Download or read book Corticotrophin ACTH written by Choh Hao Li and published by Elsevier. This book was released on 2012-12-02 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal Proteins and Peptides: Corticotrophin (ACTH) is a collection of papers dealing with the chemistry and biology of adrenocorticotropic hormone (ACTH). One paper describes the structure-function studies made on ACTH, with reference to the steroidogenic activity of synthetic ACTH fragments and analogs. The paper also discusses the melanocyte-stimulating hormone (MSH) activity, as well as the behavioral effects among the extraadrenal properties of ACTH. Some problems related to ACTH receptors include the role of extracellular calcium and the characterization of ACTH receptors in fetal and adult human adrenocortical cells. Another paper describes ACTH synthesis in the pituitary and extrapituitary tissues. One paper analyzes the role of ACTH in the regulation process concerning the production of steroid hormones, particularly, on the generation of glucocorticoids. Glucocorticoids are the characteristic products of the zona fasciculata. Another paper shows that the steady-state level of ACTH synthesis and release are due to the effects of stimulatory factors such as CRF and inhibitory hormones (namely, the glucocorticoids on the corticotroph). The maintenance of responsiveness of ACTH-secreting cells (as a response to individual stress in humans) can be a manifestation of an inherent molecular characteristic. This collection will prove valuable to microbiologists, biotechnologists, and academicians connected with the biological sciences.
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Download or read book ACTH Action in the Adrenal Cortex From Molecular Biology to Pathophysiology written by Nicole Gallo-Payet and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.
Download or read book Treatment of Multiple Sclerosis written by Richard A. Rudick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is one of the major current problems in neurol ogical practice. It remains incompletely understood, yet is a common cause of chronic disability in developed Western so cieties: Patients with the disease have difficulty understanding what has happened to them and become bewildered by the con trast between the evidently large body of knowledge concerning the clinical manifestations and course of the disease, and the conflicting views they so often receive from different specialists as to the best current management of their disease. As in so many disorders for which treatment is only partially effective, at best, "alternative" therapies abound. Dr. Rudick and Dr. Goodkin have extensive experience in the day-to-day management of multiple sclerosis at the Mellen Center for Multiple Sclerosis Treatment and Research, attached to the Cleveland Clinic. In this book they have assembled a group of experts from several countries and have provided a comprehensive review of the results of different treatments of the disease. Each treatment is considered in the light of its proposed scientific basis or mode of action, and in relation to ethical and trial design issues. This information deserves to be made widely available. As the treatment of multiple sclerosis enters a new era as a result of the new understanding of the cellular mechanisms of demyelination and the molecular biology of the immune response, this information about current treatments assumes additional importance. The book is of interest to all physicians concerned with the management of patients with the disease.
Download or read book The Hypothalamus Pituitary Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
Download or read book The Pituitary written by Shlomo Melmed and published by Academic Press. This book was released on 2010-12-09 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Download or read book Physiological and Therapeutic Effects of Corticotropin ACTH and Cortisone written by Dwight Joyce Ingle and published by . This book was released on 1953 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Adrenal Cortex written by Albert B. Eisenstein and published by . This book was released on 1967 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Peptide Hormone Synthesis and Secretory Pathways written by Jens F. Rehfeld and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.
Download or read book SAFE USES OF CORTISOL written by William McK. Jefferies and published by Charles C Thomas Publisher. This book was released on 2004-01-04 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of this popular book brings up to date the material that so many readers found helpful in the previous editions. The text has been revised and reorganized with current chapters focusing on the history of cortisol use, sources of confusion regarding cortisol therapy, the significance of normal adrenocortical function, generally accepted uses of physiological dosage, viral infections, miscellaneous clinical conditions, and future directions for research and therapy. The author provides explanation and confirmation of the rationale for the effectiveness and safety of the uses of physiological dosages of cortisol in the treatment, not only of patients with rheumatoid arthritis and other autoimmune disorders, but also of patients with chronic allergies, chronic fatigue syndrome, gonadal dysfunction, infertility, shingles, acne, hirsutism, respiratory infections, and other less common disorders. It is a known fact that the influenza virus attacks the human body by impairing the production of the adrenocorticotropic hormone (ACTH), which, in turn, impairs the production of cortisol; the only hormone that is absolutely essential for life. In addition, within the past two years, a new infection has developed in central China and has been labeled Severe Acute Respiratory Syndrome (SARS). The ACTH hormone and the SARS epidemic is addressed, and it is hoped that this type of cortisol therapy will not only be helpful in the treatment of the various disorders mentioned but will lead to a better understanding of the factors that contribute to the development of these disorders and ultimately contribute towards their prevention.
Download or read book The Cortisol Connection written by Shawn Talbott and published by Turner Publishing Company. This book was released on 2011-01-01 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why does stress make you fat? What can you ultimately do about it? Shawn Talbott answered these questions in THE CORTISOL CONNECTION. Cortisol is the body's main stress hormone, prompting our fight or flight mechanism when dealing with a highly stressful situation, like being chased by a lion. However, the human body was made to deal with short bursts of stress (like being chased by a lion), not prolonged, continuous levels of stress (like mortgage payments, project deadlines, and traffic jams). This kind of stress causes the body's cortisol levels to rise, and scientific research has shown that high cortisol levels are associated with obesity, diabetes, fatigue, and even Alzheimer's disease. This new edition describes the results of the latest research about the connection between cortisol and HSD, and cortisol and testosterone. If we keep cortisol and HSD and testosterone within normal ranges, we're able to maximize the metabolic effect of diet and exercise regimen – and improve weight loss. In the first edition, Talbott introduced his SENSE program, that teaches participants how to manage stress and reduce cortisol levels. The program has been refined in the second edition with the help of the new research and the results of Talbott's test of the SENSE program over the past 5 years – he know it works. For the past 5 years, he has been actively researching (and refining and tweaking) this popular program to make it more and more effective in helping people to lose weight. SENSE is a program that combines Stress management, Exercise, Nutrition, Supplementation, and Evaluation into a comprehensive and highly effective (yet easy to follow) program that delivers results. During these 5 years, Talbott has combined different dietary approaches with varied exercise regimens and myriad supplement combinations – until finding just the right combination that works best for the majority of people. This edition contains 25% new material and a revised program to help everyone manage cortisol, stress, and their weight.
Download or read book Evidence Based Medical Consultation E Book written by Daniel Steinberg and published by Elsevier Health Sciences. This book was released on 2007-10-30 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical consultation is an integral part of the job description for many internal medicine specialists who practice in an inpatient setting. This concise, pocket-sized handbook helps you to provide timely and effective, evidence-based consultations for a full range of commonly encountered clinical situations. Each chapter provides evidence-based answers to common medical consultation questions, giving you the practical guidance you need to successfully manage hospitalized patients. A practical organization expedites access to the most relevant health concerns for every type of hospitalized patient. 20-25 clinical questions for each patient type, followed by brief, evidence-based answers, address the most common clinical scenarios requiring medical consultation. A thorough and systematic search of current literature ensures that each clinical recommendation is based on the best available evidence.
Download or read book MCQs for MRCOG Part 1 written by Richard de Courcy-Wheeler and published by CRC Press. This book was released on 2003-09-26 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes MCQs in the basic sciences that underpin the study of obstetrics and gynaecology, as is examined in Part 1 of the membership examination. Following the syllabus recommended by the RCOG, the questions are arranged in papers of 60 questions, each question having 5 stems with True/False answer options. Full answers with explanatory
Download or read book Advanced Practice in Endocrinology Nursing written by Sofia Llahana and published by Springer. This book was released on 2019-02-26 with total page 1337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society of Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.
Download or read book Anxiety and Anxiolytic Drugs written by Florian Holsboer and published by Springer Science & Business Media. This book was released on 2005-06-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.
Download or read book Dyadic Coping A Collection of Recent Studies written by Guy Bodenmann and published by Frontiers Media SA. This book was released on 2019-09-25 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dyadic coping is a concept that has reached increased attention in psychological science within the last 20 years. Dyadic coping conceptualizes the way couples cope with stress together in sharing appraisals of demands, planning together how to deal with the stressors and engage in supportive or joint dyadic coping. Among the different theories of dyadic coping, the Systemic Transactional Model (STM; Bodenmann, 1995, 1997, 2005) has been applied to many studies on couples’ coping with stress. While a recent meta-analysis shows that dyadiccoping is a robust and consistent predictor of relationship satisfaction and couple’s functioning in community samples, some studies also reveal the significance of dyadic coping in dealing with psychological disorders (e.g., depression, anxiety) or severe illness (e.g., cancer, diabetes, COPD, etc.). Researchers all over the world build their research on this or other concepts of dyadic coping and many typically use the Dyadic Coping Inventory (DCI) for assessing dyadic coping. So far, research on dyadic coping has been systematically presented in two books, one written by Revenson, Kayser, & Bodenmann in 2005, focussing on emerging perspectives on couples’ coping, the other by Falconier, Randall, & Bodenmann more recently in 2016, addressing intercultural aspects of dyadic coping in African, American, Asian and European couples. This eBook gives an insight into recent dyadic coping research in different areas and countries.
Download or read book Handbook of Neuroendocrinology written by George Fink and published by Academic Press. This book was released on 2012 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
