Download or read book Cytokines in Hypersensitivity Pneumonitis written by Gunnar Guðmundsson and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Focus Series written by Om P Sharma and published by JP Medical Ltd. This book was released on 2012-11-30 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or moulds. Part of the Clinical Focus Series, Hypersensitivity Pneumonitis is a concise guide to the condition, discussing epidemiologic, immune-pathologic, physiologic, diagnostic and therapeutic developments. The text also examines genetics, lung function, bronchoscopy, treatment and new findings in the field. Written by an author and editor team from the USA, Europe and Asia, each chapter is enhanced with tables and illustrations, as well as X-Rays and CT images. Key Features Concise guide to hypersensitivity pneumonitis (extrinsic allergic alveolitis) Discusses epidemiology, immune-pathology, physiology, diagnosis and treatment Includes chapter on new findings in the field Experienced author and editor team from the USA, Europe and Asia Numerous tables, illustrations, X-Rays and CT images
Download or read book Indoor Allergens written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.
Download or read book Tyrosine Kinase Itk and the TH17 and T Regulatory Response in a Murine Model of Lung Inflammatory Hypersensitivity Pneumonitis written by Jessica Nikole Pamela Elmore and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary inflammatory diseases are among the top leading causes of death globally. The majority treatments for these diseases are aimed counteracting the symptoms rather than treating the underlying cause and many are not very effective. This is partly due to the poorly understood nature of the mechanisms underlying these diseases and lack of disease modifying strategies. The balance of inflammatory and suppressive cytokine is critical in controlling inflammatory responses, and the pro- and anti-inflammatory cytokines IL17A and IL10 has been implicated in numerous pulmonary inflammatory diseases. Hypersensitivity pneumonitis (HP) is a collection of lung diseases caused by repeated inhalation of environmental antigens leading to inflammation, tissue scarring, and some loss of lung function. Moreover, treatment options for HP are limited. Farmer's lung disease (FLD), a type of HP caused by Saccharopolyspora rectivirgula (SR) was originally described as a TH1-mediated disease, but has been shown to depend on IL17A, a cytokine secreted predominantly by TH17 cells. The Tec kinase Itk plays a critical role in T cell activation and has been shown to be required for the production of IL17A. Furthermore, Foxp3+ T regulatory (Tregs) cells, suppressive producers of IL10, are negatively regulated by Itk. We have previously shown that Itk-/- mice do not develop allergic airway disease coupled with reduced production of IL17A in the lungs. The objective of this work is to investigate the source of IL17A and the role of the Tec kinase Itk in regulating development of IL17A dependent airway immune response in a murine model of FLD. We used exposure to SR of WT and Itk-/ -IL17A-GFP/Foxp3-RFP reporter mice, to examine the time course, source of IL17A, and requirement for Itk, during the development of lung inflammation, and how microbial diversity effects disease outcome; additionally, we explored the use of PEG-maleimide (PEG-MAL) hydrogels crosslinked with enzymatically degradable peptides as in situ crosslinkable depots that has the potential to manipulate inflammatory immune cells in vivo, for its potential to reduce inflammation in this model of HP. Such immunomodulatory approaches have been shown in cancer immunotherapy, but to date not in airway inflammation. We found that surprisingly, exposure to SR drives robust IL17A response in the lung initially by γδ T cells and then by CD4+ αβ T cells even in the absence of Itk, accompanied by the development of pulmonary inflammation. We also found that neutrophils were not a predominant source of IL17A as has been reported. SR also induced Itk independent development of a population of Foxp3+ Tregs cells that produce IL17A or IL10, with IL10 dominating early in the disease. RNA-sequencing and ATAC-sequencing was performed to determine the transcriptome and chromatin accessible status of SR-induced TH17 cells and T regulatory cells. Transcriptomic analysis of Itk independent TH17 cells induced by SR suggest that SR-induced inflammatory signals may override signals downstream of Itk to rescue TH17 responses. In addition, we explored the role of microbial diversity in the development of lung inflammation using SR induced HP or house dust mice (HDM) induced allergic airway disease (AAD). The microbiome plays an important role in the development of allergies and can modulate immune responses to diseases. We treated mice with antibiotic to reduce microbial diversity, or co-housing with pet store mice to increase microbial diversity, to investigate how varied microbial exposure affects inflammatory T cell responses in FLD or AAD. We found that reducing the microbiota decreased TH17 responses in FLD, while increasing the diversity of microbes led to a reduction in the inflammation in FLD and an increase in AAD. These studies suggest that TCR signaling through Itk differentially regulates the development of inflammatory TH17 cells and suppressive Tregs, dependent on the type of inflammation. Understanding how Itk modulates the development of TH17/Treg cytokine responses will allow us to better understand the precise role of Itk in the regulation of cytokines involved in in airway inflammation.
Download or read book Kendig and Chernick s Disorders of the Respiratory Tract in Children E Book written by Robert W. Wilmott and published by Elsevier Health Sciences. This book was released on 2012-02-25 with total page 1163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.
Download or read book Cells and Cytokines in Lung Inflammation written by Michel Chignard and published by . This book was released on 1994 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume compares the results of investigators on the mechanisms of generation, interaction, and modulation of inflammatory cytokines and their respective cell origins and/or targets. The book, divided roughly according to cell species, advances what is currently known about the synergism of early and late mediators on resident and newly recruited target cells.
Download or read book Cytokine Ion Channel Interactions in Pulmonary Inflammation written by István Vadász and published by Frontiers Media SA. This book was released on 2019-01-24 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic assembles original contributions and reviews from an international consortium of PIs related to interactions between pro-inflammatory cytokines and ion channels during acute lung injury and chronic heart failure.
Download or read book The Role of Neutrophils in Hypersensitivity Pneumonitis written by Stephanie C. Berry-Nance and published by . This book was released on 2007 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Additional studies were performed to identify the pattern recognition receptors (PRRs) that are stimulated by SR resulting in neutrophil recruitment. Neutrophil recruitment was found to be dependent upon signaling through MyD88, an adaptor protein used in PRR signaling. Of the PRRs, several Toll-like receptors (TLR) have been shown to be dependent upon MyD88 for signaling. In vitro studies demonstrated that SR can interact with TLR2, but not TLR4, 5, or 7. Exposure of TLR2-/- mice to SR resulted in neutrophil recruitment into the lungs at similar levels as WT controls. These results suggest that signaling through TLR2 it is not necessary for neutrophil recruitment into the lung. Thus, additional receptors upstream of MyD88 interact with SR resulting in production of proinflammatory cytokines and chemokines, which leads to subsequent neutrophil recruitment.
Download or read book Cytokines and Adhesion Molecules in Lung Inflammation written by Michel Chignard and published by . This book was released on 1996 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume updates information on the mechanisms involved between adhesion molecules and cytokines in the pathogenesis of pulmonary diseases, including asthma and chronic or acute inflammatory lung disease. Presentations focus on in vitro cell-to-cell interactions and their modulation, and particular emphasis is placed on clinical end-points. Development of animal models for inflammatory lung diseases is also discussed.
Download or read book Diseases of Workers written by Bernardino Ramazzini and published by . This book was released on 1983 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathology of the Lungs E Book written by Bryan Corrin and published by Elsevier Health Sciences. This book was released on 2011-02-25 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation
Download or read book Allergy and Asthma written by Massoud Mahmoudi and published by Springer. This book was released on 2016-06-02 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly practical, easy-to-read, fully updated and expanded resource offers a wide range of targeted guidelines and insights in allergy medicine. Written by a leading allergy clinician -- along with a renowned group of nationally recognized expert contributors in allergy and immunology, pulmonary, and infectious diseases -- this title is a proven resource for front-line general practitioners, especially primary care physicians. The most clinically relevant information is provided on the pathophysiology, diagnosis, treatment, and prevention of all major allergic disorders. Each chapter has a section on “Evidence-Based Medicine” that introduces one to two recent research publications on the subject, and several chapters have been written by new authors. Covering the entire scope of adult and pediatric allergy and asthma and organized by specific organ which guides the reader to diagnostic and therapeutic solutions quickly and easily, the book offers a wealth of outstanding illustrations, key concepts, management protocols, and updated references. An invaluable contribution to the field, Allergy and Asthma: Practical Diagnosis and Management, 2nd Edition will be of immense value not only to primary care physicians, but also to fellows in training, residents, nurses, nurse practitioners, and medical and allied health students.
Download or read book Pulmonary Pathology written by Philip T. Cagle and published by Springer. This book was released on 2018-03-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the complete field of pulmonary pathology - neoplastic and non-neoplastic - from Acinic cell tumor in the lung to Wegener`s Granulomatosis. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.
Download or read book Principles of Cancer Biotherapy written by Robert K. Oldham and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.
Download or read book Pulmonary Diseases and Disorders written by Alfred P. Fishman and published by . This book was released on 1988 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diffuse Cystic Lung Diseases written by Nishant Gupta and published by Springer Nature. This book was released on 2021-01-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive reference on diffuse cystic lung diseases (DCLDs). DCLDs are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. In recent years, tremendous advancements have been made in these diseases leading to improved understanding of the underlying pathophysiology, and improved outcomes with targeted therapies. The authors, who are leading experts in the field, delineate DCLDs as a separate category distinct from other interstitial lung diseases, and have created this textbook specifically dedicated to this disease group. This book begins with a chapter introducing the definition and classification of DCLDs. Subsequent chapters address the pathogenic mechanisms underlying pulmonary cyst formation and provide a detailed overview of the radiological and pathological features of DCLDs. The common as well as uncommon causes of DCLDs are comprehensively reviewed in individual chapters, as are the varied clinical presentations and extrapulmonary manifestations, and approaches to management and treatment. The book culminates in a final chapter that presents a practical algorithmic approach to diagnosis that progresses from least invasive to most invasive approaches. This textbook provides a one-stop, comprehensive and integrated, clinical, radiologic, and pathologic overview of DCLDs that will be as useful to the practicing clinician as it is to the clinical investigator.
Download or read book Pathology of Lung Disease written by Helmut Popper and published by Springer. This book was released on 2016-12-22 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years’ experience in the field.
