Download or read book Epistemology of the Cell written by Edward R. Dougherty and published by John Wiley & Sons. This book was released on 2011-08-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Honorable mention – Biomedicine and Neuroscience, 2011 Prose Awards" An examination of how the cell should be described in order to effectively process biological data "The fruitful pursuit of biological knowledge requires one to take Einstein's admonition [on science without epistemology] as a practical demand for scientific research, to recognize Waddington's characterization of the subject matter of biology, and to embrace Wiener's conception of the form of biological knowledge in response to its subject matter. It is from this vantage point that we consider the epistemology of the cell." —from the Preface In the era of high biological data throughput, biomedical engineers need a more systematic knowledge of the cell in order to perform more effective data handling. Epistemology of the Cell is the first authored book to break down this knowledge. This text examines the place of biological knowledge within the framework of science as a whole and addresses issues focused on the specific nature of biology, how biology is studied, and how biological knowledge is translated into applications, in particular with regard to medicine. The book opens with a general discussion of the historical development of human understanding of scientific knowledge, the scientific method, and the manner in which scientific knowledge is represented in mathematics. The narrative then gets specific for biology, focusing on knowledge of the cell, the basic unit of life. The salient point is the analogy between a systems-based analysis of factory regulation and the regulation of the cell. Each chapter represents a key topic of current interest, including: Causality and randomness Translational science Stochastic validation: classification Stochastic validation: networks Model-based experimentation in biology Epistemology of the Cell is written for biomedical researchers whose interests include bioinformatics, biological modeling, biostatistics, and biological signal processing.
Download or read book Discovering Cell Mechanisms written by William Bechtel and published by Cambridge University Press. This book was released on 2006 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bechtel emphasises how mechanisms were discovered by cell biologists and the instruments that made these inquiries possible.
Download or read book Philosophy of Cancer written by Marta Bertolaso and published by Springer. This book was released on 2016-08-24 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.
Download or read book The Epistemology of Development Evolution and Genetics written by Richard Burian and published by Cambridge University Press. This book was released on 2005 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: These essays examine the developments in three fundamental biological disciplines--embryology, evolutionary biology, and genetics. These disciplines were in conflict for much of the 20th century and the essays in this collection examine key methodological problems within these disciplines and the difficulties faced in overcoming the conflicts between them. Burian skillfully weaves together historical appreciation of the settings within which scientists work, substantial knowledge of the biological problems at stake and the methodological and philosophical issues faced in integrating biological knowledge drawn from disparate sources.
Download or read book Biology and Epistemology written by Richard Creath and published by Cambridge University Press. This book was released on 2000 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2000, explores a range of diverse issues in the intersection of biology and epistemology.
Download or read book Control Theory and Systems Biology written by Pablo A. Iglesias and published by MIT Press. This book was released on 2010 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: A survey of how engineering techniques from control and systems theory can be used to help biologists understand the behavior of cellular systems.
Download or read book Issues in Evolutionary Epistemology written by Kai Hahlweg and published by State University of New York Press. This book was released on 1989-11-01 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the fullest philosophical examination of theories of evolutionary epistemology now available. Here for the first time are found major statements of new theories, new applications, and many new critical explorations. The book is divided into four parts: Part I introduces several new approaches to evolutionary epistemology; Part II attempts to widen the scope of evolutionary epistemology, either by tackling more traditional epistemological issues, or by applying evolutionary models to new areas of inquiry such as the evolution of culture or of intentionality; Part III critically discusses specific problems in evolutionary epistemology; and Part IV deals with the relationship of evolutionary epistemology to the philosophy of mind. Because of its intellectual depth and its breadth of coverage, Issues in Evolutionary Epistemology will be an important text in the field for many years to come.
Download or read book Sociobiology and Epistemology written by J.H. Fetzer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers presented in this special collection focus upon conceptual, the oretical and epistemological aspects of sociobiology, an emerging discipline that deals with the extent to which genetic factors influence or control patterns of behavior as well as the extent to which patterns of behavior, in turn, influence or control genetic evolution. The Prologue advances a compre hensive acco/unt of the field of gene-culture co-evolution, where Lumsden and Gushurst differentiate between "classical" sociobiology (represented especially by Wilson's early work) and current research on human socio biology (represented by Lumsden and Wilson's later work), which emphasizes interplay between genes, minds, and culture. The specter of genetic deter minism, no doubt, has created considerable controversy, some of which may be laid to rest by Hanna's analysis of the (ambiguous) notion of a "genetic program", which indicates the necessity for distinguishing between descriptive and prescriptive dimensions of this complex concept. Brandon offers a framework for assessing the respective contributions of nature and of nurture by advancing a means for measuring genetic and cultural influences upon "inheritance", which supports the conclusion that evolving patterns of behavior do not always maximize inclusive fitness, contrary to what socio biologists have claimed. The influence of culture upon genetic evolution, of course, can be adequately appraised only when a suitable account of culture itself has been found, a desideratum Smillie attempts to satisfy by utilizing the notion of "cinfo" as culturally transmitted ecological informa tion, a resource other species tend not to exploit.
Download or read book Molecular Theory of the Living Cell written by Sungchul Ji and published by Springer Science & Business Media. This book was released on 2012-04-05 with total page 751 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.
Download or read book Visions of Cell Biology written by Karl S. Matlin and published by University of Chicago Press. This book was released on 2018-01-19 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although modern cell biology is often considered to have arisen following World War II in tandem with certain technological and methodological advances—in particular, the electron microscope and cell fractionation—its origins actually date to the 1830s and the development of cytology, the scientific study of cells. By 1924, with the publication of Edmund Vincent Cowdry’s General Cytology, the discipline had stretched beyond the bounds of purely microscopic observation to include the chemical, physical, and genetic analysis of cells. Inspired by Cowdry’s classic, watershed work, this book collects contributions from cell biologists, historians, and philosophers of science to explore the history and current status of cell biology. Despite extraordinary advances in describing both the structure and function of cells, cell biology tends to be overshadowed by molecular biology, a field that developed contemporaneously. This book remedies that unjust disparity through an investigation of cell biology’s evolution and its role in pushing forward the boundaries of biological understanding. Contributors show that modern concepts of cell organization, mechanistic explanations, epigenetics, molecular thinking, and even computational approaches all can be placed on the continuum of cell studies from cytology to cell biology and beyond. The first book in the series Convening Science: Discovery at the Marine Biological Laboratory, Visions of Cell Biology sheds new light on a century of cellular discovery.
Download or read book Concepts and Approaches in Evolutionary Epistemology written by Franz M. Wuketits and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume brings together current interdisciplinary research which adds up to an evolutionary theory of human knowledge, Le. evolutionary epistemology. It comprises ten papers, dealing with the basic concepts, approaches and data in evolutionary epistemology and discussing some of their most important consequences. Because I am convinced that criticism, if not confused with mere polemics, is apt to stimulate the maturation of a scientific or philosophical theory, I invited Reinhard Low to present his critical view of evolutionary epistemology and to indicate some limits of our evolutionary conceptions. The main purpose of this book is to meet the urgent need of both science and philosophy for a comprehensive up-to-date approach to the problem of knowledge, going beyond the traditional disciplinary boundaries of scientific and philosophical thought. Evolutionary epistemology has emerged as a naturalistic and science-oriented view of knowledge taking cognizance of, and compatible with, results of biological, psychological, anthropological and linguistic inquiries concerning the structure and development of man's cognitive apparatus. Thus, evolutionary epistemology serves as a frame work for many contemporary discussions of the age-old problem of human knowledge.
Download or read book Integrating History and Philosophy of Science written by Seymour Mauskopf and published by Springer Science & Business Media. This book was released on 2011-09-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though the publication of Kuhn's Structure of Scientific Revolutions seemed to herald the advent of a unified study of the history and philosophy of science, it is a hard fact that history of science and philosophy of science have increasingly grown apart. Recently, however, there has been a series of workshops on both sides of the Atlantic (called '&HPS') intended to bring historians and philosophers of science together to discuss new integrative approaches. This is therefore an especially appropriate time to explore the problems with and prospects for integrating history and philosophy of science. The original essays in this volume, all from specialists in the history of science or philosophy of science, offer such an exploration from a wide variety of perspectives. The volume combines general reflections on the current state of history and philosophy of science with studies of the relation between the two disciplines in specific historical and scientific cases.
Download or read book Evolutionary Epistemology Language and Culture written by Nathalie Gontier and published by Springer Science & Business Media. This book was released on 2006-07-25 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time in history, scholars working on language and culture from within an evolutionary epistemological framework, and thereby emphasizing complementary or deviating theories of the Modern Synthesis, were brought together. Of course there have been excellent conferences on Evolutionary Epistemology in the past, as well as numerous conferences on the topics of Language and Culture. However, until now these disciplines had not been brought together into one all-encompassing conference. Moreover, previously there never had been such stress on alternative and complementary theories of the Modern Synthesis. Today we know that natural selection and evolution are far from synonymous and that they do not explain isomorphic phenomena in the world. ‘Taking Darwin seriously’ is the way to go, but today the time has come to take alternative and complementary theories that developed after the Modern Synthesis, equally seriously, and, furthermore, to examine how language and culture can merit from these diverse disciplines. As this volume will make clear, a specific inter- and transdisciplinary approach is one of the next crucial steps that needs to be taken, if we ever want to unravel the secrets of phenomena such as language and culture.
Download or read book Margins of Philosophy written by Jacques Derrida and published by University of Chicago Press. This book was released on 1982 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In this densely imbricated volume Derrida pursues his devoted, relentless dismantling of the philosophical tradition, the tradition of Plato, Kant, Hegel, Nietzsche, Husserl, Heidegger—each dealt with in one or more of the essays. There are essays too on linguistics (Saussure, Benveniste, Austin) and on the nature of metaphor ("White Mythology"), the latter with important implications for literary theory. Derrida is fully in control of a dazzling stylistic register in this book—a source of true illumination for those prepared to follow his arduous path. Bass is a superb translator and annotator. His notes on the multilingual allusions and puns are a great service."—Alexander Gelley, Library Journal
Download or read book Organizational Epistemology written by Johan Roos and published by Springer. This book was released on 2016-07-27 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a new view of organizations which has important implications for the theory, methods and practice of management. For several years the boundaries of political science, sociology and other fields in the social sciences have been significantly rethought with the help of autopoiesis theory. The authors examine how this theory can be applied in the organization and management field, by an increased focus on knowledge and the processes of knowledge development and guidance. Intended as a standard reference for all those involved in the study of advanced organizations, Organizational Epistemology will be welcomed by graduate students, researchers and reflective practitioners alike.
Download or read book Crossing the Boundaries of Life written by Karl S. Matlin and published by University of Chicago Press. This book was released on 2022-05-10 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.
Download or read book Philosophy of Stem Cell Biology written by M. Fagan and published by Springer. This book was released on 2013-01-21 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This examination of stem cell biology from a philosophy of science perspective clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. Relations to systems biology and clinical medicine are also discussed.
