Download or read book Structure to Function of G Protein Gated Inwardly Rectifying GIRK Channels written by and published by Academic Press. This book was released on 2015-09-23 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field. - Presents a comprehensive overview of the latest research into GIRK potassium channels - Serves as a perfect starting point for researchers and practitioners entering the field - Expands the literature and field of neurobiology

Download or read book Receptor Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book RGS Protein Physiology and Pathophysiology written by and published by Academic Press. This book was released on 2015-06-23 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. - Brings together information on the current state of the RGS protein field - Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking - Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery

Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer. This book was released on 2012-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Download or read book Fundamental Neuroscience for Basic and Clinical Applications E Book written by Duane E. Haines and published by Elsevier Health Sciences. This book was released on 2012-11-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Turn to Fundamental Neuroscience for a thorough, clinically relevant understanding of this complicated subject! Integrated coverage of neuroanatomy, physiology, and pharmacology, with a particular emphasis on systems neurobiology, effectively prepares you for your courses, exams, and beyond. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Easily comprehend and retain complex material thanks to the expert instruction of Professor Duane Haines, recipient of the Henry Gray/Elsevier Distinguished Teacher Award from the American Association of Anatomists and the Distinguished Teacher Award from the Association of American Colleges. Your purchase of this book entitles you to access www.studentconsult.com at no extra charge. This innovative web site offers you an interactive center with a wealth of additional resources. Grasp important anatomical concepts and their clinical applications thanks to correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos. Retain key information and efficiently study for your exams with clinical highlights integrated and emphasized within the text.

Download or read book Free Energy Calculations written by Christophe Chipot and published by Springer Science & Business Media. This book was released on 2007-01-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.

Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 2005 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Pharmacology written by John Dickenson and published by John Wiley & Sons. This book was released on 2012-11-30 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

Download or read book Application of genetically encoded indicators to mammalian central nervous system written by Yoshiyuki Yamada and published by Frontiers Media SA. This book was released on 2016-04-06 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid improvement of indicator performance as well as expanded application to many model organisms in the neuroscience community. Challenges still remain, however, concerning the mammalian central nervous system: limited sensitivity of indicators to subtle changes in activity, slow signal kinetics, cytotoxicity after a long-term and high-level expression of indicators, and variable performance across cell types. In addition to improvement of the indicators per se, development of strategies that allow combined use of the indicators and optogenetic tools is also desired. In this Research Topic, we recruited top researchers in the field and their young colleagues to present their cutting-edge research as well as insightful opinions on the following subtopics: 1) Latest breakthroughs on development of genetically encoded indicators 2) Novel scientific findings obtained with genetically encoded indicators 3) Wishlist for the next-generation genetically encoded indicators 4) Guideline for selecting an appropriate indicator 5) Optimal methodology for indicator delivery to mammalian CNS

Download or read book Elements of Molecular Neurobiology written by C. U. M. Smith and published by John Wiley & Sons. This book was released on 2003-06-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This "evodevo" (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology. * Well known and widely used as a text throughout the UK, good reviews from students and lecturers. * Good complement to Fundementals of Psychopharmacology by Brian Leonard. This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists. It is also a useful basic reference for university libraries. Maurice Elphick, Queen Mary, University of London "I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams."

Download or read book Prescriptyion Opioid Analgesic Use Among Adults United States 1999 2012 written by Steven M. Frenk and published by . This book was released on 2015 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cardiac Arrhythmias written by Ambrose S. Kibos and published by Springer Science & Business Media. This book was released on 2013-12-13 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.​

Download or read book Pharmacology of Potassium Channels written by Nikita Gamper and published by Springer Nature. This book was released on 2021-09-27 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.

Download or read book Neuropeptide Systems as Targets for Parasite and Pest Control written by Timothy G. Geary and published by Springer Science & Business Media. This book was released on 2011-01-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Download or read book Textbook of Receptor Pharmacology written by John C. Foreman and published by CRC Press. This book was released on 2010-09-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica

Download or read book The Glutamate GABA Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.