Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 494 Vitrigel Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vitrigel-Eye Irritancy Test (EIT) method is an in vitro test method that allows the identification of test chemicals not requiring classification and labelling for eye irritation or serious eye damage. This test measures the eye irritation potential of a test chemical based on its ability to induce damage to the barrier function of the human corneal epithelium (hCE) models used in the Vitrigel-EIT method. It is known that chemicals that are irritating to the eye first destroy tear film and epithelial barrier function of the eye, subsequently induce epithelial cell death, and finally produce stromal degeneration and endothelial cell death, resulting in corneal opacity. Therefore, the change of the epithelial barrier function is a relevant endpoint for detecting eye irritation. In the Vitrigel Eye Irritancy test method , time-dependent changes in the Transepithelial Electrical Resistance (TEER) values are indicative of damage to the barrier function of the corneal epithelium following exposure to a test chemical; this situation is similar to the observed damage of the rabbit cornea following exposure to a test chemical, which is an important mode of action leading to damage of the corneal epithelium and eye irritation. The Vitrigel-Eye Irritancy Test (EIT) method can be used within the limited applicability domain of test chemicals having pH > 5.0 (based on 2.5% weight/volume (w/v) preparation).

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 405 Acute Eye Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...

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Download or read book Organotypic Models in Drug Development written by Monika Schäfer-Korting and published by Springer Nature. This book was released on 2021-03-25 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.

Download or read book Steaming Tests of Coals and Related Investigations written by Lester Paige Breckenridge and published by . This book was released on 1912 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bulletin written by United States. Bureau of Mines and published by . This book was released on 1912 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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Download or read book A Preliminary Report on the Mining Districts of Idaho written by Clifford Pinkney Bowie and published by . This book was released on 1919 with total page 1676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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Download or read book Handbook of Cosmetic Science and Technology written by Frank Dreher and published by CRC Press. This book was released on 2022-08-11 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice

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Download or read book Classic Farm Tractors written by Robert N. Pripps and published by Voyageur Press (MN). This book was released on 2014-04-15 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: An entertaining look at the tractors which enthusiasts all know and love--as well as those oddball models that fans find fascinating.

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