Download or read book Respiratory Genetics written by Edwin Silverman and published by CRC Press. This book was released on 2005-09-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
Download or read book Functional Genomics of Lung Disease written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional genomics of lung disease written by and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Genomics of Lung Disease written by and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Supplement written by American Thoracic Society and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Supplement Functional Genomics of Lung Disease written by Pittsburgh International Lung Conference and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Clinical Relevance of Genetic Factors in Pulmonary Diseases written by Takeshi Kaneko and published by Springer. This book was released on 2018-07-12 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.
Download or read book Making Genomics Functional in Lung Disease written by and published by . This book was released on 2007 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Lung written by Robert A. Stockley and published by Springer Science & Business Media. This book was released on 1998 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease.- Emphysema.- 2. Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige Giuseppe Lungarella, Eleonora Cavarra and.- 3. ?1-Antitrypsin Deficiency.- 4. Recombinant SLPI: Emphysema and Asthma.- 5. Elastase Inhibitors in the Lung: Expression and Functional Relationships.- 6. Regulation of Neutrophil Proteinases.- 7. Control of Connective Tissue Genes.- Infection.- 8. Genetic Models of Bacterial Lung Infection.- 9. Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract.- 10. Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections.- 11. Cystic Fibrosis.- 12. Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy.
Download or read book Molecular Pathology of Lung Diseases written by Dani S. Zander and published by Springer Science & Business Media. This book was released on 2010-05-26 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.
Download or read book Post Genomic Perspectives in Modeling and Control of Breathing written by Jean Champagnat and published by Springer Science & Business Media. This book was released on 2010-06-28 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post Genomic Perspectives in Modeling and Control of Breathing is comprised of the proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16, 2003 in Paris, France. This publication is placed within the general framework of post-genomic neurobiology, pathology, and the precise example of the rhythmic respiratory neural assembly being used to understand how genetic networks have been selected and conserved in the vertebrate brain. Specific topics include: ion channels and synapses responsible for respiratory rhythmogenesis and plasticity; pre- and post-natal development of the respiratory rhythm; chemosensory transduction and chemo-afferent signalling. These valuable insights open new avenues as to why the genetic codes underlying a vital function such as breathing have been selected, conserved, or optimized during evolution – a major issue of post-genomic biology. This critical issue will be considered from both top-down and bottom-up integrative modeling standpoints, with a view to elucidating the functional genomics linking discrete molecules to the integrated system that regulates breathing.
Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.
Download or read book Functional Genomics written by Germana Meroni and published by BoD – Books on Demand. This book was released on 2012-09-12 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book titled "Functional Genomics" contains a selection of chapters focused on crucial topics in functional genomics, from the analysis of the genetic code, to the understanding of the role of the different genes and to the proteomic implications. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Covering all the aspects involved in such a broad theme as functional genomics and in all its applications would be impossible within the same book. The different chapters represent a brief introduction to the topic, connecting the most promising developments in functional genomics technologies, focusing on specific applications in biomedicine, agro-food technologies and zootechniques.
Download or read book The Global Impact of Respiratory Disease written by Darcy D. Marciniuk and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Asthma and Chronic Obstructive Pulmonary Disease written by Dirkje S. Postma and published by CRC Press. This book was released on 2007 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.
Download or read book Exploring the Role of Gene environment Interactions in Asthma written by Minal Caliskan and published by . This book was released on 2013 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human rhinovirus (HRV) is the most frequent causative pathogen of the common cold and is also involved in the inception and morbidity of several upper and lower respiratory illnesses including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. In this dissertation, I aimed to uncover the genetic and gene expression contributions to inter-individual variation in response to human rhinovirus infection (HRV) in relation to asthma and lung function phenotypes. In Chapter 2, I explored the suitability of lymphoblastoid cell lines (LCLs) for functional genomics studies. I found evidence suggesting that LCLs may be a faithful model for expression quantitative trait loci (eQTL) mapping studies but not for studies of perturbations that affect immune and stress response. In Chapter 3, I studied the main and interactive effects of the genotype at the 17q21 asthma susceptibility locus and HRV wheezing illnesses in early life on inception of asthma in children. I found that variation at the 17q21 locus is associated with the risk and number of HRV wheezing illnesses in the first three years of life. I also showed that 17q21 locus is associated with asthma only in children who had had HRV wheezing illness in early life, suggesting an interaction between a common genetic risk factor (17q21 genotype) and a common environmental risk factor (HRV wheezing illness) with respect to childhood-onset asthma. In Chapter 4, I integrated genome-wide gene expression and genotype data in uninfected and HRV-infected peripheral blood mononuclear cells (PBMCs). I identified local genetic variation that affects gene expression in uninfected and HRV-infected PBMCs. Additionally, I discovered genotype x HRV interactions that influence the expression levels of 32 genes, and showed that HRV-interacting regulatory variations are promising QTLs for pulmonary function phenotypes.
