Download or read book Telomeres and Telomerase written by Predrag Slijepcevic and published by S. Karger AG (Switzerland). This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomeres are essential functional elements of eukaryotic chromosomes. Their fundamental biological role as protectors of chromosome stability was identified for the first time in the 1930s by Hermann Muller and Barbara McClintock based on pioneering cytological experiments. Modern molecular research carried out more recently revealed that telomeres and telomerase play important roles in processes such as carcinogenesis and cellular senescence. This special issue presents the most recent developments in this highly active field of research. It is becoming increasingly clear that molecular pathways involved in regulation of telomere length and structure are functionally linked with pathways involved in DNA damage response, cellular stress response, chromatin organization and perhaps even pathways that regulate evolutionary chromosome rearrangements. The above functional link is explored by the leading experts in the field of telomere biology. Cell biologists, molecular biologists, oncologists, gerontologists, and radiobiologists with an interest in the role of telomeres/telomerase will appreciate the up-to-date information in this publication.

Download or read book General Catalogue written by Bernard Quaritch and published by . This book was released on 1880 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanotechnologies in Preventive and Regenerative Medicine written by Vuk Uskokovic and published by Elsevier. This book was released on 2017-10-30 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. - Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage - Explains how nanomaterials can be manipulated to create more effective drug treatments - Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Download or read book Theory Of Superconductivity written by J. Robert Schrieffer and published by CRC Press. This book was released on 2018-03-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory of Superconductivity is primarily intended to serve as a background for reading the literature in which detailed applications of the microscopic theory of superconductivity are made to specific problems.

Download or read book Linear Algebra written by Jim Hefferon and published by Orthogonal Publishing L3c. This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "This text covers a standard first course : Gauss's method, vector spaces, linear maps and matrices, determinants, and eigenvalues and eigenvectors. In addition, each chapter ends with some topics such as brief applications. What sets it apart is careful motivation, many examples, and extensive exercise sets. Together these help each student master the material of this course, and also help an instructor develop that student's level of mathematical maturity. This book has been available online for many years and is widely used, both in classrooms and for self-study. It is supported by worked answers for all exercises, beamer slides for classroom use, and a lab manual of computer work"--Page 4 of cover.

Download or read book Philosophy of Cancer written by Marta Bertolaso and published by Springer. This book was released on 2016-08-24 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.

Download or read book North American Starfishes written by Alexander Agassiz and published by . This book was released on 1877 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Future of Scientific Practice written by Marta Bertolaso and published by Routledge. This book was released on 2015-10-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on cell dynamics, molecular medicine and robotics, contributors explore the interplay between biological, technological and theoretical ways of thinking. The collection makes a strong contribution to current debates in the philosophy of science and the changing role of scientific practice.

Download or read book Political Economy and Sociolinguistics written by David Block and published by Bloomsbury Publishing. This book was released on 2018-02-08 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shortlisted for the BAAL Book Prize 2019 This book explores how political economy intersects with sociolinguistics, specifically how neoliberalism, inequality and social class mediate language in society issues. After the preface, in which the author sets the scene for the content of the book, Chapter 1 is an extensive, though selective, review of sociolinguistics research which has been framed as political economic in orientation. The chapter concludes that such research generally contains little in the way of thorough and in-depth coverage of the key ideas and conceptual frameworks said to undergird it. With this consideration in mind, Chapters 2, 3 and 4 are organised around in-depth discussions of, respectively, political economy as a general disciplinary frame; neoliberalism as the variegated variety of capitalism dominant in the world today; and stratification, inequality and social class, as phenomena intrinsic to capitalism, which in the neoliberal era have come to the fore as key issues. Drawing directly on the background provide in Chapters 2-4, Chapters 5 and 6 explore two distinct political economy-informed lines of research, on the one hand, the 'neoliberal citizen', and on the other hand, 'discursive class warfare'. The book ends with an epilogue addressing issues arising around political economy in sociolinguistics.

Download or read book Explaining Cancer written by Anya Plutynski and published by Oxford University Press. This book was released on 2018-07-18 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.

Download or read book Language Syntax and the Natural Sciences written by Ángel J. Gallego and published by Cambridge University Press. This book was released on 2018-10-18 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of human language from the perspective of the natural sciences, this outstanding book brings together leading specialists to discuss the scientific connection of language to disciplines such as mathematics, physics, chemistry and biology.

Download or read book Aromatic Interactions written by Darren W. Johnson and published by Royal Society of Chemistry. This book was released on 2016-11-24 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of aromatic interactions, the fundamental nature of substituent effects and the identification of contacts between anions and aromatic systems have generated stimulating arguments in recent years. New theoretical frameworks have been developed and tested and aromatic interactions have emerged as potential solutions for varied problems in biology and materials science. This book provides a wide ranging survey of the latest findings and advances surrounding aromatic interactions, stretching from the fundamentals to modern applications in synthesis, biology and materials chemistry. It also discusses computational, experimental and analytical approaches to understanding these interactions, including pi-pi, anion-pi, and cation-pi interactions. Aromatic Interactions: Frontiers in Knowledge and Application is a useful text for advanced students and researchers, and appeals to those working within the fields of supramolecular chemistry, computational chemistry and thermodynamics.

Download or read book The Routledge Handbook of Environmental Justice written by Ryan Holifield and published by Routledge. This book was released on 2017-09-14 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Routledge Handbook of Environmental Justice presents an extensive and cutting-edge introduction to the diverse, rapidly growing body of research on pressing issues of environmental justice and injustice. With wide-ranging discussion of current debates, controversies, and questions in the history, theory, and methods of environmental justice research, contributed by over 90 leading social scientists, natural scientists, humanists, and scholars from professional disciplines from six continents, it is an essential resource both for newcomers to this research and for experienced scholars and practitioners. The chapters of this volume examine the roots of environmental justice activism, lay out and assess key theories and approaches, and consider the many different substantive issues that have been the subject of activism, empirical research, and policy development throughout the world. The Handbook features critical reviews of quantitative, qualitative, and mixed methodological approaches and explicitly addresses interdisciplinarity, transdisciplinarity, and engaged research. Instead of adopting a narrow regional focus, it tackles substantive issues and presents perspectives from political and cultural systems across the world, as well as addressing activism for environmental justice at the global scale. Its chapters do not simply review the state of the art, but also propose new conceptual frameworks and directions for research, policy, and practice. Providing detailed but accessible overviews of the complex, varied dimensions of environmental justice and injustice, the Handbook is an essential guide and reference not only for researchers engaged with environmental justice, but also for undergraduate and graduate teaching and for policymakers and activists.

Download or read book Cerebral Localization written by K.J. Zülch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The demonstration of the basic brain mechanism through studying the partially commissure-sectioned case appears to be a most prom ising enterprise. The work with animals of HAMILTON and others in elucidating psychological brain process heretofore not imagined are mere indications of what the potential seems to be. Study of the partially disconnected patient seems equally revealing and productive in showing how many high level cognitive activities are managed in the cerebral flow of information. With respect to the issue of localization of function, it would seem clear that those cerebral areas clearly involved in the im mediate processing of raw sensory information can be selectively and specifically isolated and disconnected. In other words, the informational products of the long axonal type cells of Golgi, which MARCUS JACOBSON claims are the brain cells under strict genetic control, can be isolated, whereas the products of more complex and integrative mental activities which are managed by the more mutable Golgi type II cells do not seem to be so spec ifically disposed. Thus, these data suggest the lateralized spe cialities of the various left and right brain areas can make their contribution to the cerebral activities of the opposite hemisphere through almost any callosal area regardless of its size and loca tion. Indeed, this interpretation suggests to me that the long standing issue of the extent of localization could be better un derstood by considering the dichotomy in genetic specification as offered by HIRSCH and JACOBSON (1974).

Download or read book Rethinking Cancer written by Bernhard Strauss and published by MIT Press. This book was released on 2021-04-27 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Download or read book The Metaphysics of Biology written by John Dupré and published by Cambridge University Press. This book was released on 2021-06-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Element is an introduction to the metaphysics of biology, a very general account of the nature of the living world. The first part of the Element addresses more traditionally philosophical questions - whether biological systems are reducible to the properties of their physical parts, causation and laws of nature, substantialist and processualist accounts of life, and the nature of biological kinds. The second half will offer an understanding of important biological entities, drawing on the earlier discussions. This division should not be taken too seriously, however: the topics in both parts are deeply interconnected. Although this does not claim to be a scientific work, it does aim to be firmly grounded in our best scientific knowledge; it is an exercise in naturalistic metaphysics. Its most distinctive feature is that argues throughout for a view of living systems as processes rather than things or, in the technical philosophical sense, substances.

Download or read book Everything Flows written by Daniel J. Nicholson and published by Oxford University Press. This book was released on 2018 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The majority of the papers herein originated at the workshop 'Process Philosophy of Biology' ... held in Exeter in November 2014."--Page vii.