Download or read book From Synthesis to Antibacterial Activity of Some New Palladium II and Platinum IV Complexes written by Ivana D. Radojević and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: From Synthesis to Antibacterial Activity of Some New Palladium(II) and Platinum(IV) Complexes.
Download or read book Antimicrobial Agents written by Varaprasad Bobbarala and published by IntechOpen. This book was released on 2012-09-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. The book attempts to present emerging low cost and environmentally friendly drugs that are free from side effects studied in the overlapping disciplines of medicinal chemistry, biochemistry, microbiology and pharmacology.
Download or read book Antimicrobial Agents written by Varaprasad Bobbarala and published by BoD – Books on Demand. This book was released on 2012-09-12 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. The book attempts to present emerging low cost and environmentally friendly drugs that are free from side effects studied in the overlapping disciplines of medicinal chemistry, biochemistry, microbiology and pharmacology.
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Stephen B. Howell and published by Springer Science & Business Media. This book was released on 1991 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Download or read book Uses of Inorganic Chemistry in Medicine written by Nicholas P Farrell and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.
Download or read book Synthesis and Isomerization Studies of New Palladium II and Platinum II Alkyly Complexes written by David Glenn Garza and published by . This book was released on 1992 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Green Synthesis Characterization and Applications of Nanoparticles written by Ashutosh Kumar Shukla and published by Elsevier. This book was released on 2018-11-26 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Synthesis, Characterization and Applications of Nanoparticles shows how eco-friendly nanoparticles are engineered and used. In particular, metal nanoparticles, metal oxide nanoparticles and other categories of nanoparticles are discussed. The book outlines a range of methodologies and explores the appropriate use of each. Characterization methods include spectroscopic, microscopic and diffraction methods, but magnetic resonance methods are also included as they can be used to understand the mechanism of nanoparticle synthesis using organisms. Applications covered include targeted drug delivery, water purification and hydrogen generation. This is an important research resource for those wishing to learn more about how eco-efficient nanoparticles can best be used. Theoretical details and mathematical derivations are kept to a necessary minimum to suit the need of interdisciplinary audiences and those who may be relatively new to the field. Explores recent trends in growth, characterization, properties and applications of nanoparticles Gives readers an understanding on how they are applied through the use of case studies and examples Assesses the advantages and disadvantages of a variety of synthesis and characterization techniques for green nanoparticles in different situations
Download or read book Metal based Anticancer Agents written by Angela Casini and published by Royal Society of Chemistry. This book was released on 2019-04-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.
Download or read book Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.
Download or read book Medicinal Organometallic Chemistry written by Gérard Jaouen and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.
Download or read book Radically Different A Themed Issue in Honor of Professor Bernd Giese on the Occasion of His 80th Birthday written by Katharina M. Fromm and published by MDPI. This book was released on 2020-12-02 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue came together thanks to contributions from friends and colleagues of Prof. Bernd Giese on behalf of his 80th birthday on 2 June 2020. Reflecting on the varied interests of Bernd in all areas of chemistry, this issue contains work, including historical work, on inorganic coordination chemistry, nanomaterials, theory, and organic and radical chemistry—Bernd’s core expertise. It is wonderful that so many different publications came together from all over the world, as both review articles and original contributions, making this Special Issue worthwhile reading.
Download or read book Design and Construction of Coordination Polymers written by Mao-Chun Hong and published by John Wiley & Sons. This book was released on 2009-05-27 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Construction of Coordination Polymers Edited by Mao-Chun Hong Ling Chen A Unique Resource on coordination Polymers Coordination polymers are a growing, interdisciplinary field with numerous potential applications in chemistry and materials. Design and Construction of Coordination Polymers provides a comprehensive introduction to this field, focusing on synthetic strategies, structures, properties, and potential applications. Each chapter provides a unique perspective on coordination polymers, offering a dedicated approach as well as deeper insights on the most important facets of this interdisciplinary area. Combining the consistent editorial approach of a textbook with the up-to-date data and topics usually found in the latest monographs and handbooks, Design and Construction of Coordination Polymers offers an unparalleled reference to the state of the art. Among other topics, it covers: Coordination polymers with versatile structures Crystal engineering of coordination polymers Organic/inorganic hybrid complexes based on polyoxometalates Molecular-based magnetic and ferroelectric compounds Heavy main-group iodometalates Gas storage MOFs Bioinorganic coordination complexes Addressing a wide range of readers, Design and Construction of Coordination Polymers will prove an invaluable resource to everyone from senior-level undergraduate and graduate students to working scientists.
Download or read book Journal of the Indian Chemical Society written by and published by . This book was released on 2004 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organocatalysis written by Bimal Krishna Banik and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-06-21 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalysis are an important tool for greener catalytic processes due to the lack of precious metals used. This book explores different organocatalysts and their use in synthesis. Topics covered include zwitterionic imidazolium salt catalysts, asymmetric catalysts in aqueous media, beaker yeast catalysis, organocatalysts for Aldol and Michael reactions, amino acid-based organocatalysts, and Brönsted acidic surfactant organocatalysts.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Green Metal Nanoparticles written by Suvardhan Kanchi and published by John Wiley & Sons. This book was released on 2018-11-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book uniquely focuses on the exploration of the green synthesis of metal nanoparticles and their characterization and applications. Metal nanoparticles are the basic elements of nanotechnology as they are the primary source used in the design of nanostructured devices and materials. Nanomaterials can be manufactured either incidentally, with physical or chemical methods, or naturally; and the high demand for them has led to their large-scale production by various toxic solvents or high energy techniques. However, due to the growing awareness of environmental and safety issues, the use of clean, nontoxic and environment-friendly ways to synthesize metal nanoparticles has emerged out of necessity. The use of biological resources, such as microbes, plant parts, vegetable wastes, agricultural wastes, gums, etc., has grown to become an alternative way of synthesizing metal nanoparticles. This biogenic synthesis is green, environmentally friendly, cost-effective, and nontoxic. The current multi-authored book includes recent information and builds a database of bioreducing agents for various metal nanoparticles using different precursor systems. Green Metal Nanoparticles also highlights different simple, cost-effective, environment-friendly and easily scalable strategies, and includes parameters for controlling the size and shape of the materials developed from the various greener methods.
