Download or read book Design of Functionalized Nanoparticles as Imaging Agents for Cancer written by José Alejandro Barreto Solano and published by . This book was released on 2012 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the synthesis and characterization of three different generations of iron oxide magnetic nanoparticles derivatized with macrocyclic ligands for application as bi-modal imaging agents in the detection of cancer tumors by Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). The nanoparticles have been modified with polyethyleneglycol (PEG) in order to avoid uptake by the Reticuloendothelial System (RES), whilst the macrocyclic ligands have been introduced for chelation of the radionuclide 64Cu2+, which is detectable by PET. Apart from being a platform for the transport of the radionuclide complexes, the magnetic nanoparticles themselves act as MRI contrast agents and can be used for hyperthermia treatment of cancer due to their super paramagnetic nature. Synthesis of the first generation nanoparticles involved co precipitation of the core nanoparticles from a solution of iron(II) and iron(III) salts through addition of base. The macrocycles 1,4-bis(2-pyridylmethyl)-1,4,7-triazacyclononane (dmptacn), 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) were reacted with glycidyloxypropyltriethoxysilane (GPTES) to form the corresponding siloxane derivatives, which were then hydrolyzed over the surface of the nanoparticles to form a stable coating. Macrocycle loadings of the order of 0.2 mmol/g were achieved using this methodology, and the mean diameter of the nanoparticles was found to be ca. 7 nm, respective of the ligand used. Light scattering measurements showed that the particles form aggregates in solution, with a hydrodynamic size of 150-200 nm. The nanoparticles could be rapidly radiolabeled with 64Cu2+. Challenge experiments performed with an excess of cyclam indicated that the nanoparticles derivatized with dmptacn were the most resistant to 64Cu2+ leaching. These particles were also found to be the most stable in rat plasma. A second generation of nanoparticles was synthesized in order to diminish the aggregation of the nanoparticles. This involved synthesis of the core nanoparticles by co precipitation, followed by surface coating with oleic acid, which provided enhanced stability (reduced aggregation) in organic media. Displacement of the oleic acid chains with polyethylene glycol silane (PEG-silane) derivatives was used to produce a stable coating on the nanoparticles and to render them water soluble. Two different PEG-silane molecules, with different PEG chain lengths (Mn 250 and 600), were used to modified the nanoparticles. It was found that the nanoparticles coated with the longer PEG chains (PEG600) were less susceptible to aggregation in aqueous media. The nanoparticles were also functionalized with different macrocycles through amide coupling to the terminal carboxylic acid groups of the PEG chains. The nanoparticles were found to bind 64Cu2+both specifically (via the macrocycles) and nonspecifically, however the weakly boundions could be removed by addition of cyclam. In addition to MRI and PET, these second generation nanoparticles would be suitable for use in hyperthermia treatment as they possess a good specific absorption rate. The third generation nanoparticles consisted of iron oxide particles synthesized by thermal decomposition of iron oleate in the presence of oleic acid. Substitution of the surface oleate molecules by ligand exchange reaction with a PEG 600-silane derivative produced water dispersible nanoparticles with narrower size distribution and smaller hydrodynamic size than the first two generations of nanoparticles. The nanoparticles were found to accumulate in the liver after injection, as revealed by in vivo imaging studies performed on rats. The particles were further functionalized with the 64Cu2+ complex of a new dmptacn derivative, via the free carboxyl groups of the PEG chains, to produce an agent suitable for dual modal MRI-PET imaging.

Download or read book Design and Evaluation of Plasmonic Magnetic Au MFe2O4 M Fe Co Mn Core Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics written by Ravichandran Manisekaran and published by Springer. This book was released on 2017-10-30 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.

Download or read book Nanomaterials for Cancer Detection Using Imaging Techniques and Their Clinical Applications written by Ramesh S. Chaughule and published by Springer Nature. This book was released on 2022-10-17 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents nanomaterials for cancer detection using a variety of state-of-the-art imaging techniques. Clinical applications are also highlighted. The unique size-dependent properties and convenient surfaces for molecular assembly make these nanomaterials essential for a variety of innovative imaging techniques. This book covers important imaging modalities, synthesis of nanoparticles with specific functional properties, and clinical applications including the development of anticancer drugs. The information presented here involves contributions from chemistry, materials science, materials characterization, cell engineering, and clinical testing. The book will be essential reading to experienced clinicians as well as a wide range of scholars and researchers interested in nanotechnology and imaging techniques for cancer detection.

Download or read book Functionalized Nanoparticles for the Selective Killing of Cancer Cells written by Paul Todd Thevenot and published by ProQuest. This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanoparticles for cancer imaging and drug delivery has produced some success in improving the efficacy and safety of cancer chemotherapy. It is generally believed that the efficiency of nanoparticle-based cancer therapy would be greatly improved if such particles could be designed to directly interact with and eradicate tumor. Many recent studies have revealed that surface functionality plays an important role in particle:cell interactions. Using titanium dioxide (TiO2) nanoparticles (21 nm diameter) as test subjects, nanoparticles with different functional groups, hydroxyl ( -OH), amine ( -NH2), and carboxyl ( -COOH) were produced and used in this investigation. An in vitro cell culture system was used to evaluate the interaction of a series of surface functionalized TiO2 nanoparticles with a number of normal animal and cancer cell lines, including B16F10 melanoma, Lewis lung carcinoma (LLC), JHU prostate cancer cells, and 3T3 fibroblasts. It was observed that cell viability following exposure to TiO2 nanoparticles was dependent on particle concentration, cell line, and TiO 2 surface chemistry. Overall, the TiO2 nanoparticles, both functionalized and uncoated, exerted the strongest toxicity effects on LLC cells and least toxicity on B16F10 cells and 3T3 fibroblasts. Cell viability was observed to depend on the specific surface chemistry of the particles. In general, particles with -NH2 or -OH functional groups exhibited significantly higher toxicity than those functionalized with -COOH groups. Microscopy analysis of cell viability as well as spectophotometric analysis of lactate dehydrogenase (LDH) content and arrays of cell proliferation indicated that the TiO 2 nanoparticles disrupt the cell membrane integrity leading to cell death. Overall, the present results suggest that functionalized TiO2 nanoparticles, and presumably other nanoparticles similarly surface modified, may be engineered specifically for targeted cancer therapy. The ability to fully understand how a precisely chemically defined surface interacts with both cell monolayers and body tissues will help scientists and engineers in the design of materials that will perform their desired function while also minimizing unfavorable interactions within the body.

Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-01 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.

Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.

Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Download or read book Nanomedicine for Cancer Diagnosis and Therapy written by Arshi Malik and published by Springer Nature. This book was released on 2021-08-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.

Download or read book Bionanotechnology in Cancer written by D. Sakthi Kumar and published by CRC Press. This book was released on 2022-10-27 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer, which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews, but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer, focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles, magnetic nanoparticles, acoustically reflective nanoparticles, X-ray computed tomography, and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy, magnetic nanoparticles for hyperthermia against cancer, phototherapy, nanotechnology-mediated radiation therapy, nanoparticle-mediated small-RNA deliveries for molecular therapies, and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience, which is considered the last hope for the fight against cancer and will be a highly useful resource for the students, researchers, teachers, and curious readers working in this field or related fields.

Download or read book Functionalized Nanomaterials for Cancer Research written by Hamed Barabadi and published by Elsevier. This book was released on 2024-03-22 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients' overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. - Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments - Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities - Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research

Download or read book Nanotechnology for Biomedical Imaging and Diagnostics written by Mikhail Y. Berezin and published by John Wiley & Sons. This book was released on 2014-11-24 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike

Download or read book Functionalized Upconversion Nanoparticles for Cancer Imaging and Therapy written by and published by . This book was released on 2014 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Applications of Magnetic Nanoparticles written by Nguyen Tk Thanh and published by CRC Press. This book was released on 2018 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlling the size and the shape of uniform magnetic iron oxide nanoparticles for biomedical applications / Helena Gavilán, María Eugenia Fortes Brollo, Lucía Gutiérrez, Sabino Veintemillas-Verdaguer and María del Puerto Morales -- Magnetic nanochains : properties, syntheses and prospects / Irena Milosevic, Vincent Russier, Marie-Louise Saboungi, Laurence Motte -- Carbon coated magnetic metal nanoparticles for clinical applications / Martin Zeltner and Robert N. Grass -- Bio-inspired magnetic nanoparticles for biomedical applications / Changqian Cao, Yongxin Pan -- Main challenges in surface biofunctionalization of magnetic nanoparticles for in vivo targeting / Laurent Adumeau, Marie-Hélène Delville and Stéphane Mornet -- Experimental considerations for scalable magnetic nanoparticle synthesis and surface functionalization for clinical applications / Alec P. LaGrow, Maximilian O. Besenhard, Roxanne Hachani and Nguyen T.H. Kim Thanh -- Magnetic polymersomes for MRI and theranostic applications / Adeline Hannecart, Dimitri Stanicki, Luce Vander Elst, Robert N. Muller, Sophie Laurent -- Ultra-small iron oxide nanoparticles stabilized with multidentate polymers for applications in MRI / Jung Kwon (John) Oh and Marc-André Fortin -- Encapsulation and release of drugs from magnetic silica nanocomposites / Damien Mertz and Sylvie Bégin-Colin -- Current progress in magnetic separation-aided biomedical diagnosis technology / Sim Siong Leong, Swee Pin Yeap, Siew Chun Low, Rohimah Mohamud and JitKang Lim -- Magnetic separation in integrated micro analytical systems / Kazunori Hoshino -- Magnetic nanoparticles for organelle separation / Mari Takahashi & Shinya Maenosono -- Magnetic nanoparticle based biosensing / Kai Wu, Diqing Su, Yinglong Feng, and Jian-Ping Wang -- Immunotoxicity and safety considerations for iron oxide nanoparticles / Gary Hannon, Melissa Anne Tutty, Adriele Prina-Mello -- Impact of core and functionalized magnetic nanoparticles on human health / Bella B. Manshian, Uwe Himmelreich, Stefaan J. Soenen -- Magnetic nanoparticles for cancer treatment using magnetic hyperthermia / Laura Asin, Grazyna Stepien, Maria Moros, Raluca M. Fratila, and Jesus M. de la Fuente -- Nanoparticles for nanorobotic agents dedicated to cancer therapy / Mahmood Mohammadi [and 6 others] -- Smart nanoparticles and the effects in magnetic hyperthermia in vivo / Ingrid Hilger -- Non-invasive guidance scheme of magnetic nanoparticles for drug delivery in Alzheimer's disease / Ali Kafash Hoshiar [and 5 others] -- Design, fabrication, and characterization of magnetic porous PDMS as an on-demand drug delivery device / Ali Shademani, Hongbin Zhang, Mu Chiao -- Magnetic particle transport in complex media / Lamar O. Mair [and 7 others] -- Magnetic nanoparticles for neural engineering / Gerardo F. Goya, Vittoria Raffa -- Radionuclide labeling and imaging of magnetic nanoparticles / Benjamin P. Burke, Christopher Cawthorne and Stephen J. Archibald -- Red blood cells constructs to prolong the life span of iron-based magnetic resonance imaging/magnetic particle imaging contrast agents in vivo / Antonella Antonelli, Mauro Magnani -- Stimuli-regulated cancer theranostics based on magnetic nanoparticles / Yanmin Ju, Shiyan Tong, and Yanglong Hou -- Good manufacturing practices (GMP) of magnetic nanoparticles / Emre Tuereli and Nazende Guenday Tuereli

Download or read book Nanoparticle Drug Delivery Systems for Cancer Treatment written by Hala Gali-Muhtasib and published by CRC Press. This book was released on 2020-02-19 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Download or read book Nanoparticles in Lung Cancer Therapy Recent Trends written by Abhijit Bandyopadhyay and published by Springer. This book was released on 2014-11-14 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients. Incidents of recurrence are also very common in case of lung cancer. Researchers have shown that nanoparticles may act as a powerful anti cancer tool, especially for lung cancer. Unique surface properties and easy surface functionalization of nanoparticles enable early detection, diagnosis, imaging and treatment of lung cancer. The authors have elaborately presented how various nanoparticles (natural, semi synthetic and synthetic) may help in the treatment of lung cancer. They have also detailed works of various scientists who succeeded in developing effective nanoparticles and enabled very specific lung cancer therapy without any undesirable side effects and minimized death.

Download or read book Bioresponsive Nanomaterials for Multimodality Imaging and Therapy written by Dalong Ni and published by Frontiers Media SA. This book was released on 2021-11-16 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices written by Kalim Deshmukh and published by Elsevier. This book was released on 2024-01-12 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Magnetic Nanosystems for Diagnostic Tools and Devices: Current and Emerging Research Trends explores the various aspects of functionalization of magnetic nanosystems in great detail, providing a thorough review of the associated benefits and challenges. The book begins with an overview of each key pillar for the design and application of functionalized magnetic nanosystems, from the synthesis, processing methods, and characterization techniques, to biocompatibility and toxicity considerations. Later chapters focus on specific nanomaterials and targeted biomedical applications, including point-of-care diagnosis, cancer therapy, medical imaging, biosensing and more. Importance is given to the safety considerations; environmental, legal and ethical implications, and commercial aspects of functionalized magnetic nanosystems - providing guidance relevant for advancing research into clinical practice. - Provides an overview of fundamentals in the design and application of magnetic nanosystems, from synthesis and processing to functionalization and toxicity assessment - Explores research in industry and clinical practice, providing insights into ethical, environmental, legal, and commercial aspects - Covers a wide range of diagnostic applications for functionalized magnetic nanosystems, such as in medical imaging, drug detection, tissue engineering, and more