Download or read book EGO 1 an Essential Caenorhabditis Elegans RNA directed RNA Polymerase Modulates Gene Expression Through the Messenger RNA templated Production of Short Antisense Effector RNAs written by Jay Mahesh Maniar and published by Stanford University. This book was released on 2010 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of the germline in Caenorhabditis elegans is a complex process involving the regulation of thousands of genes in a coordinated manner. These genes must direct the regulation of cell proliferation, meiosis, and sex determination, as well as gamete formation and fertilization. Several genes required for small RNA biogenesis and function are also required for the proper organization and development of the germline. EGO-1 is a putative RNA-directed RNA polymerase (RdRP) that is required for C. elegans germ-line development and efficient RNAi of germ-line expressed genes. Additionally, ego-1 mutants have been shown to exhibit defects in heterochromatin assembly on unpaired DNA and proper chromosome segregation during meiosis. Despite our understanding of the morphology of ego-1 mutant worms, it has remained unclear how the loss of a putative RdRP can cause such dramatic phenotypes in the C. elegans germline. That is, what role does EGO-1 play in promoting the development of the germline? There is strong evidence for the requirement of the C. elegans RdRP RRF-3 in producing endogenous small RNAs that target mRNA produced from specific genes. Additionally, there is evidence that EGO-1 may interact directly with chromatin. The questions become what target (or perhaps targets) is being disrupted in the ego-1 mutant and are they being disrupted at the chromatin or RNA level? Using high-throughput small RNA and messenger RNA sequencing we found that EGO-1 is required to produce small RNAs antisense to a number of germline-expressed genes through several developmental stages. We found that these genes fall into several classes including genes required for kinetochore (klp-7) and nuclear pore (npp-3) assembly, as well as the production of histone-modifying (set-21) and centromeric proteins (hcp-3). We also found several RNAi-related genes to be targets of EGO-1 (csr-1, mut-14, mut-16, prg-1, tsn-1). Finally, we show a strong correlation between the loss of small RNAs and the rise of mRNA levels in ego-1(-) animals.
Download or read book Time Ego written by Claudiu A. Secara and published by Algora Publishing. This book was released on 2007 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first question of abstract reflection that arouses controversy is the problem of Becoming. Being persists, beings constantly change; they are born and they pass away. How can Being change and yet be eternal?
Download or read book The Unharnessed World written by Cindy Gabrielle and published by Cambridge Scholars Publishing. This book was released on 2015-06-18 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though New Zealand author Janet Frame (1924–2004) lived at a time of growing dissatisfaction with European cultural models, and though her (auto-)biography, fiction and letters all testify to the fact that a direct encounter between herself and Buddhism occurred, her work has, so far, never been examined from the vantage point of its indebtedness to Buddhism. It is of the utmost significance, however, that a Buddhist navigation of Frame’s texts should shed fresh light on large segments of the Framean corpus which have tended to remain obdurately mysterious. This includes passages centering on such themes as the existence of a non-dual world or a character’s sudden embrace of a non-ego-like self. Of equal significance is the conclusion one then draws that this unharnessed world which human beings are often unable to embrace has always been right under their nose, for, whenever the aspect of the intellect that filters perceptions into mutually excluding categories fails to function, he or she finds a place of subjective arrival in, and sees, this supposedly unknowable ‘beyond’. Thus, possibly against the grain of mainstream criticism, this study argues that Janet Frame constantly seeks ways through which the infinite and the Other can be approached, though not corrupted, by the perceiving self, and that she found in the Buddhist epistemology a pathway towards evoking such alterity.
Download or read book Otia Merseiana written by John Sampson and published by . This book was released on 1904 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book No Ego written by Cy Wakeman and published by St. Martin's Press. This book was released on 2017-09-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Times bestselling author and leadership trainer says: Getting your employees to do their work shouldn't have to be so much, well, work!
Download or read book Corpus Tibullianum written by Tibullus and published by . This book was released on 1913 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Otia Merseiana written by and published by . This book was released on 1899 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A New Method for Caesar written by Franklin Hazen Potter and published by . This book was released on 1907 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Greek Culture and the Ego written by Adrian Stokes and published by Routledge. This book was released on 2013-10-11 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tavistock Press was established as a co-operative venture between the Tavistock Institute and Routledge & Kegan Paul (RKP) in the 1950s to produce a series of major contributions across the social sciences. This volume is part of a 2001 reissue of a selection of those important works which have since gone out of print, or are difficult to locate. Published by Routledge, 112 volumes in total are being brought together under the name The International Behavioural and Social Sciences Library: Classics from the Tavistock Press. Reproduced here in facsimile, this volume was originally published in 1958 and is available individually. The collection is also available in a number of themed mini-sets of between 5 and 13 volumes, or as a complete collection.
Download or read book Ego Trip s Book of Rap Lists written by Sacha Jenkins and published by St. Martin's Griffin. This book was released on 2014-03-25 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ego Trip's Book of Rap Lists is more popular than racism! Hip hop is huge, and it's time someone wrote it all down. And got it all right. With over 25 aggregate years of interviews, and virtually every hip hop single, remix and album ever recorded at their disposal, the highly respected Ego Trip staff are the ones to do it. The Book of Rap Lists runs the gamut of hip hop information. This is an exhaustive, indispensable and completely irreverent bible of true hip hip knowledge.
Download or read book The Wisdom of the Ego written by George E. Vaillant and published by Harvard University Press. This book was released on 1998-07-21 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of America's preeminent psychiatrists draws on his famous Study of Adult Development to give us an exhilarating look at how the mind's defenses work. What we see as the mind's trickery, George Vaillant tells us, is actually healthy. What's more, it can reveal the mind at its most creative and mature, soothing and protecting us in the face of unbearable reality, managing the unmanageable, ordering disorder. And because creativity is so intrinsic to this alchemy of the ego, Vaillant mingles his studies of obscure lives with psychobiographies of famous artists and others--including Florence Nightingale, Sylvia Plath, Anna Freud, and Eugene O'Neill.
Download or read book Alter Ego written by Brian Freeman and published by Hachette UK. This book was released on 2019-10-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A GRIPPING AND EXPLOSIVE THRILLER FROM #1 BESTSELLING AUTHOR BRIAN FREEMAN Hollywood has a dark side, and it will stop at nothing to hide it... When a freak auto accident kills a driver carrying false identification on the remote roads outside Duluth, Jonathan Stride is disturbed to find a gun in the trunk - and the gun has recently been fired. The next day, a Duluth college student has also vanished, and Stride worries they're connected - but what would have put an ordinary young woman in the crosshairs of a man who has all the hallmarks of an assassin for hire? Stride's investigation leads him to a film crew in Duluth, where a movie is being made based on a case in Stride's own past. The actor playing Stride is Hollywood royalty, an award-winning icon who has charmed his way to the top of the box office. But Stride soon hears whispers that his cinematic alter ego has a dark side.
Download or read book Horace Odes and Epodes written by Horace and published by . This book was released on 1922 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ego written by Michael Taft and published by ReadHowYouWant. This book was released on 2011-09-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Baumann and Taft skillfully weave eyewitness accounts of 9/11 with insights from evolutionary theory, neuroscientific studies on brain plasticity and emotion, genetics, and other new areas of research. I highly recommend this book to all who are interested in how science can help in understanding both the human capacity for horrific action and the clear reasons for optimism about our collective future.''Alfred W. Kaszniak, Ph.D., Professor of Psychology, Neurology & Psychiatry, University of Arizona Ego: The Fall of the Twin Towers and the Rise of a New Humanity by Peter Baumann and Michael W. Taft is the first book to explore the positive evolutionary potential hidden in one of the most destructive events in history. In their examination of the evolutionary implications of 9/11 and its aftermath, the authors contend we are not falling into the grip of a new dark age at all, rather we are on the verge of a much brighter one as the Darwinian process of natural selection continues to advance humankind. The authors' inquiry led them to the root of human suffering: the ego. That the ego underlies our problems as a species may come as no surprise. But a deeper look into the ego's origin and history is full of unexpected revelations: The modern human is dominated by a Stone Age brain Energy consumption and the environmental crisis is nothing more than the evolutionary drive to survive gone haywire Evolution has wired us to be riveted to bad news, bad outcomes, and worst - case scenarios When beliefs are challenged it triggers a life or death stance in the human nervous system Emotions are mostly physical, not mental The self we identify with along with its biases and beliefs turns out to be an evolutionary tool that made its first appearance some 50,000 years ago during what's called the conceptual revolution, arguably the biggest developmental leap in human history. The emerging ego accompanied our ability to construct complex tools, create art, and redefine social structure. For the first time as a species, we were able to imagine the future, consider the thoughts of others, and picture ourselves in our own minds. The ego is a cognitive trick of natural selection intended to insure the survival of the individual. Baumann and Taft say the problem comes when we take the ego's conceptualization of reality as the truth about who we actually are. Using the latest research from cognitive neuroscience, evolutionary psychology, social anthropology, and paleontology, Baumann and Taft show that modern humanity may be on the verge of an expansion of cognitive abilities akin to the development of the ego. This next step will free the human mind to see beyond the confines of the ego and open the vast potential of conscious awareness.
Download or read book The Cum constructions written by William Gardner Hale and published by . This book was released on 1887 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Elegies of Albius Tibullus written by Tibullus and published by . This book was released on 1913 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Social Network Analysis for Ego Nets written by Nick Crossley and published by SAGE. This book was released on 2015-07-27 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ego-net approach to social network analysis, which takes discrete individual actors and their contacts as its starting point, is one of the most widely used approaches in the field. This is the first textbook to take readers through each stage of ego-net research, from conception, through research design and data gathering to analysis. It starts with the basics, assuming no prior knowledge of social network analysis, but then moves on to introduce cutting edge innovations, covering both new statistical approaches to ego-net analysis and also the most recent thinking on mixing methods (quantitative and qualitative) to achieve depth and rigour. It is an absolute must for anybody wishing to explore the importance of networks.
