Download or read book Forensic Investigative Genetic Genealogy and Fine Scale Structure of Human Populations written by Guanglin He and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dealing with Relatives written by Dominic Nelson and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "All of humanity, and indeed all living things, are connected by a complex web of ancestral relationships. How much of this shared pedigree is known, how much can be inferred, and how completely it can be described, are important factors in interpreting present-day genetic diversity and discovering genetic contributions to disease. The challenges of using pedigree information are twofold. First, in human populations, genealogical data is often unavailable or incomplete. Second, when such datasets are available, there are significant computational challenges to using them. In both cases the response has often been to use approximate models of pedigree structure, which removes the need for complete historical data and simplifies analysis. But genetic cohorts are growing, and increased sample sizes necessitate more detailed models of relatedness.The work presented here represents a first step in explicitly modeling the relatedness of millions of individuals, and using it to understand the fine-scale diversity of whole populations, as well as the genetic architecture of rare diseases. First we developed a software package, ISGen (Importance Sampling in Genealogies) for inferring the ancestral origin of rare alleles in population-scale pedigrees, as well as their distribution among present-day individuals, in a fully Bayesian framework. Similar analysis had never been possible before at that scale, and as a proof-of-concept we analyzed the distribution of the allele causing Chronic Atrial and Intestinal Dysrhythmia (CAID) within the province of Quebec. Using observations of only 11 patients and 4 heterozygous carriers of the allele, we estimated the allele frequency in 26 geographic regions of the province, finding the highest expected frequency in Charlevoix, where no carriers had yet been observed.Despite its value for supporting the design of screening programs for rare diseases, ISGen is limited to rare alleles and a single locus. Extending to whole-genome inference is a daunting challenge, and can be aided significantly by high-quality data with a known transmission history. Simulations are a natural source of such data, yet the most efficient simulation frameworks were based on coalescent models with known biases for long genomic regions and large sample sizes. We developed two tools to address this issue. One is an extension to the state-of-the-art msprime coalescent simulator which allows simulations under a Wright-Fisher model. This extension makes use of the highly efficient algorithms and data structures of msprime, and we showed more realistic relatedness among simulated individuals as well as improved performance over coalescent simulations at whole-genome scale. We then continued to develop this extension to allow simulations to be performed within a predefined pedigree, and when used with the population-scale genealogy of Quebec, Canada we showed that simulated cohorts captured much of the structure of a real dataset from the same population, and significantly more than comparable simulations of a randomly-mating population. To show the potential of large-scale pedigree simulations more generally, we further described how pedigree simulations can aid in the design of sequencing cohorts for imputation, and be used to detect rare-variant associations while explicitly accounting for relatedness among cohort members"--
Download or read book Forensic DNA Applications written by Dragan Primorac and published by CRC Press. This book was released on 2023-04-26 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic DNA Applications: An Interdisciplinary Perspective, Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence, whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas, but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such, the book pulls all relevant research and applied science together into a detailed and comprehensive collection. Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control. Part II moves on to cover the various uses and applications of analyzing collected physical evidence, victim identification in mass disasters, analyzing animal DNA, forensic botany, and other unique applications. Part III is dedicated to the latest advances and developments in human molecular biology and Part IV looks at policies and laws and ethics governing DNA evidence, and its utilization in various cases and the courts. Forensic DNA Applications, Second Edition covers cutting-edge research and advancements in the field and is the most up-to-date reference available. Edited and contributed to by the world's foremost leaders in the field, it is a must-have reference for established professionals, and an essential resource to legal professionals—lawyers and judges dealing with civil and criminal cases involving DNA technology—as well as students entering the fields of genetics and forensic DNA analysis.
Download or read book Advanced Genetic Genealogy written by Debbie Parker Wayne and published by . This book was released on 2019-03-20 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Genetic Genealogy: Techniques and Case Studies is a textbook for an advanced DNA course for genealogist. It takes those with an intermediate-level understanding of genetic genealogy to the next level. Case studies demonstrate how to analyze the DNA test results, correlate with documentary evidence, and write about findings.
Download or read book DNA Fingerprinting in Plants written by Kurt Weising and published by CRC Press. This book was released on 2005-02-28 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the explosive development of new molecular marker techniques over the last decade, newcomers and experts alike in the field of DNA fingerprinting will find an easy-to-follow guide to the multitude of techniques available in DNA Fingerprinting in Plants: Principles, Methods, and Applications, Second Edition. Along with step-by-step annotated p
Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Download or read book Pharmacogenomics in Admixed Populations written by Dr. G. Suarez-Kurtz and published by CRC Press. This book was released on 2007-08-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs
Download or read book Modes of Bio Bordering written by Nina Amelung and published by Springer Nature. This book was released on 2020-10-30 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book explores how biometric data is increasingly flowing across borders in order to limit, control and contain the mobility of selected people, namely criminalized populations. It introduces the concept of bio-bordering, using it to capture reverse patterns of bordering and ordering practices linked to transnational biometric data exchange regimes. The concept is useful to reconstruct how the territorial foundations of national state autonomy are partially reclaimed and, at the same time, partially purposefully suspended. The book focuses on the Prüm system, which facilitates the mandatory exchange of forensic DNA data amongst EU Member States. The Prüm system is an underexplored phenomenon, representing diverse instances of bio-bordering and providing a complex picture of the hidden (dis)integration of Europe. Particular legal, scientific, technical and political dimensions related to the governance and uses of biometric technologies in Germany, the Netherlands, Poland, Portugal and the United Kingdom are specifically explored to demonstrate both similar and distinct patterns.
Download or read book Routledge International Handbook of Green Criminology written by Nigel South and published by Routledge. This book was released on 2013-08-29 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Academic and general interest in environmental crimes, harms, and threats, as well as in environmental legislation and regulation, has grown sharply in recent years. The Routledge International Handbook of Green Criminology is the most in-depth and comprehensive volume on these issues to date. With contributions from leading international green criminologists and scholars in related fields, the Handbook examines a wide range of substantive issues, including: climate change corporate criminality and impacts on the environment environmental justice media representations pollution (e.g. air, water) questions of responsibility and risk wildlife trafficking The chapters explore green criminology in depth, its theory, history and development, as well as methodological concerns for this area of academic interest. With examples of environmental crimes, harms, and threats from Africa, Asia, Australia, Eastern Europe, South America, the United Kingdom, and the United States, this book will serve as a vital resource for international scholars and students in criminology, sociology, law and socio-legal studies, as well as environmental science, environmental studies, politics and international relations.
Download or read book Ancient DNA written by Beth Alison Shapiro and published by . This book was released on 2012-01-01 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ancient DNA presents an overview of the many of the protocols commonly used to study ancient DNA. These include laboratory instructions, extraction protocols, laboratory techniques, and suggestions for appropriate analytical approaches to make sense of the sequences obtained.
Download or read book Critical Forensic Studies written by Roberta Julian and published by Routledge. This book was released on 2021-12-20 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the emerging interdisciplinary field of critical forensic studies. It reviews existing research and scholarship on forensic science from a critical social science perspective, while forging a blueprint for further work in this area. Forensic science has long captured the public imagination, as evidenced by the popularity of many novels, television programmes, and true-crime podcasts. At the same time, its role in the criminal justice system has been the subject of critique from scholars and practitioners in diverse fields. In response, the international forensic science community has become more involved in the scrutiny of its own knowledge and practices in relation to criminal justice objectives. Moving beyond a discussion of forensic science as a suite of specialised scientific disciplines that aim to provide evidence to the courts, Critical Forensic Studies offers critical insights relevant to a wide range of social actors in the criminal justice system. Core content includes: • the history and public understandings of forensic science • the professionalisation of forensic science • forensic science as a social process • crime scene examination and forensic intelligence • experts and evidence in court • technological advances and human rights • interdisciplinary knowledge, practice and research This book is essential reading for forensic and criminal justice practitioners and students across criminology, sociology, forensic science, law, and psychology.
Download or read book Fundamentals of Forensic DNA Typing written by John M. Butler and published by Academic Press. This book was released on 2009-09-30 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980’s, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable. Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- "Data, Notes & Applications" sections throughout Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key
Download or read book The Genetic Gods written by John C. Avise and published by Harvard University Press. This book was released on 2009-06-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious faith. The book explains how the genetic gods figure in our development--not just our metabolism and physiology, but even our emotional disposition, personality, ethical leanings, and, indeed, religiosity. Yet genes are physical rather than metaphysical entities. Having arisen via an amoral evolutionary process--natural selection--genes have no consciousness, no sentient code of conduct, no reflective concern about the consequences of their actions. It is Avise's contention that current genetic knowledge can inform our attempts to answer typically religious questions--about origins, fate, and meaning. The Genetic Gods challenges us to make the necessary connection between what we know, what we believe, and what we embody. Table of Contents: Preface Prologue 1. The Doctrines of Biological Science 2. Geneses 3. Genetic Maladies 4. Genetic Beneficence 5. Strategies of the Genes 6. Genetic Sovereignty 7. New Lords of Our Genes? 8. Meaning Epilogue Notes Glossary Index Reviews of this book: Our genes, [Avise] says, are responsible not only for how we got here and exist day to day, but also for the core of our being--our personalities and morals. It is our genetic make-up that allows for and formulates our religious belief systems, he argues. Avise does not eschew spirituality but seeks a more informed, less confrontational approach between science and the pulpit. --Science News Reviews of this book: For the general scientific reader, the book is an excellent distillation of a broad and increasingly important field, a course of causation that cannot be ignored. From advising expectant parents to getting innocent people off death row, genetics increasingly dominates our lives. The sections on genetics are expertly written, particularly for those readers without in-depth knowledge. The author explains slowly and carefully just how genetics operates, using multiple metaphors. His genetic discourse proceeds in a neighborly fashion, as one might tell stories while sitting in a rocking chair at a country store. He seems to be invigorated by genes and just can't wait to tell about them. --David W. Hodo, Journal of the American Medical Association Reviews of this book: As a whole, this book is quite informative and stimulating, and sections of it are beautifully written. Indeed, Professor Avise has a real gift for prose and scientific expositions, and I would suspect that he must be a formidable lecturer...At its core, [The Genetic Gods] is a survey, and a very nice one at that, of evolutionary genetics, the field of the author's major research interests. There is a strong sociobiological cast to the arguments, and the work and ideas of E. O. Wilson figure prominently. The presentation of evolutionary genetics is imbedded in a more general discussion of modern human and molecular genetics...However, this book is, most of all, a philosophical treatise that attempts, admittedly with the bias of a biologist, to examine the intersection of the fundamental premises of evolution and religion. Professor Avise has given us plenty to think about in this book [and]...it was a real pleasure to wrestle with the ideas he was presenting. I would suggest that other readers give it a try. --Charles J. Epstein, Trends in Genetics Reviews of this book: [Avise's] account of the role genes play in shaping the human condition is wholly involving, paying particular attention to issues of reproduction, aging and death. In addition to presenting ample biological information in a form accessible to the nonspecialist, Avise does a superb job of discussing many of the ethical implications that have arisen from our growing knowledge of human genetics. Just a few of the topics covered are genetic engineering, the patenting of life, genetic screening, abortion, human cloning, gene therapy and insurance-related controversies. --Publishers Weekly Reviews of this book: Avise explains thoroughly how evolution operates on a genetic level. His goal is to show that humans can look to this information as a way to answer fundamental questions of life instead of looking to traditional religious beliefs...Avise includes some very interesting discussions of ethical concerns related to genetic issues. --Eric D. Albright, Library Journal This is a splendid account of a subject that affects us all: the breathtaking increase in understanding of human genetics and the insight it provides into human evolution. John Avise speaks with authority of molecular evolutionary genetics and with affecting compassion of what it might mean. --Douglas J. Futuyma, State University of New York at Stony Brook The Genetic Gods is many things. It is a wonderful introduction to modern molecular biology, by a man who knows his subject backwards. It is a stimulating account of the ways in which genetics impinges on human nature--our thinking and our behavior. It is a remarkably level-headed and sympathetic account of the implications of our new findings for traditional and not-so-traditional issues in philosophy and religion. In an age of genetic counseling, cloning, construction of new life forms, the book is worth its weight in gold for this alone. But most of all, it is a huge amount of fun to read--you want to applaud or argue with the author on nigh every page. Highly recommended! --Michael Ruse, University of Guelph The Genetic Gods makes a valuable contribution to the on-going task of sorting out the implications of evolutionary biology and genetics for human self-understanding. Avise addresses, with authority and grace, the most consequential intellectual issues of our time. A challenging and insightful book. --Loyal Rue, Harvard University A wonderfully informative and engaging book. Avise offers a lucid, accessible primer on our genes, angelic and demonic, and examines religious and ethical issues, all too human, now confronted by genetic science. He makes a compelling case that anyone seeking to 'Know Thyself' should study the DNA molecular scriptures, our most ancient and universal legacy. --Dudley Herschbach, Harvard University, Nobel Laureate in Chemistry
Download or read book Molecular Evolution written by Roderick D.M. Page and published by John Wiley & Sons. This book was released on 2009-07-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.
Download or read book Forest Genetics written by Timothy L. White and published by Cabi. This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which contains 20 chapters, integrates the varied subdisciplines of genetics and their applications in gene conservation, tree improvement and biotechnology. Topics covered include: genetic variation in natural forests, the application of genetics in tree improvement and breeding programmes, and genomic sequences and molecular technologies. This book will be a valuable resource for students, scientists and professionals in the plant sciences, especially forest geneticists, tree breeders, forest managers and other natural resource specialists.
Download or read book Future Challenges in Security and Privacy for Academia and Industry written by Jan Camenisch and published by Springer Science & Business Media. This book was released on 2011-05-24 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 26th IFIP TC 11 International Information Security Conference, SEC 2011, held in Lucerne, Switzerland, in June 2011. The 24 revised full papers presented together with a keynote talk were carefully reviewed and selected from 100 submissions. The papers are organized in topical sections on malware, information flow and DoS attacks, authentication, network security and security protocols, software security, policy compliance and obligations, privacy attacks and privacy-enhancing technologies, risk analysis and security metrics, and intrusion detection.
Download or read book African Genesis written by Sally C. Reynolds and published by Cambridge University Press. This book was released on 2012-03-29 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews key themes and developments in palaeoanthropology, exploring their impact on our understanding of human origins in Africa.