Download or read book Diet and Biomarkers with Risk of Female Cancers written by Jing Xie and published by . This book was released on 2013 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutritional Epidemiology of Breast Cancer written by Alvaro Luis Ronco and published by Springer Science & Business Media. This book was released on 2011-10-20 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is the first one published exclusively on the field of nutritional epidemiology of breast cancer. It summarizes the currently existing knowledge, with an updated and comprehensive international bibliography (~ 1.000 references). The authors also performed a review on the epidemiological studies on nutrition and breast cancer carried out in Uruguay between 1994 and 2011, which allowed exploring and identifying the main risk and protective factors for the disease in this high-risk country. Epidemiologists, Nutritionists, Public Health managers and breast specialists –from the prevention to the treatment fields – will find in this book a unique source of technical information, which will contribute in expanding their knowledge and view of the disease.
Download or read book Dietary Intake and Biomarkers of Acrylamide Exposure and Risk of Endometrial and Ovarian Cancer A Molecular Epidemiologic Study in the European Prospective Investigation Into Cancer and Nutrition written by Mireia Obón Santacana and published by . This book was released on 2016 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acrylamide is an organic chemical that has several important uses in industry, such as a flocculant in public water supplies, and in biomedical research. In 1994, acrylamide was classified by the International Agency for Research on Cancer as 'probably carcinogenic' to humans. In 2002, acrylamide was discovered in some starchy foods that are cooked at high temperature (e.g., potato crisps and chips). Acrylamide also is a common component of cigarette smoke. From 2006-2010, epidemiologic studies began to examine and report on the possible association between dietary acrylamide intake and risk of human cancer, including ovarian and endometrial cancers (two of which suggested possible associations). Endometrial and ovarian are the fourth and fifth most common cancers diagnosed in European women. The general aim of this thesis was to assess the risk of endometrial cancer (EC) and epithelial ovarian (EOC) cancer in relation to dietary acrylamide exposure based on questionnaire information and biomarkers of internal exposure. The study population for this project was 368,010 women from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary acrylamide intake in the full EPIC cohort was estimated using the most recent European acrylamide-content food databases, country-specific food intake questionnaires, and 24-hour dietary recalls at baseline. Multivariate Cox Proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for questionnaire-based acrylamide intake and EC or EOC risk. Cohort analyses were conducted in all women and in subgroups. Two nested case-control studies of acrylamide biomarkers and EC or EOC risk were conducted in non-smoking postmenopausal women. Pre-diagnostic biomarkers of acrylamide and its epoxide metabolite, glycidamide, were measured as hemoglobin adducts (Hb17 and HbGA, respectively) using HPLC/MS/MS in red blood cells collected at baseline 5-10 years before diagnosis. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% CI for the relation between acrylamide biomarkers (Hb17, HbGA, Hb17+HbGA, and HbGA/Hb17) and EC or EOC risk. The relation between dietary and demographic determinants of biomarker levels of acrylamide and glycidamide were also examined using simple and multiple linear regression analyses in 801 control women. After a mean follow-up of 11 years, there were 1,382 cases of EC and 1,191 cases of EOC in the EPIC cohort. In general, the results of the dietary acrylamide intake analyses showed no associations with EOC and EC, except for a possible association between higher acrylamide intake and type-I EC in women who were non-smokers and non-users of oral contraceptives (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62). The main food group determinants of acrylamide and glycidamide biomarker levels were biscuits, crackers and cakes; and alcohol intake and body mass index were important determinants of the ratio of glycidamide to acrylamide. The nested case-control study of acrylamide and glycidamide biomarker levels and EC (383 cases, 171 type-I, and 385 controls) did not find any support for associations between acrylamide or glycidamide and EC risk. The nested case-control study of acrylamide and glycidamide biomarkers and EOC risk (334 cases and 417 controls) found some evidence for associations with the third quintile of HbGA, and the second and third quintiles of Hb17+HbGA. Participants classified in the fifth quintile of HbGA or Hb17+HbGA showed statistically non-significant higher risks of EOC (ORHbGA. Q5vsQ1: 1.63, 95% CI: 0.92-2.86; P-trend: 0.04, and ORHb17+HbGGA. Q5vsQ1: 1.60, 95% CI: 0.89-2.87; P-trend: 0.14). In conclusion, results in women from the EPIC cohort did not provide convincing support for the hypothesis that higher acrylamide and glycidamide exposures are associated with higher risk for EC. For EOC, inconsistent results were observed in our study. Additional nested case- control studies with larger sample size in different populations, and pooled analysis of existing studies of the relation between acrylamide and glycidamide biomarkers and EOC risk should be performed.
Download or read book Effects of Dietary Fatty Acids and Soy on Hormones and Biomarkers Related to Breast Cancer Risk in Premenopausal Women written by Blakely DeVane Brown and published by . This book was released on 2000 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Food Nutrition Physical Activity and the Prevention of Cancer written by American Institute for Cancer Research and published by . This book was released on 2007 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Expert Report, Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective offers the most up-to-date recommendations for individuals and populations. They are based on the conclusions of an expert panel that certain foods, drinks and lifestyle choices protect against or lead to the development of one or more types of cancer. Additionally, the report explains how the panel reached its conclusions and what those conclusions mean to researchers, educators, practitioners and policymakers around the world. It is the largest report of its kind ever done, covering 60 exposures in relationship to 17 cancer sites. 7,000 individual studies were consulted. Book includes a CD containing the most complete bibliography and presentation of the data ever compiled.
Download or read book Nutrition Diet and Cancer written by Sharmila Shankar and published by Springer Science & Business Media. This book was released on 2012-03-16 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.
Download or read book Nutrition and Lifestyle written by International Agency for Research on Cancer and published by World Health Organization. This book was released on 2002 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search for the links between diet, nutritional and metabolic factors and cancer aetiology is an area of research, which over the past two decades has attracted increasing attention both from a scientific and a public health point of view. In this context, the Europe Against Cancer Program has supported the European Prospective Investigation into Cancer and Nutrition (EPIC), a study involving about half a million volunteers in 10 European countries. This book, derived from the European Conference on Nutrition and Cancer (IARC, Lyon 2001, with the support by the Directorate General for Public Health and Consumer Protection of the EU), gives an update of recent scientific developments in the field. It examines the relationship between nutrition and cancer with a multidisciplinary and multifactorial approach encompassing nutritional research, endocrinology, carcinogenesis, molecular biology and genetics.
Download or read book Association of Dietary Patterns Inflammatory Biomarkers and Physical Functioning Among Older Female Cancer Survivors written by Megan Ann Schmalenberger and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Nutritional status in cancer survivors is complex and often influenced by age, cancer type and stage, comorbidities, and physical function. Systemic inflammation often occurs in conjunction of carcinogenesis and this can increase risk for malnutrition. Objective: To assess the diet quality of older cancer survivors, and its association of inflammatory biomarkers and physical functioning. Methods: Participants completed study surveys via mail or phone to assess physical health (RAND-36), diet quality (DHQ-II, HEI-2015), and BMI. Participant diagnosis, comorbidities, inflammation (CRP, albumin) were obtained via the electronic medical record. Analyses: Descriptive statistics and Pearson’s correlations were used to analyze data. Results: The average age of participants (n=168) was 73.6+8.4 years. Mean physical functioning score was 59.6+24.1 out of a possible 100. Moderate negative correlation between physical functioning and self-rated health was observed (r= -.57, p
Download or read book Bioactive Compounds and Cancer written by John A. Milner and published by Springer Science & Business Media. This book was released on 2010-06-25 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of the wealth of new information generated by the scientific community during the last decade on the role of nutrition on cancer risk, this book provides a forum for presentation and discussion of recent scientific data and highlights a set of dietary recommendations. Bioactive Compounds and Cancer presents chapters that highlight laboratory and clinical findings on how selected nutrients function as signaling molecules and, as such, influence cellular behavior and cancer predisposition. This important compendium focuses on understanding the role of nutrition in cancer biology, the molecular action of bioactive food components and xenobiotics on cancer risk, the role of dietary components in cancer prevention and/or treatment, and nutrition education with the most up to date dietary recommendations that may reduce cancer risk. This volume will be of interest to specialized health professionals, clinicians, nurses, basic and clinical researchers, graduate students, and health officials of public and private organizations.
Download or read book Nutrition and Women s Cancers written by Barbara C. Pence and published by CRC Press. This book was released on 1998-04-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, there has been a gap in the scientific literature regarding women's health issues. The National Institutes of Health are encouraging more research focused on women, and many researchers are beginning to answer the call. Nutrition and Women's Cancers presents a comprehensive discussion of the etiological factors relevant to cancers that are most common in women. It covers female-specific cancers as well as lung and colon cancer, which are highly prevalent in women. The text focuses on the influence of nutrition and diet on these cancers and also discusses the impact of genetics and environmental factors, so that the reader may interpret the relative importance of diet in the complete context of multiple causes. This book presents specific studies of women's health and cancer issues and offers directions for future research in the field.
Download or read book A Study of Diet Biomarkers and Cancer Risk in the United States China and Costa Rica written by Asongate Jessie Satia and published by . This book was released on 1998 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diet and Breast Cancer written by American Institute for Cancer Research and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth annual American Institute for Cancer Research (AICR) conference on diet, nutrition and cancer was held at the L'Enfant Plaza Hotel in Washington, D. C. , September 2~3, 1993. In keeping with present concerns and in line with current trends, the theme was "Diet and Breast Cancer. " This proceedings volume is comprised of chapters from the platform presentations of the two day conference and abstracts from the poster session held at the end of the first day. Experimentally, there is sufficient evidence to support a relationship between dietary fat and the risk of breast cancer. A meta-analysis was provided by data from 114 experiments with over 10,000 animals, divided into groups fed ad libitum on diets with different levels or sources of fat, or different levels of energy restriction. This exercise suggested that linoleic acid was a major determinant of mammary tumor development but that other fatty acids also enhanced mammary tumor development in animals. However, as mentioned by several speakers, results from epidemiological studies often are conflicting, thus leading to confusion among both health professionals and the public. Surveys of specific populations which have migrated from countries with low breast cancer rates to those with higher rates are often some of the most compelling studies with respect to a high fat diet-breast cancer association. Nonetheless, various cohort and prospective studies, some quite large, did not appear to show a relationship between consumption of fat (any type) and breast cancer.
Download or read book Physical Activity Dietary Calorie Restriction and Cancer written by Anne McTiernan and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Health Organization estimates that 25 percent of common cancers can be prevented through regular physical activity and weight control. Common cancers linked to overweight/obesity and a sedentary lifestyle include breast, colon, endometrium, pancreas, renal, esophageal, and several others. There are several plausible mechanisms linking lack of physical activity and increased adiposity to cancer risk, supported by results from animal experiments and human intervention studies.
Download or read book The Effect of Dietary Factors on Biomarkers of Breast Cancer Risk in BRCA1 Mutation Carriers written by Joanne Kotsopoulos and published by . This book was released on 2007 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lifetime risk of developing breast cancer due to an inherited mutation in the breast cancer susceptibility gene, BRCA1, is estimated to be 80%. Management options include screening for early detection or primary prevention with prophylactic surgery or drug therapy. The limited uptake of these options illustrates the need to explore alternative preventive strategies that include dietary or lifestyle changes. Prospective trials using breast cancer as the principle endpoint when evaluating the protective role of nutrients is not feasible in this high-risk population. BRCA1 helps maintain genomic integrity through the participation in antioxidant responses and the repair of double-stranded DNA breaks. Thus, the overall goal of this dissertation was to exploit the known functions of the BRCA1 protein to elucidate a biomarker that could distinguish between BRCA1 mutation carriers and non-carriers, and furthermore, to correlate these markers of susceptibility with levels of dietary factors, more specifically, coffee, selenium and lycopene. These nutrients were selected based on the hypothesis that dietary changes that decrease oxidative damage (possibly linked to estrogen exposure) or enhance the DNA damage repair pathways, may modulate breast cancer risk. We evaluated the ability of a panel of biomarkers that reflected both DNA repair capacity and oxidative status to predict the presence of a BRCA1 mutation, and found no difference. Coffee consumption was associated with a significant reduction in breast cancer risk among mutation carriers. Among women with a BRCA1 mutation, toenail selenium was associated with significantly lower levels of chromosomal damage as assessed by the micronucleus test. An increase in oxidative damage to proteins, and to a lesser extent, lipids, with increasing dietary lycopene intake was limited to mutation carriers. These pro-oxidant effects require confirmation. Collectively, these findings translate into the prevention of BRCA1-associated breast cancer through interventions with selenium and other factors that may minimize chromosomal damage. The prospect of unique diets to prevent hereditary breast cancer may therefore be possible by protecting genomic stability due to an inherited BRCA1 mutation.
Download or read book Physical Activity and Cancer written by Kerry S. Courneya and published by Springer Science & Business Media. This book was released on 2010-11-26 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
Download or read book Nutrition and Cancer Prevention written by Atif B. Awad and published by CRC Press. This book was released on 2005-09-19 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what you s
Download or read book Diet Lifestyle Antioxidants and Biomarkers of Cancer Risk written by Peter Wallström and published by . This book was released on 2002 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
