Download or read book Alpha Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Birkhäuser. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.
Download or read book Molecular Biology of Assemblies and Machines written by Alasdair Steven and published by Garland Science. This book was released on 2016-02-18 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.
Download or read book Methods in Protein Sequence Analysis written by K. Imahori and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ninth International Conference on Methods in Protein Sequence Analysis was held for the first time in Asia from September 20 to September 24, 1992 in Otsu (a city near Kyoto), Japan. Approximately 400 delegates attended the meeting. Forty papers were presented orally and 147 poster presentations were discussed. Academic sessions were held from early in the morning until late in the evening. We are confident that the Conference was successful in providing up-to-date information about methods in protein sequence analysis to all participants. Moreover, with the knowledge and understanding of the present standard of various methods of analysis that are being used and will be used, we were able to clarify areas that need to be evaluated, to be improved and be explored further. Major topics in the Conference mostly covered areas in the methodology of protein sequence analysis, such as: micropreparation and microsequencing of proteins, mass spectrometry, post-translational modification, prediction and database analysis, and analysis of protein structures of special interests. The evolution of genetic engineering in molecular biology has greatly accelerated the accumulation of knowledge on the amino acid sequence of novel proteins regardless of whether they are expressed or not expressed in living organisms. In the early stage of accumulation of structural information, the amino acid sequence itself is worthy of notice.
Download or read book Characterization Properties and Applications written by Tracey Rouault and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-08-21 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures.
Download or read book Enzyme Technologies for Pharmaceutical and Biotechnological Applications written by Herbert A Kirst and published by CRC Press. This book was released on 2001-06-05 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of enzyme function in human and animal health, this book covers basic principles and applications in antibiotic biosynthesis, biocatalysis, and screening and assay optimization, as well as new and emerging technologies in the biotechnological and pharmaceutical industries. It offers real-world examples of timely laboratory, pharmaceutical and manufacturing processes, including large-scale applications of enzyme manipulations.
Download or read book Fuzzy Sets Based Heuristics for Optimization written by José-Luis Verdegay and published by Springer Science & Business Media. This book was released on 2003-05-06 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this volume is to show how Fuzzy Sets and Systems can help to provide robust and adaptive heuristic optimization algorithms in a variety of situations. The book presents the state of the art and gives a broad overview on the real practical applications that Fuzzy Sets, based on heuristic algorithms, have.
Download or read book How Proteins Work written by Michael Williamson and published by Garland Science. This book was released on 2012-03-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughputomics' projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of
Download or read book Advances in Microbial Physiology written by and published by Elsevier. This book was released on 2005-10-21 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work.First published in 1967, it is now in its 50th volume. The Editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to "traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series. - In 2004, the Institute for Scientific Information released figures showing that the series had an Impact Factor of 8.947, with a half-life of 6.3 years, placing it 5th in the highly competitive category of Microbiology.
Download or read book Signal Transduction Mechanisms written by J.A. Barnes and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of an International Symposium on `Second Messenger Systems - Molecular, Cellular and Behavioural Aspects', which was held at Tobago on June 16-17, 1994. The interaction of an extracellular agonist (First Messenger) with its plasma membrane receptor leads to the transmission of a signal across the cell membrane and results in the production and/or activation of other signalling molecules (Second Messengers). These Second Messengers control the action of many protein kinases and protein phosphatases and so lead to cellular responses. Although the biochemical basis of the transduction of signals in the main signalling systems in eukaryotic cells is probably largely known, intensified research is ongoing in the following areas: the discovery of specific substrates for many protein kinases, elucidation of the biological significance of the differential tissue expression and heterogeneity of many signalling proteins, and the unravelling of diverse interactions (such as signal potentiation, synergism, antagonism and neuronal co-transmission) between signalling systems. As knowledge from such studies accumulates, it is becoming clear that the `cross talk' interactions between signalling systems are important features of dynamic cell regulation. This volume is designed to summarize some aspects of the current work on various Second Messenger Systems and the integration of signals with respect to plasma membrane receptors. Second Messenger generation and degradation, protein kinase and phosphatase, cell cycle control, and cellular learning and memory.
Download or read book Microbiology and Biogeochemistry of Hypersaline Environments written by Aharon Oren and published by CRC Press. This book was released on 1998-09-16 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, intended for researchers and students in the fields of microbiology, biochemistry, and biogeochemistry, details the biology and biogeochemistry of various halophilic microorganisms that live in high density saline environments worldwide. These organisms are especially important to biodegradation and hazardous site clean-up. Topics include the biochemistry, genetics, and molecular biology of these organisms; new methods to type them; and osmotic adaption.
Download or read book Halophilic Microorganisms written by Antonio Ventosa and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various groups of microorganisms - bacteria, archaea, algae and even fungi - have adapted to a life in a hypersaline environment. Halophilic Microorganisms explores the many-fold aspects of life under these extreme conditions. Several contributions analyze the microbial communities in different hypersaline environments such as salterns, soda lakes, and the Dead Sea or salt sediments. Reviews of their biodiversity, phylogeny, and genetics are given as well as of the diverse adaptation strategies of salt-tolerant or salt-requiring microorganisms. Microorganisms that have adapted to moderate salt concentrations or to habitats with drastic fluctuations are also treated in addition to the extreme halophiles. Their physiological, biochemical and molecular mechanisms developed in response to salinity and high osmotic pressure as well as current and future biotechnological applications are presented.
Download or read book Lipoic Acid written by Mulchand S. Patel and published by CRC Press. This book was released on 2008-03-17 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antiox
Download or read book Iron Sulfur Clusters in Chemistry and Biology written by Tracey Rouault and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-08-20 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures. Numerous chapters discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.
Download or read book Mitochondria in Pathogenesis written by John J. Lemasters and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
Download or read book Thiamine written by Frank Jordan and published by CRC Press. This book was released on 2003-12-11 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing new insights into neurogenerative diseases, this volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states and offers novel aspects of thiamine enzymes in chiral synthesis as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.
Download or read book Computational Organic Chemistry written by Steven M. Bachrach and published by John Wiley & Sons. This book was released on 2007-07-27 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: "[This book] collects together, largely for the first time, a series of chapters dedicated to all the ways in which molecular modeling/computational chemistry can impact organic chemistry." -Christopher J. Cramer, author of Essentials ofComputational Chemistry: Theories and Models Computational Organic Chemistry provides a practical overview of the ways in which computational modeling methods and applications can be used in organic chemistry to predict the structure and reactivity of organic molecules. After a concise survey of computational methods, the book presents in-depth case studies that show how various computational methods have provided critical insight into the nature of organic mechanisms. With a focus on methodologies, this unique resource: * Discusses simple molecular properties, pericyclic reactions, carbenes and radicals, anion chemistry, solvent effects, and more * Features sidebars that offer a personal look at some of the leading practitioners in the field * Conveys the strengths and limitations of each method, so that readers develop a feel for the correct "tool" to use in the context of a specific problem * Further informs readers with a supporting Web site that provides links to materials cited and features a blog that discusses and provides links to new relevant articles at www.trinity.edu/sbachrac/coc/ This is a great reference for practicing physical organic and computational chemists, as well as a thought-provoking textbook for graduate-level courses in computational chemistry and organic chemistry.
Download or read book Proceedings written by and published by . This book was released on 1992 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
