Download or read book Adaptive Treatment Strategies in Practice Planning Trials and Analyzing Data for Personalized Medicine written by Michael R. Kosorok and published by SIAM. This book was released on 2015-12-08 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine.? The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficient heuristic and technical detail so that less quantitative readers can understand the broad principles underlying the approaches. At the same time, more quantitative readers can implement these practices. This book provides the most up-to-date summary of the current state of the statistical research in personalized medicine; contains chapters by leaders in the area from both the statistics and computer sciences fields; and also contains a range of practical advice, introductory and expository materials, and case studies.?

Download or read book Learning to Become Rational written by Markus Zenner and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. 1 Rational Expectations and Learning to Become Rational A characteristic feature of dynamic economic models is that, if future states of the economy are uncertain, the expectations of agents mat ter. Producers have to decide today which amount of a good they will produce not knowing what demand will be tomorrow. Consumers have to decide what they spend for consumption today not knowing what prices will prevail tomorrow. Adopting the neo-classical point of view that economic agents are 'rational' in the sense that they behave in their own best interest given their expectations about future states of the ecomomy it is usually assumed that agents are Bayesian deci sion makers. But, as LUCAS points out, there remains an element of indeterminacy: Unfortunately, the general hypothesis that economic agents are Bayesian decision makers has, in many applications, lit tle empirical content: without some way of infering what an agent's subjective view of the future is, this hypothesis is of no help in understanding his behavior. Even psychotic behavior can be (and today, is) understood as "rational", given a sufficiently abnormal view of relevant probabili ties. To practice economics, we need some way (short of psychoanalysis, one hopes) of understanding which decision problem agents are solving. (LucAs (1977, p. 15)) 2 CHAPTER 1. INTRODUCTION 1. 1.

Download or read book Targeted Learning written by Mark J. van der Laan and published by Springer Science & Business Media. This book was released on 2011-06-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

Download or read book Neural Engineering Techniques for Autism Spectrum Disorder written by Ayman S. El-Baz and published by Academic Press. This book was released on 2021-07-16 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Engineering for Autism Spectrum Disorder, Volume One: Imaging and Signal Analysis Techniques presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, social behaviors and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals are presented for detection and estimation of the degree of ASD. - Presents applications of Neural Engineering and other Machine Learning techniques for the diagnosis of Autism Spectrum Disorder (ASD) - Includes in-depth technical coverage of imaging and signal analysis techniques, including coverage of functional MRI, neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, and neuroanatomy of autism - Covers Signal Analysis for the detection and estimation of Autism Spectrum Disorder (ASD), including brain signal analysis, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals for ASD - Written to help engineers, computer scientists, researchers and clinicians understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)

Download or read book Machine Learning Toolbox for Social Scientists written by Yigit Aydede and published by CRC Press. This book was released on 2023-09-22 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine Learning Toolbox for Social Scientists covers predictive methods with complementary statistical "tools" that make it mostly self-contained. The inferential statistics is the traditional framework for most data analytics courses in social science and business fields, especially in Economics and Finance. The new organization that this book offers goes beyond standard machine learning code applications, providing intuitive backgrounds for new predictive methods that social science and business students can follow. The book also adds many other modern statistical tools complementary to predictive methods that cannot be easily found in "econometrics" textbooks: nonparametric methods, data exploration with predictive models, penalized regressions, model selection with sparsity, dimension reduction methods, nonparametric time-series predictions, graphical network analysis, algorithmic optimization methods, classification with imbalanced data, and many others. This book is targeted at students and researchers who have no advanced statistical background, but instead coming from the tradition of "inferential statistics". The modern statistical methods the book provides allows it to be effectively used in teaching in the social science and business fields. Key Features: The book is structured for those who have been trained in a traditional statistics curriculum. There is one long initial section that covers the differences in "estimation" and "prediction" for people trained for causal analysis. The book develops a background framework for Machine learning applications from Nonparametric methods. SVM and NN simple enough without too much detail. It’s self-sufficient. Nonparametric time-series predictions are new and covered in a separate section. Additional sections are added: Penalized Regressions, Dimension Reduction Methods, and Graphical Methods have been increasing in their popularity in social sciences.

Download or read book Partially Linear Models written by Wolfgang Härdle and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last ten years, there has been increasing interest and activity in the general area of partially linear regression smoothing in statistics. Many methods and techniques have been proposed and studied. This monograph hopes to bring an up-to-date presentation of the state of the art of partially linear regression techniques. The emphasis is on methodologies rather than on the theory, with a particular focus on applications of partially linear regression techniques to various statistical problems. These problems include least squares regression, asymptotically efficient estimation, bootstrap resampling, censored data analysis, linear measurement error models, nonlinear measurement models, nonlinear and nonparametric time series models.

Download or read book Robust Methods and Asymptotic Theory in Nonlinear Econometrics written by H. J. Bierens and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Lecture Note deals with asymptotic properties, i.e. weak and strong consistency and asymptotic normality, of parameter estimators of nonlinear regression models and nonlinear structural equations under various assumptions on the distribution of the data. The estimation methods involved are nonlinear least squares estimation (NLLSE), nonlinear robust M-estimation (NLRME) and non linear weighted robust M-estimation (NLWRME) for the regression case and nonlinear two-stage least squares estimation (NL2SLSE) and a new method called minimum information estimation (MIE) for the case of structural equations. The asymptotic properties of the NLLSE and the two robust M-estimation methods are derived from further elaborations of results of Jennrich. Special attention is payed to the comparison of the asymptotic efficiency of NLLSE and NLRME. It is shown that if the tails of the error distribution are fatter than those of the normal distribution NLRME is more efficient than NLLSE. The NLWRME method is appropriate if the distributions of both the errors and the regressors have fat tails. This study also improves and extends the NL2SLSE theory of Amemiya. The method involved is a variant of the instrumental variables method, requiring at least as many instrumental variables as parameters to be estimated. The new MIE method requires less instrumental variables. Asymptotic normality can be derived by employing only one instrumental variable and consistency can even be proved with out using any instrumental variables at all.

Download or read book Learning and Reasoning in Hybrid Structured Spaces written by P. Morettin and published by IOS Press. This book was released on 2022-04-15 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial intelligence often has to deal with uncertain scenarios, such as a partially observed environment or noisy observations. Traditional probabilistic models, while being very principled approaches in these contexts, are incapable of dealing with both algebraic and logical constraints. Existing hybrid continuous/discrete models are typically limited in expressivity, or do not offer any guarantee on the approximation errors. This book, Learning and Reasoning in Hybrid Structured Spaces, discusses a recent and general formalism called Weighted Model Integration (WMI), which enables probabilistic modeling and inference in hybrid structured domains. WMI-based inference algorithms differ with respect to most alternatives in that probabilities are computed inside a structured support involving both logical and algebraic relationships between variables. While the research in this area is at an early stage, we are witnessing an increasing interest in the study and development of scalable inference procedures and effective learning algorithms in this setting. This book details some of the most impactful contributions in context of WMI-based inference in the last 5 years. Moreover, by providing a gentle introduction to the main concepts related to WMI, the book can be useful for both theoretical researchers and practitioners alike.

Download or read book Applied Mechanics Reviews written by and published by . This book was released on 1987 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Applied Regression Analysis in Econometrics written by Howard E. Doran and published by CRC Press. This book was released on 1989-04-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook for a one-semester course for advanced undergraduate and graduate students in economics. Covers regression techniques in the context of single equation econometric models, featuring MINITAB and SHAZAM software examples for attacking real-world problems. Annotation copyright Book News, Inc

Download or read book Hands On Machine Learning with R written by Brad Boehmke and published by CRC Press. This book was released on 2019-11-07 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hands-on Machine Learning with R provides a practical and applied approach to learning and developing intuition into today’s most popular machine learning methods. This book serves as a practitioner’s guide to the machine learning process and is meant to help the reader learn to apply the machine learning stack within R, which includes using various R packages such as glmnet, h2o, ranger, xgboost, keras, and others to effectively model and gain insight from their data. The book favors a hands-on approach, providing an intuitive understanding of machine learning concepts through concrete examples and just a little bit of theory. Throughout this book, the reader will be exposed to the entire machine learning process including feature engineering, resampling, hyperparameter tuning, model evaluation, and interpretation. The reader will be exposed to powerful algorithms such as regularized regression, random forests, gradient boosting machines, deep learning, generalized low rank models, and more! By favoring a hands-on approach and using real word data, the reader will gain an intuitive understanding of the architectures and engines that drive these algorithms and packages, understand when and how to tune the various hyperparameters, and be able to interpret model results. By the end of this book, the reader should have a firm grasp of R’s machine learning stack and be able to implement a systematic approach for producing high quality modeling results. Features: · Offers a practical and applied introduction to the most popular machine learning methods. · Topics covered include feature engineering, resampling, deep learning and more. · Uses a hands-on approach and real world data.

Download or read book Fundamentals of Supervised Machine Learning written by Giovanni Cerulli and published by Springer Nature. This book was released on 2023-11-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the fundamental theoretical notions of supervised machine learning along with a wide range of applications using Python, R, and Stata. It provides a balance between theory and applications and fosters an understanding and awareness of the availability of machine learning methods over different software platforms. After introducing the machine learning basics, the focus turns to a broad spectrum of topics: model selection and regularization, discriminant analysis, nearest neighbors, support vector machines, tree modeling, artificial neural networks, deep learning, and sentiment analysis. Each chapter is self-contained and comprises an initial theoretical part, where the basics of the methodologies are explained, followed by an applicative part, where the methods are applied to real-world datasets. Numerous examples are included and, for ease of reproducibility, the Python, R, and Stata codes used in the text, along with the related datasets, are available online. The intended audience is PhD students, researchers and practitioners from various disciplines, including economics and other social sciences, medicine and epidemiology, who have a good understanding of basic statistics and a working knowledge of statistical software, and who want to apply machine learning methods in their work.

Download or read book The Inflation Targeting Debate written by Ben S. Bernanke and published by University of Chicago Press. This book was released on 2007-11-01 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past fifteen years, a significant number of industrialized and middle-income countries have adopted inflation targeting as a framework for monetary policymaking. As the name suggests, in such inflation-targeting regimes, the central bank is responsible for achieving a publicly announced target for the inflation rate. While the objective of controlling inflation enjoys wide support among both academic experts and policymakers, and while the countries that have followed this model have generally experienced good macroeconomic outcomes, many important questions about inflation targeting remain. In Inflation Targeting, a distinguished group of contributors explores the many underexamined dimensions of inflation targeting—its potential, its successes, and its limitations—from both a theoretical and an empirical standpoint, and for both developed and emerging economies. The volume opens with a discussion of the optimal formulation of inflation-targeting policy and continues with a debate about the desirability of such a model for the United States. The concluding chapters discuss the special problems of inflation targeting in emerging markets, including the Czech Republic, Poland, and Hungary.

Download or read book Dynamic Linear Models with R written by Giovanni Petris and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: State space models have gained tremendous popularity in recent years in as disparate fields as engineering, economics, genetics and ecology. After a detailed introduction to general state space models, this book focuses on dynamic linear models, emphasizing their Bayesian analysis. Whenever possible it is shown how to compute estimates and forecasts in closed form; for more complex models, simulation techniques are used. A final chapter covers modern sequential Monte Carlo algorithms. The book illustrates all the fundamental steps needed to use dynamic linear models in practice, using R. Many detailed examples based on real data sets are provided to show how to set up a specific model, estimate its parameters, and use it for forecasting. All the code used in the book is available online. No prior knowledge of Bayesian statistics or time series analysis is required, although familiarity with basic statistics and R is assumed.

Download or read book Resources in Education written by and published by . This book was released on 1998 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Deterministic and Stochastic Approaches in Computer Modeling and Simulation written by Romansky, Radi Petrov and published by IGI Global. This book was released on 2023-10-09 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the field of computer modeling and simulation, academic scholars face a pressing challenge—how to navigate the complex landscape of both deterministic and stochastic approaches to modeling. This multifaceted arena demands a unified organizational framework, a comprehensive guide that can seamlessly bridge the gap between theory and practical application. Without such a resource, scholars may struggle to harness the full potential of computer modeling, leaving critical questions unanswered and innovative solutions undiscovered. Deterministic and Stochastic Approaches in Computer Modeling and Simulation serves as the definitive solution to the complex problem scholars encounter. By presenting a comprehensive and unified organizational approach, this book empowers academics to conquer the challenges of computer modeling with confidence. It not only provides a classification of modeling methods but also offers a formalized, step-by-step approach to conducting model investigations, starting from defining objectives to analyzing experimental results. For academic scholars seeking a holistic understanding of computer modeling, this book is the ultimate solution. It caters to the diverse needs of scholars by addressing both deterministic and stochastic approaches. Through its structured chapters, it guides readers from the very basics of computer systems investigation to advanced topics like stochastic analytical modeling and statistical modeling.

Download or read book Control of Complex Systems written by Karl J. Aström and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world of artificial systems is reaching complexity levels that es cape human understanding. Surface traffic, electricity distribution, air planes, mobile communications, etc. , are examples that demonstrate that we are running into problems that are beyond classical scientific or engi neering knowledge. There is an ongoing world-wide effort to understand these systems and develop models that can capture its behavior. The reason for this work is clear, if our lack of understanding deepens, we will lose our capability to control these systems and make they behave as we want. Researchers from many different fields are trying to understand and develop theories for complex man-made systems. This book presents re search from the perspective of control and systems theory. The book has grown out of activities in the research program Control of Complex Systems (COSY). The program has been sponsored by the Eu ropean Science Foundation (ESF) which for 25 years has been one of the leading players in stimulating scientific research. ESF is a European asso ciation of more than 60 leading national science agencies spanning more than 20 countries. ESF covers has standing committees in Medical Sci ences, Life and Environmental Sciences, Physical and Engineering Sci ences, Humanities and Social Sciences. The COSY program was ESF's first activity in the Engineering Sciences. The program run for a period of five years starting January 1995.