Download or read book Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection By products written by Yahya Kargalioglu and published by . This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Cytotoxicity Genotoxicity and DNA Repair Kinetics of Drinking Water Disinfection By products written by Justin A. Pals and published by . This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Mammalian Genotoxicity and Acute Cytotoxicity of Emerging Nitrogenous Drinking Water Disinfection By products written by Jessica Monique Wallace and published by . This book was released on 2009 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Comparative Toxicity and Toxicogenomic Analyses of Nitrogenous Drinking Water Disinfection By Products written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Genotoxicity Assessment of DBPs in Drinking Water written by R. A. Minear and published by Amer Water Works Assn. This book was released on 2003 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research resulted in a quantitative analysis of the relative cytotoxicity and genotoxicity of the chlorinated and brominated disinfection by-products (DBPs) as well as DBP mixtures isolated from the disinfection of a well-characterized natural organic matter. A principal component of this study was the development of novel microplate-based cytotoxicity and genotoxicity methods for "Salmonella typhimurium" and mammalian cell assay systems. These assays allowed the analytical biology to be integrated with the analytical chemistry portion of this work -- foreword.
Download or read book Cytotoxicity Mutagenicity and Genotoxicity of Emerging Drinking Water Disinfection Byproducts written by Claire Frances McGuigan and published by . This book was released on 2014 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drinking water disinfection byproducts (DBPs) are formed unintentionally when organic matter in raw water reacts with disinfectants used to kill pathogens. Epidemiological studies have shown that an increased risk of bladder cancer is associated with consumption of chlorinated water, but little is known of the toxicity of many DBPs. This thesis examined the cytotoxic, mutagenic, and genotoxic properties of phenazine and halobenzoquinone (HBQ) DBPs in human cells. Cytotoxicity was examined with an impedance-based real-time cell analysis (RTCA) instrument, mutagenicity was examined with the Ames test (bacterial reverse mutation assay), and genotoxicity was examined with the alkaline comet assay. Phenazine showed differential toxicity in human cell lines, producing an antiproliferative cytotoxic effect in HepG2 cells but a genotoxic effect in T24 cells. The BJ/XPA RTCA in vitro assay was developed and validated to provide high-throughput screening of cytotoxicity and nucleotide excision repair (NER)-mediated DNA damage simultaneously. Selected HBQs were examined with the BJ/XPA assay; the position, type, and number of substitutions on the benzoquinone ring affected cytotoxicity. All tested HBQs caused substitution mutations in the Ames test under at least some of the experimental conditions. 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ) was the most potent HBQ compound tested, demonstrating cytotoxicity, mutagenicity, and genotoxicity. Follow-up experiments indicated that N-acetylcysteine, a ROS scavenger, reduced cytotoxicity and genotoxicity when added concomitantly with DCMBQ. Both the cytotoxic and genotoxic effects of DCMBQ appeared to be mediated, at least in part, by the formation of reactive oxygen species. DCMBQ-induced genotoxicity appeared to be refractory to repair and may involve formation of complex oxidatively generated clustered lesions. Additional in vitro and in vivo studies are required for HBQ DBPs, particularly DCMBQ, to further determine their toxic effects. In summary, the original contributions of this research are: 1) the development of a novel in vitro method to simultaneously assess cytotoxicity and NER-mediated genotoxicity; 2) new information on the cytotoxic, mutagenic, and genotoxic properties of halobenzoquinone DBPs; 3) discovery of cytotoxic and genotoxic properties of phenazine; and 4) evidence of potential toxic mechanisms of action of DCMBQ.
Download or read book Mammalian Cell Cytotoxicity and Genotoxicity of Disinfection By products written by and published by American Water Works Association. This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project represents basic research to generate quantitative, comparative in vitro mammalian cell toxicity data of emerging DBPs and related compounds. It is the first systematic cytotoxicity and genotoxicity analysis of its kind --
Download or read book Disinfection By products in Drinking Water written by Tanju Karanfil and published by Academic. This book was released on 2008 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of chapters on the latest international research findings, including emerging issues and state-of-the-art studies, related to disinfection by-product formation and control in drinking waters and treated wastewaters.
Download or read book Drinking Water Disinfection By products Toxicological Impacts and Biological Mechanisms Induced by Individual Compounds Or as Complex Mixtures written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disinfection By products in Drinking Water written by M.N.V. Prasad and published by Butterworth-Heinemann. This book was released on 2020-02-18 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection Byproducts in Drinking Water: Detection and Treatment presents cutting-edge research on how to understand the procedures, processes and considerations for detecting and treating disinfection by-products from drinking water, swimming pool water, and wastewater. The book begins with an overview of the different groups of Disinfection Byproducts (DBPs), such as: Trihalomethanes (THM), Halo acetic acids, and Haloacetonitrile (HAN). This coverage is quickly followed by a clear and rigorous exposition of the latest methods and technologies for the characterization, occurrence, formation, transformation and removal of DBPs in drinking water. Other chapters focus on ultraviolet-visible spectroscopy, electron spin resonance, and gas chromatography-mass spectrometry. Researchers will find a valuable resource to a breath of topics for DBP detection and treatment, including various recent techniques, such as microfiltration, nanofiltration membrane and nanotechnology. - Explains the latest research in detection, treatment processes and remediation technologies - Includes sampling, analytical and characterization methods and approaches - Covers cutting-edge research, including membrane based technologies, nanotechnology treatment technologies and bioremediation treatment technologies - Provides background information regarding contamination sources
Download or read book Some Drinking water Disinfectants and Contaminants Including Arsenic written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of 23 experts from 13 countries met in Lyon to evaluate the evidence for carcinogenicity of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The working group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX). High-level exposure to arsenic in drinking-water occurs in some regions such as China, Latin America, Bangladesh and West Bengal. The Working Group reviewed epidemiological studies of human cancer (mainly ecological studies in Taiwan and Chile, and several case-control and cohort studies) in relation to arsenic in drinking-water. Arsenic in drinking-water (primarily inorganic, as arsenate and to a lesser extent arsenite) was evaluated as carcinogenic to humans (Group 1) on the basis of sufficient evidence for an increased risk for cancer of the urinary bladder, lung and skin. Studies on inorganic arsenic in experimental animals provided limited evidence for its carcinogenicity, but sufficient evidence was found in experimental animals for the carcinogenicity of dimethylarsinic acid (an organic form of arsenic), which produced urinary bladder tumours in rats and lung tumours in mice after oral administration.
Download or read book Encyclopedia of Environmental Health written by and published by Elsevier. This book was released on 2019-08-22 with total page 4896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Environmental Health, Second Edition, Six Volume Set presents the newest release in this fundamental reference that updates and broadens the umbrella of environmental health, especially social and environmental health for its readers. There is ongoing revolution in governance, policies and intervention strategies aimed at evolving changes in health disparities, disease burden, trans-boundary transport and health hazards. This new edition reflects these realities, mapping new directions in the field that include how to minimize threats and develop new scientific paradigms that address emerging local, national and global environmental concerns. Represents a one-stop resource for scientifically reliable information on environmental health Fills a critical gap, with information on one of the most rapidly growing scientific fields of our time Provides comparative approaches to environmental health practice and research in different countries and regions of the world Covers issues behind specific questions and describes the best available scientific methods for environmental risk assessment
Download or read book Disinfection By Products and Human Health written by Steve E. Hrudey and published by IWA Publishing. This book was released on 2012-04-30 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection By-Products and Human Health is based on contributions from speakers who participated in May 2011 workshops on Disinfection By-Products (DBPs) and Human Health at Ozwater 11 in Adelaide, Australia or at an AWA sponsored workshop at the Curtin Water Quality Research Centre, Perth, Australia. The contributions are prepared to facilitate communication with practitioners, rather than researchers, making use of overview illustrations rather than dense text or data tables. Each chapter concludes with up to 5 key findings that are take-home messages for practitioners. Disinfection By-Products and Human Health is aimed specifically at drinking water professionals (engineers, chemists and public health professionals) working on the front lines of drinking water issues where they must encounter actual day-to-day issues of risk management concerning DBPs in relation to all the other regulatory and water quality issues they must manage. Although a topic this complex is certainly not amenable to simplistic explanations, this book aims to provide drinking water professionals with a pragmatic assessment of the current evidence and emerging issues concerning DBPs and public health. Disinfection By-Products and Human Health is an essential, practical and accessible guide for drinking water professionals, engineers, chemists and public health professionals. Editors: Steve E. Hrudey, Professor Emeritus, Analytical & Environmental Toxicology, University of Alberta, Canada, Jeffrey W.A. Charrois, Director and Associate Professor, Curtin Water Quality Research Centre, Curtin University of Technology, Australia, Steve Hrudey is professor emeritus in analytical and environmental toxicology in the University of Alberta's Faculty of Medicine & Dentistry. He spent 13 years as a cabinet-appointed member of the Alberta Environmental Appeals Board, the last four as chair, and was the first non-lawyer to hold this position. During this period, he served on 36 public hearing panels, 19 as chair of the panel. In addition he has testified before senate committees in Canada and the Legislative Council in Western Australia. Hrudey has served on a number of high-profile expert panels, including the Research Advisory Panel to the Walkerton Inquiry (2000-2002), the Expert Panel on Safe Drinking Water for First Nations (2006), the Technical Advisory Committee to the B.C. Minister of Health on turbidity and microbial risk in drinking water (2007-2008, as chair), the Expert Advisory Panel on Water Quality for Washington, D.C., to the U.S. Army Corps of Engineers (2009-2011) and chair of the Royal Society of Canada Expert Panel on Environmental and Health Impacts of Canada's Oil Sands Industry (2009-2010). He has also co-authored or edited nine books, including the widely acclaimed book inspired by the Walkerton tragedy: Safe Drinking Water - Lessons from Recent Outbreaks in Affluent Nations (IWA Publishing, 2004). He has written 26 book chapters, 19 expert panel reports, 163 refereed journal articles, 15 science discussions, six media op-eds and 73 conference proceeding papers. Hrudey is the 2012 winner of the American Water Works Association A.P. Black Research Award for contributions to water science and water supply. This book is sponsored by Australian Water Association (AWA)
Download or read book Advances in Toxicology and Risk Assessment of Nanomaterials and Emerging Contaminants written by Liang-Hong Guo and published by Springer Nature. This book was released on 2022-03-11 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the state-of-the-art methodological advances for delineating the toxicology and working mechanisms of nanomaterials, microplastics, fine aerosol particulates (PM2.5) as well as emerging organic pollutants. It also provides latest computational approaches for toxicity prediction and risk assessment of nanoscale materials which possess realistic chances to enter the environment and human organism. Written by leading scientists at the frontiers of environmental science and nanomedicine, this book is intended for both young researchers and experienced professionals working in the fields of environmental protection, human health and occupational safety, nanotechnology, material science and nanomedicine, as well as graduate students majoring in environmental and health sciences.
Download or read book Bioanalytical Tools in Water Quality Assessment written by Beate Escher and published by IWA Publishing. This book was released on 2011-12-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen
Download or read book Disinfection By products in Drinking Water written by M.N.V. Prasad and published by Butterworth-Heinemann. This book was released on 2020-03-06 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection Byproducts in Drinking Water: Detection and Treatment presents cutting-edge research on how to understand the procedures, processes and considerations for detecting and treating disinfection by-products from drinking water, swimming pool water, and wastewater. The book begins with an overview of the different groups of Disinfection Byproducts (DBPs), such as: Trihalomethanes (THM), Halo acetic acids, and Haloacetonitrile (HAN). This coverage is quickly followed by a clear and rigorous exposition of the latest methods and technologies for the characterization, occurrence, formation, transformation and removal of DBPs in drinking water. Other chapters focus on ultraviolet-visible spectroscopy, electron spin resonance, and gas chromatography-mass spectrometry. Researchers will find a valuable resource to a breath of topics for DBP detection and treatment, including various recent techniques, such as microfiltration, nanofiltration membrane and nanotechnology. Explains the latest research in detection, treatment processes and remediation technologies Includes sampling, analytical and characterization methods and approaches Covers cutting-edge research, including membrane based technologies, nanotechnology treatment technologies and bioremediation treatment technologies Provides background information regarding contamination sources
Download or read book Fluoride in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2007-01-22 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.
