Download or read book Extracellular Vesicles in Infectious Diseases written by Shulamit Michaeli and published by Frontiers Media SA. This book was released on 2021-07-22 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fungal Extracellular Vesicles written by Marcio Rodrigues and published by Springer Nature. This book was released on 2022-01-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of host’s immunity to export of hundreds of biomolecules. The book summarizes the present knowledge on the impact of extracellular vesicles on fungal biology. Extracellular vesicles participate in fundamental biological processes in all living cells but only during the last 15 years the production and functions of EVs were identified and studied in fungal species too. Up to date more than 50 independent studies have shown that extracellular vesicles are produced by at least 20 fungal species. The book addresses researchers and advanced students in Microbiology, Mycology and Biotechnology.
Download or read book Extracellular Vesicles written by and published by BoD – Books on Demand. This book was released on 2022-07-20 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular vesicles (EVs) are nanoscale vesicles secreted by cells that mediate horizontal cargo transport from donor to recipient cell, thereby establishing cell-cell communication and signaling. This book provides critical information on the fundamentals of EVs, their roles in diseases like cancer, and their use in disease management. The chapters emphasize the emerging data confirming the role of EVs in the pathogenesis of diseases and discuss the scientific advances that have made it feasible to characterize and engineer EVs, leading to their use as tools in biomarker discovery and disease diagnosis, prognosis, therapeutic application, and theranostics. This volume is a valuable resource for basic biologists, translational scientists, and clinicians.
Download or read book Extracellular Vesicles in Health and Disease written by Paul Harrison and published by CRC Press. This book was released on 2014-05-02 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book The Cell outlines of general anatomy and physiology written by Oscar Hertwig and published by . This book was released on 1895 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Extracellular Vesicles in Viral Infections written by Sara B. York and published by . This book was released on 2021 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular vesicles (EVs) are membrane-encapsulated structures released by cells which carry signaling factors, proteins and microRNAs that mediate intercellular communication. Accumulating evidence supports an important role of EVs in the spread and pathogenesis of infectious diseases. Viruses have been reported to usurp host EV biogenesis pathways to package viral products, which are capable of modulating tumor microenvironments. In addition, EVs have been shown to cross blood-brain and placental barriers, thus viruses may utilize normal EV biology to gain access to previous impassable barriers. Chapter 2 of the thesis focuses on how Zika virus infection exploits host EV biogenesis pathways to increase infectivity, evade the host immune system and possibly alter tropism of the virus. We demonstrate that Zika virus infected cells secrete distinct EV sub-populations with specific viral protein profiles and infectious genomes. Zika virus infection resulted in the enhanced production of EVs with varying sizes and density compared to those released from non-infected cells. We also show that the EV enriched tetraspanin CD63 regulates the release of EVs, and Zika viral genomes and capsids following infection. Overall, these findings provide evidence for an alternative means of Zika virus transmission and demonstrate the role of EV biogenesis and trafficking proteins in the modulation of Zika infection and virion morphogenesis. In chapter 3 of the thesis, the role of ceramide in Latent membrane protein 1 (LMP1) EV secretion and signaling is explored. Recently, the tetraspanin protein CD63 has been found to form a complex with LMP1 and knock-out of CD63 in epithelial cell lines results in reduced exosomal LMP1. In certain cell lines, CD63 is trafficked to EVs through a ceramide-dependent manner. Therefore, we hypothesized that ceramide is required for efficient packaging of LMP1 into EVs. Following treatment with GW4869, a compound that inhibits the enzyme important for ceramide synthesis, EVs from Epstein-Barr (EBV-infected lymphoblastoid (LCL) and HEK293 cells carrying doxycycline-inducible LMP1 were analyzed by nanoparticle tracking analysis (NTA) for particle numbers and immunoblotting for EV content. EVs were further purified on density gradients to examine vesicle subpopulations. LMP1 was determined to be secreted in small EV populations by gradient purification. NTA of EVs from the cells treated with GW4869 demonstrated a significant decrease in particle secretion. LMP1 localization was disrupted in the treated cells and immunoblotting of EV lysates revealed a significant reduction in extracellular LMP1. Electron microscopy of density fractions illustrated morphological disruptions to CD63- and LMP1-enriched vesicle subpopulations. Additionally, ceramide inhibition resulted in enhanced LMP1-mediated Nuclear Factor kappa-light-chain-enhancer of activated B cells (NFkB) activation in exosome producing cells. Taken together, these data reveal a critical role for the lipid ceramide in LMP1 exosomal trafficking and the oncogenic signaling properties of the viral protein.
Download or read book Role of Exosomes in Biological Communication Systems written by Faisal A. Alzahrani and published by Springer Nature. This book was released on 2020-11-20 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
Download or read book The immunological regulation of extracellular vesicles on chronic diseases written by Zhiwen Luo and published by Frontiers Media SA. This book was released on 2024-06-26 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the transformation of the human disease spectrum, chronic non-infectious diseases have become the main killer of human health in modern society. The interaction between genes and the environment will cause the body’s immune function to be disordered, thereby affecting the body's homeostasis and causing various chronic non-infectious diseases. It has been revealed that the occurrence and development of most chronic diseases, such as cancer, cardiac disease, diabetes mellitus, autoimmune disease, and neuroimmune disorders, are associated with the dysregulation of the immune system.
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Extracellular Vesicles in Human Health and Diseases written by Asit Ranjan Ghosh and published by Springer Nature. This book was released on with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases written by Jin Wang and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide an overview of the importance of exosomes in the biomedical field, which involves in novel implications of exosomes in diagnosis and treatment of cancer and infectious diseases. The book would definitely be an ideal source of scientific information of exosomes to researchers and scientists involved in biomedicine, biology, and other areas involving cancer and infectious diseases.
Download or read book Exosomes in Cardiovascular Diseases written by Junjie Xiao and published by Springer. This book was released on 2017-09-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
Download or read book Extracellular Vesicles in Health and Diseases written by Paul J. Harrison and published by . This book was released on 2014 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
