Download or read book Folding and Aggregation Studies in the Acylphosphatase like Family written by Francesco Bemporad and published by Firenze University Press. This book was released on 2009 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.

Download or read book Proteins as possible targets for antitumor metal complexes Biophysical studies of their interactions written by Chiara Gabbiani and published by Firenze University Press. This book was released on 2009 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.

Download or read book Isotopic fractionation study towards massive star forming regions across the Galaxy written by Laura Colzi and published by Firenze University Press. This book was released on 2022 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.

Download or read book Determinants of Mobility Disability in Older Adults Evidence from Population Based Epidemiologic Studies written by Marco Inzitari and published by Firenze University Press. This book was released on 2010 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gait and mobility are cardinal to maintain autonomy and independency in daily life, also for older persons. Changes in these functions might be critical in the transition towards disability and loss of autonomy during the aging process. The aim of the present work, which collects three years of research conducted between Italy and the United States, was to assess some of the main risk factors for the progressive impairment of mobility and gait in older adults living in the community. According to our results, abnormalities in the nervous and cardiovascular systems, even subtle, are associated with a subsequent worsening of these functions. These data might help to better understand the progressive development of disability in the elderly, and in the future might also have practical implications for prevention.

Download or read book Finite Size Effects in Stochastic Models of Population Dynamics Applications to Biomedicine and Biology written by Francesca Di Patti and published by Firenze University Press. This book was released on 2010 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tectono metamorphic evolution of the continental units along the edge between Alpine and Hercynian Corsica written by Maria Di Rosa and published by Firenze University Press. This book was released on 2022 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.

Download or read book Bioinformatics of Genome Evolution from Ancestral to Modern Metabolism Phylogenomics and Comparative Genomics to Understand Microbial Evolution written by Marco Fondi and published by Firenze University Press. This book was released on 2011 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics, that is the interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences, is expected to gain a central role in next feature. Indeed, it has now affected several fields of biology, providing crucial hints for the understanding of biological systems and also allowing a more accurate design of wet lab experiments. In this work, the analysis of sequence data has be used in different fields, such as evolution (e.g. the assembly and evolution of metabolism), infections control (e.g. the horizontal flow of antibiotic resistance), ecology (bacterial bioremediation).

Download or read book An Integrated Nonlinear Wind Waves Model for Offshore Wind Turbines written by Enzo Marino and published by Firenze University Press. This book was released on 2010 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents a numerical model capable of simulating offshore wind turbines exposed to extreme loading conditions. External condition-based extreme responses are reproduced by coupling a fully nonlinear wave kinematic solver with a hydro-aero-elastic simulator. First, a two-dimensional fully nonlinear wave simulator is developed. The transient nonlinear free surface problem is formulated assuming the potential theory and a high-order boundary element method is implemented to discretize Laplace's equation. For temporal evolution a second-order Taylor series expansion is used. The code, after validation with experimental data, is successfully adopted to simulate overturning plunging breakers which give rise to dangerous impact loads when they break against wind turbine substructures. Emphasis is then placed on the random nature of the waves. Indeed, through a domain decomposition technique a global simulation framework embedding the numerical wave simulator into a more general stochastic environment is developed. The proposed model is meant as a contribution to meet the more and more pressing demand for research in the offshore wind energy sector as it permits taking into account dangerous effects on the structural response so as to increase the global structural safety level.

Download or read book Molecular Imaging in Parkinson s Disease written by Cristina Polito and published by Firenze University Press. This book was released on 2011 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.

Download or read book Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy written by Raffaella Valenti and published by Firenze University Press. This book was released on 2018 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Use of Microorganisms in the Removal of Pollutants from the Wastewater written by Giovanni Colica and published by Firenze University Press. This book was released on 2009 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aims of this thesis were to test the adsorption efficiency of cyanobacterial biomasses of polysaccharide producing strains and to realize a pilot plant for galvanic waste treatment based on biosorption. First of all the different strains were tested at laboratory scale with solutions containing one or more metals, in order to gradually approach the reality of galvanic industries, where several metals at different concentrations are present at the same time in the wastes. To realize the pilot plant we tried to combine the protocols established during laboratory experiments with the necessities of the final user, the industry, by designing and realizing three prototypes. It was moreover evaluated the possibility to recover the adsorbed metal in a form easy and convenient for recycling.

Download or read book Early Stage Protein Misfolding and Amyloid Aggregation written by and published by Academic Press. This book was released on 2017-01-18 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists. Provides comprehensive reviews and current advances Presents a wide range of perspectives on specific subjects Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists

Download or read book 53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology SIB and National Meeting of Chemistry of Biological Systems Italian Chemical Society SCI Section CSB written by Italian Chemical Society and published by Firenze University Press. This book was released on with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 53rd National Congress of the Italian Society of Biochemistry and Molecular Biology (SIB), which will be held in Riccione from 23 to 26 September, is characterised by the elevated scientific level and interdisciplinary interest of the numerous sessions in which it is organised. The Scientific Programme comprises three joint Symposia of the SIB and the Chemistry of Biological Systems section of the Italian Chemistry Society (SCI) on Molecular Systems Biology, Chemistry of Nucleic Acids, Protein and Drug Structure, and Environmental Biotechnology. These Symposia address groundbreaking arguments, making the joint interest of the two societies particularly fascinating; the joint organisation of these events in fact signals the shared intention to proceed along the path of scientific exchange. The topics of the other sessions have been chosen by the Scientific Committee on the basis of their scientific relevance and topicality, with particular attention paid to the selection of the speakers. The SIB sessions will range from Signal Transduction and Biomolecular Targets, Protein Misfolding and its Relationship with Disease, Emerging Techniques in Biochemistry, Gene Silencing, Redox Signalling and Oxidative Stress, Lipids in Cell Communication and Signal Transduction, Mitochondrial Function and Dysfunction.

Download or read book Proteins written by Thomas E. Creighton and published by Macmillan. This book was released on 1993 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized on a combined basis of chronology and of structural and functional hierarchy, This comprehensive text describes all aspects of proteins--biosynthesis, evolution, dynamics, ligand binding, catalysis, and energy transduction--not just their structures. This edition (first was 1984) is thoroughly updated--especially in the area of protein biosynthesis--and features end-of-chapter exercises and problems, many of which require the student to consult the cited literature in order to obtain the answer. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Structure written by and published by . This book was released on 2005 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oncogenic gamma herpesviruses written by Christopher M. Dobson and published by . This book was released on 2001 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Philosophical Transactions of the Royal Society of London written by and published by . This book was released on 2001 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.