Download or read book Experimental and CFD Study on Scale up of Gas liquid Stirred Tank Bioreactor written by Sook Fun Pang and published by . This book was released on 2010 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Numerical and Experimental Investigation of Liquid and Gas liquid Flows in Stirred Tank Reactors written by Hamed Bashiri and published by . This book was released on 2015 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioreactors written by Carl-Fredrik Mandenius and published by John Wiley & Sons. This book was released on 2016-02-16 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Download or read book Bubbly Flows written by Martin Sommerfeld and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarises the outcom of a priority research programme: 'Analysis, Modelling and Computation of Multiphase Flows'. The results of 24 individual research projects are presented. The main objective of the research programme was to provide a better understanding of the physical basis for multiphase gas-liquid flows as they are found in numerous chemical and biochemical reactors. The research comprises steady and unsteady multiphase flows in three frequently found reactor configurations, namely bubble columns without interiors, airlift loop reactors, and aerated stirred vessels. For this purpose new and improved measurement techniques were developed. From the resulting knowledge and data, new and refined models for describing the underlying physical processes were developed, which were used for the establishment and improvement of analytic as well as numerical methods for predicting multiphase reactors. Thereby, the development, lay-out and scale-up of such processes should be possible on a more reliable basis.
Download or read book Gas Liquid Flow Modeling for Renewable Fuels Production written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aerobic/anaerobic and gas fermentation pathways have emerged as promising new technologies for the generation of renewable fuels/chemicals from biomass derived sugars, and mixtures of greenhouse/energy rich gas streams (CO2/CH4/H2/CO) via microbial action. Example pathways include sugars-to-ethanol conversion, biomethanation (CO2/H2 to CH4), biogas upgrading, CO fermentation and wet-waste conversion. Gas and liquid phase transport, mass-transfer, and mixing physics at large length scales can significantly affect microbial conversion rates, particularly when the microbial reaction requires a narrow set of conditions. These phenomena are difficult to study in small-scale bench-top reactors that are typically well-mixed. Predictive computational fluid dynamics (CFD) based simulations can therefore aid in the scale-up, design and optimization of these reactors. This work presents multiphase Euler-Euler CFD simulations of at-scale (~500 m3) bioreactors. Our mathematical model treats the gas and liquid as interpenetrating phases. This approach reduces the computational complexity of tracking individual gas bubbles that are several orders of magnitude smaller than reactor dimensions. We solve the Reynolds averaged Navier-Stokes (RANS) multiphase equations that account for phase and chemical species transport, interphase mass and momentum transfer and uses a phenomenological model for gas uptake by microbes. We use a customized solver derived from open-source CFD toolbox, OpenFOAM [1], to perform these simulations, which has been validated against small-scale reactors in our previous work [2]. There is currently a knowledge-gap regarding bubble-size distributions when using gas mixtures with vastly different properties, which can have a significant impact overall mass-transfer. For example, hydrogen bubbles are more buoyant compared to other relatively heavier gases (CO2/CH4/CO), resulting in a large distribution of residence times and bubble sizes. This work therefore develops a deeper understanding of bubble dynamics and interphase mass transfer in such heterogenous gas mixtures through well-resolved computational models. We use a population balance model (PBM) for bubble-size-distribution modeling that is validated against small-scale experiments in our solver with an uncertainty quantification study for bubble coalescence and break-up model parameters. Results pertaining to multiple simulations of gas-fermentation reactors are presented where gas mixtures with varying compositions of CO2/CH4/CO/H2 are imposed at the sparger boundaries. The spatio-temporal variations in bubble-size distribution and mass transfer coefficient are analyzed for varying superficial velocities and gas-compositions for varying sizes of bubble-column and airlift reactors. This work will also examine the performance of different reactor designs, viz. bubble column reactor, airlift reactor with an internal draft tube, and a stirred-tank reactor with Rushton impellers. Reactor mass-transfer coefficient, gas hold-up, and dissolved gas distribution are critically analyzed among reactors, and sensitivity studies pertaining to gas flow rates and reactor geometry will be presented. [1] Weller, H., Tabor, G., Jasak, H. and Fureby, C., A tensorial approach to computational continuum mechanics using object-oriented techniques, Computers in physics, 12, 6, 620--631, 1998. [2] Rahimi, M., Sitaraman, H., Humbird, D. and Stickel, J., Computational fluid dynamics study of full-scale aerobic bioreactors: Evaluation of gas-liquid mass transfer, oxygen uptake, and dynamic oxygen distribution, Chemical Engineering Research and Design, 139: 283-295.
Download or read book Advances of Computational Fluid Dynamics in Nuclear Reactor Design and Safety Assessment written by Jyeshtharaj Joshi and published by Woodhead Publishing. This book was released on 2019-06-11 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances of Computational Fluid Dynamics in Nuclear Reactor Design and Safety Assessment presents the latest computational fluid dynamic technologies. It includes an evaluation of safety systems for reactors using CFD and their design, the modeling of Severe Accident Phenomena Using CFD, Model Development for Two-phase Flows, and Applications for Sodium and Molten Salt Reactor Designs. Editors Joshi and Nayak have an invaluable wealth of experience that enables them to comment on the development of CFD models, the technologies currently in practice, and the future of CFD in nuclear reactors. Readers will find a thematic discussion on each aspect of CFD applications for the design and safety assessment of Gen II to Gen IV reactor concepts that will help them develop cost reduction strategies for nuclear power plants.
Download or read book Dynamics Of Multiphase Media written by Robert Iskanderovich Nigmatulin and published by CRC Press. This book was released on 1990-09-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 2 of a monograph on current knowledge of phenomena and the theory and analysis of multiphase systems, offering a systematic treatment of energy, mass and momentum exchange in multiphase systems along with other applications which include shock hardening of metals and boiling heat transfer.
Download or read book CFD Study of Full Scale Aerobic Bioreactors written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: If advanced biofuels are to measurably displace fossil fuels in the near term, they will have to operate at levels of scale, efficiency, and margin unprecedented in the current biotech industry. For aerobically-grown products in particular, scale-up is complex and the practical size, cost, and operability of extremely large reactors is not well understood. Put simply, the problem of how to attain fuel-class production scales comes down to cost-effective delivery of oxygen at high mass transfer rates and low capital and operating costs. To that end, very large reactor vessels (>500 m3) are proposed in order to achieve favorable economies of scale. Additionally, techno-economic evaluation indicates that bubble-column reactors are more cost-effective than stirred-tank reactors in many low-viscosity cultures. In order to advance the design of extremely large aerobic bioreactors, we have performed computational fluid dynamics (CFD) simulations of bubble-column reactors. A multiphase Euler-Euler model is used to explicitly account for the spatial distribution of air (i.e., gas bubbles) in the reactor. Expanding on the existing bioreactor CFD literature (typically focused on the hydrodynamics of bubbly flows), our simulations include interphase mass transfer of oxygen and a simple phenomenological reaction representing the uptake and consumption of dissolved oxygen by submerged cells. The simulations reproduce the expected flow profiles, with net upward flow in the center of column and downward flow near the wall. At high simulated oxygen uptake rates (OUR), oxygen-depleted regions can be observed in the reactor. By increasing the gas flow to enhance mixing and eliminate depleted areas, a maximum oxygen transfer (OTR) rate is obtained as a function of superficial velocity. These insights regarding minimum superficial velocity and maximum reactor size are incorporated into NREL's larger techno-economic models to supplement standard reactor design equations.
Download or read book CFD Study of Full Scale Aerobic Bioreactors Evaluation of Dynamic O2 Distribution Gas Liquid Mass Transfer and Reaction written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: If advanced biofuels are to measurably displace fossil fuels in the near term, they will have to operate at levels of scale, efficiency, and margin unprecedented in the current biotech industry. For aerobically-grown products in particular, scale-up is complex and the practical size, cost, and operability of extremely large reactors is not well understood. Put simply, the problem of how to attain fuel-class production scales comes down to cost-effective delivery of oxygen at high mass transfer rates and low capital and operating costs. To that end, very large reactor vessels (>500 m3) are proposed in order to achieve favorable economies of scale. Additionally, techno-economic evaluation indicates that bubble-column reactors are more cost-effective than stirred-tank reactors in many low-viscosity cultures. In order to advance the design of extremely large aerobic bioreactors, we have performed computational fluid dynamics (CFD) simulations of bubble-column reactors. A multiphase Euler-Euler model is used to explicitly account for the spatial distribution of air (i.e., gas bubbles) in the reactor. Expanding on the existing bioreactor CFD literature (typically focused on the hydrodynamics of bubbly flows), our simulations include interphase mass transfer of oxygen and a simple phenomenological reaction representing the uptake and consumption of dissolved oxygen by submerged cells. The simulations reproduce the expected flow profiles, with net upward flow in the center of column and downward flow near the wall. At high simulated oxygen uptake rates (OUR), oxygen-depleted regions can be observed in the reactor. By increasing the gas flow to enhance mixing and eliminate depleted areas, a maximum oxygen transfer (OTR) rate is obtained as a function of superficial velocity. These insights regarding minimum superficial velocity and maximum reactor size are incorporated into NREL's larger techno-economic models to supplement standard reactor design equations.
Download or read book Basic Bioreactor Design written by Klaas van't Riet and published by CRC Press. This book was released on 1991-01-07 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a graduate course in biochemical engineering, provides the basic knowledge needed for the efficient design of bioreactors and the relevant principles and data for practical process engineering, with an emphasis on enzyme reactors and aerated reactors for microorganisms. Includes exercises,
Download or read book Computational Fluid Dynamics written by Hyoung Woo Oh and published by BoD – Books on Demand. This book was released on 2010-01-01 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended to serve as a reference text for advanced scientists and research engineers to solve a variety of fluid flow problems using computational fluid dynamics (CFD). Each chapter arises from a collection of research papers and discussions contributed by the practiced experts in the field of fluid mechanics. This material has encompassed a wide range of CFD applications concerning computational scheme, turbulence modeling and its simulation, multiphase flow modeling, unsteady-flow computation, and industrial applications of CFD.
Download or read book Coupled Microbial conversion and Computational fluid dynamics CFD Models for Butanediol Production in Micro aerated Reactors written by Hariswaran Sitaraman and published by . This book was released on 2020 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scale up in Chemical Engineering written by Marko Zlokarnik and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.
Download or read book Numerical Simulation of Multiphase Reactors with Continuous Liquid Phase written by Chao Yang and published by Academic Press. This book was released on 2014-09-04 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerical simulation of multiphase reactors with continuous liquid phase provides current research and findings in multiphase problems, which will assist researchers and engineers to advance this field. This is an ideal reference book for readers who are interested in design and scale-up of multiphase reactors and crystallizers, and using mathematical model and numerical simulation as tools. Yang and Mao's book focuses on modeling and numerical applications directly in the chemical, petrochemical, and hydrometallurgical industries, rather than theories of multiphase flow. The content will help you to solve reacting flow problems and/or system design/optimization problems. The fundamentals and principles of flow and mass transfer in multiphase reactors with continuous liquid phase are covered, which will aid the reader's understanding of multiphase reaction engineering. - Provides practical applications for using multiphase stirred tanks, reactors, and microreactors, with detailed explanation of investigation methods - Presents the most recent research efforts in this highly active field on multiphase reactors and crystallizers - Covers mathematical models, numerical methods and experimental techniques for multiphase flow and mass transfer in reactors and crystallizers
Download or read book Disposable Bioreactors II written by Dieter Eibl and published by Springer. This book was released on 2013-12-17 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up, by Christian Löffelholz, Stephan C. Kaiser, Matthias Kraume, Regine Eibl , Dieter Eibl. Orbitally Shaken Single-Use Bioreactors, by Wolf Klöckner, Sylvia Diederichs, Jochen Büchs. Therapeutic Human Cells: Manufacture for Cell Therapy/Regenerative Medicine by Christian van den Bos, Robert Keefe, Carmen Schirmaier, Michael McCaman. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study by Regine Eibl, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, Dieter Eibl. Microbial High Cell Density Fermentations in a Stirred Single-Use Bioreactor by Thomas Dreher, Bart Walcarius, Ute Husemann, Franziska Klingenberg, Christian Zahnow, Thorsten Adams, Davy de Wilde, Peter Casteels, Gerhard Greller. Quorus Bioreactor: A New Perfusion-Based Technology for Microbial Cultivation by Sheena J. Fraser, Christian Endres. Cultivation of Marine Microorganisms in Single-Use Systems by Friederike Hillig, Maciej Pilarek, Stefan Junne, Peter Neubauer. Flexible Biomanufacturing Processes that Address the Needs of the Future by Bernhard Diel, Christian Manzke, Thorsten Peuker. An Approach to Quality and Security of Supply for Single-Use Bioreactors by Magali Barbaroux, Susanne Gerighausen, Heiko Hackel. A Risk Analysis for Production Processes with Disposable Bioreactors by Tobias Merseburger, Ina Pahl, Daniel Müller, Markus Tanner.
Download or read book Lead Zinc 2000 written by J. E. Dutrizac and published by John Wiley & Sons. This book was released on 2013-09-12 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Lead-Zinc 2000 Symposium is the fourth in the series of decennial conferences on the processing of lead and zinc; it isorganized by the Minerals, Metals and MaterialsSociety (TMS). The Symposium the culmination of over two years of work that included the preparation of the papers by the authors, as well as the refereeing, proof-reading and indexing by the editors. The proceedings volume contains sixty-four papers which cover all aspects of lead and zinc processing, including the global business trends of the metals, plant operations, new processing installations, emerging technologies and environmental considerations. The Lead-Zinc 2000 Symposium will also honor Dr. T.R.A. Davey for his many contributions to metallurgical science and the industry throughout his distinguished career.
Download or read book Multiphase Reactors written by Jan Harmsen and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-04-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Multiphase Reactors book is about fundamentals, selection, design, development (scale-up) and applications of two- and three-phase reactors. It is a graduate textbook focused on creating understanding of the fundamentals, as much as possible without resorting to mathematics. It also is full of real-life industrial applications and examples from the authors’ own experiences. The target audience comprises students and industrial practitioners who may or may not have had formal training in chemical reaction engineering. Each chapter explains the subject and contains take home messages, examples, worked out cases, quiz questions, and exercises.
