Download or read book Craniofacial Skeletal Anatomy in the Fetal Alcohol Syndrome written by Geoffrey Michael Greenlee and published by . This book was released on 2000 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Craniofacial Skeletal Dysmorphology Induced by Prenatal Alcohol Exposure written by Huisi Ai and published by . This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apoptosis and Craniofacial Dysmorphology in Fetal Alcohol Syndrome written by Katherine A. Kragtorp and published by . This book was released on 2003 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene ethanol Interactions Underlie Craniofacial Variability in a Zebrafish Model of FASD written by Johann K. Eberhart and published by . This book was released on 2015 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Variation is common in human birth defects and this variability is influenced by genes and the environment. How genes and the environment interact in causing birth defect variability is a fundamental question in biology. I sought to investigate these interactions using a zebrafish model of fetal alcohol spectrum disorder. Fetal alcohol spectrum disorder (FASD) is an umbrella term that describes all ethanol-induced fetal defects. It is highly variable and also highly prevalent, with an estimated 1% of the population being affected. FASD can cause variable defects, including those affecting the craniofacial skeleton, a neural crest- and mesoderm-derived structure. Although both timing and dosage can influence FASD variability, genetics is an underlying factor. Little is known of the genes that cause susceptibility to FASD, and so I sought to uncover these genes and the mechanism of their interaction with ethanol. Using a novel zebrafish genetic screen to uncover gene-ethanol interactions, we found a synergistic interaction between platelet-derived growth factor receptor alpha (pdgfra) and ethanol. Pdgfra is a receptor tyrosine kinase involved in cell migration, proliferation, and survival. Untreated pdgfra mutants display cleft palate. In a percentage of ethanol in which wildtype zebrafish are unaffected, pdgfra mutants display exacerbated loss of the entire palatal skeleton. Furthermore, pdgfra heterozygotes display variable craniofacial defects, uncovering latent haploinsufficiency. Genetic analysis of a group of children with and without FASD suggests that this interaction is highly conserved. In zebrafish, further analysis of the mechanism of this pdgfra-ethanol interaction revealed a protective role of pdgfra to ethanol-induced neural crest cell death. Analysis of the Pdgfra downstream pathway PI3K/AKT/mTOR revealed an inhibitory effect of ethanol at the level of mTOR. Together, these data suggest that genes functioning in growth factor signaling could predispose to ethanol-induced defects. Analysis of another growth factor signaling gene, fgf8a, supported this hypothesis. Ethanol interacts with fgf8a to cause posterior mesoderm-derived craniofacial defects. This phenotype can be recapitulated by blocking both fgf8a and fgf3, suggesting ethanol broadly attenuates growth factor signaling. Analysis of the fgf8a;fgf3 phenotype suggests that Fgf signaling is required for proper specification, via hyaluronan synthetase 2, of the mesoderm-derived posterior craniofacial skeleton. To test whether ethanol may also broadly attenuate Pdgf signaling, we analyzed pdgfra;pdgfrb mutant phenotypes and saw a recapitulation of the pdgfra-ethanol interaction. The synergistic pdgfra;pdgfrb phenotype may be due to a similar increase in neural crest cell death observed in the pdgfra-ethanol interaction. Together, these data reveal genes involved in growth factor signaling may act to protect against ethanol-induced craniofacial defects.
Download or read book Children s Friendship Training written by Fred D. Frankel and published by Routledge. This book was released on 2013-05-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 2003. Children's Friendship Training is a complete manualized guide for therapists treating children with peer problems. This unique, empirically validated treatment is the first to integrate parents into the therapy process to ensure generalization to school and home. Representing over twelve years of research, Children's Friendship Training presents the comprehensive social skills training program developed by these pioneering authors. Step-by-step interventions help children develop the skills to initiate mutually satisfying social interactions. These interactions can lead to higher regard within the peer group and the development of satisfying dyadic relationships that will, in turn, serve to enhance overall well being. Clinical and empirical rationales, illustrative case examples and parent handouts that educate parents and give specific guidelines for homework assignments are presented for each treatment module. Brief relevant reviews of the child development literature and selective reviews of assessment techniques and other approached to children's social skills training are presented to sufficiently acquaint therapists interested in implementing children's friendship training.
Download or read book Comprehensive Handbook of Alcohol Related Pathology written by Victor R. Preedy and published by Elsevier. This book was released on 2004-12-24 with total page 2556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures
Download or read book Fundamentals of Craniofacial Malformations written by Ulrich Meyer and published by Springer Nature. This book was released on 2021-06-24 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume in an interdisciplinary three-book series covering the full range of biological, clinical, and surgical aspects in the evaluation, diagnosis, and treatment of patients with craniofacial malformations. This volume opens by considering general topics such as developmental biology and disease classification and then examines in depth the biological basis of the various malformations, including craniosynostoses, cleft-lip and palate with complex orofacial clefts, branchio-oculo-facial syndromes, rare syndromes, soft tissue malformations, and dysgnathia. Psychological aspects, including psychological evaluation methods and therapies and quality of life issues, are then addressed. Finally, all relevant clinical, radiological, and genetic investigations are described and important diagnostic issues are explored. Featuring numerous high-quality illustrations, the book will be of high value for all clinicians, researchers, and postgraduate students who deal with these malformations. The accompanying two volumes describe treatment principles and present in an atlas manner all relevant surgical techniques in detail. The content of this multivolume set, written by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this medical field.
Download or read book Textbook of Craniofacial Growth written by Sridhar Premkumar and published by JP Medical Ltd. This book was released on 2011-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Craniofacial Growth is a "one stop" guide to craniofacial growth and development, for both undergraduate and postgraduate students. The book begins with the basics - biology of bone and cartilage, physiology of bone and craniofacial growth and development. Assisted by comprehensive flow charts and well-illustrated diagrams, the text then examines control mechanisms, development of dentition, temporomandibular joint, mycology, neuromuscular reflexes and the maturation of orofacial functions. Craniofacial anomalies and the influence of genetics on growth are also discussed, guiding students through normal versus subnormal growth.
Download or read book Fetal Alcohol Syndrome written by Ernest L. Abel and published by CRC Press. This book was released on 2022-01-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition of the relationship between alcohol abuse and adverse prenatal outcomes is reflected in the warning labels on every alcoholic beverage sold in the United States. Because alcohol abuse has serious consequences for both individuals and society as a whole, much research has been devoted to this problem. Fetal Alcohol Syndrome provides straightforward facts regarding the impact of alcohol consumption as it affects the development of the embryo and fetus. Surveying current research of fetal alcohol syndrome and its related problems, the book addresses the immediate effects on development at various stages. Long-term action of prenatal alcohol exposure later in life is also considered. A chapter devoted to assessing the behavior of children who were prenatally exposed to alcohol emphasizes the necessity of longitudinal studies of fetal alcohol syndrome. This important reference offers a thorough overview of a problem that cannot be ignored.
Download or read book Neural Crest Cells written by Paul Trainor and published by Academic Press. This book was released on 2013-11-23 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. - BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association - Provides timely, comprehensive synthesis of the current knowledge of neural crest cells - Covers the evolution and development of neural crest cells - Includes content on applications for tissue engineering, repair and regeneration
Download or read book Craniofacial Muscles written by Linda K. McLoon and published by Springer Science & Business Media. This book was released on 2012-09-13 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereotype. This book is the most comprehensive reference to date on craniofacial muscle development, structure, function, and disease. It details the state-of-the-art basic science of the craniofacial muscles, and describes their unique response to major neuromuscular conditions. Most importantly, the text highlights how the craniofacial muscles are different from most skeletal muscles, and why they have been viewed as a distinct allotype. In addition, the text points to major gaps in our knowledge about these very important skeletal muscles and identified key gaps in our knowledge and areas primed for further study and discovery.
Download or read book Fetal Alcohol Spectrum Disorder written by Albert E. Chudley and published by Springer Nature. This book was released on 2022-09-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides current state-of-the-art methods for screening, diagnosis, management, and prevention of fetal alcohol spectrum disorder (and FASD). Chapters detail animal models, mechanism of ethanol teratogenesis, genetic mechanisms, clinical perspectives, physical traits in children with FASD, managing behavior, FASD and the correction system, nutritional influences aiding FASD prevention, prenatal alcohol screening, the use of dental signatures in FASD diagnosis, the experiences of FASD research and clinical practices in Australia, Canada, UK, USA, adult FASD diagnosis, FASD and children in care, FASD and the healing journey. Authoritative and cutting-edge, Advances in Fetal Alcohol Spectrum Disorder aims to be a useful practical guide to researchers and clinicians to help further their study in this field.
Download or read book Bolton Standards of Dentofacial Developmental Growth written by Birdsall Holly Broadbent and published by . This book was released on 1975-01-01 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fetal Alcohol Syndrome written by Institute of Medicine and published by National Academies Press. This book was released on 1996-04-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: It sounds simple: Women who drink while pregnant may give birth to children with defects, so women should not drink during pregnancy. Yet in the 20 years since it was first described in the medical literature, fetal alcohol syndrome (FAS) has proved to be a stubborn problem, with consequences as serious as those of the more widely publicized "crack babies." This volume discusses FAS and other possibly alcohol-related effects from two broad perspectives: diagnosis and surveillance, and prevention and treatment. In addition, it includes several real-life vignettes of FAS children. The committee examines fundamental concepts for setting diagnostic criteria in general, reviews and updates the diagnostic criteria for FAS and related conditions, and explores current research findings and problems associated with FAS epidemiology and surveillance. In addition, the book describes an integrated multidisciplinary approach to research on the prevention and treatment of FAS. The committee: Discusses levels of preventive intervention. Reviews available data about women and alcohol abuse and treatment among pregnant women. Explores the psychological and behavioral consequences of FAS at different ages. Examines the current state of knowledge about medical and therapeutic interventions, education efforts, and family support programs. This volume will be of special interest to physicians, nurses, mental health practitioners, school and public health officials, policymakers, researchers, educators, and anyone else involved in serving families and children, especially in high risk populations.
Download or read book Anatomical Variations in Clinical Dentistry written by Joe Iwanaga and published by Springer. This book was released on 2019-01-23 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This excellently illustrated book aims to equip dentists, oral surgeons, and trainees with the detailed knowledge of anatomical variations in the oral region that is now required for optimal daily clinical practice. The book opens with an introductory section on anatomical variations from the point of view of different clinical practitioners – oral and maxillofacial surgeons, periodontists, and endodontists. The newest anatomical knowledge and variations are then presented in turn for the mandible, maxillary sinus, hard palate, floor of the mouth, lips, temporomandibular joint, and teeth. In each chapter, clinical annotations are included in order to enhance understanding of the relationships between surgery and anatomy. The internationally renowned authors have been carefully selected for their expertise in the topics that they discuss. Anatomical Variations in Clinical Dentistry will be invaluable for general dentists, endodontists, periodontists, and implantologists and will also be an asset for anatomists, oral and maxillofacial surgeons, otolaryngologists, dental students, and dental hygienists.
Download or read book Potter s Pathology of the Fetus and Infant E Book written by Enid Gilbert-Barness and published by Elsevier Health Sciences. This book was released on 2007-04-27 with total page 2444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations. Offers comprehensive coverage of all common and rare embryonic, fetal, and infant disorders in one source. Correlates clinical, pathologic, and genetic findings for each systemic disease. Emphasizes the genetic and molecular basis of birth defects. Features nearly 2,500 illustrations - 2,350 in full color - which depict each abnormality or condition as they present in practice. Presents practical information on autopsy techniques and protocols. Provides the latest guidance on molecular pathology, immunohistochemistry, DNA technology, and more. Offers an expanded discussion of developmental biology related to the pathogenesis of birth defects. Features user-friendly summary tables and diagnostic flow charts, making information quick and easy to find. Includes a CD-ROM featuring all of the illustrations from the 2-volume set.
Download or read book Handbook of Human Toxicology written by Edward J. Massaro and published by CRC Press. This book was released on 1997-07-09 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering some of the most important topics in modern toxicology, the Handbook of Human Toxicology is a unique and valuable addition to the current literature. It addresses issues, answers questions, and provides data related to. Within each of these five major sections are several carefully selected topics that reflect the current state of human to
