Download or read book Defining Microvascular Injury in Acute Myocardinal Infarction and Response After Cell Therapy Using Cardiovascular Magnetic Resonance Imaging written by and published by . This book was released on 2016 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coronary Microvascular Obstruction in Acute Myocardial Infarction written by Giampaolo Niccoli and published by Academic Press. This book was released on 2018-07-07 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon
Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Download or read book Myocardial Function and Microvascular Injury After Percutaneous Coronary Intervention for Acute Myocardial Infarction written by Robin Nijveldt and published by . This book was released on 2008 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Magnetic Resonance Imaging Guided Therapies for Chronic Hemorrhagic Myocardial Infarction written by Eric Johnson and published by . This book was released on 2021 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation aims to evaluate therapies that have the potential to improve the recovery of the left ventricle (LV) following myocardial infarction (MI) burdened with intramyocardial hemorrhage (IMH). Prior studies have shown that hemorrhagic MI results in the deposition of chronic iron in the myocardium, which induces cytotoxic effects as well as impacts the normal function of the microvasculature. In order to characterize the content of intramyocardial iron, T2* magnetic resonance imaging (MRI) was used as the gold standard in non-invasive detection of cardiac iron, and therefore acts as a diagnostic guidance tool informing the efficacy of the therapies. The dissertation may be broken down into three phases, all performed with MRI guidance to elucidate: 1) mechanistic understanding of the microvascular environment in chronic MI subjects; 2) effects of iron chelation therapy via Deferiprone (DFP) administration; and 3) effects of therapeutic hypothermia (TH) induced post reperfusion. The first phase investigated the long-term changes in myocardial perfusion assessed via MRI, in patients with reperfused myocardial infarction and an animal model of ischemia reperfusion (I/R) injury. From animal studies, histology, immunohistochemistry (IHC), and western blotting analysis were performed to elucidate the mechanistic underpinnings of MRI observations. The outcomes of this study led to the discovery that hemorrhagic MI results in reduced myocardial perfusion within hemorrhagic, but not non-hemorrhagic, MI territories. Further, the protein expression investigations enabled the proposal of a mechanistic pathway to examine the role chronic iron deposition plays in the perfusion defects observed in hemorrhagic MI. The subsequent study in a canine model of hemorrhagic MI to remove iron from within chronic infarction regions using the small-molecule iron chelator deferiprone (DFP), is the first to show the potential to abrogate resting perfusion defects observed in the hemorrhagic MI setting. Furthermore, the study showed that the recovery of rest perfusion did not persist following termination of the DFP therapy, indicating the potential need for continuous, or extended, iron chelation in this population to maintain persistent benefits. Lastly, the study showed the potential beneficial impact of DFP therapy on LV remodeling by resulting in reduced end-diastolic mass, suggesting a possible role of iron in LV hypertrophy and diastolic dysfunction. Finally, a study of post-reperfusion localized therapeutic hypothermia was conducted in a pig model to evaluate the potential impact of hypothermia therapy on IMH and chronic iron deposition. This is the first study to show the capability of therapeutic hypothermia to reduce chronic iron deposition in hemorrhagic MI. The results of this study showed that post-reperfusion hypothermia did not impact acute infarct size and did not affect hemorrhage in the acute phase (day 3 post-MI). However, by 1 month hypothermia-treated animals showed significantly reduced T2*-derived iron deposition volume, which held when normalized by infarct size. By 2 months post-MI, absolute T2* values were also indicative of decreased myocardial iron content, with significantly increased T2* values (lower iron content) in hypothermia-treated animals. Furthermore, LV ejection fraction (LVEF) was significantly elevated at 2 months in the hypothermia group, suggesting a positive effect of therapeutic hypothermia on chronic LV function. In summary, this dissertation used animal models of hemorrhagic MI to investigate two promising therapeutic methods for alleviating the adverse remodeling in hemorrhagic MI subjects, showing promising results that will aid the future development of adjunctive clinical therapies for advancing treatment in MI and ischemia reperfusion injury.
Download or read book Cardiovascular Computed Tomography written by James Stirrup and published by Oxford University Press, USA. This book was released on 2020-01-02 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a marked increase in cardiovascular computed tomography (CT) imaging, with the technique now integrated into many imaging guidelines, such as those published by ESC and NICE. Rapid clinical and technological progress has created a need for guidance on the practical aspects of CT image acquisition, analysis and interpretation. The Oxford Specialist Handbook of Cardiovascular CT, now revised for the second edition by practising international experts with many years of hands-on experience, is designed to fulfil this need. The Handbook is a practical guide on performing, analysing and interpreting cardiovascular CT scans, covering all aspects from patient safety to optimal image acquisition to differential diagnoses of tricky images. It takes an international approach to both accreditation and certification, highlighting British, European, and American examinations and courses. The format is designed to be accessible and is laid out in easy to navigate sections. It is meant as a quick-reference guide, to live near the CT scanner, workstation, or on the office shelf. The Handbook is aimed at all cardiovascular CT users (Cardiologists, Radiologists and Radiographers), particularly those new to cardiovascular CT, although even the advanced user should find useful tips and tricks within.
Download or read book Coronary Radiology written by Matthijs Oudkerk and published by Springer Science & Business Media. This book was released on 2010-04-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of the first available monograph on coronary radiology. In line with recent advances, this edition places special emphasis on the role of non-invasive techniques, detailed information being provided on CT angiography with multidetector and dual-source tomography, 2D and 3D visualization techniques, and MR coronary angiography. Sections on invasive imaging techniques and coronary calcification are included. High-quality color images compliment the text.
Download or read book Microvascular Obstruction on Delayed Enhancement Cardiac Magnetic Resonance Imaging After Acute Myocardial Infarction Compared with Myocardial 201Tl and 123I BMIPP Dual SPECT Findings written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diseases of the Chest Breast Heart and Vessels 2019 2022 written by Juerg Hodler and published by Springer. This book was released on 2019-02-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.
Download or read book Myocardial Viability written by Vasken Dilsizian and published by Wiley-Blackwell. This book was released on 2000-02-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, one that holds significant clinical and prognostic relevance. Authored by physicians of international renown, the book brings together various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of: basic concepts and mechanisms; vascular biology and cellular physiology; advances in functional imaging; and perfusion, metabolism and cell membrane integrity. New concepts, such as stunning and hibernation, are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New and sophisticated examination techniques are also presented, as well as advances in instrumentation and imaging techniques, which may result in improved use of resources and enhanced efficiency of health care delivery. This monograph will serve as a reference source for those interested in the field of myocardial viability, and hopefully improve understanding between investigators from various disciplines. Clinical cardiologists, physicians, and nurses in the field, as well as radiologists, vascular surgeons, reperfusionists, cellular biologists and physiologists, and students will all find material of interest in this book.
Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stress Echocardiography written by Eugenio Picano and published by Springer Nature. This book was released on 2023-10-19 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the seventh edition of a long-selling book (first edition 1991) that was translated into Italian, French, Chinese, Portuguese, Spanish, English. In the last ten years, stress echocardiography has exploded in its breadth and variety of applications. From a one-fits-all approach (wall motion by 2D-echo in the patient with known or suspected coronary artery disease), the field has progressed to an omnivorous, next-generation laboratory employing a variety of technologies (from M-Mode to 2D, from pulsed, continuous, color and tissue Doppler to lung ultrasound) on patients covering the entire spectrum of severity (from elite athletes to patients with end-stage heart failure) and ages (from children with congenital heart disease to the elderly with aortic stenosis). This new edition is enriched with over 300 figures, 150 tables and video-clips. In a societal and economic climate of increasing pressure for appropriate, justified and optimized imaging, stress echocardiography offers the great advantages of being radiation-free, relatively low cost, with minimal environmental impact, and with a staggering versatility: we can get more (information) with less (cost and risk). The volume will be a tremendous aid to current best practices for all health operators who intend to use stress echocardiography and ultrasound for diagnosis and guidance of optimal management in their patients.
Download or read book MRI from Picture to Proton written by Donald W. McRobbie and published by Cambridge University Press. This book was released on 2017-04-13 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.
Download or read book Primary Angioplasty in Acute Myocardial Infarction written by James E. Tcheng and published by Springer Science & Business Media. This book was released on 2009-04-29 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past 50 years have witnessed a breathtaking evolution in the approaches to the patient with an acute ST elevation myocardial infarction. In the 1960s, the now commonplace cardiac intensive care unit was but a nascent idea. Without much to offer the patient but weeks of absolute bedrest, substantial morbidity and high rates of mortality were the norm. Just 30 years ago, seminal discoveries by DeWood and colleagues suggested that the culprit was plaque rupture with thrombosis, not progressive luminal compromise. Subsequent fibrinolyt- based strategies resulted in a halving of the mortality of acute myocardial infarction. With the introduction of balloon angioplasty in the late 1970s, a few interventional cardiologists braved the question: why not perform emergency angioplasty as a primary reperfusion strategy? Indeed, reports of successful reperfusion via balloon angioplasty appeared (mostly in local newspapers) as early as 1980. Despite being thought of as heretical by mainstream cardiology, these pioneers nonetheless persevered, proving the benefit of ‘‘state-of-the-art’’ balloon angioplasty compared with ‘‘state-of-t- art’’ thrombolytic therapy in a series of landmark trials published in the New England Journal of Medicine in March of 1993. Publication of the first edition of Primary Angioplasty in Acute Myocardial Infarction in 2002 to some extent anticipated the widespread acceptance of primary percutaneous coronary intervention as the standard of care. Since then, in all respects, the evolution of emergency percutaneous revascularization has only accelerated. The universal replacement of balloon angioplasty with stent implantation was clearly one key.
Download or read book Cardioimmunology Inflammation and Immunity in Cardiovascular Disease written by Mohamed Boutjdir and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Download or read book The EACVI Textbook of Cardiovascular Magnetic Resonance written by Victor Ferrari and published by Oxford University Press. This book was released on 2018-09-13 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly comprehensive and informed textbook has been prepared by the Cardiovascular Magnetic Resonance section of the European Society of Cardiology association on imaging, the EACVI. The EACVI Textbook of Cardiovascular Magnetic Resonance is the authority on the subject. The textbook is aligned with ESC Core Curriculum and EACVI Core Syllabus for CMR. It is a practical resource and provides a disease orientated outlook on the subject. Structured with thirteen clear and detailed sections, ranging from Physics to Methodology, and featuring specific sections on ischemic heart disease, myocardial disease, pericardial disease, and congenital heart disease and adult congenital heart disease, The EACVI Textbook of Cardiovascular Magnetic Resonance provides extensive knowledge across the entire subject area in CMR. Beautifully illustrated and physical principles enriched with schematic animations, the textbook is advanced further with key video content based on clinical cases. Written by leading experts in the field from across the world, the textbook aims to summarise the existing research and clinical evidence for the various CMR indications and provide an invaluable resource for cardiologists and radiologists across the board. The textbook is ideal for cardiologists and radiologists new to the field of Cardiovascular Magnetic Resonance, those preparing for ESC certification in CMR, and those established in the field wishing to gain a deep understanding of CMR. Online access to the digital version is included with purchase of the print book, with accompanying videos referenced within the text available on Oxford Medicine Online.
