Download or read book EVOLUTION ORIENTED GENOME PERSONALISED written by Hani K. RIZK and published by Hani K. RIZK. This book was released on 2017-10-01 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABOUT THE BOOK The Book is an interdisciplinary textbook, written with the intent of introducing two new concepts. A. The Association Constant (Ka) versus Entropy and Chaos. 1. The formation and evolution of chemical and biological compounds on atomic and molecular scales are the work of the four natural forces, enhanced by the existence of the natural constants and their remarkable adjustment. And the work of the covalent and noncovalent forces (bonds) being derived from the natural forces. So is the evolution of living organisms but with the essential and indispensable impact of the environment, violent and punctuate. 2. The effects of the natural forces (through the covalent and noncovalent bonds) is expressed by Ka. Therefore, Ka preserves what nature accomplishes by protecting matter against the action of entropy (a faulty distribution of matter), and by preserving free energy (-ΔG) against the action of chaos (a faulty distribution of energy). Evolution is an obligation to elegance and wisdom. 3. The Book draws straight and clear line connecting general relativity, i.e. gravity (the infinite large), quantum mechanics (the infinite small), and biology (the infinite complex). B. Individuality of the Human Genome. 1. Our uniqueness as species (Homo sapiens) is invariantly encoded in the protein-coding genes (about 2 percent of our DNA). These genes are invariably found in every human being. They are species - specific, responsible for the human genesis and form the human genophenotype. Our uniqueness as individuals variantly resides in the rest of our DNA (the nonprotein-coding DNA, about 98 percent of our genome) and in the histones (chemical modifications and compaction of nucleosomes). They constitute the epigenetic factors responsible for the formation of the epigenetic phenotype, which is variably different from one individual to another. They are individual - specific. Epigenetic factors variantly effect and regulate gene expression. For example, the craniofacial structure in mice is encoded in 300 protein-coding genes. The expression of these genes is regulated by 4000 different sequences of nonprotein-coding DNA called enhancers. Thus, the number of different forms of the craniofacial structure that might develop in mice is 300 exponentiated 4000 epiphenotypes. Other than enhancers, there are the mobile elements of DNA, dsRNA-coding DNA, chemical modification of DNA (e.g., methylation), and so forth. 2. Mind exclusively exists in man as an emergent phenomenon. 3. All scientific data presented in the Book are entirely intended to reflect, to explain, or to prove the Two Concepts rather than to discuss their significances and originalities. The interdisciplinarity of the Book offers a unique opportunity for understanding how astrophysics, quantum mechanics, thermodynamics, and biology are interrelated. Hani K. Rizk

Download or read book Human Genetics and Genomics written by Bruce R. Korf and published by John Wiley & Sons. This book was released on 2012-11-19 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice 'Hot topics' boxes that focus on the latest developments in testing, assessment and treatment 'Ethical issues' boxes to prompt further thought and discussion on the implications of genetic developments 'Sources of information' boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

Download or read book Human Gene Mutation written by David N. Cooper and published by Taylor & Francis. This book was released on 1995 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last decade, much progress has been made in the analysis and diagnosis of human inherited disease, and in the characterization of the underlying genes and their associated pathological lesions.

Download or read book Personalised cancer medicine written by Anne Kerr and published by Manchester University Press. This book was released on 2021-01-19 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. What does it mean to personalise cancer medicine? Drawing on an ethnographic study with cancer patients, carers and practitioners in the UK, this book traces their efforts to access and interpret novel genomic tests, information and treatments as they craft personal and collective futures. Exploring multiple experiences of new diagnostic tests, research programmes and trials, advocacy and experimental therapies, the authors chart the different kinds of care and work involved in efforts to personalise cancer medicine, as well as the ways in which benefits and opportunities are unevenly realised and distributed. Comparing these experiences with policy and professional accounts of the ‘big’ future of personalised healthcare, the authors show how hope and care are multi-faceted, contingent and, at times, frustrated in the everyday complexities of living and working with cancer.

Download or read book Healthcare and Big Data Management written by Bairong Shen and published by Springer. This book was released on 2017-10-20 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the interplay of healthcare and big data management. Thanks to major advances in big data technologies and precision medicine, healthcare is now becoming the new frontier for both scientific research and economic development. This volume covers a range of aspects, including: big data management for healthcare; physiological and gut microbiota – data collection and analysis; big data standardization and ontology; and personal data privacy and systems level modeling in the healthcare context. The book offers a valuable resource for biomedical informaticians, clinicians, health practitioners and researchers alike.

Download or read book Omics for Personalized Medicine written by Debmalya Barh and published by Springer Science & Business Media. This book was released on 2013-10-14 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Download or read book Immobilisation of DNA on Chips DNA adsorption on carbonaceous materials written by S. Alegret and published by Springer Science & Business Media. This book was released on 2005-11-03 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: M.I. Pividori, S. Alegret: DNA Adsorption on Carbonaceous Materials .- F. Luderer, U. Walschus: Immobilization of Oligonucleotides for Biochemical Sensing by Self-Assembled Monolayers: Thiol-Organic Bonding on Gold and Silanization on Silica Surfaces.- Y. Okahata, T. Kawasaki: Preparation and Electron Conductivity of DNA-Aligned Cast and LB Films from DNA-Lipid Complexes.- A. del Campo, I.J. Bruce: Substrate Patterning and Active Strategies for DNA Chip Fabrication.- D.V. Nicolau, P.D. Sawant: Scanning Probe Microscopy Studies of Surface-Immobilised DNA/Oligonucleotide Molecules.- A. Guiseppi-Elie, L. Lingerfelt: Impedimetric Detection of DNA Hybridization: Towards Near Patient DNA Diagnostics

Download or read book The Biomedical Sciences in Society written by Iain Crinson and published by Springer Nature. This book was released on 2021-03-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.

Download or read book Advancing Healthcare Through Personalized Medicine written by Priya Hays and published by Springer Nature. This book was released on 2021-09-27 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Download or read book Richard Dawkins written by Alan Grafen and published by Oxford University Press (UK). This book was released on 2007 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This sparkling collection explores the impact of Richard Dawkins as scientist, rationalist, and one of the most important thinkers alive today. Specially commissioned pieces by leading figures in science, philosophy, literature, and the media, such as Daniel C. Dennett, Matt Ridley, Steven Pinker, Philip Pullman, and the Bishop of Oxford, highlight the breadth and range of Dawkins' influence on modern science and culture, from the gene's eye view of evolution to his energetic engagement in public debates on science, rationalism, and religion. The volume includes personal reminiscences and critical debate as well as accessible discussions of science - it provides a stimulating tribute to a remarkable intellectual.

Download or read book Genes on the Couch written by Paul Gilbert and published by Routledge. This book was released on 2014-07-10 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Philosophers and therapists have long theorised about how psychological mechanisms for love, jealousy, anxiety, depression and many other human characteristics may have evolved over millions of years. In the dawn of the new insights on evolution, provided by Darwin's theories of natural selection, Freud, Jung and Klein sought to identify and understand human motives, emotions and information processing as functions deeply-rooted in our evolved history. Despite this promising start and major developments in modern evolutionary psychology, anthropology and sociobiology, the last fifty years has seen little in the way of therapies derived from an evolutionary understanding of human psychology. The contributors to this timely book illuminate how an evolution focused approach to psychopathology can offer new insights for different schools of therapy and provide a rationale for therapeutic integration. Genes on the Couch brings together respected clinicians who have integrated evolutionary insights into their case conceptualisations and therapeutic interventions. Various psychotherapy schools are represented, and each author provides illustrative examples of the interventions used. Specific topics addressed include the nature of evolved mental mechanisms; regulation/dysregulation of internal processes; attachment and kinship in therapy; the importance of internalising warmth as a therapeutic goal; kin selection and incest avoidance; co-operation and deception in social relations; difficulties in working with certain male clients; gender differences in therapy and the roles of shame and guilt in treatment. Providing up-to-date summaries of recent thinking in this increasing important but diverse area, Genes on the Couch will be of interest to psychotherapists, psychiatrists and a wide range of mental health professionals.

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Download or read book Evolution Driven by Organismal Behavior written by Rui Diogo and published by Springer. This book was released on 2017-03-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes a new way to think about evolution. The author carefully brings together evidence from diverse fields of science. In the process, he bridges the gaps between many different--and usually seen as conflicting--ideas to present one integrative theory named ONCE, which stands for Organic Nonoptimal Constrained Evolution. The author argues that evolution is mainly driven by the behavioral choices and persistence of organisms themselves, in a process in which Darwinian natural selection is mainly a secondary--but still crucial--evolutionary player. Within ONCE, evolution is therefore generally made of mistakes and mismatches and trial-and-error situations, and is not a process where organisms engage in an incessant, suffocating struggle in which they can't thrive if they are not optimally adapted to their habitats and the external environment. Therefore, this unifying view incorporates a more comprehensive view of the diversity and complexity of life by stressing that organisms are not merely passive evolutionary players under the rule of external factors. This insightful and well-reasoned argument is based on numerous fascinating case studies from a wide range of organisms, including bacteria, plants, insects and diverse examples from the evolution of our own species. The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet.

Download or read book Genetic Programming Theory and Practice II written by Una-May O'Reilly and published by Springer Science & Business Media. This book was released on 2006-03-16 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work described in this book was first presented at the Second Workshop on Genetic Programming, Theory and Practice, organized by the Center for the Study of Complex Systems at the University of Michigan, Ann Arbor, 13-15 May 2004. The goal of this workshop series is to promote the exchange of research results and ideas between those who focus on Genetic Programming (GP) theory and those who focus on the application of GP to various re- world problems. In order to facilitate these interactions, the number of talks and participants was small and the time for discussion was large. Further, participants were asked to review each other's chapters before the workshop. Those reviewer comments, as well as discussion at the workshop, are reflected in the chapters presented in this book. Additional information about the workshop, addendums to chapters, and a site for continuing discussions by participants and by others can be found at http://cscs.umich.edu:8000/GPTP-20041. We thank all the workshop participants for making the workshop an exciting and productive three days. In particular we thank all the authors, without whose hard work and creative talents, neither the workshop nor the book would be possible. We also thank our keynote speakers Lawrence ("Dave") Davis of NuTech Solutions, Inc., Jordan Pollack of Brandeis University, and Richard Lenski of Michigan State University, who delivered three thought-provoking speeches that inspired a great deal of discussion among the participants.

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Download or read book The Pangenome written by Hervé Tettelin and published by Springer Nature. This book was released on 2020-04-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Download or read book Genes and Genomes written by R.S. Verma and published by Elsevier. This book was released on 1998-06-03 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laws of inheritance were considered quite superficial until 1903, when the chromosome theory of heredity was established by Sutton and Boveri. The discovery of the double helix and the genetic code led to our understanding of gene structure and function. For the past quarter of a century, remarkable progress has been made in the characterization of the human genome in order to search for coherent views of genes. The unit of inheritance termed factor or gene, once upon a time thought to be a trivial an imaginary entity, is now perceived clearly as the precise unit of inheritance that has continually deluged us with amazement by its complex identity and behaviour, sometimes bypassing the university of Mendel's law. The aim of the fifth volume, entitled Genes and Genomes, is to cover the topics ranging from the structure of DNA itself to the structure of the complete genome, along with everything in between, encompassing 12 chapters. These chapters relate much of the information accumulated on the role of DNA in the organization of genes and genomes per se. Several distinguished scientists, all pre-eminent authorities in each field to share their expertise. Obviously, since the historical report on the double helix configuration in 1953, voluminous reports on the meteoric advances in genetics have been accumulated, and to cover every account in a single volume format would be a Herculean task. Therefore, only a few topics are chosen, which are of great interest to molecular geneticists. This volume is intended for advanced graduate students who would wish to keep abreast with the most recent trends in genome biology.