Download or read book Excitatory Amino Acids and Synaptic Transmission written by H. V. Wheal and published by . This book was released on 1995 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitatory amino acids (EAAs) as neurotransmitters are the subject of vast and rapidly expanding interest. The First Edition of Excitatory Amino Acids and Synaptic Transmission was the first text to provide anoverview of the function of EAAs in transmission at the synapses and in the organization of the nervous system. The First Edition is a well-respected reference text for neuroscience researchers; it provides a comprehensive account of the physiological, pharmacological, chemical, molecular, biological, and neural networking aspects of the EAAs. The Second Edition has been revised so that its text is even more user-friendly; plus its coverage has been expanded to include the up-to-date approaches of molecular biology and biophysics. The well-praised explanatory glossary has also been improved.
Download or read book Excitatory Amino Acids and the Cerebral Cortex written by Fiorenzo Conti and published by MIT Press. This book was released on 1996 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years.
Download or read book Excitatory Amino Acids and Neuronal Plasticity written by Yehezkel Ben-Ari and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Neuroscience Association Satellite Symposium held in Fillerval, France, August 27-31, 1989
Download or read book Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Download or read book Excitatory Amino Acids written by Lechoslaw Turski and published by IOS Press. This book was released on 2001 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.
Download or read book Synaptic Transmission Mediated by Excitatory Amino Acids in Slices of Prefrontal Cortex Studied Using Antibodies written by Kafi Najuma Meadows and published by . This book was released on 1995 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.
Download or read book Excitatory Amino Acid Receptors in Synaptic Transmission in the Hippocampus written by Alan Harvey Ganong and published by . This book was released on 1985 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Excitatory Amino Acid Transmission in Health and Disease written by Robert Balazs and published by Oxford University Press. This book was released on 2006 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation of excitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Altheimer's disease, and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology and new therapeutic strategies.
Download or read book Excitatory Amino Acids written by Paul L. Herrling and published by Elsevier. This book was released on 1997-01-10 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists Reports of potential drugs in early and late clinical stages of development
Download or read book Excitatory Amino Acids Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitatory Amino Acids—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Excitatory Amino Acids. The editors have built Excitatory Amino Acids—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Excitatory Amino Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Excitatory Amino Acids—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Factors Affecting Neurological Aging written by Colin R Martin and published by Academic Press. This book was released on 2021-06-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging Features sections on the genetic components that influence aging and diseases of aging Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables
Download or read book Excitatory Amino Acids and the Cerebral Cortex written by Fiorenzo Conti and published by . This book was released on 1996-08-07 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thirty original contributions in this book provide an up-to-date, interdisciplinary account of current research activity in all aspects of excitatory amino acid transmitters, particularly glutamate and aspartate, in the context of the structure and function of the cerebral cortex in health and in disease.It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years.The topics are dealt with from electrophysiological, biochemical, anatomical, pharmacological, clinical, and behavioral perspectives to provide a thorough account of the functional roles played by these compounds in the part of the brain dealing with higher processes. The material is broad-based yet presented in a style that allows clinical and basic scientists alike easy access to integrated material across chapters and between sections.
Download or read book Consciousness Transitions written by Hans Liljenström and published by Elsevier. This book was released on 2011-10-13 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was not long ago when the consciousness was not considered a problem for science. However, this has now changed and the problem of consciousness is considered the greatest challenge to science. In the last decade, a great number of books and articles have been published in the field, but very few have focused on the how consciousness evolves and develops, and what characterizes the transitions between different conscious states, in animals and humans. This book addresses these questions. Renowned researchers from different fields of science (including neurobiology, evolutionary biology, ethology, cognitive science, computational neuroscience and philosophy) contribute with their results and theories in this book, making it a unique collection of the state-of-the-art of this young field of consciousness studies. First book on the topic Focus on different levels of consciousness, including: Evolutionary, developmental, and functional Highly interdisciplinary
Download or read book The NMDA Receptors written by Kenji Hashimoto and published by Springer. This book was released on 2017-02-08 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochemical, and behavioral aspects, to highlight their distinctive regulatory properties, their functional significance, and their therapeutic potential in a number of diseases. A group of international experts discuss the development of NMDA receptors, their basic functions, and how they are implicated in a wide range of diseases including depression, psychosis, and pain.
