Download or read book Drugs and the Cell Cycle written by A Zimmerman and published by Elsevier. This book was released on 2012-12-02 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids, alkylating agents, mercurials, adrenergic agents, radiomimetics, narcotics, hallucinogens, mitogens, hepatotoxins, antiobiotics, and antimetabolites of various types. The text also emphasizes the drugs used in cancer chemotherapy, and the in vitro and in vivo cell systems of bacteria, protozoa, sea urchins, and mammals. The concepts are presented with comprehensive illustrations and tables to help readers obtain more efficient understanding and learning. The information and concepts presented in this volume will be of great interest to scientists and students in many disciplines, including physiology, pharmacology, and oncology, as well as cellular, molecular, and developmental biology. The book will also fill the gap between drug experimental observations and their potential relevance to man.

Download or read book Cell Cycle Effects of Drugs written by Lyle A. Dethlefsen and published by Pergamon. This book was released on 1986 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the mechanism of action of anticancer agents depends on investigations into the cell cycle effects of these agents. The intent of this volume is to review our current knowledge about these basic cell cycle effects and suggest what directions future investigations should take. Chapters 1 and 2 are general, basic chapters dealing with the biology of the cell cycle per se and quantitative cytokinetics (techniques) respectively. The remaining nine chapters each cover a specific anticancer compound as examples of various classes of anticancer agents. In bringing this information together for the first time this volume represents a major step in the understanding of the mechanisms that are involved in the treatment of cell cycle disorders.

Download or read book Drugs and the Cell Cycle Edited by A M Zimmerman G M Padilla And I L Cameron written by Arthur M. Zimmerman and published by . This book was released on 1973 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Drugs on the Cell Nucleus written by Harris Busch and published by . This book was released on 1979 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Cycle Inhibitors in Cancer Therapy written by Antonio Giordano and published by Springer Science & Business Media. This book was released on 2002-11-20 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Download or read book Cell Cycle Effects of Anti tumour Cancer Drugs written by Ariel Luo Yun Chun and published by . This book was released on 2003 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Some Antiinflammatory Drugs on the Cell Cycle Studied by Means of Maximal Labelling Index written by Monique Adolphe and published by . This book was released on 1970 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Preparation Technology and Pharmacology of Biological Drugs written by Cheng-Hao Jin and published by Scientific Research Publishing, Inc. USA. This book was released on 2021-04-07 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on modern life science, biological drugs combine advanced engineering technology and scientific principles of other basic disciplines, and transform organisms or process biological raw materials according to leading designs. Biopharmaceutical raw materials are mainly natural biological materials, including microorganisms, human body, animals, plants, Marine organisms and so on. With the development of biotechnology, purposeful artificial biological raw materials have become the main source of biopharmaceutical raw materials. Biological drugs are characterized by high pharmacological activity, small toxic and side effects and high nutritional value. Biological drugs mainly include proteins, nucleic acids, carbohydrates, lipids and so on. The constituent units of these substances are amino acids, nucleotides, monosaccharides, fatty acids, etc., which are not only harmless to the human body but also important nutrients.

Download or read book Evaluation of the Complexity of Cell Cycle Effects Induced by Anticancer Drugs written by Monica Lupi and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Download or read book Cell Cycle Regulation written by Robert R. Ruffolo, Jr. and published by CRC Press. This book was released on 1997-12-23 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on recent key discoveries made relating to the cell cycle and its regulation - a critical new horizon in therapeutics. Research into all aspects of cell cycle regulation has undergone explosive growth during the past decade due to the powerful techniques of molecular biology. An overall view of the cellular processes, both at the enzymatic and genetic level, has been identified in continually finer detail, as described inside this text. This has enabled significant progress in the identification of drugs capable of acting on specific components of the cell cycle, with the result that we may soon have the ability to manipulate the cell cycle pharmacologically. The potential impact on clinical conditions such as cancer, hematopoiesis, angiogenesis, inflammation, organ remodelling and apoptosis is vast. Originating from presentations at the Eighth SmithKline Beecham Pharmaceuticals United States Research Symposium, each chapter in this volume is written by an opinion leader in the field.

Download or read book Anticancer Drug Development written by Bruce C. Baguley and published by Elsevier. This book was released on 2001-11-17 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Download or read book Cell Division Machinery and Disease written by Monica Gotta and published by Springer. This book was released on 2017-06-09 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Download or read book Repurposed Drugs Targeting Cancer Signaling Pathways Dissecting New Mechanisms of Action Through in vitro and in vivo Analyses written by Alma D. Campos-Parra and published by Frontiers Media SA. This book was released on 2021-11-29 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Discovery written by Robert A. Maxwell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.

Download or read book Chemical Dissection of the Cell Cycle for Anticancer Drug Discovery and Target Identification written by Yu-Chen Lo and published by . This book was released on 2016 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cell cycle is governed by highly regulated mechanisms that mandate organism's proliferation and survival. On the other hand, malignant human diseases like cancer often arise by uncontrolled cell cycle progression. The cell cycle of mammalian cells can be easily perturbed by chemical compounds (drugs), leading to check point activation, cell cycle arrests and eventual apoptosis (cell death). Consequently, identifying critical cell cycle targets whose bioactivities can be modulated by small molecules present a promising strategy to advance our understanding and treatment of neoplasm disease. Here, we present a new approach to dissect mammalian cell cycles using small molecule cell cycle screen to identify diverse hit compounds with potent anticancer activities. In particular, we identified MI-181, a potent tubulin destabilizing agent that is active against multiple cancer cell lines. Further structure study indicates that it binds to a distinct site close to the colchicines binding pocket. As an alternative, we further applied cell cycle analysis to repurpose anticancer agents from non-cancer drugs and have identified six FDA compounds with novel cytotoxic properties. To enable large-scale profiling of cell cycle targets, we developed a new computational approach for target identification called "CSNAP" based on network algorithm and consensus statistics. CSNAP analysis of M-phase inhibitors identified three novel mitotic targets not previous associated with mitosis and one novel mitotic inhibitor interacting with the colchicine site of beta tubulin. To improve target predictability and identify scaffold hoppers, we considered ligand 3D conformation in an improved CSNAP3D program. CSNAP3D analysis of M-phase compounds discovered low molecular weight taxol mimetics that bound to the taxane site, stabilized microtubule formation, and demonstrated promising transport properties.