Download or read book Estimating a Cost effective Individualized Treatment Rule CE ITR Based on Machine Learning written by Qing Zhang and published by . This book was released on 2022 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Policy makers employ Cost-Effectiveness Analysis (CEA) to evaluate a new treatment based on its cost and effectiveness. ITR is the treatment recommendation based on patient's characteristics. However, the recommends generated from ITR and CEA could mismatch, even opposite since their aim is different. Therefore, policy makers need a tool to trade-off between ITR and CEA. Traditionally, optimal ITR focus on the mean benefit on population level, not on individual level. In the era of precision medicine, an ideal intervention needs to be optimized based on individual level.
Download or read book Evaluating Optimal Individualized Treatment Rules written by Alexander Ryan Luedtke and published by . This book was released on 2016 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Suppose we observe baseline covariates, a binary indicator of treatment, and an outcome occuring after treatment. An individualized treatment rule (ITR) is a treatment rule which assigns treatments to individuals based on their measured covariates. An optimal ITR is the ITR which maximizes the population mean outcome. The mean outcome of the optimal ITR is referred to as the optimal value. This dissertation considers three inferential challenges related to these parameters in the large semiparametric model that at most places restrictions on the probability of receiving treatment given covariates. The first is to develop confidence intervals for the optimal value. Constructing valid confidence intervals for this quantity is surprisingly difficult when the stratum specific treatment effect, also called the blip function, is null with positive probability. This null treatment effect seems possible in many studies. While it has been claimed in the literature that no regular and asymptotically linear (RAL) estimator exists in this case, we prove that RAL estimators of the optimal value can exist in a slightly more general setting. We then describe an approach to obtain root-n rate confidence intervals for the optimal value even when regular estimation is not possible. We also provide sufficient conditions under which our estimator is RAL and asymptotically efficient -- a necessary condition is of course that regular estimation is possible under the data generating distribution. We have thus far assumed that treatment is an unlimited resource so that the entire population can be treated if this strategy maximizes the population mean outcome. In the second part of this dissertation, we consider optimal ITRs in settings where the treatment resource is limited so that there is a maximum proportion of the population that can be treated. We give a general closed-form expression for an optimal stochastic ITR in this resource-limited setting, and a closed-form expression for the optimal deterministic ITR under an additional assumption. We also present an estimator of the mean outcome under the optimal stochastic ITR and give conditions under which our estimator is efficient among all RAL estimators. Both of the first two inferential challenges considered give parametric-rate confidence intervals for finite-dimensional parameters in our large semiparametric model. In the third part of this dissertation we focus on developing hypothesis tests and confidence sets for infinite-dimensional parameters that one typically estimates using data adaptive techniques. Parametric-rate inference is not typically expected in this setting. Our primary motivating example concerns the blip function, which is closely related to the optimal ITRs in both the resource-unconstrained and constrained settings. For any fixed function, we give valid hypothesis tests that the blip function is equal to this fixed function. These tests can then be inverted to develop a confidence set for the blip function. Surprisingly, the hypothesis test achieves a parametric rate in the sense that it is consistent against local alternatives converging to the data generating distribution at the rate of one divided by the square root of sample size. We prove the validity of this procedure in great generality that applies far beyond this particular inference problem, and reference several other examples to which it applies. The results in this third component of the dissertation have been developed using the theory of higher-order influence functions.
Download or read book The Structuring of Organizations written by Henry Mintzberg and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizes the empirical literature on organizationalstructuring to answer the question of how organizations structure themselves --how they resolve needed coordination and division of labor. Organizationalstructuring is defined as the sum total of the ways in which an organizationdivides and coordinates its labor into distinct tasks. Further analysis of theresearch literature is neededin order to builda conceptualframework that will fill in the significant gap left by not connecting adescription of structure to its context: how an organization actuallyfunctions. The results of the synthesis are five basic configurations (the SimpleStructure, the Machine Bureaucracy, the Professional Bureaucracy, theDivisionalized Form, and the Adhocracy) that serve as the fundamental elementsof structure in an organization. Five basic parts of the contemporaryorganization (the operating core, the strategic apex, the middle line, thetechnostructure, and the support staff), and five theories of how it functions(i.e., as a system characterized by formal authority, regulated flows, informalcommunication, work constellations, and ad hoc decision processes) aretheorized. Organizations function in complex and varying ways, due to differing flows -including flows of authority, work material, information, and decisionprocesses. These flows depend on the age, size, and environment of theorganization; additionally, technology plays a key role because of itsimportance in structuring the operating core. Finally, design parameters aredescribed - based on the above five basic parts and five theories - that areused as a means of coordination and division of labor in designingorganizational structures, in order to establish stable patterns of behavior.(CJC).
Download or read book Proceedings of the Second Seattle Symposium in Biostatistics written by Danyu Lin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a selection of papers presented at the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data. The symposium was held in 2000 to celebrate the 30th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by Norman Breslow, David Cox and Ross Prentice and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important areas, such as longitudinal data, multivariate failure time data and genetic data, as well as innovative applications of the existing theory and methods. This volume is a valuable reference for researchers and practitioners in the field of correlated data analysis.
Download or read book Reinforcement Learning and Dynamic Programming Using Function Approximators written by Lucian Busoniu and published by CRC Press. This book was released on 2017-07-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: From household appliances to applications in robotics, engineered systems involving complex dynamics can only be as effective as the algorithms that control them. While Dynamic Programming (DP) has provided researchers with a way to optimally solve decision and control problems involving complex dynamic systems, its practical value was limited by algorithms that lacked the capacity to scale up to realistic problems. However, in recent years, dramatic developments in Reinforcement Learning (RL), the model-free counterpart of DP, changed our understanding of what is possible. Those developments led to the creation of reliable methods that can be applied even when a mathematical model of the system is unavailable, allowing researchers to solve challenging control problems in engineering, as well as in a variety of other disciplines, including economics, medicine, and artificial intelligence. Reinforcement Learning and Dynamic Programming Using Function Approximators provides a comprehensive and unparalleled exploration of the field of RL and DP. With a focus on continuous-variable problems, this seminal text details essential developments that have substantially altered the field over the past decade. In its pages, pioneering experts provide a concise introduction to classical RL and DP, followed by an extensive presentation of the state-of-the-art and novel methods in RL and DP with approximation. Combining algorithm development with theoretical guarantees, they elaborate on their work with illustrative examples and insightful comparisons. Three individual chapters are dedicated to representative algorithms from each of the major classes of techniques: value iteration, policy iteration, and policy search. The features and performance of these algorithms are highlighted in extensive experimental studies on a range of control applications. The recent development of applications involving complex systems has led to a surge of interest in RL and DP methods and the subsequent need for a quality resource on the subject. For graduate students and others new to the field, this book offers a thorough introduction to both the basics and emerging methods. And for those researchers and practitioners working in the fields of optimal and adaptive control, machine learning, artificial intelligence, and operations research, this resource offers a combination of practical algorithms, theoretical analysis, and comprehensive examples that they will be able to adapt and apply to their own work. Access the authors' website at www.dcsc.tudelft.nl/rlbook/ for additional material, including computer code used in the studies and information concerning new developments.
Download or read book Beyond the Laboratory written by Leonard Bickman and published by McGraw-Hill Companies. This book was released on 1971 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Field Manual of Wildlife Diseases written by and published by Geological Survey (USGS). This book was released on 1999 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Guide to Starting a Business in Minnesota written by Charles A. Schaffer and published by . This book was released on 1983 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Using R for Introductory Statistics written by John Verzani and published by CRC Press. This book was released on 2018-10-03 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a bestselling textbook, Using R for Introductory Statistics guides students through the basics of R, helping them overcome the sometimes steep learning curve. The author does this by breaking the material down into small, task-oriented steps. The second edition maintains the features that made the first edition so popular, while updating data, examples, and changes to R in line with the current version. See What’s New in the Second Edition: Increased emphasis on more idiomatic R provides a grounding in the functionality of base R. Discussions of the use of RStudio helps new R users avoid as many pitfalls as possible. Use of knitr package makes code easier to read and therefore easier to reason about. Additional information on computer-intensive approaches motivates the traditional approach. Updated examples and data make the information current and topical. The book has an accompanying package, UsingR, available from CRAN, R’s repository of user-contributed packages. The package contains the data sets mentioned in the text (data(package="UsingR")), answers to selected problems (answers()), a few demonstrations (demo()), the errata (errata()), and sample code from the text. The topics of this text line up closely with traditional teaching progression; however, the book also highlights computer-intensive approaches to motivate the more traditional approach. The authors emphasize realistic data and examples and rely on visualization techniques to gather insight. They introduce statistics and R seamlessly, giving students the tools they need to use R and the information they need to navigate the sometimes complex world of statistical computing.
Download or read book Modeling Discrete Time to Event Data written by Gerhard Tutz and published by Springer. This book was released on 2016-06-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on statistical methods for the analysis of discrete failure times. Failure time analysis is one of the most important fields in statistical research, with applications affecting a wide range of disciplines, in particular, demography, econometrics, epidemiology and clinical research. Although there are a large variety of statistical methods for failure time analysis, many techniques are designed for failure times that are measured on a continuous scale. In empirical studies, however, failure times are often discrete, either because they have been measured in intervals (e.g., quarterly or yearly) or because they have been rounded or grouped. The book covers well-established methods like life-table analysis and discrete hazard regression models, but also introduces state-of-the art techniques for model evaluation, nonparametric estimation and variable selection. Throughout, the methods are illustrated by real life applications, and relationships to survival analysis in continuous time are explained. Each section includes a set of exercises on the respective topics. Various functions and tools for the analysis of discrete survival data are collected in the R package discSurv that accompanies the book.
Download or read book The United Nations world water development report 2018 written by WWAP and published by UNESCO Publishing. This book was released on 2018-03-26 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Doing Business 2019 written by World Bank and published by World Bank Publications. This book was released on 2018-11-30 with total page 1734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixteenth in a series of annual reports comparing business regulation in 190 economies, Doing Business 2019 measures aspects of regulation affecting 10 areas of everyday business activity: • Starting a business • Dealing with construction permits • Getting electricity • Registering property • Getting credit • Protecting minority investors • Paying taxes • Trading across borders • Enforcing contracts • Resolving insolvency These areas are included in the distance to frontier score and ease of doing business ranking. Doing Business also measures features of labor market regulation, which is not included in these two measures. This edition also presents the findings of the pilot indicator entitled 'Contracting with the Government,' which aims at benchmarking the efficiency, quality and transparency of public procurement systems worldwide. The report updates all indicators as of May 1, 2018, ranks economies on their overall 'ease of doing business', and analyzes reforms to business regulation -- identifying which economies are strengthening their business environment the most. Doing Business illustrates how reforms in business regulations are being used to analyze economic outcomes for domestic entrepreneurs and for the wider economy. It is a flagship product produced in partnership by the World Bank Group that garners worldwide attention on regulatory barriers to entrepreneurship. Almost 140 economies have used the Doing Business indicators to shape reform agendas and monitor improvements on the ground.
Download or read book Inequality and Economic Development in Brazil written by and published by World Bank Publications. This book was released on 2004-01-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: What makes Brazil so unequal? This title looks at this question and shows how inequalities weaken Brazil's economic development and what are the best policy options to reduce this inequity.
Download or read book Links Between Business Accounting and National Accounting written by United Nations and published by United Nations Publications. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is one of a series of handbooks prepared by the United Nations Statistics Division (UNSD) to help countries, particularly developing countries, implement the 1993 system of national accounts (SNA). It attempts to cover the conceptual and practical aspects of linking business accounts to national accounts through countries' experiences. The handbook aims to provide a general guide to business accounts and the possibility of linking items in them to SNA concepts allowing for local rules and regulations. It cannot provide a set of concrete and detailed international guidelines due to the diversity of business account standards among countries and the extent to which business accounts are made available to statisticians. The main target audiences for this handbook are staff responsible for the compilation of national accounts although it is also a useful reference tool for those who prepare statistics for the preparation of national accounts.
Download or read book Medical Support of the Army Air Forces in World War II written by United States. Air Force Medical Service and published by . This book was released on 1955 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recommender Systems written by Charu C. Aggarwal and published by Springer. This book was released on 2016-03-28 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the topic of recommender systems, which provide personalized recommendations of products or services to users based on their previous searches or purchases. Recommender system methods have been adapted to diverse applications including query log mining, social networking, news recommendations, and computational advertising. This book synthesizes both fundamental and advanced topics of a research area that has now reached maturity. The chapters of this book are organized into three categories: Algorithms and evaluation: These chapters discuss the fundamental algorithms in recommender systems, including collaborative filtering methods, content-based methods, knowledge-based methods, ensemble-based methods, and evaluation. Recommendations in specific domains and contexts: the context of a recommendation can be viewed as important side information that affects the recommendation goals. Different types of context such as temporal data, spatial data, social data, tagging data, and trustworthiness are explored. Advanced topics and applications: Various robustness aspects of recommender systems, such as shilling systems, attack models, and their defenses are discussed. In addition, recent topics, such as learning to rank, multi-armed bandits, group systems, multi-criteria systems, and active learning systems, are introduced together with applications. Although this book primarily serves as a textbook, it will also appeal to industrial practitioners and researchers due to its focus on applications and references. Numerous examples and exercises have been provided, and a solution manual is available for instructors.
Download or read book Combinatorial Auctions written by Peter C. Cramton and published by MIT Press (MA). This book was released on 2006 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: A synthesis of theoretical and practical research on combinatorial auctions from the perspectives of economics, operations research, and computer science.
