Download or read book Comparative Pharmacokinetics written by Jim E. Riviere and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
Download or read book Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs written by Arthur L. Craigmill and published by CRC Press. This book was released on 2018-01-18 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs is a unique compilation of comparative pharmacokinetic data for veterinary therapeutic drugs. The book features an excellent introductory chapter on basic veterinary pharmacokinetics and includes pharmacological data taken from hundreds of primary research references. These data are presented in standardized units and are arranged in conveniently organized tables so that comparisons between data can be made easily. Much of the data is new and was taken from articles in which data was not subjected to pharmacokinetic analysis.
Download or read book Comparative Pharmacokinetics written by Jim E. Riviere and published by Wiley-Blackwell. This book was released on 2011-04-12 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
Download or read book Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials written by Jim E Riviere and published by CRC Press. This book was released on 2018-01-18 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major objective of this handbook is to compile-in tabular form-the pharmacokinetic parameters of antimicrobial drugs used in food animals. This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.S.D.A. and contains significant amounts of previously unavailable information. This updated, one-of-a-kind volume even features additional data on laboratory rodents, dogs, cats, and horses in order to facilitate broader interspecies extrapolations. This easy-to-use reference is timely as well as invaluable to animal scientists, veterinarians, pharmacologists, and toxicologists who work with antimicrobials in chickens, turkeys, dairy and beef cattle, swine, goats, and sheep.
Download or read book Comparative and Veterinary Pharmacology written by Fiona Cunningham and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human–animal bond has evolved and diversi?ed down the ages. Dogs, cats and even horses, have long ful?lled the role of faithful companion and indeed, as exempli?ed by the introduction of seeing and hearing dogs, there may be a critical level of co-dependency between the species. In the twenty-?rst century, the animal types that are kept as pets in many parts of the world are extensive ranging from reptiles through rodents to ruminants and beyond. As would be predicted by the nature of the relationship, the approach to treatment of a companion animal is often closely aligned to that which would have been offered to their owner. However, an increasing awareness of welfare issues, such as the recognition that animals expe- ence pain and the proven bene?ts of disease prevention in intensive farming units, together with the growth in zoos and wildlife parks, has increased the likelihood of food producing and non-domesticated animals receiving medicinal products during their life-time. Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another. The impact of the anatomical, physiological and pathophysiological variability that spans the animal kingdom can often profoundly alter drug response.
Download or read book Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials written by Jim E Riviere and published by CRC Press. This book was released on 2018-01-18 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major objective of this handbook is to compile-in tabular form-the pharmacokinetic parameters of antimicrobial drugs used in food animals. This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.S.D.A. and contains significant amounts of previously unavailable information. This updated, one-of-a-kind volume even features additional data on laboratory rodents, dogs, cats, and horses in order to facilitate broader interspecies extrapolations. This easy-to-use reference is timely as well as invaluable to animal scientists, veterinarians, pharmacologists, and toxicologists who work with antimicrobials in chickens, turkeys, dairy and beef cattle, swine, goats, and sheep.
Download or read book Testosterone written by Susan Nieschlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.
Download or read book CRC Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials written by Jim E. Riviere and published by CRC Press. This book was released on 1991-01-09 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major objective of this handbook is to compile-in tabular form-the pharmacokinetic parameters of antimicrobial drugs used in food animals. This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.S.D.A. and contains significant amounts of previously unavailable information. This updated, one-of-a-kind volume even features additional data on laboratory rodents, dogs, cats, and horses in order to facilitate broader interspecies extrapolations. This easy-to-use reference is timely as well as invaluable to animal scientists, veterinarians, pharmacologists, and toxicologists who work with antimicrobials in chickens, turkeys, dairy and beef cattle, swine, goats, and sheep.
Download or read book Comparative Pharmacokinetics and Pharmacodynamics of Paclitaxel Formulations written by Gerald J. Jr Fetterly and published by . This book was released on 2000 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants written by Stephen F. Sundlof and published by CRC Press. This book was released on 1995-11-03 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume. For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.
Download or read book Comparative Pharmacokinetics in Non human Primates written by E. Doyle and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fluoride in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2007-01-22 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.
Download or read book The Comparative Pharmacokinetics of Selected Brominated and Chlorinated Trihalomethanes After Singel Peroral Dose in the Rat written by Thomas J. Brown and published by . This book was released on 1980 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Pharmacokinetics of Methadone in Neonatal Rats Following Intragastric Intubation Using Various Nutrient Vehicles written by Haijuan Yang and published by . This book was released on 1995 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetic Pharmacodynamic Model of Drugs and Their Pharmacokinetic Differences between Normal and Disease States written by Zipeng Gong and published by Frontiers Media SA. This book was released on 2024-08-14 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the main frame of the above research topic, 16 contributions have been published including but not limited to the comparative pharmacokinetics between normal and disease status, the changes in the expression and function of drug-metabolizing enzymes and drug transporters in disease status and their related regulatory mechanisms, ADME/toxicity of drugs as well as their regulation, drug-drug interactions mediated by nuclear receptors, transporters and metabolic enzymes based on the methods and techniques of pharmacokinetics, transcriptomics, and metabolomics. However , the pharmacokinetic study is not only crucial in the development of new drugs, but also the study of pharmacokinetic-pharmacokinetic(PK-PD) model plays an important role in the process of new drug development. PK-PD model can reveal the internal relationship between drug concentration and effect, help to understand the dynamic characteristics of the drug action site in vivo and deduce the action site producing effect and drug concentration at the action site, which enables researchers to recognize the comprehensive characteristics of drug PK and PD processes in vivo. However, preclinical pharmacokinetic data are mainly derived from healthy animals, which is unreasonable. On the one hand, patients are the final consumers of drugs because drugs are mainly used to treat patients with diseases. On the other hand, whether the body is in a pathological state and the severity of the disease have different effects on the ADMEof drugs, which is closely related to whether the clinical drug is safe and effective. Therefore, studying the pharmacokinetics and PK-PD model in disease states is more meaningful and clinically relevant.
Download or read book Comparative Pharmacokinetic Approaches to Estimating the Pharmacokinetics of Water Medications in Swine written by Sharon E. Mason and published by . This book was released on 2010 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: pharmacokinetics, swine, PBPK, population pharmacokinetics, water medication.
Download or read book Rational Therapeutics for Infants and Children written by Institute of Medicine and published by National Academies Press. This book was released on 2000-04-07 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.
