Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Download or read book Handbook of Pharmaceutical Manufacturing Formulations written by Safaraz K. Niazi and published by CRC Press. This book was released on 2016-04-19 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: No other area of regulatory compliance receives more attention and scrutiny by regulatory authorities than the regulation of sterile products, for obvious reasons. With the increasing number of potent products, particularly the new line of small protein products, joining the long list of proven sterile products, the technology of manufacturing ster

Download or read book Biological Activities and Application of Marine Polysaccharides written by Emad Shalaby and published by BoD – Books on Demand. This book was released on 2017-01-11 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine organisms have been under research for the last decades as a source for different active compounds with various biological activities and application in agriculture, pharmacy, medicine, environment, and industries. Marine polysaccharides from these active compounds are used as antibacterial, antiviral, antioxidant, anti-inflammation, bioremediations, etc. During the last three decades, several important factors that control the production of phytoplankton polysaccharides have been identified such as chemical concentrations, temperature, light, etc. The current book includes 14 chapters contributed by experts around the world; the chapters are categorized into three sections: Marine Polysaccharides and Agriculture, Marine Polysaccharides and Biological Activities, and Marine Polysaccharides and Industries.

Download or read book Smart Nanovesicles for Drug Targeting and Delivery written by Maria Carafa and published by MDPI. This book was released on 2019-05-20 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: We can use the short text on the SI page for the description, or you make slight modifications on it. The description/summary is only for promotion (flyer, distribution channels), and will not be included in the book You can use the short text on the SI page for the description Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action. The drug/contrast agent-containing vesicles need to be directed to precise locations within the body to obtain desired magnitude and duration of the therapeutic or diagnostic effect. This spatial control in the delivery might open new avenues to modulate drug activity while avoiding side-effects and to optimize contrast agent properties while avoiding a broad distribution in the organism. However, delivering and targeting active substances into specific tissues and cells is still a challenge in designing novel therapeutic approaches against untreatable disorders, such as tumors and degenerative diseases.

Download or read book Handbook of Modern Pharmaceutical Analysis written by Satinder Ahuja and published by Academic Press. This book was released on 2010-11-11 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. - Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it - Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations - Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS

Download or read book Hot Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.

Download or read book Mucosal Delivery of Drugs and Biologics in Nanoparticles written by Pavan Muttil and published by Springer Nature. This book was released on 2020-03-18 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Download or read book Pharmaceutics written by Alekha Dash and published by Elsevier. This book was released on 2023-09-13 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutics: Basic Principles and Application to Pharmacy Practice, Second Edition is a valuable textbook covering the role and application of pharmaceutics within pharmacy practice. This updated resource is geared toward meeting and incorporating the current curricular guidelines on pharmaceutics and laboratory skills mandated by the American Council for Pharmacy Education. It includes a number of student-friendly features, including chapter objectives and summaries, practical examples, case studies, numerous images and key-concept text boxes. Two new chapters are included, as well as a new end of chapter section covering "critical reflections and practice applications". Divided into three sections – Physical Principles and Properties of Pharmaceutics; Practical Aspects of Pharmaceutics; and Biological Applications of Pharmaceutics – this new edition covers all aspects of pharmaceutics and providing a single and compelling source for students. - Facilitates an integrated and extensive coverage of the study of pharmaceutics due to the clear and engaging language used by the authors - Includes chapter objectives and summaries to illustrate and reinforce key ideas - Meets curricular guidelines for pharmaceutics and laboratory skills mandated by the Accreditation Council for Pharmacy Education (ACPE) - Includes new practice questions, answers, and case studies for experiential learning

Download or read book Chemistry of Phytopotentials Health Energy and Environmental Perspectives written by LD Khemani and published by Springer Science & Business Media. This book was released on 2011-12-02 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of human civilization, plants have been our true companions. Plants contribute not only to our existence but also serve us through discovery, design and the treatment of various diseases where there is no satisfactory cure in modern medicine. This has focused Natural Product Chemists to unravel plants therapeutic potential in the light of modern analytical and pharmacological understandings. Presence of multiple active phytochemicals in medicinal plants offers exciting opportunity for the development of novel therapeutics, providing scientific justification for their use in traditional medicines. Non-food plants have been recognized as biofactories for the production of eco-friendly value added materials including agricultural, food products, enzymes, nutraceuticals etc. They have also been widely explored for personal care, industrial products and sources of energy generation. The proven efficacy of botanicals has been appreciated by the scientific community and strengthened plant-human relationship. The synergism in the Phytoproducts, the result of the interaction of two or more moieties, is not simply additive but multiplicative. Recent acceptance of the Food and Drug Administration (US) for herbal-medicine based preparation has renewed interest in Natural Product Research. The year 2011 is declared as the International Year of Chemistry (IYC 2011) by the United Nations Assembly. On this occasion, the present conference CPHEE 2011 aims to offer chemists from diverse areas to come to a common platform to share the knowledge and unveil the chemistry and magic potentials of phytoproducts for the mankind.

Download or read book Pharmaceutical Suspensions written by Alok K. Kulshreshtha and published by Springer Science & Business Media. This book was released on 2009-11-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Download or read book Calcium Phosphates in Biological and Industrial Systems written by Zahid Amjad and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Phosphates in Biological and Industrial Systems provides a comprehensive discussion on calcium phosphates in the diverse areas of their applications. The authors are all respected specialists in their particular fields, possessing wide knowledge and experience and able to analyze recent results and relate them to their respective areas of expertise. New information, as well as a review of current concepts, highlights the individual contributions. Due to the broad scope of the subject covered and the large number of contributions, this book is divided into three parts. Whilst each section contains a basic theme, there is a considerable overlapping of ideas and approaches. This reflects the excitement and interdisciplinary nature of investigations by researchers interested in dissimilar aspects of calcium phosphates. Considering the general interest in calcium phosphates, Calcium Phosphates in Biological and Industrial Systems is directed at an audience of researchers in the fields of biology, chemistry, dentistry, geology, chemical engineering, environmental engineering, and medicine. It will also be useful to technology-focused researchers in industry whose investigations might be related directly or indirectly to calcium phosphates.

Download or read book Polymorphism written by Rolf Hilfiker and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries. With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.

Download or read book Pharmaceutical Dosage Forms written by Herbert Lieberman and published by CRC Press. This book was released on 2020-08-26 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stressing the theory involved in formulating suspensions, emulsions, and colloidal drug products, this Second Edition of a well-received reference test highlights typical formulations, the avoidance of formulation pitfalls, and compliance with established regulatory principles.

Download or read book Colloid and Interface Science in Pharmaceutical Research and Development written by Hiroyuki Ohshima and published by Elsevier. This book was released on 2014-07-23 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. - Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development - Explains the physicochemical/colloidal basis of pharmaceutical science - Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data - Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Download or read book Clinical Pharmacy Education Practice and Research written by Dixon Thomas and published by Elsevier. This book was released on 2018-11-23 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally. - Covers the core information needed for pharmacy practice courses - Includes multiple case studies and practical situations with 70% focused on practical clinical pharmacology knowledge - Designed for educational settings, but also useful as a refresher for advanced students and researchers

Download or read book Cellulose and Cellulose Derivatives written by Kenji Kamide and published by Elsevier. This book was released on 2005-08-31 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many highly acclaimed and authoritative books on polymer science tend to focus on synthetic polymers. Cellulose and Cellulose Derivatives is the first authoritative book on the subject. It examines recent developments, with particular reference to cellulose (in aqueous alkali) and cellulose acetate. Packed with examples, the author takes an in-depth look at the topic, using the most reliable experimental data available. A comprehensive approach to the fundamental principles of cellulose and its derivatives in solution makes Cellulose and Cellulose Derivatives ideal reading for novices as well as experienced cellulose scientists.* Outlines the theoretical fundamentals of cellulose and cellulose derivatives* Presents comprehensive and reliable experimental results in figures and tables * Highly illustrated and easy to read

Download or read book Adsorption Fundamental Processes and Applications written by Mehrorang Ghaedi and published by Academic Press. This book was released on 2021-03-19 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adsorption: Fundamental Processes and Applications, Volume 33 in the Interface Science and Technology Series, discusses the great technological importance of adsorption and describes how adsorbents are used on a large scale as desiccants, catalysts, catalyst supports, in the separation of gases, the purification of liquids, pollution control, and in respiratory protection. Finally, it explores how adsorption phenomena play a vital role in many solid-state reactions and biological mechanisms, as well as stressing the importance of the widespread use of adsorption techniques in the characterization of surface properties and the texture of fine powders. - Covers the fundamental aspects of adsorption process engineering - Reviews the environmental impact of key aquatic pollutants - Discusses and analyzes the importance of adsorption processes for water treatment - Highlights opportunity areas for adsorption process intensification - Edited by a world-leading researcher in interface science