Download or read book Exposition Des Perturbateurs Endocriniens Non persistants Pendant la Grossesse written by Céline Vernet and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenols and phthalates include chemicals widely used in daily-life products, resulting in ubiquitous exposure of the general population. There is growing concern regarding the effects on human health of these compounds, suspected to be endocrine disruptors, particularly during early life. Epidemiological research on the health effects of phenols and phthalates in offspring generally rely on a few biospecimens to assess exposure. These studies are limited by the possibly strong within-subject variability, which may result in exposure misclassification. The within-subject variability in the context of pregnancy and its possible impact on dose-response functions are poorly characterized.The aim of this thesis was to study the exposure to several phenols and phthalates during pregnancy by: 1) investigating the possible associations between this exposure and respiratory outcomes in childhood; 2) characterizing the temporal within-subject variability of these compounds during pregnancy; and finally 3) studying the efficiency of a within-subject pooling approach using a small number of daily biospecimens for exposure assessment.Associations between exposure to phenols and phthalates and respiratory health relied on n = 587 mother-child pairs from the French EDEN prospective cohort. Developments about the assessment of exposure during pregnancy relied on n = 16 pregnant participants of the SEPAGES-feasibility study who had collected all their urine samples for three weeks.This work quantified the within-subject variability of phenol and phthalate biomarker concentrations during pregnancy over various time scales (day to months), and confirmed empirically that this variability is likely to strongly bias the doseresponse functions in human-based epidemiological studies exploring the effects of gestational exposure to these chemicals.This thesis adds to the emerging literature on respiratory health impacts of early-life exposure to several phenols and phthalates. However, as for most studies on the human health effects of phenol and phthalate exposure, it is potentially challenged by this exposure assessment issue. Thus, this work emphasizes the relevance of more elaborate sampling strategies for exposure biomarkers in future epidemiological studies. These results have relevance for studies outside the context of pregnancy, and also for other nonpersistent compounds. New designs, such as the within-subject pooling of biospecimens validated in this study, are needed so as to efficiently characterize the health impact of nonpersistent chemicals.
Download or read book Exposition aux perturbateurs endocriniens pendant la grossesse written by Clotilde Duret and published by . This book was released on 2020 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction : Nous sommes exposés à de nombreux polluants et notamment aux perturbateurs endocriniens. Ils ont des effets néfastes sur notre organisme. La plus grande fenêtre de vulnérabilité à ces substances est la période du développement in utero. Méthode : Etude quantitative sur les connaissances des médecins généralistes sur l'exposition des femmes enceintes aux perturbateurs endocriniens. Objectif principal : évaluer leurs connaissances par un questionnaire. Objectif secondaire : établir des outils de prévention. 168 médecins généralistes libéraux de Champagne-Ardenne ont répondu au questionnaire, entre le 25 mars 2020 et le 23 juin 2020. Les analyses statistiques ont été réalisées à l'aide du site internet BiostaTGV. Le test utilisé était le test exact de Fisher avec un seuil de significativité fixé à 0,05. Résultats : Les perturbateurs endocriniens sont un problème de santé publique pour lesquels les médecins généralistes portent un intérêt certain, et plus particulièrement les femmes. Cependant, 91,7% des médecins estiment leurs connaissances comme insuffisantes. Respectivement 58,3% et 43,4% des médecins ne connaissent pas les conséquences des perturbateurs endocriniens sur la grossesse et sur l'enfant à naître. Un quart des médecins annonce faire spontanément de la prévention sur les perturbateurs endocriniens. 43,5% ne savent pas quels conseils de prévention apporter aux patients pour limiter l'exposition. 78% des médecins annoncent ne pas avoir eu de formation spécifique sur le sujet et 95,2% notent leur intérêt pour suivre une formation supplémentaire. Conclusion : Cette étude montre que les médecins généralistes portent un intérêt au sujet des perturbateurs endocriniens mais que leurs connaissances sont limitées, par manque de formation, de temps et de support. C'est pourquoi nous avons réalisé des fiches de synthèse regroupant les informations principales et quelques conseils simples à appliquer.
Download or read book Cannabis and the Developing Brain written by Miriam Melis and published by Academic Press. This book was released on 2022-08-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior. Cannabis and the Developing Brain aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors. Reviews exposure effects on different areas and circuits of the brain Identifies effects of exposure at prenatal, perinatal, infant, and adolescent ages Includes cannabis interaction with known genetic and environmental risk factors Contains neurodevelopment and neuropsychiatric disorders associated with cannabis exposure
Download or read book Preventing Disease Through Healthy Environments written by Annette Prüss-Üstün and published by World Health Organization. This book was released on 2016 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The main message emerging from this new comprehensive global assessment is that premature death and disease can be prevented through healthier environments--and to a significant degree. Analysing the latest data on the environment-disease nexus and the devastating impact of environmental hazards and risks on global health, backed up by expert opinion, this report covers more than 130 diseases and injuries. The analysis shows that 23% of global deaths (and 26% of deaths among children under five) are due to modifiable environmental factors--and therefore can be prevented. Stroke, ischaemic heart disease, diarrhoea and cancers head the list. People in low-income countries bear the greatest disease burden, with the exception of noncommunicable diseases. The report's unequivocal evidence should add impetus to coordinating global efforts to promote healthy environments--often through well-established, cost-effective interventions. This analysis will inform those who want to better understand the transformational spirit of the Sustainable Development Goals agreed by Heads of State in September 2015. The results of the analysis underscore the pressing importance of stronger intersectoral action to create healthier environments that will contribute to sustainably improving the lives of millions around the world."--Page 4 of cover.
Download or read book Molecular Mechanisms of Hormone Action written by Gesellschaft für Biologische Chemie. Colloquium and published by . This book was released on 1989 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book One Health 2nd Edition written by Jakob Zinsstag and published by CABI. This book was released on 2020-09-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: One Health, the concept of combined veterinary and human health, has now expanded beyond emerging infectious diseases and zoonoses to incorporate a wider suite of health issues. Retaining its interdisciplinary focus which combines theory with practice, this new edition illustrates the contribution of One Health collaborations to real-world issues such as sanitation, economics, food security and vaccination programmes. It includes more non-infectious disease issues and climate change discussion alongside revised case studies and expanded methodology chapters to draw out implications for practice. Promoting an action-based, solutions-oriented approach, One Health: The Theory and Practice of Integrated Health Approaches highlights the lessons learned for both human and animal health professionals and students.
Download or read book Outdoor Air Pollution written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC Monographs on the Evaluat. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risk to Humans, which met in Lyon, 8-15 October 2013."
Download or read book Pediatric AIDS written by Philip A. Pizzo and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recommended in the Brandon/Hill selected list of print books and journals for the small medical library - April 2001 & 2003 The Third Edition of this very popular book offers the most authoritative and comprehensive review of the impact of the HIV disease in infants, children, and adolescents.
Download or read book Karen s New Bike Baby Sitters Little Sister 62 written by Ann M. Martin and published by Scholastic Inc.. This book was released on 2016-05-31 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the bestselling author of the generation-defining series The Baby-sitters Club comes a series for a new generation! Yikes, My Bike! Karen is learning all about bike safety in school. She is even going to enter a bike-a-thon. But Karen’s bike is too small for her. So with Daddy’s help, Karen buys a new bike. Then Karen’s new bike is stolen. Can Karen catch the thief and get her bike back?
Download or read book Organochlorine Insecticides written by F. Moriarty and published by . This book was released on 1975 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring persistent organic pollhitants; exposure and residues; variationin the intake and elimination of pollutants; the role of the thy roid in the production of sublethal effec by organochlorine insecticides and polychlorine insecticides on amimal populations; persistent percides an economic and legal analysis.
Download or read book The Ladybird Illustrated written by D H Lawrence and published by . This book was released on 2020-11-09 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Ladybird is a long tale or novella by D. H. Lawrence. It was first drafted in 1915 as a short story entitled The Thimble. Lawrence rewrote and extended it under a new title in December 1921 and sent the final version to his English agent on 9 January 1922. It was collected with two other tales, The Captain's Doll and The Fox, and the three novellas were then published in London by Martin Secker in March 1923 under the title The Ladybird and in New York by Thomas Seltzer as The Captain's Doll in April 1923."
Download or read book Notes on the Minor Prophets written by Henry Allan Ironside and published by . This book was released on 1955 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cattle Priests and Progress in Medicine written by Calvin W. Schwabe and published by U of Minnesota Press. This book was released on 1978-05-26 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cattle, Priests, and Progress in Medicine was first published in 1978. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. The author shows that over the centuries many of the most significant breakthroughs in improving humans health have been closely associated with observations and experiments on animals other than man. Because human medical progress has been so dependent on veterinary studies, he urges that schools of veterinary medicine assume a much greater role in the training of persons for research in human medicine. To illuminate the historical link between animals and man in medical progress, Professor Schwabe recounts highlights in the history of medicine from ancient times onward. He describes the early history of man in terms of animal cultures, focusing on the prehistoric Nile Valley, and points to similarities in medical knowledge between present-day "cattle" societies in Northeastern Africa and the ancient people of the Nile. He discusses the comparative healers of ancient Egypt, the comparative foundations of Greek medicine, the Arabic contribution, Sicily and the beginnings of modern medicine, and subsequent developments through the Renaissance .Bringing the history down to modern times, Professor Schwabe emphasizes the role of veterinary medicine in medical research. He outlines specific reforms in the curricula of schools and colleges of veterinary medicine which would provide for the education of medical investigators.
Download or read book The Quick And The Dead written by Andrew Andrew Hunt Gordon and published by BRILL. This book was released on 2004 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cross-disciplinary approach suggesting that the origin of ancient Egyptian medicine began with the domestication of cattle in Africa and the attempt to control disease. With the sacrifice of these animals, the Egyptians began to understand anatomy and physiology, which they then applied to humans.
Download or read book Laboratory Disease written by Christoph Gradmann and published by Johns Hopkins University Press. This book was released on 2009-09-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the nineteenth century, the new field of medical bacteriology identified microorganisms and explained how they spread disease. This book interweaves the history of this discipline and the biography of one of its founders, Nobel Prize–winning German physician Robert Koch (1843–1910). Koch contributed to modern medicine by inventing or improving fundamental techniques such as bacterial staining, solid culture media, mass pure cultures, and the use of animal models. His discoveries, which dominated medical science at the turn of the last century, are epitomized in a set of rules named after him. "Koch's Postulates" are still invoked today in attempts to prove the causal involvement of pathogens in infectious diseases. In a double history, Christoph Gradmann narrates the development of a discipline and the biography of a scientist. Drawing on Koch's extensive laboratory notes, Gradmann details how Koch developed his scientific method and discovered the bacterial causes of anthrax, tuberculosis, and cholera. Koch tried to bring this knowledge to clinical medicine by developing medicines that would specifically target the bacterial pathogens he identified. And Koch’s passion for personal travel developed into a career signature, as he became a pioneer in the study of tropical diseases. A fascinating look into Koch's personality and his experimental work in medical bacteriology, Laboratory Disease reveals both the biographical and the historical roots of our modern understanding of infectious diseases.
Download or read book Physical Chemical and Thermal Technologies written by Godage B. Wickramanayake and published by . This book was released on 1998 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Thermal Desorption- In Situ Thermal Technologies- Plasma Technologies- In Situ Steam Processes- Soil Vapor Extraction/Multiphase Extraction- Enhancements to Pump-and-Treat-Systems- Groundwater Circulating Wells- Air Sparging- Dehalogenation Technologies- Oxidation Technologies- Photo-, Electro-, and Catalytic Mechanisms.
Download or read book Frontiers in Comparative Medicine written by W. I. B. Beveridge and published by . This book was released on 1972-10-25 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Comparative Medicine was first published in 1972.In this initial volume of the series to be based on the Wesley W. Spink Lectures on Comparative Medicine, Dr. Beveridge, the noted British scientist, discusses the contributions to human medicine resulting from studies of disease in animals. The book serves as an excellent introduction to this important aspect of science, suitable for general readers as well as for those studying or working in the medical, biological, or social sciences.Dr. Beveridge examines the methodology of comparative science and tells of the remarkable series of key discoveries of disease agents which have emerged from research on animals. He explains the reasons for the success of animal studies in connection with human disease and makes a strong case for more research on naturally occurring animal models.The author describes current comparative studies in cancer, cardiovascular diseases, neuropathology, immunopathology, congenial defects, metal health, reproduction, and population regulation. He shows that in each of these subjects results that have far-reaching implications for human welfare and medicine are being obtained. In the final section he assembles the available evidence about the origin of human influenza pandemics. He points to a conclusion that they probably result from a hybridization of human and animal strains of the disease agent and that the usual place where this occurs appears to be the plains of Central Asia. He emphasizes the need for an international investigation of the problem of influenza, in the hope of preventing these pandemics.
