Download or read book Tumour microenvironment in cancer research and drug discovery written by Syed Mahmood and published by Frontiers Media SA. This book was released on 2024-05-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
Download or read book Innate immunity and neurodegenerative diseases triggers from self and non self written by Kiran Bhaskar and published by Frontiers Media SA. This book was released on 2023-06-30 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Systemic immune dysregulation in malignant disease Insights monitoring and therapeutic exploitation written by Petros Christopoulos and published by Frontiers Media SA. This book was released on with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Innate Lymphoid Cells in Cancer Friends or Foes written by Nicolas Jacquelot and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Directions in Mobile Media and Performance written by Camille Baker and published by Routledge. This book was released on 2018-09-03 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Directions in Mobile Media and Performance explores various performative projects and forms of expression that have emerged since the onset of the smartphone. It focuses mainly on new concepts and developments that have emerged in mobile media performance. It showcases the intimate and phenomenological mobile aesthetic that has been unfolding within networked performance and media art projects for over a decade and a half. This aesthetic utilises the potential and affordances with each iteration and update of modern smartphones. Themes of embodiment, presence, liveness and connection through mobile, networked, and remote technology are revisited in the context of HD mobile cameras, selfies and live video streaming from the phone, as well as the impact of peer production, opensource and Maker culture on mobile media performance practices. It explores the surge in development of wearable devices in performance, as well as how the ‘quantified-self movement’ has affected performance works. It deals with concepts and developments in intermedial performance that incorporate mobile and wearable devices, especially from the artist’s, designer’s or dramaturge’s perspective as the creator and their creative process, working with technology as a collaborator, not just a tool or guide. The book demonstrates how artists have repurposed the device – transforming it from merely a communication device, using voice and text only – to become a new collaborative medium, a full visual, synaesthetic, interactive and performative tool of deeper expression and social change. It discusses seminal works and the evolution of the medium, within intermedial digital art and performance practices as medium for artistic expression, creative process and staged performances. It focuses on projects and artists who have pushed mobile media performance beyond the conventional blackbox. Emerging visual, digital, interactive, tactile, gestural and theatrical or performance projects that incorporate mobile or wearable devices, used as vehicles for more challenging, experimental, experiential and immersive performative artworks are highlighted. The book also contextualises Baker’s own media research and performance practice within the larger landscape with the field. It is bookended with interviews with the artists themselves on their creative process and intentions. It is the outcome of three years of research of artistic works around the world, interviews, in-person viewings of performances, as well as incorporating and reflecting on her own ongoing practice and projects in context.
Download or read book ADAM ADAMTS and Astacin Proteases Challenges and Breakthroughs in the Omics Era written by Salvatore Santamaria and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor Hang Fai Kwok has two filed patents on ADAM17 antibody applications in cancer and cardiovascular disease. All other Topic Editors declare no competing interests with regards to the Research Topic.
Download or read book Mucus Hypersecretion in Respiratory Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2003-07-07 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.
Download or read book Learning and Memory written by Michael A. Yassa and published by Frontiers Media SA. This book was released on 2022-01-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Translational Medicine in the Diagnosis and Treatment of Cancer based on Oncogenetics From Bench to Bedside written by Changjing Cai and published by Frontiers Media SA. This book was released on 2023-12-07 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational medicine was first mentioned in 1992 by Choi D. W and has since become a rapidly expanding area within biomedical research. It is based on the ‘bench to bedside’ approach, which describes it’s relationship between basic science and clinical practice. In 2008, Drs Conway and Dougherty provided a 3 step process to translational medicine and how it should be implemented to transform healthcare systems. The first step is the translation of basic science into clinical research (T1). The second step (T2) focuses on making healthcare more patient specific, basing itself on providing ‘the right treatment for the right patient in the right way at the right time’. T2 also looks for this science to be translated into practice guidelines for clinicians, policy makers and the patients themselves. The final step (T3) addresses the ‘how’ of implementing these ideas, so that high quality healthcare can be delivered reliably to all patients in all settings of care. T3 activities would include policy changes that could serve to bring about meaningful change towards this goal. Cancer is a major public health problem worldwide. Clarifying the etiology and pathogenesis of cancer is of great significance to the prevention, diagnosis, and treatment of the disease. The bench to bedside pattern can be a useful method for cancer-related studies. This Research Topic aims to highlight the emerging role of oncogenetics in cancer, and discuss potential challenges of diagnosis and treatment, from the bench to the bedside.
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer Science & Business Media. This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
Download or read book Immunomodulatory role of metalloproteases in chronic inflammatory diseases written by Chao Yang and published by Frontiers Media SA. This book was released on 2023-05-03 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tissue Repair and Fibrosis written by Alexis Desmouliere and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book The Cellular Biomineralization Pathways of Marine Organisms written by Andrew Stanley Mount and published by Frontiers Media SA. This book was released on 2022-01-05 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 2002 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Download or read book New Directions in Mobile Media and Performance written by Camille C. Baker and published by . This book was released on 2019 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mobile media affordances -- Mobile performance : evolving practices -- Artist perspectives
Download or read book State of the Art Research on C1q and the Classical Complement Pathway written by Uday Kishore and published by Frontiers Media SA. This book was released on 2016-11-22 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate immunity, C1q can engage a broad range of ligands derived from self, non-self and altered self via its heterotrimeric globular (gC1q) domain and thus trigger the classical complement pathway. The trimeric gC1q signature domain has been identified in a variety of non-complement proteins that can be grouped together as a C1q family. C1q circulates in serum as part of the C1 complex, in association with a catalytic tetrameric assembly of two homologous yet distinct serine proteases, C1r and C1s. Binding of C1q to appropriate targets leads to sequential activation of C1r and C1s, the latter being able to cleave complement components C4 and C2 thereby triggering the complement cascade. Activation of the classical pathway plays an important role in innate immune protection against pathogens and damaged elements from self. However, its involvement has been shown in various pathologies including ischemia-reperfusion injury and hereditary angioedema. Unexpected roles for the classical pathway have also been discovered recently, linked to both physiological and pathological aspects of development, including brain and cancer cells. These new perspectives should arouse renewed interest in a search for specific inhibitors of the classical pathway. In addition, C1q has recently been shown to have a number of functions that are independent of the activation of the classical pathway. This research topic is aimed at providing a state-of-the-art overview of the classical pathway, including, but not restricted to emerging functions of C1q and of the C1 complex, as well as pathological consequences of C1 activation or of the presence of anti-C1q autoantibodies . Contributions are included in the areas such as structural basis of C1q ligand recognition, C1q family proteins, inhibitors of the classical pathway identified in pathogens and improved derived inhibitors, structural determinants of the substrate specificities of C1r and C1s, elucidation of the architecture of C1, structural and functional homology of C1 with the initiating complexes of the lectin complement pathway, and novel involvement of C1q in processes such as ageing, cancer, synaptic pruning, and pregnancy.
