Download or read book Craniofacial Skeletal Dysmorphology Induced by Prenatal Alcohol Exposure written by Huisi Ai and published by . This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apoptosis and Craniofacial Dysmorphology in Fetal Alcohol Syndrome written by Katherine A. Kragtorp and published by . This book was released on 2003 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics and Epigenetics of Fetal Alcohol Spectrum Disorders written by Feng C. Zhou and published by Frontiers Media SA. This book was released on 2015-08-06 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women drinking during pregnancy can result in Fetal Alcohol Spectrum Disorder (FASD), which may feature variable neurodevelopmental deficits, facial dysmorphology, growth retardation, and learning disabilities. Research suggests the human brain is precisely formed through an intrinsic, genetic-cellular expression that is carefully orchestrated by an epigenetic program. This program can be influenced by environmental inputs such as alcohol. Current research suggests the genetic and epigenetic elements of FASD are heavily intertwined and highly dependent on one another. As such, now is the time for investigators to combine genetic, genomic and epigenetic components of alcohol research into a centralized, accessible platform for discussion. Genetic analyses inform gene sets which may be vulnerable to alcohol exposure during early neurulation. Prenatal alcohol exposure indeed alters expression of gene subsets, including genes involved in neural specification, hematopoiesis, methylation, chromatin remodeling, histone variants, eye and heart development. Recently, quantitative genomic mapping has revealed loci (QTLs) that mediate alcohol-induced phenotypes identified between two alcohol-drinking mouse strains. One question to consider is (besides the role of dose and stage of alcohol exposure) why only 5% of drinking women deliver newborns diagnosed with FAS (Fetal Alcohol Syndrome)? Studies are ongoing to answer this question by characterizing genome-wide expression, allele-specific expression (ASE), gene polymorphisms (SNPs) and maternal genetic factors that influence alcohol vulnerability. Alcohol exposure during pregnancy, which can lead to FASD, has been used as a model to resolve the epigenetic pathway between environment and phenotype. Epigenetic mechanisms modify genetic outputs through alteration of 3D chromatin structure and accessibility of transcriptional machinery. Several laboratories have reported altered epigenetics, including DNA methylation and histone modification, in multiple models of FASD. During development DNA methylation is dynamic yet orchestrated in a precise spatiotemporal manner during neurulation and coincidental with neural differentiation. Alcohol can directly influence epigenetics through alterations of the methionine pathway and subsequent DNA or histone methylation/acetylation. Alcohol also alters noncoding RNA including miRNA and transposable elements (TEs). Evidence suggests that miRNA expression may mediate ethanol teratology, and TEs may be affected by alcohol through the alteration of DNA methylation at its regulatory region. In this manner, the epigenetic and genetic components of FASD are revealing themselves to be mechanistically intertwined. Can alcohol-induced epigenomic alterations be passed across generations? Early epidemiological studies have revealed infants with FASD-like features in the absence of maternal alcohol, where the fathers were alcoholics. Novel mechanisms for alcohol-induced phenotypes include altered sperm DNA methylation, hypomethylated paternal allele and heritable epimutations. These studies predict the heritability of alcohol-induced epigenetic abnormalities and gene functionality across generations. We opened a forum to researchers and investigators the field of FASD to discuss their insights, hypotheses, fresh data, past research, and future research themes embedded in this rising field of the genetics and epigenetics of FASD. This eBook is a product of the collective sharing and debate among researchers who have contributed or reviewed each subject.
Download or read book Craniofacial Skeletal Anatomy in the Fetal Alcohol Syndrome written by Geoffrey Michael Greenlee and published by . This book was released on 2000 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Children s Friendship Training written by Fred D. Frankel and published by Routledge. This book was released on 2013-05-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 2003. Children's Friendship Training is a complete manualized guide for therapists treating children with peer problems. This unique, empirically validated treatment is the first to integrate parents into the therapy process to ensure generalization to school and home. Representing over twelve years of research, Children's Friendship Training presents the comprehensive social skills training program developed by these pioneering authors. Step-by-step interventions help children develop the skills to initiate mutually satisfying social interactions. These interactions can lead to higher regard within the peer group and the development of satisfying dyadic relationships that will, in turn, serve to enhance overall well being. Clinical and empirical rationales, illustrative case examples and parent handouts that educate parents and give specific guidelines for homework assignments are presented for each treatment module. Brief relevant reviews of the child development literature and selective reviews of assessment techniques and other approached to children's social skills training are presented to sufficiently acquaint therapists interested in implementing children's friendship training.
Download or read book Prevention Recognition and Management of Fetal Alcohol Spectrum Disorders written by Raja A. S. Mukherjee and published by Springer Nature. This book was released on 2021-07-31 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents clinical assessment and management solutions for those people who are exposed to Alcohol in Pregnancy. Over the last few decades we have begun to understand the enduring effects of prenatal alcohol exposure on the developing fetus. The consequence of prenatal alcohol exposure - Fetal Alcohol Spectrum Disorders is a lifelong disorder and affects children and adults. It is a condition which is significantly under-recognised for many reasons. Assessment and diagnosis requires the input of multiple different professionals, and referral pathways are often poorly developed or non-existent. Information to support and guide these professionals in practical ways, what to do and how to help, remains limited. This book seeks to fill some of that gap by offering professionals, clear and useable research-based information and guidance that will help in their practice whilst also being a useful resource for anyone new to this increasingly recognised area of work. The book is divided into four broad areas bringing together chapters authored by experts in their field including those with lived experiences. Part one focuses on presenting an overview of the condition, and approaching women about their alcohol use and risk followed by part two focusing more around diagnostic issues. Part three follows with management advice, and part four revolves around policy and health prevention in general. Each chapter is designed to offer insight but also practical tips and support in an accessible manner. The book offers an essential guide for a broad range of health and social care professionals working with this condition.
Download or read book Experimental and Clinical Approaches in the Pursuit of Novel Therapeutic Strategies for Perinatal Brain Injury and its Neurological Sequelae written by Changlian Zhu and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamentals of Craniofacial Malformations written by Ulrich Meyer and published by Springer Nature. This book was released on 2021-06-24 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume in an interdisciplinary three-book series covering the full range of biological, clinical, and surgical aspects in the evaluation, diagnosis, and treatment of patients with craniofacial malformations. This volume opens by considering general topics such as developmental biology and disease classification and then examines in depth the biological basis of the various malformations, including craniosynostoses, cleft-lip and palate with complex orofacial clefts, branchio-oculo-facial syndromes, rare syndromes, soft tissue malformations, and dysgnathia. Psychological aspects, including psychological evaluation methods and therapies and quality of life issues, are then addressed. Finally, all relevant clinical, radiological, and genetic investigations are described and important diagnostic issues are explored. Featuring numerous high-quality illustrations, the book will be of high value for all clinicians, researchers, and postgraduate students who deal with these malformations. The accompanying two volumes describe treatment principles and present in an atlas manner all relevant surgical techniques in detail. The content of this multivolume set, written by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this medical field.
Download or read book Craniofacial Growth and Development Novel Insights written by Erika Kuchler and published by Frontiers Media SA. This book was released on 2021-10-13 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Embryo and Fetal Pathology written by Enid Gilbert-Barness and published by Cambridge University Press. This book was released on 2004-05-31 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaustively illustrated in color with over 1000 photographs, figures, histopathology slides, and sonographs, this uniquely authoritative atlas provides the clinician with a visual guide to diagnosing congenital anomalies, both common and rare, in every organ system in the human fetus. It covers the full range of embryo and fetal pathology, from point of death, autopsy and ultrasound, through specific syndromes, intrauterine problems, organ and system defects to multiple births and conjoined twins. Gross pathologic findings are correlated with sonographic features in order that the reader may confirm visually the diagnosis of congenital abnormalities for all organ systems. Obstetricians, perinatologists, neonatologists, geneticists, anatomic pathologists, and all practitioners of maternal-fetal medicine will find this atlas an invaluable resource.
Download or read book Preventing Child Maltreatment written by and published by . This book was released on 2007 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on 1982 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fetal Alcohol Syndrome written by Institute of Medicine and published by National Academies Press. This book was released on 1996-04-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: It sounds simple: Women who drink while pregnant may give birth to children with defects, so women should not drink during pregnancy. Yet in the 20 years since it was first described in the medical literature, fetal alcohol syndrome (FAS) has proved to be a stubborn problem, with consequences as serious as those of the more widely publicized "crack babies." This volume discusses FAS and other possibly alcohol-related effects from two broad perspectives: diagnosis and surveillance, and prevention and treatment. In addition, it includes several real-life vignettes of FAS children. The committee examines fundamental concepts for setting diagnostic criteria in general, reviews and updates the diagnostic criteria for FAS and related conditions, and explores current research findings and problems associated with FAS epidemiology and surveillance. In addition, the book describes an integrated multidisciplinary approach to research on the prevention and treatment of FAS. The committee: Discusses levels of preventive intervention. Reviews available data about women and alcohol abuse and treatment among pregnant women. Explores the psychological and behavioral consequences of FAS at different ages. Examines the current state of knowledge about medical and therapeutic interventions, education efforts, and family support programs. This volume will be of special interest to physicians, nurses, mental health practitioners, school and public health officials, policymakers, researchers, educators, and anyone else involved in serving families and children, especially in high risk populations.
Download or read book Neuroscience of Alcohol written by Victor R. Preedy and published by Academic Press. This book was released on 2019-03-19 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects
Download or read book Comprehensive Handbook of Alcohol Related Pathology written by Victor R. Preedy and published by Elsevier. This book was released on 2004-12-24 with total page 2556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures
Download or read book Trauma Autism and Neurodevelopmental Disorders written by Jason M. Fogler and published by Springer. This book was released on 2018-11-29 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the diagnostic overlap and frequent confusion between the newly named DSM-5 diagnostic categories of neurodevelopmental disorders (NDDs), which include autism spectrum disorder (ASD), and trauma and stressor related disorders (TSRDs). These conditions are similar in that a) children with developmental disorders are particularly vulnerable to traumatic events and b) all have pervasive effects on the brain and development. Chapters provide a wealth of effective clinical, family, and school-based interventions, developed from established studies and important new findings. In addition, chapters use illustrative case studies to survey assessment challenges in today’s healthcare climate and consider alternative routes for improving correct diagnoses, identifying appropriate interventions, and referring proper targeted, evidence-based treatment and services. The book concludes with the editors’ recommendations for needs-based service access, including a more widespread use and acceptance of the Research Domain Criteria (RDoC) and the International Classification of Functioning, Disability, and Health (ICF) framework. Topics featured in this book include: The neurobiological contributors to posttraumatic stress disorder (PTSD). Fetal alcohol spectrum disorders (FASDs) and its diagnosis in children with a history of trauma. Interventions for trauma and stressor-related disorders in preschool-aged children. Reactive attachment disorder (RAD) and autism spectrum disorder (ASD) diagnosis and care in a cultural context. Special population consideration in ASD identification and treatment. Challenges associated with the transition to adulthood. Trauma and neurodevelopmental disorders from a public health perspective. Trauma, Autism, and Neurodevelopmental Disorders is a must-have resource for researchers, clinicians and related professionals, and graduate students in developmental psychology, child and adolescent psychiatry, public health, social work, pediatrics, and special education.
Download or read book Anatomical Variations in Clinical Dentistry written by Joe Iwanaga and published by Springer. This book was released on 2019-01-23 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This excellently illustrated book aims to equip dentists, oral surgeons, and trainees with the detailed knowledge of anatomical variations in the oral region that is now required for optimal daily clinical practice. The book opens with an introductory section on anatomical variations from the point of view of different clinical practitioners – oral and maxillofacial surgeons, periodontists, and endodontists. The newest anatomical knowledge and variations are then presented in turn for the mandible, maxillary sinus, hard palate, floor of the mouth, lips, temporomandibular joint, and teeth. In each chapter, clinical annotations are included in order to enhance understanding of the relationships between surgery and anatomy. The internationally renowned authors have been carefully selected for their expertise in the topics that they discuss. Anatomical Variations in Clinical Dentistry will be invaluable for general dentists, endodontists, periodontists, and implantologists and will also be an asset for anatomists, oral and maxillofacial surgeons, otolaryngologists, dental students, and dental hygienists.
