examples to explain key concepts, Time Series Analysis and Forecasting by Example is an excellent book for courses on time series analysis at the upper-undergraduate and graduate levels. it also serves as a valuable resource for practitioners and researchers who carry out data and time series analysis in the fields of engineering, business, and economics.

Book Clinical Trial Design

    Book Details:
  • Author : Guosheng Yin
  • Publisher : John Wiley & Sons
  • Release : 2013-06-07
  • ISBN : 1118183320
  • Pages : 368 pages

Download or read book Clinical Trial Design written by Guosheng Yin and published by John Wiley & Sons. This book was released on 2013-06-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Book Multivariate Statistics

Download or read book Multivariate Statistics written by Yasunori Fujikoshi and published by John Wiley & Sons. This book was released on 2011-08-15 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive examination of high-dimensional analysis of multivariate methods and their real-world applications Multivariate Statistics: High-Dimensional and Large-Sample Approximations is the first book of its kind to explore how classical multivariate methods can be revised and used in place of conventional statistical tools. Written by prominent researchers in the field, the book focuses on high-dimensional and large-scale approximations and details the many basic multivariate methods used to achieve high levels of accuracy. The authors begin with a fundamental presentation of the basic tools and exact distributional results of multivariate statistics, and, in addition, the derivations of most distributional results are provided. Statistical methods for high-dimensional data, such as curve data, spectra, images, and DNA microarrays, are discussed. Bootstrap approximations from a methodological point of view, theoretical accuracies in MANOVA tests, and model selection criteria are also presented. Subsequent chapters feature additional topical coverage including: High-dimensional approximations of various statistics High-dimensional statistical methods Approximations with computable error bound Selection of variables based on model selection approach Statistics with error bounds and their appearance in discriminant analysis, growth curve models, generalized linear models, profile analysis, and multiple comparison Each chapter provides real-world applications and thorough analyses of the real data. In addition, approximation formulas found throughout the book are a useful tool for both practical and theoretical statisticians, and basic results on exact distributions in multivariate analysis are included in a comprehensive, yet accessible, format. Multivariate Statistics is an excellent book for courses on probability theory in statistics at the graduate level. It is also an essential reference for both practical and theoretical statisticians who are interested in multivariate analysis and who would benefit from learning the applications of analytical probabilistic methods in statistics.

Book Structural Equation Modeling

Download or read book Structural Equation Modeling written by Sik-Yum Lee and published by John Wiley & Sons. This book was released on 2007-04-04 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: ***Winner of the 2008 Ziegel Prize for outstanding new book of the year*** Structural equation modeling (SEM) is a powerful multivariate method allowing the evaluation of a series of simultaneous hypotheses about the impacts of latent and manifest variables on other variables, taking measurement errors into account. As SEMs have grown in popularity in recent years, new models and statistical methods have been developed for more accurate analysis of more complex data. A Bayesian approach to SEMs allows the use of prior information resulting in improved parameter estimates, latent variable estimates, and statistics for model comparison, as well as offering more reliable results for smaller samples. Structural Equation Modeling introduces the Bayesian approach to SEMs, including the selection of prior distributions and data augmentation, and offers an overview of the subject’s recent advances. Demonstrates how to utilize powerful statistical computing tools, including the Gibbs sampler, the Metropolis-Hasting algorithm, bridge sampling and path sampling to obtain the Bayesian results. Discusses the Bayes factor and Deviance Information Criterion (DIC) for model comparison. Includes coverage of complex models, including SEMs with ordered categorical variables, and dichotomous variables, nonlinear SEMs, two-level SEMs, multisample SEMs, mixtures of SEMs, SEMs with missing data, SEMs with variables from an exponential family of distributions, and some of their combinations. Illustrates the methodology through simulation studies and examples with real data from business management, education, psychology, public health and sociology. Demonstrates the application of the freely available software WinBUGS via a supplementary website featuring computer code and data sets. Structural Equation Modeling: A Bayesian Approach is a multi-disciplinary text ideal for researchers and students in many areas, including: statistics, biostatistics, business, education, medicine, psychology, public health and social science.

Book Combinatorial Methods in Discrete Distributions

Download or read book Combinatorial Methods in Discrete Distributions written by Charalambos A. Charalambides and published by John Wiley & Sons. This book was released on 2005-06-24 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique approach illustrating discrete distribution theory through combinatorial methods This book provides a unique approach by presenting combinatorial methods in tandem with discrete distribution theory. This method, particular to discreteness, allows readers to gain a deeper understanding of theory by using applications to solve problems. The author makes extensive use of the reduction approach to conditional distributions of independent random occupancy numbers, and provides excellent studies of occupancy and sequential occupancy distributions, convolutions of truncated discrete distributions, and compound and mixture distributions. Combinatorial Methods in Discrete Distributions begins with a brief presentation of set theory followed by basic counting principles. Fundamental principles of combinatorics, finite differences, and discrete probability are included to give readers the necessary foundation to the topics presented in the text. A thorough examination of the field is provided and features: Stirling numbers and generalized factorial coefficients Occupancy and sequential occupancy distributions n-fold convolutions of truncated distributions Compound and mixture distributions Thoroughly worked examples aid readers in understanding complex theory and discovering how theory can be applied to solve practical problems. An appendix with hints and answers to the exercises helps readers work through the more complex sections. Reference notes are provided at the end of each chapter, and an extensive bibliography offers readers a resource for additional information on specialized topics.

Book Preparing for the Worst

Download or read book Preparing for the Worst written by Hrishikesh (Rick) D. Vinod and published by John Wiley & Sons. This book was released on 2004-11-11 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely approach to downside risk and its role in stock market investments When dealing with the topic of risk analysis, most books on investments treat downside and upside risk equally. Preparing for the Worst takes an entirely novel approach by focusing on downside risk and explaining how to incorporate it into investment decisions. Highlighting this asymmetry of the stock market, the authors describe how existing theories miss the downside and follow with explanations of how it can be included. Various techniques for calculating downside risk are demonstrated. This book presents the latest ideas in the field from the ground up, making the discussion accessible to mathematicians and statisticians interested in applications in finance, as well as to finance professionals who may not have a mathematical background. An invaluable resource for anyone wishing to explore the critical issues of finance, portfolio management, and securities pricing, this book: Incorporates Value at Risk into the theoretical discussion Uses many examples to illustrate downside risk in U.S., international, and emerging market investments Addresses downside risk arising from fraud and corruption Includes step-by-step instructions on how to implement the methods introduced in this book Offers advice on how to avoid pitfalls in calculations and computer programming Provides software use information and tips

Book Handbook of Monte Carlo Methods

Download or read book Handbook of Monte Carlo Methods written by Dirk P. Kroese and published by John Wiley & Sons. This book was released on 2013-06-06 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of Monte Carlo simulation that explores the latest topics, techniques, and real-world applications More and more of today’s numerical problems found in engineering and finance are solved through Monte Carlo methods. The heightened popularity of these methods and their continuing development makes it important for researchers to have a comprehensive understanding of the Monte Carlo approach. Handbook of Monte Carlo Methods provides the theory, algorithms, and applications that helps provide a thorough understanding of the emerging dynamics of this rapidly-growing field. The authors begin with a discussion of fundamentals such as how to generate random numbers on a computer. Subsequent chapters discuss key Monte Carlo topics and methods, including: Random variable and stochastic process generation Markov chain Monte Carlo, featuring key algorithms such as the Metropolis-Hastings method, the Gibbs sampler, and hit-and-run Discrete-event simulation Techniques for the statistical analysis of simulation data including the delta method, steady-state estimation, and kernel density estimation Variance reduction, including importance sampling, latin hypercube sampling, and conditional Monte Carlo Estimation of derivatives and sensitivity analysis Advanced topics including cross-entropy, rare events, kernel density estimation, quasi Monte Carlo, particle systems, and randomized optimization The presented theoretical concepts are illustrated with worked examples that use MATLAB®, a related Web site houses the MATLAB® code, allowing readers to work hands-on with the material and also features the author's own lecture notes on Monte Carlo methods. Detailed appendices provide background material on probability theory, stochastic processes, and mathematical statistics as well as the key optimization concepts and techniques that are relevant to Monte Carlo simulation. Handbook of Monte Carlo Methods is an excellent reference for applied statisticians and practitioners working in the fields of engineering and finance who use or would like to learn how to use Monte Carlo in their research. It is also a suitable supplement for courses on Monte Carlo methods and computational statistics at the upper-undergraduate and graduate levels.