Download or read book Concurrent Diffuse Optical Tomography Spectroscopy and Magnetic Resonance Imaging of Breast Cancer written by Vasilis Ntziachristos and published by . This book was released on 2000 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Concurrent MR NIR Imaging for Breast Cancer Diagnosis written by Birsen Yazici and published by . This book was released on 2007 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary objective of this research program is to investigate concurrent near infrared (NIR) optical and magnetic resonance (MR) imaging for breast cancer diagnosis. The NIR diffuse optical imaging offers novel criteria for cancer differentiation with the ability to measure (in vivo) oxygenation and vascularization state, the uptake and release of contrast agents and chromophore concentrations with high sensitivity. However, NIR diffuse optical tomography is inherently a low spatial resolution imaging modality due to diffuse nature of light photons. Alternatively, MRI provides high spatial resolution with excellent tissue discrimination, but has limited ability to monitor hemoglobin dynamics and other contrast mechanisms that optical imaging provides. Therefore, concurrent MRI-NIR optical imaging brings together the most advantageous aspects of the two imaging modalities for breast cancer diagnosis.
Download or read book A Multimodal Breast Cancer Imaging System Using Coregistered Dynamic Diffuse Optical Tomography and Digital Breast Tomosynthesis written by Bernhard B. Zimmermann and published by . This book was released on 2017 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) is an emerging noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (1 Hz+) image acquisition rate to enable tracking of hemodynamic changes induced by the mammographic breast compression. The most significant advance enabling fast acquisition was the design and construction of a direct analog-to-digital conversion frequency-domain near-infrared spectroscopy (FD-NIRS) component. It achieves simultaneous dual wavelength operation at 685 nm and 830 nm by concurrent 67.5 MHz and 75 MHz frequency modulation of each laser source, respectively, followed by digitization using a high-speed analog to digital converter and real-time hybrid FPGA-assisted demodulation by discrete Fourier transform (DFT). The overall DOT system integrates 96 CW-NIRS and 24 FD-NIRS source locations, as well as 32 CW-NIRS and 20 FD-NIRS detection locations into low-profile plates that mate to the DBT compression paddle and x-ray detector cover, respectively. The plates and the embedded optical fibers are made of plastic to minimize x-ray absorption and thus allow true simultaneous acquisition of the DBT image. We first characterize each major system component individually, and then demonstrate overall performance using static and dynamic tissue-like phantoms, as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.
Download or read book Alternative Breast Imaging written by Keith D. Paulsen and published by Springer Science & Business Media. This book was released on 2005 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical imaging has been transformed over the past 30 years by the advent of computerized tomography (CT), magnetic resonance imaging (MRI), and various advances in x-ray and ultrasonic techniques. An enabling force behind this progress has been the (so far) exponentially increasing power of computers, which has made it practical to explore fundamentally new approaches. In particular, what our group terms "model-based" modalities-which produce tissue property images from data using nonlinear, iterative numerical modeling techniques-have become increasingly feasible. Alternative Breast Imaging: Four Model-Based Approaches explores our research on four such modalities, particularly with regard to imaging of the breast: (1) MR elastography (MRE), (2) electrical impedance spectroscopy (EIS), (3) microwave imaging spectroscopy (MIS), and (4) near infrared spectroscopic imaging (NIS). Chapter 1 introduces the present state of breast imaging and discusses how our alternative modalities can contribute to the field. Chapter 2 looks at the computational common ground shared by all four modalities. Chapters 2 through 10 are devoted to the four modalities, with each modality being discussed first in a theory chapter and then in an implementation-and-results chapter. The eleventh and final chapter discusses statistical methods for image analysis in the context of these four alternative imaging modalities. Imaging for the detection of breast cancer is a particularly interesting and relevant application of the four imaging modalities discussed in this book. Breast cancer is an extremely common health problem for women; the National Cancer Institute estimates that one in eight US women will develop breast cancer at least once in her lifetime. Yet the efficacy of the standard (and notoriously uncomfortable) early-detection test, the x-ray mammogram, has been disputed of late, especially for younger women. Conditions are thus ripe for the development of affordable techniques that replace or complement mammography. The breast is both anatomically accessible and small enough that the computing power required to model it, is affordable. Alternative Breast Imaging: Four Model-Based Approaches is structured to meet the needs of a professional audience composed of researchers and practitioners in industry. This book is also suitable for graduate-level students in computer science, electrical engineering and biomedical imaging.
Download or read book Translational Multimodality Optical Imaging written by Fred S. Azar and published by Artech House. This book was released on 2008 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supported with 119 illustrations, this milestone work discusses key optical imaging techniques in self-contained chapters; describes the integration of optical imaging techniques with other modalities like MRI, X-ray imaging, and PET imaging; provides a software platform for multimodal integration; presents cutting-edge computational and data processing techniques that ensure rapid, cost-effective, and precise quantification and characterization of the clinical data; covers advances in photodynamic therapy and molecular imaging, and reviews key clinical studies in optical imaging along with regulatory and business issues.
Download or read book Compact and Robust Ultrasound guided Diffuse Optical Tomography for Breast Imaging System and Algorithm Developments written by Hamed Vavadi and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, breast cancer is the most common cancer among women worldwide, claiming lives of hundreds of thousands of women each year. Mammography, ultrasound (US) and magnetic resonance imaging (MRI) are widely used to detect and diagnose breast lesions and each of them have some disadvantages which motivates researchers to find a new and high sensitive imaging method. Diffuse optical tomography (DOT) is a noninvasive functional imaging modality that utilizes near-infrared (NIR) light to probe tissue optical properties. Minimal light absorption in the NIR spectrum allows for several centimeters of light penetration in soft tissue. NIR is sensitive to hemoglobin which is directly related to tumor angiogenesis. If multiple wavelengths are used, it can probe tumor oxygen saturation. However, DOT has drawbacks on location uncertainty and low light quantification accuracy due to tissue scattering of NIR light. Ultrasound (US)-guided Diffuse Optical Tomography has overcome these problems. The overall objective of my research is to move US-guided DOT one step closer from a research imaging modality to a commercial prototype for future wide use in clinics. To achieve this goal, I have overcome several challenges in both imaging hardware and software. In this Dissertation, I will discuss the progress we have made on development of two generations of US-guided DOT systems along with the software improvements. The developed systems have been improved in terms of robustness, stability, clinical safety and standards and user friendliness. In terms of software and algorithm development, automated methods for data selection, outlier removal and reference and perturbation filtering are presented. These methods have improved the robustness of the technique and increased speed of image formation by eliminating the need for an expert to perform data preprocessing and data selection. Phantom and clinical experimental results will be demonstrated to evaluate the performance of the developed systems and algorithms.
Download or read book Characterization of Breast Cancer Using an Endogenous Tumor Spectral Marker written by Shanshan Xu and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging has enjoyed a large following in cancer in general and breast cancer in particular (i.e., diffuse optical imaging, DOI and diffuse optical tomography, DOT). Optical imaging biomarkers emerge from modeling specific near-infrared (NIR) absorption signatures that are sensitive indicators of important molecular concentration and disposition. We have developed Diffuse Optical Spectroscopic Imaging (DOSI) by increasing spectral information content for the purpose of increasing access to molecular targets and states. Malignancy-specific optical imaging biomarkers may be important because the above-mentioned changes in tumor hemoglobin, water and lipids are a necessary but not a sufficient condition to classify therapeutic response. We note that for all therapeutic imaging assessments (i.e., mammography, ultrasound, MRI, PET) that the same case is true for their respective contrast mechanisms. By a novel spectral analysis method, we have discovered the presence of absorption signatures that are unique to malignant lesions. A reproducible absorption spectrum (Specific Tumor Component, STC) with several distinct spectral features emerges when compared with the normal absorption spectra (the flat line near zero) measured from the normal tissue of these subjects plus an additional 21 patients without any evidence of malignancy. These data demonstrate the existence of a spectral signature that acts as an optical biomarker for malignancy. We are not aware of any other such biomarker that combines high specificity with ease of application in the imaging field. This DOSI-measured malignancy-specific biomarker STC provides an ideal non-invasive surrogate biomarker for breast lesion detection and differentiation. Although STC offers both spectroscopic and quantitative information for breast malignancy, this method relies on complicated data analysis and lacks of standardization. Thus, it is still far from a clinical reality. In order to carry out a quantitative assessment of its potential in becoming a standardized clinical detection modality for tumor detection/prediction/prognosis, the longitudinal temporal stability of signatures must be evaluated and the detection limit must be set. The overall clinical goal is to evaluate the possibilities for STC detection method to become a future clinical practice. Building the linkage between pre-existing detection modalities (pathological biomarkers, DCE-MRI) and novel spectral signature detection is essential. The medical interpretation of the findings from conventional tools will shed light on the understanding and further employment of STC biomarker. Similarly, STC detection with a high diagnosis sensitivity and specificity could be very well an adjunct method for traditional modalities.
Download or read book Biomedical Optical Imaging written by James G. Fujimoto and published by Oxford University Press. This book was released on 2009-04-22 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
Download or read book Diagnostic Breast Imaging written by Sylvia H. Heywang-Köbrunner and published by Thieme. This book was released on 2014-01-15 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encompassing the entire spectrum of breast imaging and diagnostics, this acclaimed text provides a systematic and pragmatic guide for all clinicians involved in diagnosing breast disease. The new third edition has been fully updated to include advances in mammography, ultrasound, breast MRI, percutaneous interventions, and emerging technologies, with pros and cons and evidence-based approaches throughout. Special features of the third edition: Coverage of the field, with comprehensive sections on examination procedures and technical requirements; histologic, clinical, and radiologic appearance of a wide range of breast pathologies; results of international screening studies; and much more Nearly 1,200 clear radiographic images showing normal findings, benign and malignant disorders, and post-traumatic, post-surgical, and post-therapeutic changes to the breast Innovations in digital mammography, tomosynthesis, and computer assisted detection (CAD); new chapters on imaging of implants, lesions of uncertain malignant potential, developing technologies; and more A systematic, highly reproducible methodology for detection, diagnosis, and assessment of findings Easy-to-follow flowcharts for the diagnostic work-up of both typical and atypical cases Written by world-renowned authorities with decades of clinical experience, this book provides a brilliant orientation to the multimodality diagnostic approach and therapeutic significance of breast imaging findings. It is an essential reference and board review for radiologists, residents and fellows, gynecologists, oncologists, surgeons, technologists, and any other interdisciplinary specialist working to improve outcomes in breast disease.
Download or read book Advances in Optical Imaging for Clinical Medicine written by Nicusor Iftimia and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Download or read book Principles of Diffuse Light Propagation written by Jorge Ripoll Lorenzo and published by World Scientific. This book was released on 2012 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Diffuse Light Propagation: Light Propagation in Tissues with Applications in Biology and Medicine.
Download or read book Emerging Imaging Technologies in Medicine written by Mark A. Anastasio and published by CRC Press. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the discovery of x-rays in 1895 through the emergence of computed tomography (CT) in the 1970s and magnetic resonance imaging (MRI) in the 1980s, non-invasive imaging has revolutionized the practice of medicine. While these technologies have thoroughly penetrated clinical practice, scientists continue to develop novel approaches that promise to push imaging into entirely new clinical realms, while addressing the issues of dose, sensitivity, or specificity that limit existing imaging approaches. Emerging Imaging Technologies in Medicine surveys a number of emerging technologies that have the promise to find routine clinical use in the near- (less than five years), mid- (five to ten years) and long-term (more than ten years) time frames. Each chapter provides a detailed discussion of the associated physics and technology, and addresses improvements in terms of dose, sensitivity, and specificity, which are limitations of current imaging approaches. In particular, the book focuses on modalities with clinical potential rather than those likely to have an impact mainly in preclinical animal imaging. The last ten years have been a period of fervent creativity and progress in imaging technology, with improvements in computational power, nanofabrication, and laser and detector technology leading to major new developments in phase-contrast imaging, photoacoustic imaging, and optical imaging.
Download or read book Optical Spectroscopy Guided by Structural and Functional MRI for Breast Cancer Imaging written by Colin Carpenter and published by . This book was released on 2009 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multi spectral and Fluorescence Diffuse Optical Tomography of Breast Cancer written by Alper Corlu and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diagnostic Breast Imaging written by Sylvia Helen Heywang-Koebrunner and published by Thieme. This book was released on 2011-01-01 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and systematic, this important new edition covers all imaging modalities for diagnosing breast disorders. You will find expert guidelines on the role of mammography, high-resolution ultrasound, MRI and percutaneous biopsy to achieve your diagnostic goals, and benefit from a practical review of the physics, histology, pathology, and quality control needed by those who perform breast imaging procedures. New key features: PET and novel modalities, Lymph nodes (sentinel node), Staging breast cancerNew ACR classifications, Doppler ultrasound, Stereotactic ultrasound biopsy, Full-breast digital imaging and computer-aided diagnosis, Mammotome, Updated references
Download or read book Breast MRI Interpretation written by Gillian M. Newstead and published by Thieme. This book was released on 2021-01-06 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: State-of-the-art resource details effective breast MRI techniques for improved screening and diagnosis Magnetic resonance imaging (MRI) of the breast has evolved into an important breast cancer screening tool and major advance in women's health. Breast MRI is currently the most sensitive detection technique for both non-invasive and invasive cancers and follow-up in women with a new breast cancer diagnosis. It is increasingly becoming the go-to imaging method for screening women at high and intermediate risk of breast cancer and those with dense breast tissue on mammography. Yet despite its reliability and growing use, many radiologists lack the expertise to accurately perform breast MR image interpretation. Breast MRI Interpretation: Text and Case Analysis for Screening and Diagnosis by Gillian M. Newstead reflects insights and expertise from one of the leading authorities on breast imaging. The book is a highly practical reference on evaluation and interpretation of breast MR imaging, with discussion of the modality as a screening and diagnostic tool. Topics include image acquisition and interpretation, clinical implementation, managing findings, and overcoming problems. Key Highlights About 3,000 illustrations from the University of Chicago including single selected images, side-by-side images at different time points and acquisition parameters, and 3-D images enhance understanding of breast imaging Discussion of advanced acquisition techniques and future potential applications including non-contrast imaging, quantitative dynamic imaging, and artificial intelligence using advanced computer analytic methods This remarkable resource streamlines the breast MRI process, enabling radiologists to incorporate this imaging modality into practice, conduct screening and diagnostic exams more efficaciously, and interpret findings accurately.
