Download or read book Free Energy Transduction and Biochemical Cycle Kinetics written by Terrell L. Hill and published by Courier Corporation. This book was released on 2013-01-09 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-part treatment translates the technical language of research monographs on the theory of free energy transfer in biology, making the subject more accessible to those entering the field. Designed for upper-level classes in biochemistry or biophysics, it can also be used for independent study. 36 figures. 1989 edition.
Download or read book Enzyme Kinetics written by Arthur R. Schulz and published by Cambridge University Press. This book was released on 1994-11-25 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the field of steady-state kinetics from basic principles to the control of the multi-enzyme systems which constitute metabolic pathways. Emphasis is placed on the interpretation of the kinetic behaviour of enzyme-catalyzed reactions in terms of mechanisms. Algorithms are developed which can be implemented in computer programs for the derivation of equations. The treatment of steady-state enzyme kinetics is extended to allosteric enzymes and subunit interactions in polymeric enzymes. Principles are presented which provide for mathematical analysis of the control of multi-enzyme systems. Problems are included at the end of each chapter and their solutions are found at the end of the book. This book will be a useful text for advanced undergraduates and graduate students taking courses in enzyme chemistry and enzyme kinetics.
Download or read book Hierarchical Genome And Differentiation Waves The Novel Unification Of Development Genetics And Evolution In 2 Volumes written by Richard Gordon and published by World Scientific. This book was released on 1999-07-12 with total page 1930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
Download or read book Kinetics of Enzyme Modifier Interactions written by Antonio Baici and published by Springer. This book was released on 2015-06-24 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Download or read book Reviews of Physiology Biochemistry and Pharmacology written by and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: H. Wegele, L. Müller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schülein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease.
Download or read book Cell Membrane Transport written by Z.I. Cabantchik and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental science is a complicated creature. At the head there is a Gordian knot of ideas and hypotheses; behind is the accumulated mass of decades of research. Only the laboratory methods, the legs which propel science forward, remain firmly in touch with the ground. Growth, however is uneven; dinosaurs develop by solid means to give a vast body of results, but few ideas. Others sprint briefly to success with brilliant, though ill-supported, ideas. The problems which this book addresses is to maintain an organic unity between new ideas and the current profusion of innovative experimental tools. Only then can we have the framework on which our research thoughts may flourish. The contributors are outstanding scientists in their respective fields and they record here in a clear manner the methodology with which they perform their experiments. They also illustrate some of their most exciting findings. In all chapters the emphasis is on the critical analysis of the methodology which is often avoided in refereed Journals. These techniques are explained in this book in adequate detail. Each chapter is extensively referenced and contains the most recent material available from author's laboratory at the time of going to press.
Download or read book Mathematical Modeling in Experimental Nutrition Vitamins Proteins Methods written by and published by Academic Press. This book was released on 1996-12-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book developed from a series of conferences to facilitate the application of mathematical modeling to experimental nutrition. As nutrition science moves from prevention of gross deficiencies to identifying requirements for optimum long term health, more sophisticated methods of nutritional assessment will be needed. Collection and evaluation of kinetic data may be one such method.This books opens with chapters giving specific examples of the application of modeling techniques to vitamin A, carotenoids, folate, vitamin b-6, glycogen phosphorylase, transthyretin, amino acids, and energy metabolism. Obtaining kinetic data on internal processes is a major challenge; therefore, the text includes chapters on the use of microdialysis and ultrafiltration, use of membrane vesicles, and culture of mammary tissue.Many of the authors use the Simulation, Analysis and Modeling program which allows compartmental models to be described without specifying the required differential equations. The final sections of the book, however, present some more mathematical descriptions of physiological processes, including bioperiodicity, metabolic control, and membrane transport; discussions of some computational aspects of modeling such as parameter distributions, linear integrators and identifiability; and alternative mathematical approaches such as neural networks and graph theory. - Specific, detailed examples of applications of modeling to vitamins, proteins, amino acids, and energy metabolism - Novel methods for collecting kinetic data--microdialysis, ultrafiltration, membrane vesicles, and the culture of mammary tissue - Mathematical treatment of complex metabolic processes including bioperiodicity, metabolic control, and membrane transport - Computational approaches to distribution of kinetic parameters, evaluation of linear integrators, and identifiability - Alternative mathematical approaches--neural networks and graph theory - Detailed descriptions of the application of modeling to a variety of nutrients
Download or read book Biomolecular Kinetics written by Clive R. Bagshaw and published by CRC Press. This book was released on 2017-10-04 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: "a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.
Download or read book Experimental Thermodynamics Volume X written by Dick Bedeaux and published by Royal Society of Chemistry. This book was released on 2016 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering recent developments in the theory of non-equilibrium thermodynamics and its applications, this title is aimed at a predominantly, but not exclusively, academic audience of practitioners of thermodynamics and energy conversion.
Download or read book Mathematical Technology of Networks written by Delio Mugnolo and published by Springer. This book was released on 2015-07-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamical models on graphs or random graphs are increasingly used in applied sciences as mathematical tools to study complex systems whose exact structure is too complicated to be known in detail. Besides its importance in applied sciences, the field is increasingly attracting the interest of mathematicians and theoretical physicists also because of the fundamental phenomena (synchronization, phase transitions etc.) that can be studied in the relatively simple framework of dynamical models of random graphs. This volume was developed from the Mathematical Technology of Networks conference held in Bielefeld, Germany in December 2013. The conference was designed to bring together functional analysts, mathematical physicists, and experts in dynamical systems. The contributors to this volume explore the interplay between theoretical and applied aspects of discrete and continuous graphs. Their work helps to close the gap between different avenues of research on graphs, including metric graphs and ramified structures.
Download or read book Thinking About Biology written by Wilfred Stein and published by CRC Press. This book was released on 2018-03-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the emergence of life, the development of the individual, and the study of the interaction between individuals and species. It gives the student of theoretical biology some idea of the flavor of current research in the field.
Download or read book Mathematical Theory of Nonequilibrium Steady States written by Da-Quan Jiang and published by Springer Science & Business Media. This book was released on 2004 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stochastic Methods in Neuroscience written by Carlo Laing and published by Oxford University Press. This book was released on 2010 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Great interest is now being shown in computational and mathematical neuroscience, fuelled in part by the rise in computing power, the ability to record large amounts of neurophysiological data, and advances in stochastic analysis. These techniques are leading to biophysically more realistic models. It has also become clear that both neuroscientists and mathematicians profit from collaborations in this exciting research area.Graduates and researchers in computational neuroscience and stochastic systems, and neuroscientists seeking to learn more about recent advances in the modelling and analysis of noisy neural systems, will benefit from this comprehensive overview. The series of self-contained chapters, each written by experts in their field, covers key topics such as: Markov chain models for ion channel release; stochastically forced single neurons and populations of neurons; statistical methods for parameterestimation; and the numerical approximation of these stochastic models.Each chapter gives an overview of a particular topic, including its history, important results in the area, and future challenges, and the text comes complete with a jargon-busting index of acronyms to allow readers to familiarize themselves with the language used.
Download or read book The Physics of Living Systems written by Fabrizio Cleri and published by Springer. This book was released on 2016-10-08 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, physics in its many aspects (thermodynamics, mechanics, electricity, fluid dynamics) is the guiding light on a fascinating journey through biological systems, providing ideas, examples and stimulating reflections for undergraduate physics, chemistry and life-science students, as well as for anyone interested in the frontiers between physics and biology. Rather than introducing a lot of new information, it encourages young students to use their recently acquired knowledge to start seeing the physics behind the biology. As an undergraduate textbook in introductory biophysics, it includes the necessary background and tools, including exercises and appendices, to form a progressive course. In this case, the chapters can be used in the order proposed, possibly split between two semesters. The book is also an absorbing read for researchers in the life sciences who wish to refresh or go deeper into the physics concepts gleaned in their early years of scientific training. Less physics-oriented readers might want to skip the first chapter, as well as all the "gray boxes" containing the more formal developments, and create their own á-la-carte menu of chapters.
Download or read book International Review of Cytology written by and published by Academic Press. This book was released on 1993-10-14 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology
Download or read book Application of Thermodynamics to Biological and Materials Science written by Mizutani Tadashi and published by BoD – Books on Demand. This book was released on 2011-01-14 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress of thermodynamics has been stimulated by the findings of a variety of fields of science and technology. The principles of thermodynamics are so general that the application is widespread to such fields as solid state physics, chemistry, biology, astronomical science, materials science, and chemical engineering. The contents of this book should be of help to many scientists and engineers.
Download or read book Computational Cell Biology written by Christopher P. Fall and published by Springer Science & Business Media. This book was released on 2007-06-04 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.
