Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Download or read book Brazilian Bodies and Their Choreographies of Identification written by Cristina F. Rosa and published by Springer. This book was released on 2015-08-26 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brazilian Bodies, and their Choreographies of Identification retraces the presence of a particular way of swaying the body that, in Brazil, is commonly known as ginga . Cristina Rosa its presence across distinct and specific realms: samba-de-roda (samba-in-a-circle) dances, capoeira angola games, and the repertoire of Grupo Corpo.

Download or read book How to Read a Book written by Mortimer Jerome Adler and published by . This book was released on 1963 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endangerment Biodiversity and Culture written by Fernando Vidal and published by Routledge. This book was released on 2015-06-19 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The notion of Endangerment stands at the heart of a network of concepts, values and practices dealing with objects and beings considered threatened by extinction, and with the procedures aimed at preserving them. Usually animated by a sense of urgency and citizenship, identifying endangered entities involves evaluating an impending threat and opens the way for preservation strategies. Endangerment, Biodiversity and Culture looks at some of the fundamental ways in which this process involves science, but also more than science: not only data and knowledge and institutions, but also affects and values. Focusing on an "endangerment sensibility," it encapsulates tensions between the normative and the utilitarian, the natural and the cultural. The chapters situate that specifically modern sensibility in historical perspective, and examine central aspects of its recent and present forms. This timely volume offers the most cutting-edge insights into the Environmental Humanities for researchers working in Environmental Studies, History, Anthropology, Sociology and Science and Technology Studies.

Download or read book Preclinical Safety Evaluation of Biopharmaceuticals written by Joy A. Cavagnaro and published by John Wiley & Sons. This book was released on 2013-03-07 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Download or read book Crime Control As Industry written by Nils Christie and published by Routledge. This book was released on 2016-10-04 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crime Control As Industry, translated into many languages, is a modern classic of criminology and sociology. Nils Christie, one of the leading criminologists of his era, argues that crime control, rather than crime itself is the real danger for our future. Prison populations, especially in Russia and America, have grown at an increasingly rapid rate and show no signs of slowing. Christie argues that this vast and growing population is the equivalent of a modern gulag, run by a rapacious industry, both public and private, with vested interests in incarceration. Pain and confinement are products, like any other, with a potentially limitless supply of resources. Widely hailed as a classic account of crime and restorative justice Crime Control As Industry's prophetic insights and proposed solutions are essential reading for anyone interested in crime and the global penal system. This Routledge Classics edition includes a new foreword by David Garland.

Download or read book Global Pathways to Education written by Kerstin Martens and published by Springer Nature. This book was released on 2021-09-30 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this open access volume, the editors identify the trajectories and patterns displayed by education systems and investigate the causes of change from a global and historical perspective. The contributors argue that the emergence and development of education systems can be traced back to inherent national factors, as well as to the international diffusion of ideas. The research presented in this volume is a wide-ranging analysis and explanation of the dynamics of emergence, diffusion, and change in relation to state education systems. The chapters offer an empirical investigation into whether the global diffusion of Western-rational educational content and organizational forms occurs as expected by neoinstitutionalist theory, or whether culturally specific developmental paths dominate in different parts of the world. The book will be of interest to students and researchers in various social science disciplines, including social policy, education, sociology, political science, international relations, organizational theory, and economics.

Download or read book Greening Brazil written by Kathryn Hochstetler and published by Duke University Press. This book was released on 2007-08-29 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Greening Brazil challenges the claim that environmentalism came to Brazil from abroad. Two political scientists, Kathryn Hochstetler and Margaret E. Keck, retell the story of environmentalism in Brazil from the inside out, analyzing the extensive efforts within the country to save its natural environment, and the interplay of those efforts with transnational environmentalism. The authors trace Brazil’s complex environmental politics as they have unfolded over time, from their mid-twentieth-century conservationist beginnings to the contemporary development of a distinctive socio-environmentalism meant to address ecological destruction and social injustice simultaneously. Hochstetler and Keck argue that explanations of Brazilian environmentalism—and environmentalism in the global South generally—must take into account the way that domestic political processes shape environmental reform efforts. The authors present a multilevel analysis encompassing institutions and individuals within the government—at national, state, and local levels—as well as the activists, interest groups, and nongovernmental organizations that operate outside formal political channels. They emphasize the importance of networks linking committed actors in the government bureaucracy with activists in civil society. Portraying a gradual process marked by periods of rapid advance, Hochstetler and Keck show how political opportunities have arisen from major political transformations such as the transition to democracy and from critical events, including the well-publicized murders of environmental activists in 1988 and 2004. Rather than view foreign governments and organizations as the instigators of environmental policy change in Brazil, the authors point to their importance at key moments as sources of leverage and support.

Download or read book Trafficking in Persons Report 2017 written by Office of the Undersecretary for Civilian Security, Democracy, and Human Ri and published by Government Printing Office. This book was released on 2017-08-18 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2017 Trafficking in Persons Report highlights the successes achieved and the remaining challenges before us on this important issue. The primary focus is to showcase the responsibility of governments to criminalize human trafficking and hold offenders accountable. This year's report theme is increasing criminal accountability of human traffickers and addressing challenges in prosecution - an essential component of 3P- paradigm of prosecution, protection, and prevention. It provides an overview of the type of human trafficking offenses that are taking place around the world in violation of human rights. The text includes side bars of situational human trafficking experiences to allow the reader to understand the different types that occur throughout the world. High school students and above may find this report helpful for research and writing essays about human rights and law enforcement of human trafficking. American citizens, policy analysts and decision-makers, law enforcement personnel, and human rights policy activists and advocates and world leaders may refer to this report as a reference on these crimes. Related products: Explore ourHuman Rights resources collection and other products produced by the U.S. State Department.

Download or read book Volkswagen in the Amazon written by Antoine Acker and published by Cambridge University Press. This book was released on 2017-09-21 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 1973 to 1987, Volkswagen's (VW) 140,000 hectare 'pioneer' cattle ranch on the Amazon frontier laid bare the limits of capitalist development. These limits were not only economic, with the core management of a multinational company engaged in the 'integration' of an extreme world periphery, but they were also legal and ethical, with the involvement of indentured labor and massive forest burning. Its physical limits were exposed by an unpredictable ecosystem refusing to submit to VW's technological arsenal. Antoine Acker reveals how the VW ranch, a major project supported by the Brazilian military dictatorship, was planned, negotiated, and eventually undone by the intervention of internationally connected actors and events.

Download or read book Towards Resilient Organizations and Societies written by Rómulo Pinheiro and published by Springer Nature. This book was released on 2021-11-16 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book brings together scholars in the fields of management, public policy, regional studies, and organization theory around the concept of resilience. The aim is to provide a more holistic understanding of the complex phenomenon of resilience from a multi-sectorial, cross-national, and multidisciplinary perspective. The book facilitates a conversation across diverse disciplinary specializations and empirical domains. The authors contribute both to theory testing and theory development and provide key empirical insights useful for societies, organizations, and individuals experiencing disruptive pressures, not least in the context of a post-COVID-19 world. Diverse chapters are held together by a clear organization of the volume across levels of analysis (resilience in organizations and societies) and by an original perspective on resilience derived from an extended review, by the editors, of the existing literature and knowledge gaps, according to which each of the individual chapter contributions is positioned and connected to.

Download or read book Research Anthology on Strategies for Maintaining Successful Family Firms written by Management Association, Information Resources and published by IGI Global. This book was released on 2021-08-27 with total page 1146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Family-owned businesses account for many of the small and medium-sized enterprises that exist around the world in various industries. Due to their unique make up, these firms are often heavily influenced by family dynamics that must be reconciled by family and non-family workers alike in order to ensure the sustainability of the business. As smaller businesses competing against an increasingly globalized economy and more directly impacted by economic instability, especially in the wake of the COVID-19 pandemic, these businesses must continue to improve their practices and processes in order to not only survive but thrive. The Research Anthology on Strategies for Maintaining Successful Family Firms discusses the strategies, sustainability, and human aspects of family firms in order to understand what sets them apart from other businesses and how they can survive and compete in a globalized economy. This book discusses the unique dynamic brought by family firms that offers both opportunities and challenges for a growing business. Covering topics such as corporate venturing, the family unit, and business ethics, this text is an essential resource for family firms, entrepreneurs, managers, business students, business professors, researchers, and academicians.

Download or read book With Broadax and Firebrand written by Warren Dean and published by Univ of California Press. This book was released on 1997-04-10 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: "An unprecedented historical account of the destruction of Brazil's Atlantic Forest, a required reading for those committed to its preservation, written with genuine love and knowledge."—José Roberto Borges, Brazil Program Director, Rainforest Action Network "After reading this volume, no one could fail to realize the uniqueness and importance of these coastal forests, which have played such a fascinating role in the history of Brazil."—Ghillean T. Prance, Director, Royal Botanic Gardens, Kew

Download or read book Indian Modern Dance Feminism and Transnationalism written by Prarthana Purkayastha and published by Springer. This book was released on 2014-10-29 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines modern dance as a form of embodied resistance to political and cultural nationalism in India through the works of five selected modern dance makers: Rabindranath Tagore, Uday Shankar, Shanti Bardhan, Manjusri Chaki Sircar and Ranjabati Sircar.

Download or read book Regional Organizations and Democracy Human Rights and the Rule of Law written by Sören Stapel and published by Springer Nature. This book was released on 2022-01-10 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores when, why, and how regional organizations adopt and design institutions to promote and protect fundamental standards of democracy, human rights, and rule of law in their member states. These regional institutions have spread globally. While their institutional designs have become increasingly similar over time, regional particularities persist. The book identifies factors that generate the demand for regional institutions and shape its institutional design. The argument combines hitherto juxtaposed explanatory factors of demands and diffusion by integrating them in a single framework and clarifying under what conditions the interplay between demands and diffusion plays out in the adoption and design of regional institutions. The book provides a comprehensive overview of regional democracy, human rights, and rule of law institutions based on two original datasets and draws on multivariate statistical analysis as well as case studies on the making and change of regional institutions in the Organization of American States and the Organization of African Unity/African Union.

Download or read book Dance Dramaturgy written by Pil Hansen and published by Springer. This book was released on 2015-08-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ten international dramaturg-scholars advance proposals that reset notions of agency in contemporary dance creation. Dramaturgy becomes driven by artistic inquiry, distributed among collaborating artists, embedded in improvisation tasks, or weaved through audience engagement, and the dramaturg becomes a facilitator of dramaturgical awareness.

Download or read book The Chronicle of the Discovery and Conquest of Guinea Vol 1 2 written by Gomes Eannes de Zurara and published by Good Press. This book was released on 2023-12-12 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chronicle of Discovery and Conquest of Guinea in two volumes is a historical source which is considered the main authority for the early Portuguese voyages of discovery down the African coast and in the ocean, more especially for those undertaken under the auspices of Prince Henry the Navigator. The work is written by Portuguese chronicler Zurara and is serves as the principal historical source for modern conception of Prince Henry the Navigator and the Henrican age of Portuguese discoveries (although Zurara only covers part of it, the period 1434-1448). Zurara's chronicle is openly hagiographic of the prince and reliant on his recollections. It contains some account of the life work of that prince, and has a biographical as a geographical interest.