Download or read book Galenics of Insulin written by Jens Brange and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Galenical pharmacy or galenics is the science dealing with the pro duction of drug substances from raw materials, the purity of such substances, their formulation into pharmaceutical preparations with the desired effects and safety in use, and the quality control, stability and storage of the preparations. The field has taken its name from the Greek physician Galen (131-201 A.D.), who had a profound influence on medicine for many centuries because he collected and systematized the medicinal knowledge of his time. The discovery of insulin is attributed to Banting and Best who, in 1921, prepared an extract of the pancreas of the fetal calf and showed that the extract was capable of reducing the blood sugar level of a diabetic dog. This outstanding discovery gave rise to the rapid develop ment of the manufacture of insulin of bovine and porcine origin. By 1925, two Danish manufacturers of insulin preparations were established; both have since been in the forefront ofthe development of insulin preparations, the latest achievement being the marketing of human insulin by Novo in 1982. The development of highly purified human insulin produced semisynthetically from porcine insulin or by DNA recombinant methods are significant contributions to safe and efficient insulin therapy. Insulin is a protein which is destroyed in the gastrointestinal tract.
Download or read book Galenics of Insulin written by Jens Brange and published by Springer. This book was released on 1987 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concise summary of diagnosis and treatment of poisoning. Intended for medical students, house officers, and practicing physicians. Contains updated information, as well as a new index to tables. Poisons are arranged according to type, i.e., agricultural, household, medicinal, industrial, and natural hazards. Clinical findings, prevention, treatment, prognosis, and references are given in the entries. General index.
Download or read book Pharmaceutical Biotechnology written by Daan J. A. Crommelin and published by Springer. This book was released on 2019-04-13 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.
Download or read book Successful Drug Discovery written by János Fischer and published by John Wiley & Sons. This book was released on 2015-02-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Download or read book Insulin written by Pedro Cuatrecasas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is fourteen years since insulin was last reviewed in The Handbook of Ex perimental Pharmacology, in volume 32. The present endeavor is more modest in scope. Volume 32 appeared in two separate parts, each having its own subeditors, and together the two parts covered nearly all areas of insulin pharmacology. Such comprehensiveness seemed impractical in a new volume. The amount of in formation related to insulin that is now available simply would not fit in a reasonable amount of space. Furthermore, for better or worse, scientists have be come so specialized that a volume providing such broad coverage seemed likely in its totality to be of interest or value to very few individuals. We therefore decided to limit the present volume to the following areas: insulin chemistry and structure, insulin biosynthesis and secretion, insulin receptor, and insulin action at the cellular level. We felt these areas formed a coherent unit. We also felt, perhaps as much because of our own interests and perspectives as any objective reality, that these were the areas in which recent progress has been most dramatic, and yet, paradoxically and tantalizingly, these were the areas in which most has yet to be learned. Even with this limited scope, there are some major gaps in coverage. Regrettably, two important areas, the beta cell ATP-sensitive potassium channel and the glucose transporter, were among these. Nevertheless, the authors who con tributed have done an excellent job, and we would like to thank them for their diligence.
Download or read book Functional Insulin Treatment written by Kinga Howorka and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Insulin Treatment (FIT) is the most effective method of treatment for type 1(insulin-dependent) diabetes available today. Whether with an insulin pump or with multiple daily injections, the diabetic patient trained in FIT is able to dose his insulin on the basis of actual fuction so that he achieves near-normoglycemia and the freedom to eat when, what and how much he wants. The goal of FIT is to adapt the therapy to the lifestyle of the patient. This book creates a common basis for communication among therapists (physicians, nurses, dietitians, diabetes educators) and patients involved in FIT. It clearly defines the principles of the treatment and describes the contents, media and techniques of a practical program for training patients to carry it out.
Download or read book Insulin like Growth Factors written by Derek LeRoith and published by CRC Press. This book was released on 1991-05-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Download or read book RSSDI Textbook of Diabetes Mellitus written by Hemraj B Chandalia and published by JP Medical Ltd. This book was released on 2012-01-15 with total page 1353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition was published in 2008, only two years after the first, but went out of print before a third edition could be prepared, so this revised version of the second edition is published to bridge the gap. Under the auspices of the Research Society for the Study of Diabetes in India, endocrinologists, immunologists, and other specialists present a broad reference on the disease of which India has more cases than any other country. After a review of landmarks in the history of diabetes, they cover physiology and metabolism, diagnosis and classification, epidemiology, etiopathogenesis of diabetes mellitus, genetics and immunology, clinical profile, management, co-morbid conditions, complications, diabetes through life and events, living with diabetes, health care delivery, and prevention. The two volumes are paged continuously, and both contain the combined index. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).
Download or read book Endocrine System Diseases New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Stability and Characterization of Protein and Peptide Drugs written by Rodney Pearlman and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.
Download or read book Protein Design and the Development of New Therapeutics and Vaccines written by Jerry B. Hook and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a symposium held November 1988, in King of Prussia, Penn. Among the topics: structural analysis of proteins, protein folding and stability, receptor design and regulation, guanine nucleotide binding protein family, modeling and structure prediction in macromolecules, protein engineering and
Download or read book Absorbable and Biodegradable Polymers written by Shalaby W. Shalaby and published by CRC Press. This book was released on 2003-10-27 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in biodegradable and absorbable polymers is growing rapidly in large part because of their biomedical implant and drug delivery applications. This text illustrates creative approaches to custom designing unique, fiber-forming materials for equally unique applications. It includes an example of the development and application of a new absor
Download or read book Biopolymers at Interfaces Second Edition written by Martin Malmsten and published by CRC Press. This book was released on 2003-01-15 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition features research from nearly 60 of the profession's most distinguished international authorities. Recognizing emerging developments in biopolymer systems research with fully updated and expanded chapters, the second edition discusses the biopolymer-based multilayer structures and their application in biosensors, the progress made in the understanding of protein behaviour at the air-water interface, experimental findings in ellipsometry and reflectometry, and recent developments concerning protein interfacial behaviour in microfabricated total analysis systems and microarrays. With over 3000 references, this is an essential reference for professionals and students in surface, pharmaceutical, colloid, polymer, and medicinal chemistry; chemical, formulation, and application engineering; and pharmacy.
Download or read book Pharmaceutical Formulation Development of Peptides and Proteins written by Lars Hovgaard and published by CRC Press. This book was released on 2012-11-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap
Download or read book Polypeptide Protein Drugs written by Robert Charles Hider and published by CRC Press. This book was released on 1991-04-01 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of recent developments in polypeptide and protein chemistry and biology relevant to their exploitation as pharmaceuticals. Topics covered include the structure and folding of proteins, polypeptide function, the current status of polypeptide pharmaceuticals, quality control and safety.
Download or read book The Discovery of Insulin written by Michael Bliss and published by University of Toronto Press. This book was released on 2017-06-22 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
Download or read book Therapeutic Peptides and Proteins written by Ajay K. Banga and published by CRC Press. This book was released on 2005-09-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up
