Download or read book Development of Multispectral Scatter Correction Techniques for High resolution Positron Emission Tomography microform written by Rutao Yao and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1997 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Correction Techniques in Emission Tomography written by Mohammad Dawood and published by CRC Press. This book was released on 2012-04-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an interdisciplinary team of medical doctors, computer scientists, physicists, engineers, and mathematicians, Correction Techniques in Emission Tomography presents various correction methods used in emission tomography to generate and enhance images. It discusses the techniques from a computer science, mathematics, and physics viewpoint. The book gives a comprehensive overview of correction techniques at different levels of the data processing workflow. It covers nuclear medicine imaging, hybrid emission tomography (PET-CT, SPECT-CT, PET-MRI, PET-ultrasound), and optical imaging (fluorescence molecular tomography). It illustrates basic principles as well as recent advances, such as model-based iterative algorithms and 4D methods. An important aspect of the book is on new and sophisticated motion correction techniques in PET imaging. These techniques enable high-resolution, high-quality images, leading to better imaging analysis and image-based diagnostics. Reflecting state-of-the-art research, this volume explores the range of problems that occur in emission tomography. It looks at how the resulting images are affected and presents practical compensation methods to overcome the problems and improve the images.
Download or read book Development of Scatter Reconstruction Algorithms to 3 dimensional Positron Emission Tomography written by Mohammadreza Teimoorisichani and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 3-dimensional positron emission tomography (PET), the proportion of the detected photon coincidences arising from scatter can be very high, up to 60%. A standard approach to scatter correction in 3D PET is to estimate the scattered coincidences and subtract them from the list of recorded events. More recently, novel techniques have been proposed in which the information carried by the scattered photons was extracted and directly used in the image reconstruction step. In this work, the algorithms were extended for use in non-TOF 3D PET systems and were qualitatively and quantitatively evaluated. Despite some promising initial outcomes, standard performance metrics of images reconstructed with each technique, representing the quality of images, was shown to be deteriorated under specified conditions. Further work is required to investigate potential benefits of the proposed algorithms for both ideal and clinical conditions.
Download or read book Quantification in Positron Emission Tomography written by Pablo Aguiar and published by LAP Lambert Academic Publishing. This book was released on 2010-10 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is focused on the development of processing, quantification and standarization methods, aimed at enhancing the quality and accuracy of Positron Emission Tomography (PET) images, both for human brain studies and for high-resolution small animal studies. Firstly, the effects of scatter, reconstruction method, anatomical variability, positron range, partial volume effect and non-colinearity on the quantification of PET studies are investigated. Several correction methods for the essential degradations are presented. Finally, the suitability of Monte Carlo techniques for simulating PET studies is also assessed.
Download or read book Partial volume Correction for High resolution Positron Emission Tomography Using Cortical Surface Information written by Thomas Funck and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: " Images from high resolution brain positron emission tomography (PET) scanners (CTI/Siemens HRRT) can measure differences in neuroreceptor concentrations in the gray matter that are related to cytoarchitectonic differences. However, the loss of resolution due to the PET imaging process results in partial-volume effects (PVE) that obscure the true radiotracer distribution. Although several partial-volume correction algorithms exist, these frequently require severely limiting assumptions. We developed a new iterative deconvolution algorithm for the partial-volume correction of PET images that aims to overcome the limitations of previous methods. The proposed method does so using two innovative techniques. One is the incorporation anatomic information from a cortical gray matter surface representation, extracted from magnetic resonance imaging (MRI). The second is the use of anatomically constrained smoothing to attenuate noise in the image. This method was validated using simulated and clinical data. The results show that our method consistently recovers accurate radiotracer concentrations on simulated data sets and produces similar, though slightly overestimated, results on the real clinical data when compared to the gold-standard partial-volume correction method. " --
Download or read book Development of a Motion Correction and Partial Volume Correction Algorithm for High Resolution Imaging in Positron Emission Tomography written by Shailendra Hemun Segobin and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Positron Emission Tomography written by Timothy H. Witney and published by Springer Nature. This book was released on 2023-11-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores key concepts and experimental design related to Positron Emission Tomography (PET) imaging that have revolutionized our understanding of human biology. The first part focuses on recent advances in radiotracer probe development to enable the detection of materials, from large macromolecules to complicated drug-like structures. The next section describes how key physiological and pathophysiological processes can be interrogated and quantifiably measured with this imaging technique. Finally, chapters examine important technological developments in the field that are revolutionizing the way these innovative PET probes are utilized in the clinic. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Positron Emission Tomography: Methods and Protocols serves as an ideal guide for researchers looking to use imaging to revolutionize the way we diagnose and treat disease.
Download or read book Quantification and Optimization Techniques for Dynamic Brian Imaging in High Resolution Positron Emission Tomography written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern positron emission tomography (PET) scanners have a large number of detector crystals which corresponds to an even larger number of lines of response (LOR) addressing the coincidence events. This increasing complexity makes the image reconstruction much more challenging especially in dynamic imaging where the acquired number of counts per frame or per LOR is much less as compared to that in the static case. The low statistical quality of the data thus degrades the quantitative accuracy of the images. Moreover, the increasing number of LORs and dynamic frames requires a longer computational time and larger data storage for the image reconstruction task. A dual reconstruction scheme, a novel scatter calibration, and a practical scatter and randoms approximation methods were developed in this work. These methods have been validated using phantom, non-human primate, and human studies and have been demonstrated to improve the quantification accuracy of the images, to accelerate the image formation task, and to reduce the data storage requirement for dynamic brain imaging in high resolution PET. In conclusion, these studies contribute to increasing the accuracy and to decreasing the computational burden for dynamic high resolution quantitative PET imaging. The proposed methods are modular and can be applied to any PET scanners with the exception of the dual reconstruction scheme which requires list-mode acquisition capability. These methods are particularly beneficial for high resolution scanners which have a large number of LORs, such as the high resolution research tomograph (HRRT).
Download or read book Instrumentation and Methodology for Correction of Photon Scatter Effects in Positron Emission Tomography written by Paul Jeffrey Cutler and published by Ann Arbor, Mich. : University Microfilms International. This book was released on 1992 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An Improved Positron Emission Tomography PET Reconstruction of 2D Activity Distribution Using Higher Order Scattered Data written by Hongwei Sun and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography (PET) images reconstructed without adequate scatter corrections introduce noise and degrade image contrast. In commercial imaging systems, misalignment between computed tomography (CT) and PET images can introduce biases in the activity distribution. Recently, several reconstruction algorithms have been proposed, which made direct use of single scattered photons in the activity reconstruction. However, the realistic dataset contains single and higher order scattered photons, and current scatter reconstruction methods do not distinguish them. In this study, a novel reconstruction algorithm that is capable of processing higher order scattered photons was developed. A restricted attenuation correction method was created to avoid overcorrecting for scattered photons. The simulation outcomes have shown that the proposed methods can, under ideal energy resolution, reconstruct images that are qualitatively and quantitatively better than those obtained using existing algorithms, and that the methods show promise for use under more realistic clinical conditions.
Download or read book An Energy based Method for Scatter Correction in Positron Emission Tomography written by Hsing-Tsuen Chen and published by . This book was released on 2005 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Development of a 1mm Resolution Clinical Positron Emission Tomography PET System written by Frances Wing Yee Lau and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography (PET) is an in-vivo medical imaging modality that extracts information about molecular processes associated with disease. A PET system produces an image of radiopharmaceuticals that have preferentially accumulated in certain cells of tissues in the body, such as cancerous lesions. Clinical PET systems have about 5-10mm spatial resolution, and thus have difficulty resolving very small lesions. So, improving the resolution of PET is an active area of research. This thesis describes the design of a 1mm resolution PET system for breast cancer imaging and the strategies used to overcome the challenges of developing such a high resolution PET system. The detectors in this PET system consist of lutetium yttrium oxyorthosilicate (LYSO) scintillation crystal arrays coupled to position-sensitive avalanche photodiodes (PSAPDs). There will be over 2000 Dual-LYSO-PSAPD detector modules in the final system, each requiring a bias voltage of 1750 Volts. A programmable high voltage distribution method allows the bias voltage to be optimized for each detector module. Multiplexing of detector signals reduced the number of interconnects by 40% and front-end electronic channels by 33%. Charge division and charge sharing signal conditioning compensate for the mismatch between the detector signal and the front-end electronics input dynamic range, as well as for parasitic capacitance introduced by interconnect. A model of the detectors and electronics was created to help understand the system and to assist in the system design process. Two cartridges of the system, consisting of 256 Dual-LYSO-PSAPD detectors, were constructed and characterized. The system energy resolution was 11% FWHM (full-width-at-half-maximum) and the measured spatial resolution was less than 1mm. The system was able to produce reconstructed images of a phantom with 1.2mm rods filled with a solution of the positron emitter Fluorine-18.
Download or read book An Investigation Into the Use of Scattered Photons to Improve 2D Position Emission Tomography PET Functional Imaging Quality written by Hongyan Sun and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a powerful metabolic imaging modality, which is designed to detect two anti-parallel 511 keV photons origniating from a positron-electron annihilation. However, it is possible that one or both of the annihilation photons undergo a Compton scattering in the object. This is more serious for a scanner operated in 3D mode or with large patients, where the scatter fraction can be as high as 40-60%. When one or both photons are scattered, the line of response (LOR) defined by connecting the two relevant detectors no longer passes through the annihilation position. Thus, scattered coincidences degrade image contrast and compromise quantitative accuracy. Various scatter correction methods have been proposed but most of them are based on estimating and subtracting the scatter from the measured data or incorporating it into an iterative reconstruction algorithm. By accurately measuring the scattered photon energy and taking advantage of the kinematics of Compton scattering, two circular arcs (TCA) in 2D can be identified, which describe the locus of all the possible scattering positions and encompass the point of annihilation. In the limiting case where the scattering angle approaches zero, the TCA approach the LOR for true coincidences. Based on this knowledge, a Generalized Scatter (GS) reconstruction algorithm has been developed in this thesis, which can use both true and scattered coincidences to extract the activity distribution in a consistent way. The annihilation position within the TCA can be further confined by adding a patient outline as a constraint into the GS algorithm. An attenuation correction method for the scattered coincidences was also developed in order to remove the imaging artifacts. A geometrical model that characterizes the different probabilities of the annihilation positions within the TCA was also proposed. This can speed up image convergence and improve reconstructed image quality. Finally, the GS algorithm has been adapted to deal with non-ideal energy resolutions. In summary, an algorithm that implicitly incorporates scattered coincidences into the image reconstruction has been developed. Our results demonstrate that this eliminates the need for scatter correction and can improve system sensitivity and image quality.
Download or read book Residual Correction Algorithms for Statistical Image Reconstruction in Positron Emission Tomography written by Lin Fu and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a radionuclide imaging modality that plays important roles in visualizing, targeting, and quantifying functional processes in vivo. High-resolution and quantitative PET images are reconstructed by solving large-scale inverse problems with iterative methods that incorporate accurate physics and noise modeling of the imaging process. The computation demands of PET image reconstruction are rapidly increasing as higher-resolution detectors, larger imaging field-of-view, and dynamic or adaptive data acquisition modes are being adopted by modern PET scanners. The trend of the increase in the computation demands is even faster than Moore's law that describes the exponential growth in the number of transistors placed on an integrated circuit. In this project a residual correction mechanism is introduced to PET image reconstruction to create computationally efficient yet accurate tomographic reconstruction algorithms. By using residual correction, reconstruction methods are able to adopt a more simplified physical model for fast computation while retaining the accuracy of the final solution. Residual correction can accelerate existing image reconstruction packages. It allows iterative reconstruction with more accurate physical models which are currently impractical due to the high computation cost. Two illustrative applications of the residual correction approach are provided. One is image reconstruction with an object-dependent Monte Carlo based physics model. The other is image reconstruction using an ultra fast GPU-accelerated simplified geometric model.
Download or read book Topics in Image Reconstruction for High Resolution Positron Emission Tomography microform written by Vitali Selivanov and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2002 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Derivation and Analysis of Scatter Correction Algorithms for Quantitative Positron Emission Tomography written by Thomas Kösters and published by . This book was released on 2010 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Algorithms for High resolution Positron Emission Tomography written by Kyle Morgan Champley and published by . This book was released on 2010 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
