Download or read book Elements of Synthesis Planning written by R. W. Hoffmann and published by Springer Science & Business Media. This book was released on 2009-01-07 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.
Download or read book The logic of chemical synthesis written by E.J. Corey and published by Рипол Классик. This book was released on 1991 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Download or read book Organic Synthesis written by Michael Smith and published by Academic Press. This book was released on 2016-11-22 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors
Download or read book Flow Chemistry Guided by Computer aided Synthesis Planning written by Christopher Paul Breen and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Portions of this thesis have been reprinted, adapted, or both, with permission from their respective publishers.
Download or read book Organic Synthesis written by Paul Wyatt and published by John Wiley & Sons. This book was released on 2013-05-20 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. * A comprehensive, practical account of the key concepts involved in synthesising compounds * Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations * Focuses on reactions that really work rather than those with limited application * Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.
Download or read book Le Corbusier written by Stanislaus von Moos and published by 010 Publishers. This book was released on 2009 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in Germany in 1968, this first comprehensive and critical survey of Le Corbusier's life and work soon became the standard text on the architect and polymath. French, Spanish, English, Japanese and Korean editions followed, but the book has now been out of print for almost two decades. In the meantime, Le Corbusier's archives in Paris have become available for research, resulting in an avalanche of scholarship. Von Moos' critical take and the basic criteria by which the subject is organized and historicized remain surprisingly pertinent in the context of this recent jungle of Corbusier studies. This new, completely revised edition is based on the 1979 version published in English by the MIT Press but offers a substantially updated body of illustrations. Each of the seven chapters is supplemented by a critical survey of recent scholarship on the respective issues. An updated edition of this acclaimed book, an essential read for students of architecture and architectural history.
Download or read book Analysis Synthesis and Design of Chemical Processes written by Richard Turton and published by Pearson Education. This book was released on 2008-12-24 with total page 1562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leading Integrated Chemical Process Design Guide: Now with New Problems, New Projects, and More More than ever, effective design is the focal point of sound chemical engineering. Analysis, Synthesis, and Design of Chemical Processes, Third Edition, presents design as a creative process that integrates both the big picture and the small details–and knows which to stress when, and why. Realistic from start to finish, this book moves readers beyond classroom exercises into open-ended, real-world process problem solving. The authors introduce integrated techniques for every facet of the discipline, from finance to operations, new plant design to existing process optimization. This fully updated Third Edition presents entirely new problems at the end of every chapter. It also adds extensive coverage of batch process design, including realistic examples of equipment sizing for batch sequencing; batch scheduling for multi-product plants; improving production via intermediate storage and parallel equipment; and new optimization techniques specifically for batch processes. Coverage includes Conceptualizing and analyzing chemical processes: flow diagrams, tracing, process conditions, and more Chemical process economics: analyzing capital and manufacturing costs, and predicting or assessing profitability Synthesizing and optimizing chemical processing: experience-based principles, BFD/PFD, simulations, and more Analyzing process performance via I/O models, performance curves, and other tools Process troubleshooting and “debottlenecking” Chemical engineering design and society: ethics, professionalism, health, safety, and new “green engineering” techniques Participating successfully in chemical engineering design teams Analysis, Synthesis, and Design of Chemical Processes, Third Edition, draws on nearly 35 years of innovative chemical engineering instruction at West Virginia University. It includes suggested curricula for both single-semester and year-long design courses; case studies and design projects with practical applications; and appendixes with current equipment cost data and preliminary design information for eleven chemical processes–including seven brand new to this edition.
Download or read book Structure based Synthesis Planning written by Kai Sommer and published by . This book was released on 2019 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.
Download or read book Notes on the Synthesis of Form written by Christopher Alexander and published by Harvard University Press. This book was released on 1964 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: "These notes are about the process of design: the process of inventing things which display new physical order, organization, form, in response to function." This book, opening with these words, presents an entirely new theory of the process of design. In the first part of the book, Christopher Alexander discusses the process by which a form is adapted to the context of human needs and demands that has called it into being. He shows that such an adaptive process will be successful only if it proceeds piecemeal instead of all at once. It is for this reason that forms from traditional un-self-conscious cultures, molded not by designers but by the slow pattern of changes within tradition, are so beautifully organized and adapted. When the designer, in our own self-conscious culture, is called on to create a form that is adapted to its context he is unsuccessful, because the preconceived categories out of which he builds his picture of the problem do not correspond to the inherent components of the problem, and therefore lead only to the arbitrariness, willfulness, and lack of understanding which plague the design of modern buildings and modern cities. In the second part, Mr. Alexander presents a method by which the designer may bring his full creative imagination into play, and yet avoid the traps of irrelevant preconception. He shows that, whenever a problem is stated, it is possible to ignore existing concepts and to create new concepts, out of the structure of the problem itself, which do correspond correctly to what he calls the subsystems of the adaptive process. By treating each of these subsystems as a separate subproblem, the designer can translate the new concepts into form. The form, because of the process, will be well-adapted to its context, non-arbitrary, and correct. The mathematics underlying this method, based mainly on set theory, is fully developed in a long appendix. Another appendix demonstrates the application of the method to the design of an Indian village.
Download or read book Designing Organic Syntheses written by Stuart Warren and published by John Wiley & Sons. This book was released on 1991-01-08 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaches students to use the language of sythesis directly (utilizing the grammar of synthon and disconnection) rather than translating it into that of organic chemistry.
Download or read book Understanding Experimental Planning For Advanced Level Chemistry The Learner s Approach written by Kim Seng Chan and published by World Scientific Publishing Company. This book was released on 2015-05-22 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a continuation of authors' previous six books — Understanding Advanced Physical Inorganic Chemistry, Understanding Advanced Organic and Analytical Chemistry, Understanding Advanced Chemistry Through Problem Solving Vol. I & II, Understanding Basic Chemistry and Understanding Basic Chemistry Through Problem Solving, retaining the main refutational characteristics of the previous books with the strategic inclusion of think-aloud questions to promote conceptual understanding during an experimental planning. These essential questions would make learners aware of the rationale behind each procedural step, the amount of chemical used and types of apparatus that are appropriate for the experiment.The book provides a fundamental important scaffolding to aid students to create their own understanding of how to plan an experiment based on the given reagent and apparatus. It guides the students in integrating the various concepts that they have learnt into a coherent and meaningful conceptual network during experimental planning.Existing A-level or IB guidebooks generally introduce concepts in a matter-of-fact manner. This book adds a unique pedagogical edge which few can rival. This book is essential and useful in order for students to be adequately prepared for their high stake examinations.
Download or read book Elements of Information Organization and Dissemination written by Amitabha Chatterjee and published by Chandos Publishing. This book was released on 2016-11-05 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elements of Information Organization and Dissemination provides Information on how to organize and disseminate library and information science (LIS), a subject that is taught in many international Library Information Science university programs. While there are many books covering different areas of the subject separately, this book covers the entire subject area and incorporates the latest developments. - Presets an overview of the entire subject, covering all relevant areas of library and information science - Contains bulletpoints that highlight key features in each chapter - Written in an accessible language, this book is aimed at a wide audience of LIS academics
Download or read book Mcdp 5 Planning written by Department of Defense and published by Createspace Independent Publishing Platform. This book was released on 2017-05-22 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication describes the theory and philosophy of military planning as practiced by the U.S. Marine Corps. The intent is to describe how we can prepare effectively for future action when the future is uncertain and unpredictable. In so doing, this publication provides all Marines a conceptual framework for planning in peace, in crisis, or in war. This approach to planning is based on our common understanding of the nature of war and on our warfighting philosophy of maneuver warfare as described in Marine Corps Doctrinal Publication (MCDP) 1, Warfighting.
Download or read book Computer Assistance in Organic Synthesis Planning and Execution written by Connor Wilson Coley and published by . This book was released on 2019 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification and synthesis of molecules that exhibit a desired function is an essential part of addressing contemporary problems in science and technology. Small molecules are the predominant solution to challenges in the development of medicines, chemical probes, specialty polymers, and organocatalysts, among others. The typical discovery paradigm is an iterative process of designing candidate compounds, synthesizing those compounds, and testing their performance. The rate at which this process yields successful compounds can be limited by bottlenecks and mispredictions at all three stages and is plagued by inefficiencies, not the least of which is the manual nature of synthesis planning and execution. This thesis describes techniques to streamline the synthesis of small molecules in this context of pharmaceutical discovery from two perspectives: one experimental and the other using techniques in data science and machine learning. Part I focuses on the time-, material-, and experimental-efficiency of data collection. It describes the development of an automated microfluidic reactor platform for studying physical and chemical processes at the micromole scale. Synthesis and purification of small molecule compound libraries are performed without human intervention at a scale suitable for a medicinal chemistry setting. Integration of online analytics enables efficient, closed-loop self-optimization using an optimal design of experiments algorithm to identify reaction conditions suitable for production-scale flow synthesis. To complement the generation of new data through automated experimentation, Part II is driven by the goal of applying existing reaction data to problems in synthesis and synthesis design. This includes the development of data-driven methodologies for the design and validation of small molecule synthetic routes. An enabling factor in ensuring the feasibility of computationally-proposed reactions is the use of models to predict organic reaction outcomes in silico-also useful for impurity prediction–that leverage the flexibility in pattern recognition afforded by neural networks to understand chemical reactivity in the same way we might by reading the literature. Several predictive models are integrated into an overall framework for computer-aided synthesis planning that can rapidly propose routes to new molecules with the complexity of modern active pharmaceutical ingredients. As a final demonstration, machine learning assisted synthesis planning is brought together with laboratory automation to illustrate an accelerated approach to target-oriented flow synthesis. This is a proof-of-concept for how chemical development might one day occur with less human intervention.
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
