Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2014 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Molecular Basis of Human Cancer written by William B. Coleman and published by Humana Press. This book was released on 2016-11-11 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

Download or read book The Biology of Tumors written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media tion of gene products. Important methodologies that would allow scientists to measure dif ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Download or read book Dail and Hammar s Pulmonary Pathology written by Joseph F. Tomashefski and published by Springer Science & Business Media. This book was released on 2010-05-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dail and Hammar’s Pulmonary Pathology has established itself as the definitive reference in the field. This third edition is now a two-volume, full color text. The new editorial board has continued to build upon the excellence previously achieved by reorganizing, expanding and substantially revising the text. This authoritative reference work has been updated to cover newly recognized entities and the latest advances in molecular diagnostic techniques. Abundantly illustrated with more than 2000 full color illustrations, this outstanding contribution to pathology literature is a must-have for the library of every surgical and pulmonary pathologist.

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2007-08 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Head and Neck Cancer written by John Frederick Ensley and published by Elsevier. This book was released on 2003-01-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. - Presents a multi-disciplinary perspective from authorities in diverse fields - Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field - Provides comprehensive yet easily comprehendible source of information

Download or read book Science In Medicine written by Ushma S. Neill and published by Jones & Bartlett Learning. This book was released on 2007-10-31 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers.

Download or read book Gene Expression and Regulation in Mammalian Cells written by Fumiaki Uchiumi and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Download or read book Epigenetic Markers written by M. Widschwendter and published by IOS Press. This book was released on 2007 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA's four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. This book contains ten articles that explore the details and challenges of cancer epigenetics.

Download or read book Molecularly Targeted Therapy for Childhood Cancer written by Peter J. Houghton and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Download or read book Medical Epigenetics written by Trygve Tollefsbol and published by Academic Press. This book was released on 2016-06-21 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Download or read book Oncogene Directed Therapies written by Janusz W. Rak and published by Springer Science & Business Media. This book was released on 2002-12-03 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.

Download or read book Ovarian Cancer written by Robert F. Ozols and published by PMPH-USA. This book was released on 2003 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Featuring more than 300 illustrations, the text covers pathology, biology, epidemiology, genetics, and screening through surgical management, the latest in chemotherapeutic regimens, and finally, palliative care"--P. [4] of cover.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oncology of Infancy and Childhood E Book written by Stuart H. Orkin and published by Elsevier Health Sciences. This book was released on 2009-06-09 with total page 1387 pages. Available in PDF, EPUB and Kindle. Book excerpt: To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.