Download or read book Frontiers in Neurodegenerative Disorders and Aging written by Tomris Özben and published by IOS Press. This book was released on 2004 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Metabolic Inflammatory Axis in Brain Aging and Neurodegeneration written by Fei Yin and published by Frontiers Media SA. This book was released on 2017-08-16 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
Download or read book New Frontiers in Cognitive Aging written by Roger A. Dixon and published by Oxford : Oxford University Press. This book was released on 2004 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an ever increasing population of aging people in the western world, it is more crucial than ever that we try to understand how and why cognitive competence breaks down with advancing age; why do some people follow normal patterns of cognitive change, while others follow a path of progressive decline, with neurodegenerative diseases such as Alzheimer's. What can be done to prevent cognitive decline - or to avoid neurodegenerative diseases? The answers, if they come, will not emerge from research within one discipline, but from work being done across a range of scientific and medical specialities. This volume brings together leading experts from a range of fields studying cognitive aging, including neuroscience, pharmacology, health, genetics, sensory biology, and epidemiology. Unlike other books in this area, this book is more about 'new frontiers' than past research and accomplishments. Recently cognitive aging research has taken several new directions, linking with, and benefiting from, rapid technological and theoretical advances in these neighbouring disciplines. This book provides unique interdisciplinary coverage of the topic. With each chapter including commentaries from specialists in related fields, the book provides an integrative study of the topic. For those within the fields of psychology, cognitive neuroscience, and geriatrics, this volume will make an important contribution in furthering our understanding of a problem that affects us all.
Download or read book Frontiers in Aging Neuroscience Editor s Pick 2021 written by Thomas Wisniewski and published by Frontiers Media SA. This book was released on 2021-08-03 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
Download or read book Interphase Between Aging and Neurodegenerative Diseases written by Walter E. Müller and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Metals and Neurodegeneration Restoring the Balance written by Anthony R. White and published by Frontiers Media SA. This book was released on 2016-02-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.
Download or read book Hormones and Neural Aging Lessons From Experimental Models written by Isabel Varela-Nieto and published by Frontiers Media SA. This book was released on 2019-01-23 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can we slow the signs of aging? Although aging is a natural process for all living things, doing so without dramatic alterations of health and well-being is an important aim in health care. Understanding this gradual but continuous process is fundamental in order to avoid, or at least improve, aging associated illnesses and conditions. The reviews and studies compiled here address various aspects of the relationship between systemic and central changes during the aging process, with hormonal signals as the important liaison.
Download or read book Deep Learning in Aging Neuroscience written by Javier Ramírez and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Pathogenesis of Neurodegenerative Disorders written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2001 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade many advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disorders have been made. This book elucidates the fundamental mechanisms involved in neurodegenerative disorders such as Alzheimer's Parkinson's, and Huntington's diseases. In addition mechanisms that may prevent age-related neurodegenerative disorders are also provided. Pathogenesis of Neurodegenerative disorders will provide a valuable reference to graduate students and post docs as well as to senior scientists by allowing them to integrate information on cellular and molecular mechanisms across the wide field of neurodegenerative disorders.
Download or read book The Role of Glia in Alzheimer s Disease written by Beatriz G. Perez-Nievas and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.
Download or read book Brain Protein Aging and Dementia Control written by Gen Sobue and published by Frontiers Media SA. This book was released on 2019-06-28 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomarkers to Disentangle the Physiological From Pathological Brain Aging written by F. G. Guerini and published by Frontiers Media SA. This book was released on 2020-06-22 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iron and Neurodegeneration written by Isabella Zanella and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Neuroscientific Research for Management of Dementia written by Mohammad Amjad Kamal and published by Frontiers Media SA. This book was released on 2019-08-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this eBook are divided into three main chapters. Chapter 1 focuses on the role of specific proteins in the pathological processes of neurodegeneration, specifically Alzheimer's disease. Chapter 2 describes novel candidates and risk factors for the diagnosis of Alzheimer's disease. Chapter 3 targets various therapeutic interventions from pharmacological targets to cognitive function. This eBook thus provides an overall overview of the latest research in understanding mechanisms leading to the development of Alzheimer's disease, diagnosis, and therapeutic interventions.
Download or read book Trends in biomarkers for neurodegenerative diseases Current research and future perspectives written by Suman Dutta and published by Frontiers Media SA. This book was released on 2023-03-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropsychology and Neuropsychiatry of Neurodegenerative Disorders written by Manuel Menéndez-González and published by Frontiers Media SA. This book was released on 2016-01-25 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles all articles within the Research Topic "Neuropsychology and neuropsychiatry of neurodegenerative disorders" published in the journal Frontiers in Aging Neuroscience. The call was launched in 2014 and closed in 2015 with 21 articles published. Papers deal on several important topics of neuropsychology -such as language and visuospatial functions- and neuropsychiatry - such us the emotional or motivational spheres - , and the interphase between them. There are also articles on psychometry, brain morphometry, brain connectivity, diagnostic tests and interventional studies. All these articles are focused on neurodegenerative conditions, mostly Alzheimer’s disease and Parkinson’s disease. Interestingly, several articles addressed the early stages of these diseases. All together, this Research Topic provides a rich perspective of the research made today around neuropsychological and neuropsychiatric aspects of neurodegenerative diseases. We hope readers enjoy this collection of articles.
