Download or read book Design Synthesis and Applications of Polymer supported Methyl Azodicarboxylate and Other Resin bound Reagents for Use in Novel Mitsunobu Studies written by Carla Ann Maria Arena and published by . This book was released on 2001 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Novel Polymer supported Ion complexing Reagents written by Kelly P. Ripperger and published by . This book was released on 1997 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of New Polymer Supported Reagents written by Kwok-Wai Matthew Choi and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Development of New Polymer Supported Reagents" by Kwok-wai, Matthew, Choi, 蔡國偉, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DEVELOPMENT OF NEW POLYMER SUPPORTED REAGENTS Submitted by Choi Kwok Wai Matthew for the degree of Master of Philosophy at The Universiry of Hong Kong in December 2003 The use of polymer-supported reagents has emerged as a powerful technique in organic synthesis in what is known as polymer-assisted organic synthesis. The inherent advantages of attaching reagents to insoluble supports lie in the ease of product purification, since the supports can be filtered and also because a given reaction can be driven to completion through the convenient use of excess of such reagents. Soluble polymers are alternative supports to insoluble resins for reagent delivery and this are becoming widely used. These reagents may be used to either selectively remove impurities from synthetic products or to deliver reagents to dissolved synthesis substrates A series of new polymer-supported reagents based on both non-cross- TM linked and cross-linked (JandaJel ) polystyrene were prepared and the utility of these polymers was demonstracted by their use in organic synthesis. In this thesis, the development of two new soluble polystyrene-based sulfoxide reagents for Swern oxidation reactions are introduced. i Secondly, a simplified synthesis of 4-styryldiphenylphosphine is described and used this monomer to prepare non-cross-linked polymer-supported triphenylphosphine using a homogeneous polymerization process. It is noteworthy that the 4-styryldiphenylphosphine monomer can be incorporated into the polymers at predictable levels, depending upon the ratio of monomers used in the polymerization reaction. The utility of this polymer was demonstrated by its use in Mitsunobu reactions. Thirdly, a straightforward synthesis of trityl alcohols in which one of the aryl rings is substituted with a vinyl group was presented. These compounds were used to incorporate trityl linker groups in polystyrene-based reagent supports. TM Both non-cross-linked and cross-linked (JandaJel ) polystyrene can be prepared with these monomers and these polymers are suitable as supports for solid-phase organic and peptide synthesis. Finally, a new cross-linked polystyrene-supported thioanisole reagent was reported. This reagent incorporates the flexible JandaJel cross-linker and can be treated with methyl trifluoromethanesulfonate to form the corresponding sulfonium salt. This salt in turn can be deprotonated to form a polymer-supported sulfur ylide that is able to react with carbonyl compounds to form epoxides. The thioanisole reagent can also be oxidized to form an insoluble sulfoxide reagent that is useful in Swern oxidation reactions. These reagents derived from the polymer-supported thioanisole can be recovered, regenerated, and reused. DOI: 10.5353/th_b2923052 Subjects: Polymers Supported reagents
Download or read book Development and Applications of Polymer supported Reagents and Ion Exchange Resins in Organic Synthesis and Combinatorial Chemistry written by Stephen J. Shuttleworth and published by . This book was released on 2002 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Application of New Polymer Bound Catalysts written by Brandon Michael Fetterly and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric acid has been shown to be a weak acid in acetonitrile. It is conceivable that a nitrate salt of a weakly Lewis acidic cation could furnish a ''naked'' nitrate anion as a basic catalyst in a variety of reactions in non-aqueous solvents. Such a nitrate salt could also be bound to a polymeric support via the cation, thereby allowing for reclamation and recycling of the nitrate ion. This subject is dealt with in Chapter 2, wherein my contributions consisted of performing all the reactions with the polymer supported catalyst and carrying out the experiments necessary to shed light on the reaction mechanisms. Chapter 3 contains a description of the structure and catalytic properties of an azidoproazaphosphatrane. This compound is an air-stable versatile catalyst that has proven useful not only homogeneously, but also when bound to a solid support. The synthesis of a polymer bound proazaphosphatrane containing a trivalent phosphorus is presented in Chapter 4. Such a compound has been sought after by our group for a number of years. Not only does the synthesis I have accomplished for it allow for easier separation of proazaphosphatrane catalysts from reaction mixtures, but recycling of the base is made much simpler. Proazaphosphatranes are useful homogeneous catalysts that activate atoms in other reagents, thus enhancing their reactivity. The next chapters deal with two such reactions with aldehydes and ketones, namely silylcyanations with trialkylsilylcyanides (Chapters 5 and 6) and reductions with poly(methylhydrosiloxane), in Chapter 7. In Chapter 5, Zhigang Wang performed the initial optimization and scoping of the reaction, while repetitions of the scoping experiments for reproducibility, determination of diastereomeric ratios, and experiments aimed at elucidating aspects of the mechanism were performed by me. The proazaphosphatrane coordinates to the silicon atom in both cases, thereby allowing the aforementioned reactions to proceed under much milder conditions. Proazaphosphatranes are also effective Broensted-Lowry bases. This is illustrated in Chapter 8 wherein a wide variety of conjugate addition reactions are catalyzed by proazaphosphatranes. In that chapter, repetitions of the nitroalkane addition reactions for reproducibility, improved spectral data for the products and comparisons of literature yields of all reactions were performed by the author.
Download or read book Polymeric Reagents and Catalysts written by Warren T. Ford and published by . This book was released on 1986 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines recent advances in the use of polymeric reagents and catalysts with a special emphasis on new compounds, synthetic methods, and industrial processes. Brings these advances to the attention of those who are involved in organic synthesis and desire a more thorough understanding of polymers and polymeric reagents. Contains comprehensive chapters devoted to polymeric oxidizing agents, Wittig reagents, and synthesis of cross-linked polymeric templates for chiral recognition. Presents opportunities for invention and use of many new polymeric reagents and catalysts.
Download or read book Part 1 Design Synthesis and Validation of Polymer supported Siloxane Transfer Agents for Transition metal mediated Cross coupling Reactions of Organolithiums Part 2 Total Synthesis of mandelalide A Exploiting Anion Relay Chemistry written by Minh Huu Nguyen and published by . This book was released on 2016 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 2: This work described a highly modular, convergent total synthesis of the highly cytotoxic, scarce marine macrolide (-)-mandelalide A exploiting Anion Relay Chemistry tactic. The northern hemisphere was constructed via a new three-component type II ARC/CuCN cross-coupling protocol, while the southern hemisphere was secured via a highly efficient, four-component type I ARC union, both performed on preparative scale employing commercially available and/or readily accessible building blocks. This work showcases ARC as a powerful synthetic tactic for the rapid union of multiple, structurally simple starting materials to access diverse complex molecular fragments with excellent stereochemical control.
Download or read book Superbases for Organic Synthesis written by Tsutomu Ishikawa and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.
Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. - The first reference work on named reactions to present colored schemes for easier understanding - 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples - An opening list of abbreviations includes both structures and chemical names - Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works - Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools - Extensive index quickly locates information using words found in text and drawings
Download or read book Protective Groups in Organic Chemistry written by J. McOmie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Download or read book Greene s Protective Groups in Organic Synthesis written by Peter G. M. Wuts and published by John Wiley & Sons. This book was released on 2012-12-20 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
Download or read book Organic Azides written by Stefan Bräse and published by John Wiley & Sons. This book was released on 2011-09-23 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applications The number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new publications a year Covers basic chemistry as well as state-of-the-art applications in life science and materials science World-ranked authors describe their own research in the wider context of azide chemistry Includes a chapter on safe synthesis and handling (azides can decompose explosively)
Download or read book Handbook of Fluorous Chemistry written by John A. Gladysz and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the leading experts John Gladysz, Dennis Curran, and István Horváth, this handbook is the first to summarize all the essential aspects of this emerging field of chemistry. Whether the reader is seeking an introduction to the concept of fluorous biphase catalysis, summaries of partition coefficients involving fluorous and organic solvents, or information on the latest fluorous mixture separation techniques, this authoritative compilation of contributions, written by the world's top authors, provides key information needed for successfully working with the diverse and fascinating families of fluorous molecules. The large number of reliable experimental procedures in particular makes this the ideal guide for newcomers wanting to use this elegant method in the laboratory. In addition, experts will also find a wealth of important information concisely contained in one ready reference. The result is an indispensable resource for everyone currently working or intending to work in this field.
Download or read book Organic Synthesis in Water written by P.A. Grieco and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of water as a medium for promoting organic reactions has been rather neglected in the development of organic synthesis, despite the fact that it is the solvent in which almost all biochemical processes take place. Chemists have only recently started to appreciate the enormous potential water has to offer in the development of new synthetic reactions and strategies, where it can offer benefits in both unique chemistry and reduced environmental impact. In this new book, the editor, well known for his contribution to the development of water as a useful medium in synthetic organic chemistry, has assembled an international team of authors, themselves at the forefront of research into the use of the unique properties of water carrying out organic transformations, to provide a timely and concise overview of current research. By focusing on the practical use of water in synthetic organic chemistry, and with the concern for the use of solvents in organic chemistry, professional chemists, particularly those involved in industrial research and development, will find this book an essential guide to the current state of the art, and a useful starting point in their own research. Academic chemists, including postgraduate and advanced undergraduate students, will find this book an invaluable guide to this exciting and important area of chemistry.
Download or read book Organic Synthesis with Carbohydrates written by Geert-Jan Boons and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates offer a ready source of enantiomerically pure starting materials. They have been used for the imaginative synthesis of a wide range of compounds, and have been found to be effective chiral auxiliaries which enable the introduction of a range of functionalities in a highly enantioselective manner. In a subject dominated by volumes at research and professional level, this book provides a broad understanding of the use of carbohydrates in organic synthesis, at postgraduate student level. Emphasis is placed on retrosynthetic analysis, with discussion of why a particular synthetic route has been chosen, and mechanistic explanations are provided for key and novel reactions. Wherever possible, the authors highlight points of general significance to organic synthesis. Selected experimental conditions and reaction details are incorporated to ensure that information can be utilised in research. The book is extensively referenced and so provides a convenient point of entry to the primary literature.
Download or read book Molecules with Silly Or Unusual Names written by Paul W. May and published by World Scientific. This book was released on 2008 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This popular science book shows that chemists do have a sense of humor, and this book is a celebration of the quirky side of scientific nomenclature. Here, some molecules are shown that have unusual, rude, ridiculous or downright silly names. Written in an easy-to-read style, anyone ? not just scientists ? can appreciate the content. Each molecule is illustrated with a photograph and/or image that relates directly or indirectly to its name and molecular structure. Thus, the book is not only entertaining, but also educational.
Download or read book Esterification written by Junzo Otera and published by Wiley-VCH. This book was released on 2003 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, Professor J. Otera brings together for the first time the combined knowledge about this elementary reaction. Starting from the methodical basics right up to applications, this book represents a comprehensive overview of this type of reaction, and so should become a standard reference for every organic chemist.
